3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates-fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors

Tetrahedron Letters

Volumn 49, Issue 46, 2008, Pages 6556-6558

  Kinzel, Olaf D ^a   Ball, Richard G ^b   Donghi, Monica ^a   Maguire, Courtney K ^b   Muraglia, Ester ^a   Pesci, Silvia ^a   Rowley, Michael ^a   Summa, Vincenzo ^a  

^a IRBM   (Italy)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 4 OXO 4H PYRIDO[1,2 A]PYRIMIDINE 2 CARBOXYLATE; CARBOXYLIC ACID DERIVATIVE; INTEGRASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BROMINATION; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CYCLIZATION; DEGRADATION KINETICS; DEHYDROGENATION; DERIVATIZATION; HUMAN IMMUNODEFICIENCY VIRUS 1; NUCLEAR MAGNETIC RESONANCE; POLYMERIZATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 52949106444     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.09.010     Document Type: Article

References (13)

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9. +. Mp (recrystallized from methanol): 149.2 °C.
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11. -3. CCDC 692685 contains the supplementary crystallographic data for this Letter. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.
12. Donghi, M.; Kinzel, O.; Summa, V. HIV Integrase Inhibitors. WO 2007039218 A1.
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