Matrine determination and pharmacokinetics in human plasma using LC/MS/MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 27, 2009, Pages 3253-3256

  Zhang, Xiao Lin ^a   Xu, Hong Rong ^a   Chen, Wei Li ^a   Chu, Nan Nan ^a   Li, Xue Ning ^a   Liu, Gang Yi ^b   Yu, Chen ^b  

^a FUDAN UNIVERSITY   (China)

^b Xuhui District Central Hospital   (China)

Author keywords

LC MS MS; Matrine; Pharmacokinetics

Indexed keywords

AQUEOUS AMMONIUM; CHROMATOGRAPHIC SEPARATIONS; CLINICAL PHARMACOKINETICS; CONCENTRATION RANGES; CROSSOVER DESIGN; ETHYL ACETATES; HUMAN PLASMAS; HUPERZINE A; INTERNAL STANDARDS; ION ELECTROSPRAY; ISO-PROPANOLS; LC/MS/MS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MATRINE; MOBILE-PHASE COMPOSITION; ORAL ADMINISTRATION; SINGLE-DOSE;

ACETONITRILE; AMMONIUM COMPOUNDS; ESTERS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; PLASMA (HUMAN); PLASMAS;

PHARMACOKINETICS;

2 PROPANOL; ACETIC ACID ETHYL ESTER; ACETONITRILE; AMMONIUM ACETATE; HUPERZINE A; MATRINE;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; EXTRACTION; FLOW RATE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; STANDARD; TANDEM MASS SPECTROMETRY;

ALKALOIDS; AREA UNDER CURVE; CALIBRATION; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; LEAST-SQUARES ANALYSIS; QUINOLIZINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SESQUITERPENES; TANDEM MASS SPECTROMETRY;

EID: 69749101967     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.08.026     Document Type: Article

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