Simultaneous determination and pharmacokinetic study of oxymatrine and matrine in beagle dog plasma after oral administration of Kushen formula granule, oxymatrine and matrine by LC-MS/MS

Biomedical Chromatography

Volumn 21, Issue 8, 2007, Pages 876-882

  Wang, Yiqi ^a   Ma, Yuanyuan ^a   Li, Xiaohong ^a   Qin, Feng ^a   Lu, Xiumei ^a   Li, Famei ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Kushen formula granule; LC ESI MS MS; Matrine; Oxymatrine; Pharmacokinetics

Indexed keywords

GRANULATION; MASS SPECTROMETRY; PHARMACOKINETICS; POSITIVE IONS;

BEAGLE DOG; DOG PLASMA; KUSHEN FORMULA GRANULE; LC-ELECTROSPRAY IONIZATION-MS/MS; LC-MS-MS; MATRINE; ORAL ADMINISTRATION; OXYMATRINE; PHARMACOKINETIC STUDIES; SIMULTANEOUS DETERMINATIONS;

ELECTROSPRAY IONIZATION;

ACETIC ACID; CAFFEINE; EPHEDRINE; MATRINE; METHANOL; OXYMATRINE; PHENACETIN; SOPHORA FLAVESCENS EXTRACT; THEOPHYLLINE; WATER;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MONITORING; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; LINEAR SYSTEM; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SOPHORA; SOPHORA FLAVESCENS; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

CANIS FAMILIARIS;

EID: 34547699674     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.834     Document Type: Article

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