Epitope mapping on the dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) pathogen-attachment factor

Molecular Immunology

Volumn 47, Issue 4, 2010, Pages 840-848

  Sierra Filardi, Elena ^a   Estecha, Ana ^b   Samaniego, Rafael ^b   Fernández Ruiz, Elena ^c   Colmenares, María ^a   Sánchez Mateos, Paloma ^b   Steinman, Ralph M ^d   Granelli Piperno, Angela ^d   Corbí, Angel L ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Adhesion molecules; DC SIGN; Dendritic cells; Human; Pathogen recognition

Indexed keywords

CD209 ANTIGEN; CHIMERIC PROTEIN; DECTIN 2; EPITOPE; ISOPROTEIN; MONOCLONAL ANTIBODY; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DENDRITIC CELL; EPITOPE MAPPING; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; INTERNALIZATION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CROSS LINKING; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; CELL ADHESION MOLECULES; CELL LINE; DENDRITIC CELLS; ENDOCYTOSIS; EPITOPE MAPPING; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; LECTINS, C-TYPE; MONOCYTES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE;

EID: 72949095649     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.09.036     Document Type: Article

References (55)

1. Alvarez C.P., Lasala F., Carrillo J., Muniz O., Corbi A.L., and Delgado R. C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. J. Virol. 76 (2002) 6841-6844
2. Bernhard O.K., Lai J., Wilkinson J., Sheil M.M., and Cunningham A.L. Proteomic analysis of DC-SIGN on dendritic cells detects tetramers required for ligand binding but no association with CD4. J. Biol. Chem. 279 (2004) 51828-51835
3. Bleijs D.A., Geijtenbeek T.B., Figdor C.G., and van Kooyk Y. DC-SIGN and LFA-1: a battle for ligand. Trends Immunol. 22 (2001) 457-463
4. Cambi A., Beeren I., Joosten B., Fransen J.A., and Figdor C.G. The C-type lectin DC-SIGN internalizes soluble antigens and HIV-1 virions via a clathrin-dependent mechanism. Eur. J. Immunol. 39 (2009) 1923-1928
5. Cambi A., and Figdor C.G. Dual function of C-type lectin-like receptors in the immune system. Curr. Opin. Cell Biol. 15 (2003) 539-546
6. Cambi A., Gijzen K., de Vries J.M., Torensma R., Joosten B., Adema G.J., Netea M.G., Kullberg B.J., Romani L., and Figdor C.G. The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells. Eur. J. Immunol. 33 (2003) 532-538
7. Caparros E., Munoz P., Sierra-Filardi E., Serrano-Gomez D., Puig-Kroger A., Rodriguez-Fernandez J.L., Mellado M., Sancho J., Zubiaur M., and Corbi A.L. DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production. Blood 107 (2006) 3950-3958
8. Colmenares M., Corbi A.L., Turco S.J., and Rivas L. The dendritic cell receptor DC-SIGN discriminates among species and life cycle forms of Leishmania. J. Immunol. 172 (2004) 1186-1190
9. Colmenares M., Puig-Kroger A., Pello O.M., Corbi A.L., and Rivas L. Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes. J. Biol. Chem. 277 (2002) 36766-36769
10. Curtis B.M., Scharnowske S., and Watson A.J. Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 8356-8360
11. Dakappagari N., Maruyama T., Renshaw M., Tacken P., Figdor C., Torensma R., Wild M.A., Wu D., Bowdish K., and Kretz-Rommel A. Internalizing antibodies to the C-type lectins, L-SIGN and DC-SIGN, inhibit viral glycoprotein binding and deliver antigen to human dendritic cells for the induction of T cell responses. J. Immunol. 176 (2006) 426-440
12. den Dunnen J., Gringhuis S.I., and Geijtenbeek T.B. Innate signaling by the C-type lectin DC-SIGN dictates immune responses. Cancer Immunol. Immunother. 58 (2009) 1149-1157
13. Dominguez-Soto A., Aragoneses-Fenoll L., Martin-Gayo E., Martinez-Prats L., Colmenares M., Naranjo-Gomez M., Borras F.E., Munoz P., Zubiaur M., Toribio M.L., Delgado R., and Corbi A.L. The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells. Blood 109 (2007) 5337-5345
14. Engering A., Geijtenbeek T.B., van Vliet S.J., Wijers M., van Liempt E., Demaurex N., Lanzavecchia A., Fransen J., Figdor C.G., Piguet V., and van Kooyk Y. The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells. J. Immunol. 168 (2002) 2118-2126
15. Feinberg H., Guo Y., Mitchell D.A., Drickamer K., and Weis W.I. Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR. J. Biol. Chem. 280 (2005) 1327-1335
16. Feinberg H., Mitchell D.A., Drickamer K., and Weis W.I. Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR. Science 294 (2001) 2163-2166
17. Frison N., Taylor M.E., Soilleux E., Bousser M.T., Mayer R., Monsigny M., Drickamer K., and Roche A.C. Oligolysine-based oligosaccharide clusters: selective recognition and endocytosis by the mannose receptor and dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin. J. Biol. Chem. 278 (2003) 23922-23929
18. Geijtenbeek T.B., Krooshoop D.J., Bleijs D.A., van Vliet S.J., van Duijnhoven G.C., Grabovsky V., Alon R., Figdor C.G., and van Kooyk Y. DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking. Nat. Immunol. 1 (2000) 353-357
19. Geijtenbeek T.B., Kwon D.S., Torensma R., van Vliet S.J., van Duijnhoven G.C., Middel J., Cornelissen I.L., Nottet H.S., KewalRamani V.N., Littman D.R., Figdor C.G., and van Kooyk Y. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 100 (2000) 587-597
20. Geijtenbeek T.B., Torensma R., van Vliet S.J., van Duijnhoven G.C., Adema G.J., van Kooyk Y., and Figdor C.G. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 100 (2000) 575-585
21. Geijtenbeek T.B., and van Kooyk Y. DC-SIGN: a novel HIV receptor on DCs that mediates HIV-1 transmission. Curr. Top. Microbiol. Immunol. 276 (2003) 31-54
22. Geijtenbeek T.B., Van Vliet S.J., Koppel E.A., Sanchez-Hernandez M., Vandenbroucke-Grauls C.M., Appelmelk B., and Van Kooyk Y. Mycobacteria target DC-SIGN to suppress dendritic cell function. J. Exp. Med. 197 (2003) 7-17
23. Geijtenbeek T.B., van Vliet S.J., van Duijnhoven G.C., Figdor C.G., and van Kooyk Y. DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review. Placenta 22 Suppl. A (2001) S19-S23
24. Gijzen K., Tacken P.J., Zimmerman A., Joosten B., de Vries I.J., Figdor C.G., and Torensma R. Relevance of DC-SIGN in DC-induced T cell proliferation. J. Leukoc. Biol. 81 (2007) 729-740
25. Granelli-Piperno A., Pritsker A., Pack M., Shimeliovich I., Arrighi J.F., Park C.G., Trumpfheller C., Piguet V., Moran T.M., and Steinman R.M. Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction. J. Immunol. 175 (2005) 4265-4273
26. Gringhuis S.I., den Dunnen J., Litjens M., van der Vlist M., and Geijtenbeek T.B. Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. Nat. Immunol. 10 (2009) 1081-1088
27. Gringhuis S.I., den Dunnen J., Litjens M., van Het Hof B., van Kooyk Y., and Geijtenbeek T.B. C-Type lectin DC-SIGN modulates toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB. Immunity 26 (2007) 605-616
28. Hodges A., Sharrocks K., Edelmann M., Baban D., Moris A., Schwartz O., Drakesmith H., Davies K., Kessler B., McMichael A., and Simmons A. Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication. Nat. Immunol. 8 (2007) 569-577
29. Kwon D.S., Gregorio G., Bitton N., Hendrickson W.A., and Littman D.R. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity 16 (2002) 135-144
30. Lee B., Leslie G., Soilleux E., O'Doherty U., Baik S., Levroney E., Flummerfelt K., Swiggard W., Coleman N., Malim M., and Doms R.W. cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor. J. Virol. 75 (2001) 12028-12038
31. Liu H., Hladik F., Andrus T., Sakchalathorn P., Lentz G.M., Fialkow M.F., Corey L., McElrath M.J., and Zhu T. Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoforms. Eur. J. Hum. Genet. 13 (2005) 707-715
32. Liu H., Hwangbo Y., Holte S., Lee J., Wang C., Kaupp N., Zhu H., Celum C., Corey L., McElrath M.J., and Zhu T. Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1. J. Infect. Dis. 190 (2004) 1055-1058
33. Lozach P.Y., Amara A., Bartosch B., Virelizier J.L., Arenzana-Seisdedos F., Cosset F.L., and Altmeyer R. C-type lectins L-SIGN and DC-SIGN capture and transmit infectious hepatitis C virus pseudotype particles. J. Biol. Chem. 279 (2004) 32035-32045
34. Lozach P.Y., Lortat-Jacob H., de Lacroix de Lavalette A., Staropoli I., Foung S., Amara A., Houles C., Fieschi F., Schwartz O., Virelizier J.L., Arenzana-Seisdedos F., and Altmeyer R. DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2. J. Biol. Chem. 278 (2003) 20358-20366
35. Marzi A., Gramberg T., Simmons G., Moller P., Rennekamp A.J., Krumbiegel M., Geier M., Eisemann J., Turza N., Saunier B., Steinkasserer A., Becker S., Bates P., Hofmann H., and Pohlmann S. DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus. J. Virol. 78 (2004) 12090-12095
36. Mitchell D.A., Fadden A.J., and Drickamer K. A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. J. Biol. Chem. 276 (2001) 28939-28945
37. Mummidi S., Catano G., Lam L., Hoefle A., Telles V., Begum K., Jimenez F., Ahuja S.S., and Ahuja S.K. Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts. J. Biol. Chem. 276 (2001) 33196-33212
38. Neumann A.K., Thompson N.L., and Jacobson K. Distribution and lateral mobility of DC-SIGN on immature dendritic cells-implications for pathogen uptake. J. Cell Sci. 121 (2008) 634-643
39. Pohlmann S., Zhang J., Baribaud F., Chen Z., Leslie G.J., Lin G., Granelli-Piperno A., Doms R.W., Rice C.M., and McKeating J.A. Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. J. Virol. 77 (2003) 4070-4080
40. Puig-Kroger A., Serrano-Gomez D., Caparros E., Dominguez-Soto A., Relloso M., Colmenares M., Martinez-Munoz L., Longo N., Sanchez-Sanchez N., Rincon M., Rivas L., Sanchez-Mateos P., Fernandez-Ruiz E., and Corbi A.L. Regulated expression of the pathogen receptor dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin in THP-1 human leukemic cells, monocytes, and macrophages. J. Biol. Chem. 279 (2004) 25680-25688
41. Relloso M., Puig-Kroger A., Pello O.M., Rodriguez-Fernandez J.L., de la Rosa G., Longo N., Navarro J., Munoz-Fernandez M.A., Sanchez-Mateos P., and Corbi A.L. DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-beta, and anti-inflammatory agents. J. Immunol. 168 (2002) 2634-2643
42. Robinson M.J., Sancho D., Slack E.C., Leibundgut-Landmann S., and Sousa C.R. Myeloid C-type lectins in innate immunity. Nat. Immunol. 7 (2006) 1258-1265
43. Sakuntabhai A., Turbpaiboon C., Casademont I., Chuansumrit A., Lowhnoo T., Kajaste-Rudnitski A., Kalayanarooj S.M., Tangnararatchakit K., Tangthawornchaikul N., Vasanawathana S., Chaiyaratana W., Yenchitsomanus P.T., Suriyaphol P., Avirutnan P., Chokephaibulkit K., Matsuda F., Yoksan S., Jacob Y., Lathrop G.M., Malasit P., Despres P., and Julier C. A variant in the CD209 promoter is associated with severity of dengue disease. Nat. Genet. 37 (2005) 507-513
44. Serrano-Gomez D., Dominguez-Soto A., Ancochea J., Jimenez-Heffernan J.A., Leal J.A., and Corbi A.L. Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages. J. Immunol. 173 (2004) 5635-5643
45. Serrano-Gomez D., Martinez-Nunez R.T., Sierra-Filardi E., Izquierdo N., Colmenares M., Pla J., Rivas L., Martinez-Picado J., Jimenez-Barbero J., Alonso-Lebrero J.L., Gonzalez S., and Corbi A.L. AM3 modulates dendritic cell pathogen recognition capabilities by targeting DC-SIGN. Antimicrob. Agents Chemother. 51 (2007) 2313-2323
46. Serrano-Gomez D., Sierra-Filardi E., Martinez-Nunez R.T., Caparros E., Delgado R., Munoz-Fernandez M.A., Abad M.A., Jimenez-Barbero J., Leal M., and Corbi A.L. Structural requirements for multimerization of the pathogen receptor dendritic cell-specific ICAM3-grabbing non-integrin (CD209) on the cell surface. J. Biol. Chem. 283 (2008) 3889-3903
47. Smith A.L., Ganesh L., Leung K., Jongstra-Bilen J., Jongstra J., and Nabel G.J. Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells. J. Exp. Med. 204 (2007) 421-430
48. Soilleux E.J., Morris L.S., Lee B., Pohlmann S., Trowsdale J., Doms R.W., and Coleman N. Placental expression of DC-SIGN may mediate intrauterine vertical transmission of HIV. J. Pathol. 195 (2001) 586-592
49. Soilleux E.J., Morris L.S., Leslie G., Chehimi J., Luo Q., Levroney E., Trowsdale J., Montaner L.J., Doms R.W., Weissman D., Coleman N., and Lee B. Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro. J. Leukoc. Biol. 71 (2002) 445-457
50. Tacken P.J., de Vries I.J., Gijzen K., Joosten B., Wu D., Rother R.P., Faas S.J., Punt C.J., Torensma R., Adema G.J., and Figdor C.G. Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody. Blood 106 (2005) 1278-1285
51. Tailleux L., Schwartz O., Herrmann J.L., Pivert E., Jackson M., Amara A., Legres L., Dreher D., Nicod L.P., Gluckman J.C., Lagrange P.H., Gicquel B., and Neyrolles O. DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. J. Exp. Med. 197 (2003) 121-127
52. Tassaneetrithep B., Burgess T.H., Granelli-Piperno A., Trumpfheller C., Finke J., Sun W., Eller M.A., Pattanapanyasat K., Sarasombath S., Birx D.L., Steinman R.M., Schlesinger S., and Marovich M.A. DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. J. Exp. Med. 197 (2003) 823-829
53. van Gisbergen K.P., Ludwig I.S., Geijtenbeek T.B., and van Kooyk Y. Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils. FEBS Lett. 579 (2005) 6159-6168
54. van Gisbergen K.P., Sanchez-Hernandez M., Geijtenbeek T.B., and van Kooyk Y. Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN. J. Exp. Med. 201 (2005) 1281-1292
55. van Kooyk Y., and Geijtenbeek T.B. DC-SIGN: escape mechanism for pathogens. Nat. Rev. Immunol. 3 (2003) 697-709