Internalizing antibodies to the C-type lectins, L-SIGN and DC-SIGN, inhibit viral glycoprotein binding and deliver antigen to human dendritic cells for the induction of T cell responses

Journal of Immunology

Volumn 176, Issue 1, 2006, Pages 426-440

  Dakappagari, Naveen ^a   Maruyama, Toshiaki ^a   Renshaw, Mark ^a   Tacken, Paul ^b   Figdor, Carl ^b   Torensma, Ruurd ^b   Wild, Martha A ^a   Wu, Dayang ^c   Bowdish, Katherine ^a   Kretz Rommel, Anke ^a  

^a Alexion Antibody Technologies Inc   (United States)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ALEXION PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CROSS REACTING ANTIBODY; DENDRITIC CELL SPECIFIC ICAM GRABBING NONINTEGRIN; EBOLA GLYCOPROTEIN; EPITOPE; FC RECEPTOR; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN F(AB) FRAGMENT; INTERCELLULAR ADHESION MOLECULE 3; LECTIN; LIGAND; LIVER LYMPH NODE SPECIFIC ICAM 3 GRABBING NONINTEGRIN; TETANUS TOXOID; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANIMAL EXPERIMENT; ANTIBODY ISOLATION; ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITIC CELL; ENDOTHELIUM CELL; EVALUATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOMODULATION; INTERNALIZATION; LIVER SINUSOID; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE; VIRUS INFECTION;

EID: 29644436434     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.1.426     Document Type: Article

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