Determination and pharmacokinetic study of oxymatrine and its metabolite matrine in human plasma by liquid chromatography tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 41, Issue 3, 2006, Pages 918-924

  Wu, Xiao luan ^a   Hang, Tai jun ^a   Shen, Jian ping ^b   Zhang, Yin di ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Human plasma; LC tandem MS; Matrine; Metabolism; Oxymatrine; Pharmacokinetics

Indexed keywords

AMMONIUM ACETATE; ARGON; DRUG METABOLITE; GLUCOSE; MATRINE; METHANOL; OXYMATRINE; PAPAVERINE;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHINESE; COLLISIONALLY ACTIVATED DISSOCIATION; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; ELECTROSPRAY; FLOW RATE; HEMOCONCENTRATION; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; STANDARD; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ALKALOIDS; AREA UNDER CURVE; CHROMATOGRAPHY, LIQUID; HALF-LIFE; HUMANS; MALE; QUINOLIZINES; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 33646388386     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.01.029     Document Type: Article

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