메뉴 건너뛰기




Volumn 38, Issue 1, 2010, Pages 200-207

Tamoxifen-induced adduct formation and cell stress in human endometrial glands

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CHAPERONE; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; GLUCOSE REGULATING PROTEIN 78; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REGULATOR PROTEIN; SULFOTRANSFERASE; SULFOTRANSFERASE 2A1; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 73149095813     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.029488     Document Type: Article
Times cited : (19)

References (40)
  • 1
    • 0032555775 scopus 로고    scopus 로고
    • Localization of cytochrome P4501A1 and covalent binding of a mutagenic heterocyclic amine in blood vessel endothelia of rodents
    • Annas A and Brittebo EB (1998) Localization of cytochrome P4501A1 and covalent binding of a mutagenic heterocyclic amine in blood vessel endothelia of rodents. Toxicology 129:145-156.
    • (1998) Toxicology , vol.129 , pp. 145-156
    • Annas, A.1    Brittebo, E.B.2
  • 3
    • 0030827474 scopus 로고    scopus 로고
    • Cell- and tissue-specific metabolic activation of chemicals as determined by autoradiography: In vitro-in vivo correlations
    • Brittebo EB and Brandt I (1997) Cell- and tissue-specific metabolic activation of chemicals as determined by autoradiography: in vitro-in vivo correlations. Toxicol In Vitro 11:417-421.
    • (1997) Toxicol In Vitro , vol.11 , pp. 417-421
    • Brittebo, E.B.1    Brandt, I.2
  • 5
    • 0033981437 scopus 로고    scopus 로고
    • Mosaic characteristics of human endometrial epithelium in vitro: Analysis of secretory markers and cell surface ultrastructure
    • Campbell S, Larsen J, Seif MW, Allen TD, Knox F, Jones CJ, and Aplin JD (2000) Mosaic characteristics of human endometrial epithelium in vitro: analysis of secretory markers and cell surface ultrastructure. Mol Hum Reprod 6:41-49.
    • (2000) Mol Hum Reprod , vol.6 , pp. 41-49
    • Campbell, S.1    Larsen, J.2    Seif, M.W.3    Allen, T.D.4    Knox, F.5    Jones, C.J.6    Aplin, J.D.7
  • 9
    • 0029866506 scopus 로고    scopus 로고
    • Evidence that the catechol 3,4-dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins
    • Dehal SS and Kupfer D (1996) Evidence that the catechol 3,4-dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins. Cancer Res 56:1283-1290.
    • (1996) Cancer Res , vol.56 , pp. 1283-1290
    • Dehal, S.S.1    Kupfer, D.2
  • 10
    • 0033017135 scopus 로고    scopus 로고
    • Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: Involvement of catechols in covalent binding to hepatic proteins
    • Dehal SS and Kupfer D (1999) Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. Drug Metab Dispos 27:681-688.
    • (1999) Drug Metab Dispos , vol.27 , pp. 681-688
    • Dehal, S.S.1    Kupfer, D.2
  • 11
    • 4243063941 scopus 로고    scopus 로고
    • Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6
    • Desta Z, Ward BA, Soukhova NV, and Flockhart DA (2004) Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther 310:1062-1075.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 1062-1075
    • Desta, Z.1    Ward, B.A.2    Soukhova, N.V.3    Flockhart, D.A.4
  • 12
    • 0034931645 scopus 로고    scopus 로고
    • From adjuvant therapy to breast cancer prevention: BCPT and STAR
    • Dunn BK and Ford LG (2001) From adjuvant therapy to breast cancer prevention: BCPT and STAR. Breast J 7:144-157.
    • (2001) Breast J , vol.7 , pp. 144-157
    • Dunn, B.K.1    Ford, L.G.2
  • 13
    • 0024791035 scopus 로고
    • Phenol red mimics biological actions of estradiol: Enhancement of osteoblast proliferation in vitro and of type I collagen gene expression in bone and uterus of rats in vivo
    • Ernst M, Schmid C, and Froesch ER (1989) Phenol red mimics biological actions of estradiol: enhancement of osteoblast proliferation in vitro and of type I collagen gene expression in bone and uterus of rats in vivo. J Steroid Biochem 33:907-914.
    • (1989) J Steroid Biochem , vol.33 , pp. 907-914
    • Ernst, M.1    Schmid, C.2    Froesch, E.R.3
  • 14
    • 26944503023 scopus 로고    scopus 로고
    • Toxicant-induced ER-stress and caspase activation in the olfactory mucosa
    • Franzén A and Brittebo EB (2005) Toxicant-induced ER-stress and caspase activation in the olfactory mucosa. Arch Toxicol 79:561-570.
    • (2005) Arch Toxicol , vol.79 , pp. 561-570
    • Franzén, A.1    Brittebo, E.B.2
  • 15
    • 29144496090 scopus 로고    scopus 로고
    • Tamoxifen treatment for breast cancer enforces a distinct gene-expression profile on the human endometrium: An exploratory study
    • Gielen SC, Kühne LC, Ewing PC, Blok LJ, and Burger CW (2005) Tamoxifen treatment for breast cancer enforces a distinct gene-expression profile on the human endometrium: an exploratory study. Endocr Relat Cancer 12:1037-1049.
    • (2005) Endocr Relat Cancer , vol.12 , pp. 1037-1049
    • Gielen, S.C.1    Kühne, L.C.2    Ewing, P.C.3    Blok, L.J.4    Burger, C.W.5
  • 16
    • 0037372835 scopus 로고    scopus 로고
    • CYP1A1 and CYP1B1 in blood-brain interfaces: CYP1A1-dependent bioactivation of 7,12-dimethylbenz(a)anthracene in endothelial cells
    • Granberg L, Ostergren A, Brandt I, and Brittebo EB (2003) CYP1A1 and CYP1B1 in blood-brain interfaces: CYP1A1-dependent bioactivation of 7,12-dimethylbenz(a)anthracene in endothelial cells. Drug Metab Dispos 31:259-265.
    • (2003) Drug Metab Dispos , vol.31 , pp. 259-265
    • Granberg, L.1    Ostergren, A.2    Brandt, I.3    Brittebo, E.B.4
  • 17
    • 0027201501 scopus 로고
    • Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats
    • Greaves P, Goonetilleke R, Nunn G, Topham J, and Orton T (1993) Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. Cancer Res 53:3919-3924.
    • (1993) Cancer Res , vol.53 , pp. 3919-3924
    • Greaves, P.1    Goonetilleke, R.2    Nunn, G.3    Topham, J.4    Orton, T.5
  • 19
    • 0029745072 scopus 로고    scopus 로고
    • Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients
    • Hemminki K, Rajaniemi H, Lindahl B, and Moberger B (1996) Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients. Cancer Res 56:4374-4377.
    • (1996) Cancer Res , vol.56 , pp. 4374-4377
    • Hemminki, K.1    Rajaniemi, H.2    Lindahl, B.3    Moberger, B.4
  • 22
    • 0018199702 scopus 로고
    • The distribution of [14C]dimethylnitrosamine in mice. Autoradiographic studies in mice with inhibited and noninhibited dimethylnitrosamine metabolism and a comparison with the distribution of [14C]formaldehyde
    • Johansson EB and Tjälve H (1978) The distribution of [14C]dimethylnitrosamine in mice. Autoradiographic studies in mice with inhibited and noninhibited dimethylnitrosamine metabolism and a comparison with the distribution of [14C]formaldehyde. Toxicol Appl Pharmacol 45:565-575.
    • (1978) Toxicol Appl Pharmacol , vol.45 , pp. 565-575
    • Johansson, E.B.1    Tjälve, H.2
  • 23
    • 27544464442 scopus 로고    scopus 로고
    • Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers
    • Kim SY, Laxmi YR, Suzuki N, Ogura K, Watabe T, Duffel MW, and Shibutani S (2005a) Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers. Drug Metab Dispos 33:1673-1678.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1673-1678
    • Kim, S.Y.1    Laxmi, Y.R.2    Suzuki, N.3    Ogura, K.4    Watabe, T.5    Duffel, M.W.6    Shibutani, S.7
  • 25
    • 3042653655 scopus 로고    scopus 로고
    • Genotoxic mechanism of tamoxifen in developing endometrial cancer
    • Kim SY, Suzuki N, Laxmi YR, and Shibutani S (2004) Genotoxic mechanism of tamoxifen in developing endometrial cancer. Drug Metab Rev 36:199-218.
    • (2004) Drug Metab Rev , vol.36 , pp. 199-218
    • Kim, S.Y.1    Suzuki, N.2    Laxmi, Y.R.3    Shibutani, S.4
  • 26
    • 0036234436 scopus 로고    scopus 로고
    • Apoptosis and apoptosis-associated parameters in relation to tamoxifen exposure in postmenopausal endometrium
    • Mourits MJ, Hollema H, De Vries EG, Ten Hoor KA, Willemse PH, and Van Der Zee AG (2002) Apoptosis and apoptosis-associated parameters in relation to tamoxifen exposure in postmenopausal endometrium. Hum Pathol 33:341-346.
    • (2002) Hum Pathol , vol.33 , pp. 341-346
    • Mourits, M.J.1    Hollema, H.2    De Vries, E.G.3    Ten Hoor, K.A.4    Willemse, P.H.5    Van Der Zee, A.G.6
  • 27
    • 27144459972 scopus 로고    scopus 로고
    • Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives
    • Notley LM, Crewe KH, Taylor PJ, Lennard MS, and Gillam EM (2005) Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives. Chem Res Toxicol 18:1611-1618.
    • (2005) Chem Res Toxicol , vol.18 , pp. 1611-1618
    • Notley, L.M.1    Crewe, K.H.2    Taylor, P.J.3    Lennard, M.S.4    Gillam, E.M.5
  • 28
    • 0029588524 scopus 로고
    • The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity
    • Park BK, Pirmohamed M, and Kitteringham NR (1995) The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity. Pharmacol Ther 68:385-424.
    • (1995) Pharmacol Ther , vol.68 , pp. 385-424
    • Park, B.K.1    Pirmohamed, M.2    Kitteringham, N.R.3
  • 30
    • 24044434878 scopus 로고    scopus 로고
    • Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: Implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment
    • Phillips DH, Hewer A, Osborne MR, Cole KJ, Churchill C, and Arlt VM (2005) Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment. Mutagenesis 20:297-303.
    • (2005) Mutagenesis , vol.20 , pp. 297-303
    • Phillips, D.H.1    Hewer, A.2    Osborne, M.R.3    Cole, K.J.4    Churchill, C.5    Arlt, V.M.6
  • 31
    • 10044264513 scopus 로고    scopus 로고
    • Gene expression changes induced by estrogen and selective estrogen receptor modulators in primary-cultured human endometrial cells: Signals that distinguish the human carcinogen tamoxifen
    • Pole JC, Gold LI, Orton T, Huby R, and Carmichael PL (2005) Gene expression changes induced by estrogen and selective estrogen receptor modulators in primary-cultured human endometrial cells: signals that distinguish the human carcinogen tamoxifen. Toxicology 206:91-109.
    • (2005) Toxicology , vol.206 , pp. 91-109
    • Pole, J.C.1    Gold, L.I.2    Orton, T.3    Huby, R.4    Carmichael, P.L.5
  • 32
    • 33746631295 scopus 로고    scopus 로고
    • Bip is a molecular link between the phase I and phase II estrogenic responses in uterus
    • Ray S, Hou X, Zhou HE, Wang H, and Das SK (2006) Bip is a molecular link between the phase I and phase II estrogenic responses in uterus. Mol Endocrinol 20:1825-1837.
    • (2006) Mol Endocrinol , vol.20 , pp. 1825-1837
    • Ray, S.1    Hou, X.2    Zhou, H.E.3    Wang, H.4    Das, S.K.5
  • 33
    • 0032748919 scopus 로고    scopus 로고
    • Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy
    • Rubin GL, Harrold AJ, Mills JA, Falany CN, and Coughtrie MW (1999) Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy. Mol Hum Reprod 5:995-1002.
    • (1999) Mol Hum Reprod , vol.5 , pp. 995-1002
    • Rubin, G.L.1    Harrold, A.J.2    Mills, J.A.3    Falany, C.N.4    Coughtrie, M.W.5
  • 34
    • 33646371740 scopus 로고    scopus 로고
    • Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis
    • Shang Y (2006) Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis. Nat Rev Cancer 6:360-368.
    • (2006) Nat Rev Cancer , vol.6 , pp. 360-368
    • Shang, Y.1
  • 38
    • 0031721571 scopus 로고    scopus 로고
    • Sulfation of alpha-hydroxytamoxifen catalyzed by human hydroxysteroid sulfotransferase results in tamoxifen-DNA adducts
    • Shibutani S, Shaw PM, Suzuki N, Dasaradhi L, Duffel MW, and Terashima I (1998) Sulfation of alpha-hydroxytamoxifen catalyzed by human hydroxysteroid sulfotransferase results in tamoxifen-DNA adducts. Carcinogenesis 19:2007-2011.
    • (1998) Carcinogenesis , vol.19 , pp. 2007-2011
    • Shibutani, S.1    Shaw, P.M.2    Suzuki, N.3    Dasaradhi, L.4    Duffel, M.W.5    Terashima, I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.