Diarylpropane-1,3-dione derivatives as TetR-inducing tetracycline mimetics: Synthesis and biological investigations

ChemBioChem

Volumn 10, Issue 18, 2009, Pages 2924-2933

  Kormann, Christian ^a   Pimenta, Irina ^a   Löber, Stefan ^a   Wimmer, Cornelius ^a   Lanig, Harald ^a   Clark, Timothy ^a   Hillen, Wolfgang ^a   Gmeiner, Peter ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Antibiotics; Beta keto ester; Structure activity relationships; Tet repressor; Tetracycline

Indexed keywords

1 (5 CHLORO 2 HYDROXYPHENYL) 3 HYDROXY 3 (4 HYDROXY 3 IODOPHENYL)PROPENONE; 1 (5 CHLORO 2 HYDROXYPHENYL) 3 HYDROXY 3 (4 HYDROXYPHENYL) PROPENONE; 1 (5 CHLORO 2 HYDROXYPHENYL) 3 HYDROXY 3 (4 METHOXYPHENYL)PROPENONE; 1 (5 CHLORO 2 HYDROXYPHENYL) 3 HYDROXY 3 HYDROXY PHENYLPROPANE; 1,3 DIMETHYL 2,4 DIOXYPYRIMIDINE 5 CARBALDEHYDE; 2 HYDROXY 5 [3 (2 HYDROXYPHENYL) 3 OXOPROPENYL]BENZAMIDE; 3 (3 DIMETHYLAMINO 4 HYDROXYPHENYL) 3 HYDROXY 1(2 HYDROXYPHENYL)PROPANE; 3 HYDROXY (2 HYDROXYPHENYL) 1 (4 HYDROXY 3 IODOPHENYL) PROPAN 1,3 DIONE; 3 HYDROXY (2 HYDROXYPHENYL) 1 (4 METHOXYPHENYL) PROPAN 1,3 DIONE; 3 HYDROXY 1 (2 HYDROXY 5 NITROPHENYL) 3 (4 HYDROX 3 IODOPHENYL)PROPENONE; 3 HYDROXY 1 (2 HYDROXY 5 NITROPHENYL) 3 (4 HYDROXYPHENYL)PROPENONE; 3 HYDROXY 1 (2 HYDROXY 5 NITROPHENYL) 3 (4 METHOXYPHENYL)PROPENONE; 3 HYDROXY 1 (2 HYDROXY 5 NITROPHENYL) 3 PHENYLPROPENONE; 3 HYDROXY 1 (2 HYDROXYPHENYL) 3 PROPENONE; 3 HYDROXY 1,3 DIPHENYLPROPENONE; 3 HYDROXY 3 (4 HYDROXYPHENYL 3 IODOPHENYL) 1 PHENYLPROPENONE; 3 HYDROXY 3 (4 HYDROXYPHENYL) 1 (2 HYDROXYOPHENYL)PROPENONE; 3 HYDROXY 3 (4 HYDROXYPHENYL) 1 PHENYLPROPENONE; 3 HYDROXY 3 (4 METHOXYPHENYL) 1 DIPHENYLPROPENONE; ANTIBIOTIC AGENT; BETA GALACTOSIDASE; DIARYLPROPANE 1,3 DIONE DERIVATIVE; TETRACYCLINE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; CHALCONES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; MOLECULAR CONFORMATION; PROTEIN BINDING; REPRESSOR PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRACYCLINES;

EID: 72949113632     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900564     Document Type: Article

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