The evolution of the relaxin peptide family and their receptors

Advances in Experimental Medicine and Biology

Volumn 612, Issue , 2007, Pages 1-13

  Wilkinson, Tracey N ^a   Bathgate, Ross A D ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GPCR135; GPCR142; INSULIN LIKE PEPTIDE 3; INSULIN LIKE PEPTIDE 4; INSULIN LIKE PEPTIDE 5; INSULIN LIKE PEPTIDE 6; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 7; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 8; RELAXIN; RELAXIN 1; RELAXIN 2; RELAXIN 3; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; RECEPTOR; RELAXIN RECEPTORS; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; BINDING AFFINITY; DATA BASE; DOG; FISH; GENOME; HUMAN; INVERTEBRATE; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVIEW; SEQUENCE HOMOLOGY; UNINDEXED SEQUENCE; VERTEBRATE; ANIMAL; GENETICS; MULTIGENE FAMILY; PHYSIOLOGY;

CANIS FAMILIARIS; INVERTEBRATA; RATTUS; VERTEBRATA;

ANIMALS; EVOLUTION, MOLECULAR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MULTIGENE FAMILY; PHYLOGENY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RELAXIN; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 38749099842     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-74672-2_1     Document Type: Review

References (63)

1. Lander ES, Linton LM, Birren B et al. Initial sequencing and analysis of the human genome. Nature 2001; 409(6822):860-921.
2. Venter JC, Adams MD, Myers EW et al. The sequence of the human genome. Science 2001; 291(5507):1304-1351.
3. Bathgate RA, Samuel CS, Burazin TC et al. Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. J Biol Chem 2002; 277(2):1148-1157.
4. Bathgate RAD, Hsueh AJ, Sherwood OD. Physiology and Molecular Biology of the Relaxin Peptide Family. In: Neill JD, ed. Physiology of Reproduction. 3rd ed. San Diego: Elsevier 2006:679-770.
5. Sherwood CD, O'Byrne EM. Purification and characterization of porcine relaxin. Arch Biochem Biophys 1974; 160(1):185-196.
6. Liu C, Eriste E, Sutton S et al. Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135. J Biol Chem 2003; 278(50):50754-50764.
7. Bullesbach EE, Schwabe C. The primary structure and the disulfide links of the bovine relaxin-like factor (RLE). Biochemistry 2002; 41(1):274-281.
8. Hudson P, Haley J, John M et al. Structure of a genomic clone encoding biologically active human relaxin. Nature 1983; 301(5901):628-631.
9. Hudson P, John M, Crawford R et al. Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones. EMBO J 1984; 3(10):2333-2339.
10. Evans BA, Fu P, Tregear GW. Characterization of two relaxin genes in the chimpanzee. J Endocrinol 1994; 140(3):385-392.
11. Evans BA, Fu P, Tregear GW. Characterization of primate relaxin genes. Endocr J 1994; 2:81-86.
12. Wilkinson TN, Speed TP, Tregear GW, Bathgate RAD. Evolution of the Relaxin-like peptide family. BMC Evol Biol 2005; 5:14.
13. Winslow JW, Shih A, Bourell JH et al. Human seminal relaxin is a product of the same gene as human luteal relaxin. Endocrinology 1992; 130(5):2660-2668.
14. Hansell DJ, Bryant-Greenwood GD, Greenwood FC. Expression of the human relaxin H1 gene in the decidua, trophoblast and prostate. J Clin Endocrinol Metab 1991; 72(4):899-904.
15. Bathgate RAD, Lin F, Hanson NF et al. Relaxin-3: Improved synthesis strategy and demonstration of its high affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo. Biochemistry 2006; 45:1043-1053.
16. Burazin TC, Bathgate RA, Macris M et al. Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain. J Neurochem 2002; 82(6):1553-1557.
17. Tanaka M, Iijima N, Miyamoto Y et al. Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress. Eur J Neurosci 2005; 21(6):1659-1670.
18. Adham IM, Burkhardt E, Benahmed M et al. Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells. J Biol Chem 1993; 268(35):26668-26672.
19. Rosengren KJ, Zhang S, Lin F et al. Solution structure and characterization of the receptor binding surface of insulin-like peptide 3. J Biol Chem 2006; 38:28287-28295.
20. Chassin D, Laurent A, Janneau JL et al. Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta. Genomics 1995; 29(2):465-470.
21. Veitia R, Laurent A, Quintana-Murci L et al. The INSL4 gene maps close to WI-5527 at 9p24.1->p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome. Cytogenet Cell Genet 1998; 81(3-4):275-277.
22. Bieche I, Laurent A, Laurendeau I et al. Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element. Biol Reprod 2003; 68(4):1422-1429.
23. Bellet D, Lavaissiere L, Mock P et al. Identification of pro-EPIL and EPIL peptides translated from insulin-like 4 (INSL4) mRNA in human placenta. J Clin Endocrinol Metab 1997; 82(9):3169-3172.
24. Bullesbach EE, Schwabe C. Synthesis and conformational analysis of the insulin-like 4 gene product. J Pept Res 2001; 57(1):77-83.
25. Lin F, Otvos Jr. L, Kumagai J et al. Synthetic human insulin 4 does not activate the G-protein-coupled receptors LGR7 or LGR8. J Pept Sci 2004; 10(5):257-264.
26. Conklin D, Lofton-Day CE, Haldeman BA et al. Identification of INSL5, a new member of the insulin superfamily. Genomics 1999; 60(1):50-56.
27. Hsu SY. Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney. Mol Endocrinol 1999; 13(12):2163-2174.
28. Liu C, Kuei C, Sutton S et al. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). J Biol Chem 2005; 280(1):292-300.
29. Jaspers S, Lok S, Lofton-Day CE et al. The genomics of INSL5. In: Tregear GW, Ivell R, Bathgate RA, Wade JD, eds. Relaxin 2000: Proceedings of the third international conference on relaxin and related peptides. Dordrecht: Kluwer, 2001.
30. Kasik J, Muglia L, Stephan DA et al. Identification, chromosomal mapping and partial characterization of mouse Insl6: a new member of the insulin family. Endocrinology 2000; 141(1):458-461.
31. Lok S, Johnston DS, Conklin D et al. Identification of INSL6, a new member of the insulin family that is expressed in the testis of the human and rat. Biol Reprod 2000; 62(6):1593-1599.
32. Lu C, Walker WH, Sun J et al. Insulin-like peptide 6 (Insl6): Characterization of secretory status and posttranslational modifications. Endocrinology 2006.
33. Liu C, Chen J, Sutton S et al. Identification of relaxin-3/INSL7 as a ligand for GPCR142. J Biol Chem 2003; 278(50):50765-50770.
34. Bogatcheva NV, Truong A, Feng S et al. GREAT/LGR8 is the only receptor for insulin-like 3 peptide. Mol Endocrinol 2003; 17(12):2639-2646.
35. Schwabe C, Bullesbach EE, Heyn H et al.Cetacean relaxin. Isolation and sequence of relaxins from Balaenoptera acutorostrata and Balaenoptera edeni. J Biol Chem 1989; 264(2):940-943.
36. Schwabe C, LeRoith D, Thompson RP et al. Relaxin extracted from protozoa (Tetrahymena pyriformis). Molecular and immunologic properties. J Biol Chem 1983; 258(5):2778-2781.
37. Georges D, Viguier-Martinez MC, Poirier JC. Relaxin-like peptide in ascidians. II. Bioassay and immunolocalization with anti-porcine relaxin in three species. Gen Comp Endocrinol 1990; 79(3):429-438.
38. Georges D, Schwabe C. Porcine relaxin, a 500 million-year-old hormone? the tunicate Ciona intestinalis has porcine relaxin. FASEB J 1999; 13(10):1269-1275.
39. Hafner M, Korthof G. Does a "500 million-year-old hormone" disprove Darwin? FASEB J 2006; 20(9):1290-1292.
40. Roche PJ, Crawford RJ, Tregear GW. A single-copy relaxin-like gene sequence is present in sheep. Mol Cell Endocrinol 1993; 91(1-2):21-28.
41. Bathgate R, Balvers M, Hunt N et al. Relaxin-like factor gene is highly expressed in the bovine ovary of the cycle and pregnancy: sequence and messenger ribonucleic acid analysis. Biol Reprod 1996; 55(6):1452-1457.
42. Brackett KH, Fields PA, Dubois W et al. Relaxin: an ovarian hormone in an avian species (Gallus domesticus). Gen Comp Endocrinol 1997; 105(2):155-163.
43. Hsu SY. New insights into the evolution of the relaxin-LGR signaling system. Trends Endocrinol Metab 2003; 14(7):303-309.
44. de Rienzo G, Aniello F, Branno M et al. Isolation and characterization of a novel member of the relaxin/ insulin family from the testis of the frog Rana esculenta. Endocrinology 2001; 142(7):3231-3238.
45. Bullesbach EE, Schwabe C, Callard IP. Relaxin from an oviparous species, the skate (Raja erinacea). Biochem Biophys Res Commun 1987; 143(1):273-280.
46. Bullesbach EE, Gowan LK, Schwabe C et al. Isolation, purification and the sequence of relaxin from spiny dogfish (Squalus acanthias). Eur J Biochem 1986; 161(2):335-341.
47. Bullesbach EE, Schwabe C, Lacy ER. Identification of a glycosylated relaxin-like molecule from the male Atlantic stingray, Dasyatis sabina. Biochemistry 1997; 36(35):10735-10741.
48. Reinig JW, Daniel LN, Schwabe C et al. Isolation and characterization of relaxin from the sand tiger shark (Odontaspis taurus). Endocrinology 1981; 109(2):537-543.
49. Hsu SY, Nakabayashi K, Nishi S et al. Activation of orphan receptors by the hormone relaxin. Science 2002; 295(5555):671-674.
50. Kumagai J, Hsu SY, Matsumi H et al. INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J Biol Chem 2002; 277(35):31283-31286.
51. Scott DJ, Fu P, Shen PJ et al. Characterization of the Rat INSL3 Receptor. Ann NY Acad Sci 2005; 1041:13-16.
52. Overbeek PA, Gorlov IP, Sutherland RW et al. A transgenic insertion causing cryptorchidism in mice. Genesis 2001; 30(1):26-35.
53. Nef S, Parada LF. Cryptorchidism in mice mutant for Insl3. Nat Genet 1999; 22(3):295-299.
54. Krajnc-Franken MA, van Disseldorp AJ, Koenders JE et al. Impaired nipple development and parturition in LGR7. Mol Cell Biol 2004; 24(2):687-696.
55. Kamat AA, Feng S, Bogatcheva NV et al. Genetic targeting of relaxin and Insl3 receptors in mice. Endocrinology 2004.
56. Hsu SY, Kudo M, Chen T et al. The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol Endocrinol 2000; 14(8):1257-1271.
57. Scott DJ, Layfield S, Yan Y et al. Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique LDLa modules. J Biol Chem 2006; 281:34942-34954.
58. Matsumoto M, Kamohara M, Sugimoto T et al. The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors. Gene 2000; 248(1-2):183-189.
59. Wilkinson TN, Speed TP, Tregear GW et al. Coevolution of the relaxin-like peptides and their receptors. Ann N Y Acad Sci 2005; 1041:534-539.
60. Boels K, Schaller HC. Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor. Br J Pharmacol 2003; 140(5):932-938.
61. Chen J, Kuei C, Sutton SW et al. Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species. J Pharmacol Exp Ther 2005; 312(1):83-95.
62. Bathgate RA, Ivell R, Sanborn BM et al. International Union of Pharmacology: Recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol Rev 2006; 58:7-31.
63. Liu C, Bonaventure P, Sutton SW et al. Recent progress in relaxin-3-related research. Ann NY Acad Sci 2005; 1041:47-60.