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Volumn 23, Issue 12, 2009, Pages 4168-4180

Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro

Author keywords

Cardiac differentiation; Electrophysiology; iPS cells; Patch clamp; Reprogramming

Indexed keywords

ACTININ; ATRIAL NATRIURETIC FACTOR; TRANSCRIPTION FACTOR NKX2.5; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

EID: 72749100443     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.08-128546     Document Type: Article
Times cited : (109)

References (73)
  • 1
    • 0034983625 scopus 로고    scopus 로고
    • Multilineage differentiation from human embryonic stem cell lines
    • Odorico, J. S., Kaufman, D. S., and Thomson, J. A. (2001) Multilineage differentiation from human embryonic stem cell lines. Stem Cells 19, 193-204 (Pubitemid 32524540)
    • (2001) Stem Cells , vol.19 , Issue.3 , pp. 193-204
    • Odorico, J.S.1    Kaufman, D.S.2    Thomson, J.A.3
  • 3
    • 0035797898 scopus 로고    scopus 로고
    • Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells
    • DOI 10.1016/S0960-9822(01)00459-6
    • Tada, M., Takahama, Y., Abe, K., Nakatsuji, N., and Tada, T. (2001) Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr. Biol. 11, 1553-1558 (Pubitemid 32931020)
    • (2001) Current Biology , vol.11 , Issue.19 , pp. 1553-1558
    • Tada, M.1    Takahama, Y.2    Abe, K.3    Nakatsuji, N.4    Tada, T.5
  • 4
    • 23944457397 scopus 로고    scopus 로고
    • Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells
    • Cowan, C. A., Atienza, J., Melton, D. A., and Eggan, K. (2005) Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science 309, 1369-1373
    • (2005) Science , vol.309 , pp. 1369-1373
    • Cowan, C.A.1    Atienza, J.2    Melton, D.A.3    Eggan, K.4
  • 5
    • 33745632618 scopus 로고    scopus 로고
    • Nuclear reprogramming and pluripotency
    • Hochedlinger, K., and Jaenisch, R. (2006) Nuclear reprogramming and pluripotency. Nature 441, 1061-1067
    • (2006) Nature , vol.441 , pp. 1061-1067
    • Hochedlinger, K.1    Jaenisch, R.2
  • 6
    • 11144219959 scopus 로고    scopus 로고
    • Human cloning - The science and ethics of nuclear transplantation
    • DOI 10.1056/NEJMp048304
    • Jaenisch, R. (2004) Human cloning: the science and ethics of nuclear transplantation. N. Engl. J. Med. 351, 2787-2791 (Pubitemid 40051900)
    • (2004) New England Journal of Medicine , vol.351 , Issue.27 , pp. 2787-2791
    • Jaenisch, R.1
  • 7
    • 33845917511 scopus 로고    scopus 로고
    • Targeted chromosome elimination from ES-somatic hybrid cells
    • DOI 10.1038/nmeth973, PII NMETH973
    • Matsumura, H., Tada, M., Otsuji, T., Yasuchika, K., Nakatsuji, N., Surani, A., and Tada, T. (2007) Targeted chromosome elimination from ES-somatic hybrid cells. Nat. Methods 4, 23-25 (Pubitemid 46029469)
    • (2007) Nature Methods , vol.4 , Issue.1 , pp. 23-25
    • Matsumura, H.1    Tada, M.2    Otsuji, T.3    Yasuchika, K.4    Nakatsuji, N.5    Surani, A.6    Tada, T.7
  • 8
    • 33747195353 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • Takahashi, K., and Yamanaka, S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 9
    • 34249908901 scopus 로고    scopus 로고
    • In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
    • DOI 10.1038/nature05944, PII NATURE05944
    • Wernig, M., Meissner, A., Foreman, R., Brambrink, T., Ku, M., Hochedlinger, K., Bernstein, B. E., and Jaenisch, R. (2007) In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448, 318-324 (Pubitemid 47080337)
    • (2007) Nature , vol.448 , Issue.7151 , pp. 318-324
    • Wernig, M.1    Meissner, A.2    Foreman, R.3    Brambrink, T.4    Ku, M.5    Hochedlinger, K.6    Bernstein, B.E.7    Jaenisch, R.8
  • 11
    • 55049122748 scopus 로고    scopus 로고
    • Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression
    • Eminli, S., Utikal, J., Arnold, K., Jaenisch, R., and Hochedlinger, K. (2008) Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells 26, 2467-2474
    • (2008) Stem Cells , vol.26 , pp. 2467-2474
    • Eminli, S.1    Utikal, J.2    Arnold, K.3    Jaenisch, R.4    Hochedlinger, K.5
  • 14
    • 44349103591 scopus 로고    scopus 로고
    • A Combined Chemical and Genetic Approach for the Generation of Induced Pluripotent Stem Cells
    • DOI 10.1016/j.stem.2008.05.011, PII S1934590908002257
    • Shi, Y., Do, J. T., Desponts, C., Hahm, H. S., Scholer, H. R., and Ding, S. (2008) A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2, 525-528 (Pubitemid 351729222)
    • (2008) Cell Stem Cell , vol.2 , Issue.6 , pp. 525-528
    • Shi, Y.1    Tae Do, J.2    Desponts, C.3    Hahm, H.S.4    Scholer, H.R.5    Ding, S.6
  • 15
    • 45449094570 scopus 로고    scopus 로고
    • Reprogramming of pancreatic beta cells into induced pluripotent stem cells
    • Stadtfeld, M., Brennand, K., and Hochedlinger, K. (2008) Reprogramming of pancreatic beta cells into induced pluripotent stem cells. Curr. Biol. 18, 890-894
    • (2008) Curr. Biol. , vol.18 , pp. 890-894
    • Stadtfeld, M.1    Brennand, K.2    Hochedlinger, K.3
  • 17
    • 36248966518 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
    • DOI 10.1016/j.cell.2007.11.019, PII S0092867407014717
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (Pubitemid 350138099)
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 20
    • 50849142559 scopus 로고    scopus 로고
    • A high-efficiency system for the generation and study of human induced pluripotent stem cells
    • Maherali, N., Ahfeldt, T., Rigamonti, A., Utikal, J., Cowan, C., and Hochedlinger, K. (2008) A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell 3, 340-345
    • (2008) Cell Stem Cell , vol.3 , pp. 340-345
    • Maherali, N.1    Ahfeldt, T.2    Rigamonti, A.3    Utikal, J.4    Cowan, C.5    Hochedlinger, K.6
  • 26
    • 49649120250 scopus 로고    scopus 로고
    • Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells
    • Narazaki, G., Uosaki, H., Teranishi, M., Okita, K., Kim, B., Matsuoka, S., Yamanaka, S., and Yamashita, J. K. (2008) Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation 118, 498-506
    • (2008) Circulation , vol.118 , pp. 498-506
    • Narazaki, G.1    Uosaki, H.2    Teranishi, M.3    Okita, K.4    Kim, B.5    Matsuoka, S.6    Yamanaka, S.7    Yamashita, J.K.8
  • 31
    • 0032407328 scopus 로고    scopus 로고
    • Cardiac specific expression of the green fluorescent protein during early murine embryonic development
    • DOI 10.1016/S0014-5793(98)01476-8, PII S0014579398014768
    • Fleischmann, M., Bloch, W., Kolossov, E., Andressen, C., Muller, M., Brem, G., Hescheler, J., Addicks, K., and Fleischmann, B. K. (1998) Cardiac specific expression of the green fluorescent protein during early murine embryonic development. FEBS Lett. 440, 370-376 (Pubitemid 29052317)
    • (1998) FEBS Letters , vol.440 , Issue.3 , pp. 370-376
    • Fleischmann, M.1    Bloch, W.2    Kolossov, E.3    Andressen, C.4    Muller, M.5    Brem, G.6    Hescheler, J.7    Addicks, K.8    Fleischmann, B.K.9
  • 32
    • 0033044008 scopus 로고    scopus 로고
    • 2+ channel during cardiomyogenesis: Switch from NO to adenylyl cyclase-mediated inhibition
    • Ji, G. J., Fleischmann, B. K., Bloch, W., Feelisch, M., Andressen, C., Addicks, K., and Hescheler, J. (1999) Regulation of the L-type Ca2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase-mediated inhibition. FASEB J. 13, 313-324 (Pubitemid 29072408)
    • (1999) FASEB Journal , vol.13 , Issue.2 , pp. 313-324
    • Ji, G.J.1    Fleischmann, B.K.2    Bloch, W.3    Feelisch, M.4    Andressen, C.5    Addicks, K.6    Hescheler, J.7
  • 33
    • 0019441262 scopus 로고
    • Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
    • DOI 10.1007/BF00656997
    • Hamill, O. P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F. J. (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391, 85-100 (Pubitemid 11012976)
    • (1981) Pflügers Archiv European Journal of Physiology , vol.391 , Issue.2 , pp. 85-100
    • Hamill, O.P.1    Marty, A.2    Neher, E.3
  • 35
    • 0030024562 scopus 로고    scopus 로고
    • Developmental changes in ionic channel activity in the embryonic murine heart
    • Davies, M. P., An, R. H., Doevendans, P., Kubalak, S., Chien, K. R., and Kass, R. S. (1996) Developmental changes in ionic channel activity in the embryonic murine heart. Circ. Res. 78, 15-25 (Pubitemid 26004116)
    • (1996) Circulation Research , vol.78 , Issue.1 , pp. 15-25
    • Davies, M.P.1    An, R.H.2    Doevendans, P.3    Kubalak, S.4    Chien, K.R.5    Kass, R.S.6
  • 36
    • 0033837121 scopus 로고    scopus 로고
    • Differentiation of cardiomyocytes in floating embryoid bodies is comparable to fetal cardiomyocytes
    • Doevendans, P. A., Kubalak, S. W., An, R. H., Becker, D. K., Chien, K. R., and Kass, R. S. (2000) Differentiation of cardiomyocytes in floating embryoid bodies is comparable to fetal cardiomyocytes. J. Mol. Cell. Cardiol. 32, 839-851
    • (2000) J. Mol. Cell. Cardiol. , vol.32 , pp. 839-851
    • Doevendans, P.A.1    Kubalak, S.W.2    An, R.H.3    Becker, D.K.4    Chien, K.R.5    Kass, R.S.6
  • 37
    • 0028365627 scopus 로고
    • Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents
    • Maltsev, V. A., Wobus, A. M., Rohwedel, J., Bader, M., and Hescheler, J. (1994) Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents. Circ. Res. 75, 233-244 (Pubitemid 24228315)
    • (1994) Circulation Research , vol.75 , Issue.2 , pp. 233-244
    • Maltsev, V.A.1    Wobus, A.M.2    Rohwedel, J.3    Bader, M.4    Hescheler, J.5
  • 38
    • 0037123934 scopus 로고    scopus 로고
    • 1D) calcium channel in sinoatrial nodes: Insight gained using gene-targeted null mutant mice
    • DOI 10.1161/01.RES.0000018003.14304.E2
    • Zhang, Z., Xu, Y., Song, H., Rodriguez, J., Tuteja, D., Namkung, Y., Shin, H. S., and Chiamvimonvat, N. (2002) Functional roles of Ca(v)1.3 (alpha(1D)) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice. Circ. Res. 90, 981-987 (Pubitemid 34633864)
    • (2002) Circulation Research , vol.90 , Issue.9 , pp. 981-987
    • Zhang, Z.1    Xu, Y.2    Song, H.3    Rodriguez, J.4    Tuteja, D.5    Namkung, Y.6    Shin, H.-S.7    Chiamvimonvat, N.8
  • 41
    • 0032576570 scopus 로고    scopus 로고
    • Functional characteristics of ES cell-derived cardiac precursor cells identified by tissue-specific expression of the green fluorescent protein
    • DOI 10.1083/jcb.143.7.2045
    • Kolossov, E., Fleischmann, B. K., Liu, Q., Bloch, W., Viatchenko-Karpinski, S., Manzke, O., Ji, G. J., Bohlen, H., Addicks, K., and Hescheler, J. (1998) Functional characteristics of ES cell-derived cardiac precursor cells identified by tissue-specific expression of the green fluorescent protein. J. Cell. Biol. 143, 2045-2056 (Pubitemid 29022623)
    • (1998) Journal of Cell Biology , vol.143 , Issue.7 , pp. 2045-2056
    • Kolossov, E.1    Fleischmann, B.K.2    Liu, Q.3    Bloch, W.4    Viatchenko-Karpinski, S.5    Manzke, O.6    Ji, G.J.7    Bohlen, H.8    Addicks, K.9    Hescheler, J.10
  • 43
    • 13444304421 scopus 로고    scopus 로고
    • Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart
    • DOI 10.1113/jphysiol.2004.074047
    • Marionneau, C., Couette, B., Liu, J., Li, H., Mangoni, M. E., Nargeot, J., Lei, M., Escande, D., and Demolombe, S. (2005) Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J. Physiol. 562, 223-234 (Pubitemid 40207799)
    • (2005) Journal of Physiology , vol.562 , Issue.1 , pp. 223-234
    • Marionneau, C.1    Couette, B.2    Liu, J.3    Li, H.4    Mangoni, M.E.5    Nargeot, J.6    Lei, M.7    Escande, D.8    Demolombe, S.9
  • 44
    • 0037123990 scopus 로고    scopus 로고
    • Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function
    • DOI 10.1161/01.RES.0000018627.89528.6F
    • Schram, G., Pourrier, M., Melnyk, P., and Nattel, S. (2002) Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function. Circ. Res. 90, 939-950 (Pubitemid 34633859)
    • (2002) Circulation Research , vol.90 , Issue.9 , pp. 939-950
    • Schram, G.1    Pourrier, M.2    Melnyk, P.3    Nattel, S.4
  • 46
    • 85047696118 scopus 로고    scopus 로고
    • Outwards currents in embryonic stem cell-derived cardiomyocytes
    • Gryschenko, O., Lu, Z. J., Fleischmann, B. K., and Hescheler, J. (2000) Outwards currents in embryonic stem cell-derived cardiomyocytes. Pflügers Arch. 439, 798-807
    • (2000) Pflügers Arch. , vol.439 , pp. 798-807
    • Gryschenko, O.1    Lu, Z.J.2    Fleischmann, B.K.3    Hescheler, J.4
  • 47
    • 0030831837 scopus 로고    scopus 로고
    • + current modulates repolarization and excitation-contraction coupling in adult mouse ventricle
    • DOI 10.1111/j.1469-7793.1997.557bd.x
    • Fiset, C., Clark, R. B., Larsen, T. S., and Giles, W. R. (1997) A rapidly activating sustained K+ current modulates repolarization and excitation-contraction coupling in adult mouse ventricle. J. Physiol. 504(Pt. 3), 557-563 (Pubitemid 27493855)
    • (1997) Journal of Physiology , vol.504 , Issue.3 , pp. 557-563
    • Fiset, C.1    Clark, R.B.2    Larsen, T.S.3    Giles, W.R.4
  • 48
    • 0031281873 scopus 로고    scopus 로고
    • Embryonic stem cells: A model to study structural and functional properties in cardiomyogenesis
    • DOI 10.1016/S0008-6363(97)00193-4, PII S0008636397001934
    • Hescheler, J., Fleischmann, B. K., Lentini, S., Maltsev, V. A., Rohwedel, J., Wobus, A. M., and Addicks, K. (1997) Embryonic stem cells: a model to study structural and functional properties in cardiomyogenesis. Cardiovasc. Res. 36, 149-162 (Pubitemid 27527340)
    • (1997) Cardiovascular Research , vol.36 , Issue.2 , pp. 149-162
    • Hescheler, J.1    Fleischmann, B.K.2    Lentini, S.3    Maltsev, V.A.4    Rohwedel, J.5    Wobus, A.M.6    Addicks, K.7
  • 49
    • 0027718107 scopus 로고
    • Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types
    • DOI 10.1016/0925-4773(93)90015-P
    • Maltsev, V. A., Rohwedel, J., Hescheler, J., and Wobus, A. M. (1993) Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types. Mech. Dev. 44, 41-50 (Pubitemid 24037697)
    • (1993) Mechanisms of Development , vol.44 , Issue.1 , pp. 41-50
    • Maltsev, V.A.1    Rohwedel, J.2    Hescheler, J.3    Wobus, A.M.4
  • 50
    • 0030589479 scopus 로고    scopus 로고
    • Differential regulation of gap junction protein (connexin) genes during cardiomyocytic differentiation of mouse embryonic stem cells in vitro
    • DOI 10.1006/excr.1996.0377
    • Oyamada, Y., Komatsu, K., Kimura, H., Mori, M., and Oyamada, M. (1996) Differential regulation of gap junction protein (connexin) genes during cardiomyocytic differentiation of mouse embryonic stem cells in vitro. Exp. Cell. Res. 229, 318-326 (Pubitemid 27026922)
    • (1996) Experimental Cell Research , vol.229 , Issue.2 , pp. 318-326
    • Oyamada, Y.1    Komatsu, K.2    Kimura, H.3    Mori, M.4    Oyamada, M.5
  • 51
    • 34249863603 scopus 로고    scopus 로고
    • Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells
    • DOI 10.1016/j.stem.2007.05.012, PII S1934590907000185
    • Yamanaka, S. (2007) Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 1, 39-49 (Pubitemid 46865811)
    • (2007) Cell Stem Cell , vol.1 , Issue.1 , pp. 39-49
    • Yamanaka, S.1
  • 53
    • 0017253018 scopus 로고
    • The beta-adrenergic receptor
    • Lefkowitz, R. J. (1976) The beta-adrenergic receptor. Life Sci. 18, 461-472
    • (1976) Life Sci. , vol.18 , pp. 461-472
    • Lefkowitz, R.J.1
  • 54
    • 0033534658 scopus 로고    scopus 로고
    • Muscarinic cholinergic signaling in cardiac myocytes: Dynamic targeting of M2AChR to sarcolemmal caveolae and eNOS activation
    • DOI 10.1016/S0024-3205(98)00590-6, PII S0024320598005906
    • Feron, O., Han, X., and Kelly, R. A. (1999) Muscarinic cholinergic signaling in cardiac myocytes: dynamic targeting of M2AChR to sarcolemmal caveolae and eNOS activation. Life Sci. 64, 471-477 (Pubitemid 29066695)
    • (1999) Life Sciences , vol.64 , Issue.6-7 , pp. 471-477
    • Feron, O.1    Han, X.2    Kelly, R.A.3
  • 55
    • 0020539664 scopus 로고
    • Calcium-channel-blocking agents
    • Insel, P. A., and Motulsky, H. J. (1983) Calcium-channel-blocking agents. N. Engl. J. Med. 308, 1361-1362
    • (1983) N. Engl. J. Med. , vol.308 , pp. 1361-1362
    • Insel, P.A.1    Motulsky, H.J.2
  • 56
    • 0021070217 scopus 로고
    • Calcium antagonists
    • Nayler, W. G. (1983) Calcium antagonists. Med. J. Aust. 2, 506-512
    • (1983) Med. J. Aust. , vol.2 , pp. 506-512
    • Nayler, W.G.1
  • 57
    • 0026516632 scopus 로고
    • Voltage-dependent calcium channels: Structures and drug-binding sites
    • Spedding, M., and Kenny, B. (1992) Voltage-dependent calcium channels: structures and drug-binding sites. Biochem. Soc. Trans. 20, 147-153
    • (1992) Biochem. Soc. Trans. , vol.20 , pp. 147-153
    • Spedding, M.1    Kenny, B.2
  • 58
    • 0024419958 scopus 로고
    • Blockade of cardiac sodium channels by lidocaine. Single-channel analysis
    • Grant, A. O., Dietz, M. A., Gilliam, F. R., III, and Starmer, C. F. (1989) Blockade of cardiac sodium channels by lidocaine. Single-channel analysis. Circ. Res. 65, 1247-1262
    • (1989) Circ. Res. , vol.65 , pp. 1247-1262
    • Grant, A.O.1    Dietz, M.A.2    Gilliam III, F.R.3    Starmer, C.F.4
  • 59
    • 0024361475 scopus 로고
    • Use-dependent block of single sodium channels by lidocaine in guinea pig ventricular myocytes
    • McDonald, T. V., Courtney, K. R., and Clusin, W. T. (1989) Use-dependent block of single sodium channels by lidocaine in guinea pig ventricular myocytes. Biophys. J. 55, 1261-1266 (Pubitemid 19158529)
    • (1989) Biophysical Journal , vol.55 , Issue.6 , pp. 1261-1266
    • McDonald, T.V.1    Courtney, K.R.2    Clusin, W.T.3
  • 60
    • 0025351245 scopus 로고
    • Two components of cardiac delayed rectifier K+ current: Differential sensitivity to block by class III antiarrhythmic agents
    • Sanguinetti, M. C., and Jurkiewicz, N. K. (1990) Two components of cardiac delayed rectifier K+ current: differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol. 96, 195-215
    • (1990) J. Gen. Physiol. , vol.96 , pp. 195-215
    • Sanguinetti, M.C.1    Jurkiewicz, N.K.2
  • 61
    • 0028895513 scopus 로고
    • Role of rapidly activating delayed rectifier K+ current in sinoatrial node pacemaker activity
    • Ono, K., and Ito, H. (1995) Role of rapidly activating delayed rectifier K+ current in sinoatrial node pacemaker activity. Am. J. Physiol. 269, H453-H462
    • (1995) Am. J. Physiol. , vol.269
    • Ono, K.1    Ito, H.2
  • 62
    • 0028935894 scopus 로고
    • Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit
    • Verheijck, E. E., van Ginneken, A. C., Bourier, J., and Bouman, L. N. (1995) Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ. Res. 76, 607-615
    • (1995) Circ. Res. , vol.76 , pp. 607-615
    • Verheijck, E.E.1    Van Ginneken, A.C.2    Bourier, J.3    Bouman, L.N.4
  • 63
    • 0021591865 scopus 로고
    • The relationship between action potential duration and force of contraction in rat myocardium
    • Schouten, V. J. (1984) The relationship between action potential duration and force of contraction in rat myocardium. Eur. Heart. J. 5, 984-992 (Pubitemid 15079487)
    • (1984) European Heart Journal , vol.5 , Issue.12 , pp. 984-992
    • Schouten, V.J.A.1
  • 64
    • 0033680088 scopus 로고    scopus 로고
    • Effects of inhibition of calcium and potassium currents in guinea-pig cardiac contraction: Comparison of beta-caryophyllene oxide, eugenol, and nifedipine
    • Sensch, O., Vierling, W., Brandt, W., and Reiter, M. (2000) Effects of inhibition of calcium and potassium currents in guinea-pig cardiac contraction: comparison of beta-caryophyllene oxide, eugenol, and nifedipine. Br. J. Pharmacol. 131, 1089-1096 (Pubitemid 30953559)
    • (2000) British Journal of Pharmacology , vol.131 , Issue.6 , pp. 1089-1096
    • Sensch, O.1    Vierling, W.2    Brandt, W.3    Reiter, M.4
  • 65
    • 0141870053 scopus 로고    scopus 로고
    • Cellular electrophysiology of canine pulmonary vein cardiomyocytes: Action potential and ionic current properties
    • DOI 10.1113/jphysiol.2003.046417
    • Ehrlich, J. R., Cha, T. J., Zhang, L., Chartier, D., Melnyk, P., Hohnloser, S. H., and Nattel, S. (2003) Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties. J. Physiol. 551, 801-813 (Pubitemid 37221074)
    • (2003) Journal of Physiology , vol.551 , Issue.3 , pp. 801-813
    • Ehrlich, J.R.1    Cha, T.-J.2    Zhang, L.3    Chartier, D.4    Melnyk, P.5    Hohnloser, S.H.6    Nattel, S.7
  • 67
    • 0029762672 scopus 로고    scopus 로고
    • K, in rabbit sino-atrial node cells
    • Lei, M., and Brown, H. F. (1996) Two components of the delayed rectifier potassium current, IK, in rabbit sino-atrial node cells. Exp. Physiol. 81, 725-741 (Pubitemid 126735539)
    • (1996) Experimental Physiology , vol.81 , Issue.5 , pp. 725-741
    • Lei, M.1    Brown, H.F.2
  • 70
    • 0027186122 scopus 로고
    • Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent: Specific block of rapidly activating delayed rectifier K+ current by dofetilide
    • Jurkiewicz, N. K., and Sanguinetti, M. C. (1993) Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent: specific block of rapidly activating delayed rectifier K+ current by dofetilide. Circ. Res. 72, 75-83
    • (1993) Circ. Res. , vol.72 , pp. 75-83
    • Jurkiewicz, N.K.1    Sanguinetti, M.C.2
  • 71
    • 0026635995 scopus 로고
    • Modulation of potassium channels by antiarrhythmic and antihypertensive drugs
    • Sanguinetti, M. C. (1992) Modulation of potassium channels by antiarrhythmic and antihypertensive drugs. Hypertension 19, 228-236
    • (1992) Hypertension , vol.19 , pp. 228-236
    • Sanguinetti, M.C.1


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