-
1
-
-
0032555775
-
Localization of cytochrome P4501A1 and covalent binding of a mutagenic heterocyclic amine in blood vessel endothelia of rodents
-
Annas A and Brittebo EB (1998) Localization of cytochrome P4501A1 and covalent binding of a mutagenic heterocyclic amine in blood vessel endothelia of rodents. Toxicology 129:145-156.
-
(1998)
Toxicology
, vol.129
, pp. 145-156
-
-
Annas, A.1
Brittebo, E.B.2
-
2
-
-
2942741026
-
Analysis of tamoxifen-DNA adducts in endometrial explants by MS and 32P-postlabeling
-
Beland FA, Churchwell MI, Hewer A, Phillips DH, da Costa GG, and Marques MM (2004) Analysis of tamoxifen-DNA adducts in endometrial explants by MS and 32P-postlabeling. Biochem Biophys Res Commun 320:297-302.
-
(2004)
Biochem Biophys Res Commun
, vol.320
, pp. 297-302
-
-
Beland, F.A.1
Churchwell, M.I.2
Hewer, A.3
Phillips, D.H.4
da Costa, G.G.5
Marques, M.M.6
-
3
-
-
0030827474
-
Cell- and tissue-specific metabolic activation of chemicals as determined by autoradiography: In vitro-in vivo correlations
-
Brittebo EB and Brandt I (1997) Cell- and tissue-specific metabolic activation of chemicals as determined by autoradiography: in vitro-in vivo correlations. Toxicol In Vitro 11:417-421.
-
(1997)
Toxicol In Vitro
, vol.11
, pp. 417-421
-
-
Brittebo, E.B.1
Brandt, I.2
-
4
-
-
56749178706
-
Cell death and autophagy: Cytokines, drugs, and nutritional factors
-
Bursch W, Karwan A, Mayer M, Dornetshuber J, Fröhwein U, Schulte-Hermann R, Fazi B, Di Sano F, Piredda L, Piacentini M, et al. (2008) Cell death and autophagy: cytokines, drugs, and nutritional factors. Toxicology 254:147-157.
-
(2008)
Toxicology
, vol.254
, pp. 147-157
-
-
Bursch, W.1
Karwan, A.2
Mayer, M.3
Dornetshuber, J.4
Fröhwein, U.5
Schulte-Hermann, R.6
Fazi, B.7
Di Sano, F.8
Piredda, L.9
Piacentini, M.10
-
5
-
-
0033981437
-
Mosaic characteristics of human endometrial epithelium in vitro: Analysis of secretory markers and cell surface ultrastructure
-
Campbell S, Larsen J, Seif MW, Allen TD, Knox F, Jones CJ, and Aplin JD (2000) Mosaic characteristics of human endometrial epithelium in vitro: analysis of secretory markers and cell surface ultrastructure. Mol Hum Reprod 6:41-49.
-
(2000)
Mol Hum Reprod
, vol.6
, pp. 41-49
-
-
Campbell, S.1
Larsen, J.2
Seif, M.W.3
Allen, T.D.4
Knox, F.5
Jones, C.J.6
Aplin, J.D.7
-
6
-
-
0032930665
-
Lack of evidence from HPLC 32P-post-labelling for tamoxifen-DNA adducts in the human endometrium
-
Carmichael PL, Sardar S, Crooks N, Neven P, Van Hoof I, Ugwumadu A, Bourne T, Tomas E, Hellberg P, Hewer AJ, et al. (1999) Lack of evidence from HPLC 32P-post-labelling for tamoxifen-DNA adducts in the human endometrium. Carcinogenesis 20:339-342.
-
(1999)
Carcinogenesis
, vol.20
, pp. 339-342
-
-
Carmichael, P.L.1
Sardar, S.2
Crooks, N.3
Neven, P.4
Van Hoof, I.5
Ugwumadu, A.6
Bourne, T.7
Tomas, E.8
Hellberg, P.9
Hewer, A.J.10
-
7
-
-
0029978834
-
Lack of genotoxicity of tamoxifen in human endometrium
-
Carmichael PL, Ugwumadu AH, Neven P, Hewer AJ, Poon GK, and Phillips DH (1996) Lack of genotoxicity of tamoxifen in human endometrium. Cancer Res 56:1475-1479.
-
(1996)
Cancer Res
, vol.56
, pp. 1475-1479
-
-
Carmichael, P.L.1
Ugwumadu, A.H.2
Neven, P.3
Hewer, A.J.4
Poon, G.K.5
Phillips, D.H.6
-
9
-
-
0029866506
-
Evidence that the catechol 3,4-dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins
-
Dehal SS and Kupfer D (1996) Evidence that the catechol 3,4-dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins. Cancer Res 56:1283-1290.
-
(1996)
Cancer Res
, vol.56
, pp. 1283-1290
-
-
Dehal, S.S.1
Kupfer, D.2
-
10
-
-
0033017135
-
Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: Involvement of catechols in covalent binding to hepatic proteins
-
Dehal SS and Kupfer D (1999) Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. Drug Metab Dispos 27:681-688.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 681-688
-
-
Dehal, S.S.1
Kupfer, D.2
-
11
-
-
4243063941
-
Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6
-
Desta Z, Ward BA, Soukhova NV, and Flockhart DA (2004) Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther 310:1062-1075.
-
(2004)
J Pharmacol Exp Ther
, vol.310
, pp. 1062-1075
-
-
Desta, Z.1
Ward, B.A.2
Soukhova, N.V.3
Flockhart, D.A.4
-
12
-
-
0034931645
-
From adjuvant therapy to breast cancer prevention: BCPT and STAR
-
Dunn BK and Ford LG (2001) From adjuvant therapy to breast cancer prevention: BCPT and STAR. Breast J 7:144-157.
-
(2001)
Breast J
, vol.7
, pp. 144-157
-
-
Dunn, B.K.1
Ford, L.G.2
-
13
-
-
0024791035
-
Phenol red mimics biological actions of estradiol: Enhancement of osteoblast proliferation in vitro and of type I collagen gene expression in bone and uterus of rats in vivo
-
Ernst M, Schmid C, and Froesch ER (1989) Phenol red mimics biological actions of estradiol: enhancement of osteoblast proliferation in vitro and of type I collagen gene expression in bone and uterus of rats in vivo. J Steroid Biochem 33:907-914.
-
(1989)
J Steroid Biochem
, vol.33
, pp. 907-914
-
-
Ernst, M.1
Schmid, C.2
Froesch, E.R.3
-
14
-
-
26944503023
-
Toxicant-induced ER-stress and caspase activation in the olfactory mucosa
-
Franzén A and Brittebo EB (2005) Toxicant-induced ER-stress and caspase activation in the olfactory mucosa. Arch Toxicol 79:561-570.
-
(2005)
Arch Toxicol
, vol.79
, pp. 561-570
-
-
Franzén, A.1
Brittebo, E.B.2
-
15
-
-
29144496090
-
Tamoxifen treatment for breast cancer enforces a distinct gene-expression profile on the human endometrium: An exploratory study
-
Gielen SC, Kühne LC, Ewing PC, Blok LJ, and Burger CW (2005) Tamoxifen treatment for breast cancer enforces a distinct gene-expression profile on the human endometrium: an exploratory study. Endocr Relat Cancer 12:1037-1049.
-
(2005)
Endocr Relat Cancer
, vol.12
, pp. 1037-1049
-
-
Gielen, S.C.1
Kühne, L.C.2
Ewing, P.C.3
Blok, L.J.4
Burger, C.W.5
-
16
-
-
0037372835
-
CYP1A1 and CYP1B1 in blood-brain interfaces: CYP1A1-dependent bioactivation of 7,12-dimethylbenz(a)anthracene in endothelial cells
-
Granberg L, Ostergren A, Brandt I, and Brittebo EB (2003) CYP1A1 and CYP1B1 in blood-brain interfaces: CYP1A1-dependent bioactivation of 7,12-dimethylbenz(a)anthracene in endothelial cells. Drug Metab Dispos 31:259-265.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 259-265
-
-
Granberg, L.1
Ostergren, A.2
Brandt, I.3
Brittebo, E.B.4
-
17
-
-
0027201501
-
Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats
-
Greaves P, Goonetilleke R, Nunn G, Topham J, and Orton T (1993) Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. Cancer Res 53:3919-3924.
-
(1993)
Cancer Res
, vol.53
, pp. 3919-3924
-
-
Greaves, P.1
Goonetilleke, R.2
Nunn, G.3
Topham, J.4
Orton, T.5
-
18
-
-
59849129827
-
Endometrial cytologic findings in tamoxifen-treated breast cancer patients
-
Hachisuga T, Emoto M, Kawarabayashi T, Kamihara Y, and Nabeshima K (2009) Endometrial cytologic findings in tamoxifen-treated breast cancer patients. Acta Cytol 53:24-28.
-
(2009)
Acta Cytol
, vol.53
, pp. 24-28
-
-
Hachisuga, T.1
Emoto, M.2
Kawarabayashi, T.3
Kamihara, Y.4
Nabeshima, K.5
-
19
-
-
0029745072
-
Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients
-
Hemminki K, Rajaniemi H, Lindahl B, and Moberger B (1996) Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients. Cancer Res 56:4374-4377.
-
(1996)
Cancer Res
, vol.56
, pp. 4374-4377
-
-
Hemminki, K.1
Rajaniemi, H.2
Lindahl, B.3
Moberger, B.4
-
20
-
-
0031882874
-
Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium
-
Hukkanen J, Mäntylä M, Kangas L, Wirta P, Hakkola J, Paakki P, Evisalmi S, Pelkonen O, and Raunio H (1998) Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium. Pharmacol Toxicol 82:93-97.
-
(1998)
Pharmacol Toxicol
, vol.82
, pp. 93-97
-
-
Hukkanen, J.1
Mäntylä, M.2
Kangas, L.3
Wirta, P.4
Hakkola, J.5
Paakki, P.6
Evisalmi, S.7
Pelkonen, O.8
Raunio, H.9
-
21
-
-
19944434201
-
CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
-
Jin Y, Desta Z, Stearns V, Ward B, Ho H, Lee KH, Skaar T, Storniolo AM, Li L, Araba A, et al. (2005) CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst 97:30-39.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 30-39
-
-
Jin, Y.1
Desta, Z.2
Stearns, V.3
Ward, B.4
Ho, H.5
Lee, K.H.6
Skaar, T.7
Storniolo, A.M.8
Li, L.9
Araba, A.10
-
22
-
-
0018199702
-
The distribution of [14C]dimethylnitrosamine in mice. Autoradiographic studies in mice with inhibited and noninhibited dimethylnitrosamine metabolism and a comparison with the distribution of [14C]formaldehyde
-
Johansson EB and Tjälve H (1978) The distribution of [14C]dimethylnitrosamine in mice. Autoradiographic studies in mice with inhibited and noninhibited dimethylnitrosamine metabolism and a comparison with the distribution of [14C]formaldehyde. Toxicol Appl Pharmacol 45:565-575.
-
(1978)
Toxicol Appl Pharmacol
, vol.45
, pp. 565-575
-
-
Johansson, E.B.1
Tjälve, H.2
-
23
-
-
27544464442
-
Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers
-
Kim SY, Laxmi YR, Suzuki N, Ogura K, Watabe T, Duffel MW, and Shibutani S (2005a) Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers. Drug Metab Dispos 33:1673-1678.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 1673-1678
-
-
Kim, S.Y.1
Laxmi, Y.R.2
Suzuki, N.3
Ogura, K.4
Watabe, T.5
Duffel, M.W.6
Shibutani, S.7
-
24
-
-
18944400868
-
Formation of tamoxifen-DNA adducts in human endometrial explants exposed to alpha-hydroxytamoxifen
-
Kim SY, Suzuki N, Laxmi YR, McGarrigle BP, Olson JR, Sharma M, Sharma M, and Shibutani S (2005b) Formation of tamoxifen-DNA adducts in human endometrial explants exposed to alpha-hydroxytamoxifen. Chem Res Toxicol 18:889-895.
-
(2005)
Chem Res Toxicol
, vol.18
, pp. 889-895
-
-
Kim, S.Y.1
Suzuki, N.2
Laxmi, Y.R.3
McGarrigle, B.P.4
Olson, J.R.5
Sharma, M.6
Sharma, M.7
Shibutani, S.8
-
25
-
-
3042653655
-
Genotoxic mechanism of tamoxifen in developing endometrial cancer
-
Kim SY, Suzuki N, Laxmi YR, and Shibutani S (2004) Genotoxic mechanism of tamoxifen in developing endometrial cancer. Drug Metab Rev 36:199-218.
-
(2004)
Drug Metab Rev
, vol.36
, pp. 199-218
-
-
Kim, S.Y.1
Suzuki, N.2
Laxmi, Y.R.3
Shibutani, S.4
-
26
-
-
0036234436
-
Apoptosis and apoptosis-associated parameters in relation to tamoxifen exposure in postmenopausal endometrium
-
Mourits MJ, Hollema H, De Vries EG, Ten Hoor KA, Willemse PH, and Van Der Zee AG (2002) Apoptosis and apoptosis-associated parameters in relation to tamoxifen exposure in postmenopausal endometrium. Hum Pathol 33:341-346.
-
(2002)
Hum Pathol
, vol.33
, pp. 341-346
-
-
Mourits, M.J.1
Hollema, H.2
De Vries, E.G.3
Ten Hoor, K.A.4
Willemse, P.H.5
Van Der Zee, A.G.6
-
27
-
-
27144459972
-
Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives
-
Notley LM, Crewe KH, Taylor PJ, Lennard MS, and Gillam EM (2005) Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives. Chem Res Toxicol 18:1611-1618.
-
(2005)
Chem Res Toxicol
, vol.18
, pp. 1611-1618
-
-
Notley, L.M.1
Crewe, K.H.2
Taylor, P.J.3
Lennard, M.S.4
Gillam, E.M.5
-
28
-
-
0029588524
-
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity
-
Park BK, Pirmohamed M, and Kitteringham NR (1995) The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity. Pharmacol Ther 68:385-424.
-
(1995)
Pharmacol Ther
, vol.68
, pp. 385-424
-
-
Park, B.K.1
Pirmohamed, M.2
Kitteringham, N.R.3
-
29
-
-
0032883218
-
N-demethylation accompanies alpha-hydroxylation in the metabolic activation of tamoxifen in rat liver cells
-
Phillips DH, Hewer A, Horton MN, Cole KJ, Carmichael PL, Davis W, and Osborne MR (1999) N-demethylation accompanies alpha-hydroxylation in the metabolic activation of tamoxifen in rat liver cells. Carcinogenesis 20:2003-2009.
-
(1999)
Carcinogenesis
, vol.20
, pp. 2003-2009
-
-
Phillips, D.H.1
Hewer, A.2
Horton, M.N.3
Cole, K.J.4
Carmichael, P.L.5
Davis, W.6
Osborne, M.R.7
-
30
-
-
24044434878
-
Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: Implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment
-
Phillips DH, Hewer A, Osborne MR, Cole KJ, Churchill C, and Arlt VM (2005) Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment. Mutagenesis 20:297-303.
-
(2005)
Mutagenesis
, vol.20
, pp. 297-303
-
-
Phillips, D.H.1
Hewer, A.2
Osborne, M.R.3
Cole, K.J.4
Churchill, C.5
Arlt, V.M.6
-
31
-
-
10044264513
-
Gene expression changes induced by estrogen and selective estrogen receptor modulators in primary-cultured human endometrial cells: Signals that distinguish the human carcinogen tamoxifen
-
Pole JC, Gold LI, Orton T, Huby R, and Carmichael PL (2005) Gene expression changes induced by estrogen and selective estrogen receptor modulators in primary-cultured human endometrial cells: signals that distinguish the human carcinogen tamoxifen. Toxicology 206:91-109.
-
(2005)
Toxicology
, vol.206
, pp. 91-109
-
-
Pole, J.C.1
Gold, L.I.2
Orton, T.3
Huby, R.4
Carmichael, P.L.5
-
32
-
-
33746631295
-
Bip is a molecular link between the phase I and phase II estrogenic responses in uterus
-
Ray S, Hou X, Zhou HE, Wang H, and Das SK (2006) Bip is a molecular link between the phase I and phase II estrogenic responses in uterus. Mol Endocrinol 20:1825-1837.
-
(2006)
Mol Endocrinol
, vol.20
, pp. 1825-1837
-
-
Ray, S.1
Hou, X.2
Zhou, H.E.3
Wang, H.4
Das, S.K.5
-
33
-
-
0032748919
-
Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy
-
Rubin GL, Harrold AJ, Mills JA, Falany CN, and Coughtrie MW (1999) Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy. Mol Hum Reprod 5:995-1002.
-
(1999)
Mol Hum Reprod
, vol.5
, pp. 995-1002
-
-
Rubin, G.L.1
Harrold, A.J.2
Mills, J.A.3
Falany, C.N.4
Coughtrie, M.W.5
-
34
-
-
33646371740
-
Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis
-
Shang Y (2006) Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis. Nat Rev Cancer 6:360-368.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 360-368
-
-
Shang, Y.1
-
35
-
-
0345724797
-
Biotransformation of tamoxifen in a human endometrial explant culture model
-
Sharma M, Shubert DE, Sharma M, Lewis J, McGarrigle BP, Bofinger DP, and Olson JR (2003a) Biotransformation of tamoxifen in a human endometrial explant culture model. Chem Biol Interact 146:237-249.
-
(2003)
Chem Biol Interact
, vol.146
, pp. 237-249
-
-
Sharma, M.1
Shubert, D.E.2
Sharma, M.3
Lewis, J.4
McGarrigle, B.P.5
Bofinger, D.P.6
Olson, J.R.7
-
36
-
-
0038387788
-
Antioxidant inhibits tamoxifen-DNA adducts in endometrial explant culture
-
Sharma M, Shubert DE, Sharma M, Rodabaugh KJ, McGarrigle BP, Vezina CM, Bofinger DP, and Olson JR (2003b) Antioxidant inhibits tamoxifen-DNA adducts in endometrial explant culture. Biochem Biophys Res Commun 307:157-164.
-
(2003)
Biochem Biophys Res Commun
, vol.307
, pp. 157-164
-
-
Sharma, M.1
Shubert, D.E.2
Sharma, M.3
Rodabaugh, K.J.4
McGarrigle, B.P.5
Vezina, C.M.6
Bofinger, D.P.7
Olson, J.R.8
-
37
-
-
0033859582
-
Identification of tamoxifen-DNA adducts in the endometrium of women treated with tamoxifen
-
Shibutani S, Ravindernath A, Suzuki N, Terashima I, Sugarman SM, Grollman AP, and Pearl ML (2000) Identification of tamoxifen-DNA adducts in the endometrium of women treated with tamoxifen. Carcinogenesis 21:1461-1467.
-
(2000)
Carcinogenesis
, vol.21
, pp. 1461-1467
-
-
Shibutani, S.1
Ravindernath, A.2
Suzuki, N.3
Terashima, I.4
Sugarman, S.M.5
Grollman, A.P.6
Pearl, M.L.7
-
38
-
-
0031721571
-
Sulfation of alpha-hydroxytamoxifen catalyzed by human hydroxysteroid sulfotransferase results in tamoxifen-DNA adducts
-
Shibutani S, Shaw PM, Suzuki N, Dasaradhi L, Duffel MW, and Terashima I (1998) Sulfation of alpha-hydroxytamoxifen catalyzed by human hydroxysteroid sulfotransferase results in tamoxifen-DNA adducts. Carcinogenesis 19:2007-2011.
-
(1998)
Carcinogenesis
, vol.19
, pp. 2007-2011
-
-
Shibutani, S.1
Shaw, P.M.2
Suzuki, N.3
Dasaradhi, L.4
Duffel, M.W.5
Terashima, I.6
-
39
-
-
44649149538
-
Quantifiable mRNA transcripts for tamoxifen-metabolising enzymes in human endometrium
-
Singh MN, Stringfellow HF, Walsh MJ, Ashton KM, Paraskevaidis E, Abdo KR, Martin-Hirsch PL, Phillips DH, and Martin FL (2008) Quantifiable mRNA transcripts for tamoxifen-metabolising enzymes in human endometrium. Toxicology 249:85-90.
-
(2008)
Toxicology
, vol.249
, pp. 85-90
-
-
Singh, M.N.1
Stringfellow, H.F.2
Walsh, M.J.3
Ashton, K.M.4
Paraskevaidis, E.5
Abdo, K.R.6
Martin-Hirsch, P.L.7
Phillips, D.H.8
Martin, F.L.9
-
40
-
-
0035127479
-
Tamoxifen modulates apoptotic pathways in primary endometrial cell cultures
-
Stackievicz R, Drucker L, Radnay J, Beyth Y, Yarkoni S, and Cohen I (2001) Tamoxifen modulates apoptotic pathways in primary endometrial cell cultures. Clin Cancer Res 7:415-420.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 415-420
-
-
Stackievicz, R.1
Drucker, L.2
Radnay, J.3
Beyth, Y.4
Yarkoni, S.5
Cohen, I.6
|