Mechanical but not painful electrical stimuli trigger TNF alpha release in human skin

Experimental Neurology

Volumn 221, Issue 1, 2010, Pages 246-250

  Eberle, T ^a   Doganci, B ^a   Kramer H ^a   Fechir, M ^a   Wagner, I ^a   Sommer, C ^b   Birklein, F ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Constant current stimulation; Cytokines; Keratinocytes; Mechanical impact stimulation; Microdialysis; Nociceptors; Tumor Necrosis Factor alpha

Indexed keywords

SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CONTROLLED STUDY; ELECTRIC CURRENT; ELECTROSTIMULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; EXPERIMENTAL DESIGN; FEMALE; HUMAN; HUMAN EXPERIMENT; LASER FLOWMETER; MALE; MECHANICAL STIMULATION; MICRODIALYSIS; NORMAL HUMAN; PERFUSION; PRIORITY JOURNAL; SKIN SENSITIVITY; SKIN STIMULATION; VELOCITY;

ADULT; ANALYSIS OF VARIANCE; ELECTRIC STIMULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; LASER-DOPPLER FLOWMETRY; MALE; MICRODIALYSIS; PAIN; PAIN MEASUREMENT; PHYSICAL STIMULATION; SKIN; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 72749098094     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2009.11.008     Document Type: Article

References (43)

1. Anderson C., Andersson T., and Wardell K. Changes in skin circulation after insertion of a microdialysis probe visualized by laser Doppler perfusion imaging. J. Invest. Dermatol. 102 (1994) 807-811
2. Angst M.S., Clark J.D., Carvalho B., Tingle M., Schmelz M., and Yeomans D.C. Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: a microdialysis study. Pain 139 (2008) 15-27
3. Angst M.S., Clark J.D., Carvalho B., Tingle M., Schmelz M., and Yeomans D.C. Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: a microdialysis study. Pain 139 (2008) 15-27
4. Bernateck M., Rolke R., Birklein F., Treede R.D., Fink M., and Karst M. Successful intravenous regional block with low-dose tumor necrosis factor-alpha antibody infliximab for treatment of complex regional pain syndrome 1. Anesth. Analg. 105 (2007) 1148-1151 table
5. Bronneberg D., Spiekstra S.W., Cornelissen L.H., Oomens C.W., Gibbs S., Baaijens F.P., and Bouten C.V. Cytokine and chemokine release upon prolonged mechanical loading of the epidermis. Exp. Dermatol. 16 (2007) 567-573
6. Cuellar J.M., Montesano P.X., and Carstens E. Role of TNF-alpha in sensitization of nociceptive dorsal horn neurons induced by application of nucleus pulposus to L5 dorsal root ganglion in rats. Pain 110 (2004) 578-587
7. Geber C., Fondel R., Kramer H.H., Rolke R., Treede R.D., Sommer C., and Birklein F. Psychophysics, flare, and neurosecretory function in human pain models: capsaicin versus electrically evoked pain. J. Pain 8 (2007) 503-514
8. George A., Marziniak M., Schafers M., Toyka K.V., and Sommer C. Thalidomide treatment in chronic constrictive neuropathy decreases endoneurial tumor necrosis factor-alpha, increases interleukin-10 and has long-term effects on spinal cord dorsal horn met-enkephalin. Pain 88 (2000) 267-275
9. Gordon J.R., and Galli S.J. Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin. Nature 346 (1990) 274-276
10. Grellner W. Time-dependent immunohistochemical detection of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in human skin wounds. Forensic Sci. Int. 130 (2002) 90-96
11. Hao S., Mata M., Glorioso J.C., and Fink D.J. HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain. Mol. Pain 2 (2006) 6
12. Heijmans-Antonissen C., Wesseldijk F., Munnikes R.J., Huygen F.J., van der M.P., Hop W.C., Hooijkaas H., and Zijlstra F.J. Multiplex bead array assay for detection of 25 soluble cytokines in blister fluid of patients with complex regional pain syndrome type 1. Mediat. Inflamm. 2006 (2006) 28398
13. Huygen F.J., Niehof S., Zijlstra F.J., van Hagen P.M., and van Daele P.L. Successful treatment of CRPS 1 with anti-TNF. J. Pain Symp. Manag. 27 (2004) 101-103
14. Junger H., and Sorkin L.S. Nociceptive and inflammatory effects of subcutaneous TNFalpha. Pain 85 (2000) 145-151
15. Kawasaki Y., Zhang L., Cheng J.K., and Ji R.R. Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J. Neurosci. 28 (2008) 5189-5194
16. Kohllöffel L.U.E., Koltzenburg M., and Handwerker H.O. A novel technique for the evaluation of mechanical pain and hyperalgesia. Pain 46 (1991) 81-87
17. Koltzenburg M., and Handwerker H.O. Differential ability of human cutaneous nociceptors to signal mechanical pain and to produce vasodilatation. J. Neurosci. 14 (1994) 1756-1765
18. Kramer H.H., Schmelz M., Birklein F., and Bickel A. Electrically stimulated axon reflexes are diminished in diabetic small fiber neuropathies. Diabetes 53 (2004) 769-774
19. Langberg H., Bjorn C., Boushel R., Hellsten Y., and Kjaer M. Exercise-induced increase in interstitial bradykinin and adenosine concentrations in skeletal muscle and peritendinous tissue in humans. J. Physiol. 542 (2002) 977-983
20. Langberg H., Olesen J.L., Gemmer C., and Kjaer M. Substantial elevation of interleukin-6 concentration in peritendinous tissue, in contrast to muscle, following prolonged exercise in humans. J. Physiol. 542 (2002) 985-990
21. Lindenlaub T., and Sommer C. Cytokines in sural nerve biopsies from inflammatory and non-inflammatory neuropathies. Acta Neuropathol. (Berl.) 105 (2003) 593-602
22. Maihofner C., Handwerker H.O., Neundorfer B., and Birklein F. Mechanical hyperalgesia in complex regional pain syndrome: a role for TNF-alpha?. Neurology 65 (2005) 311-313
23. McMahon S.B., Cafferty W.B., and Marchand F. Immune and glial cell factors as pain mediators and modulators. Exp. Neurol. 192 (2005) 444-462
24. Milligan E.D., Sloane E.M., Langer S.J., Hughes T.S., Jekich B.M., Frank M.G., Mahoney J.H., Levkoff L.H., Maier S.F., Cruz P.E., Flotte T.R., Johnson K.W., Mahoney M.M., Chavez R.A., Leinwand L.A., and Watkins L.R. Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain 126 (2006) 294-308
25. Nickoloff B.J., and Naidu Y. Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin. J. Am. Acad. Dermatol. 30 (1994) 535-546
26. Nickoloff B.J., Fivenson D.P., Kunkel S.L., Strieter R.M., and Turka L.A. Keratinocyte interleukin-10 expression is upregulated in tape-stripped skin, poison ivy dermatitis, and Sezary syndrome, but not in psoriatic plaques. Clin. Immunol. Immunopathol. 73 (1994) 63-68
27. Rosendal L., Sogaard K., Kjaer M., Sjogaard G., Langberg H., and Kristiansen J. Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise. J. Appl. Physiol. 98 (2005) 477-481
28. Sabsovich I., Guo T.Z., Wei T., Zhao R., Li X., Clark D.J., Geis C., Sommer C., and Kingery W.S. TNF signaling contributes to the development of nociceptive sensitization in a tibia fracture model of complex regional pain syndrome type I. Pain 137 (2008) 507-519
29. Sabsovich I., Wei T., Guo T.Z., Zhao R., Shi X., Li X., Yeomans D.C., Klyukinov M., Kingery W.S., and Clark J.D. Effect of anti-NGF antibodies in a rat tibia fracture model of complex regional pain syndrome type I. Pain 138 (2008) 47-60
30. Sahbaie P., Shi X., Guo T.Z., Qiao Y., Yeomans D.C., Kingery W.S., and Clark J.D. Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision. Pain 145 (2009) 341-349
31. Schafers M., Sorkin L.S., and Sommer C. Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats. Pain 104 (2003) 579-588
32. Schafers M., Sommer C., Geis C., Hagenacker T., Vandenabeele P., and Sorkin L.S. Selective stimulation of either tumor necrosis factor receptor differentially induces pain behavior in vivo and ectopic activity in sensory neurons in vitro. Neuroscience 157 (2008) 414-423
33. Schmelz M., Luz O., Averbeck B., and Bickel A. Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysis. Neurosci. Lett. 230 (1997) 117-120
34. Schmelz M., Michael K., Weidner C., Schmidt R., Torebjork H.E., and Handwerker H.O. Which nerve fibers mediate the axon reflex flare in human skin?. NeuroReport 11 (2000) 645-648
35. Scholz J., and Woolf C.J. The neuropathic pain triad: neurons, immune cells and glia. Nat. Neurosci. 10 (2007) 1361-1368
36. Sieweke N., Birklein F., Riedl B., Neundorfer B., and Handwerker H.O. Patterns of hyperalgesia in complex regional pain syndrome. Pain 80 (1999) 171-177
37. Smith M.D., Triantafillou S., Parker A., Youssef P.P., and Coleman M. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J. Rheumatol. 24 (1997) 365-371
38. Sommer C., and Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci. Lett. 361 (2004) 184-187
39. Uceyler N., Eberle T., Rolke R., Birklein F., and Sommer C. Differential expression patterns of cytokines in complex regional pain syndrome. Pain 132 (2007) 195-205
40. Uceyler N., Rogausch J.P., Toyka K.V., and Sommer C. Differential expression of cytokines in painful and painless neuropathies. Neurology 69 (2007) 42-49
41. Uceyler N., Schafers M., and Sommer C. Mode of action of cytokines on nociceptive neurons. Exp. Brain Res. 196 (2009) 67-78
42. Wei X., Gong J., Zhu J., Wang P., Li N., Zhu W., and Li J. The suppressive effect of triptolide on chronic colitis and TNF-alpha/TNFR2 signal pathway in interleukin-10 deficient mice. Clin. Immunol. 129 (2008) 211-218
43. Weidner C., Schmelz M., Schmidt R., Hansson B., Handwerker H.O., and Torebjork H.E. Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin. J. Neurosci. 19 (1999) 10184-10190