A prolongation of the postspike afterhyperpolarization following spike trains can partly explain the lower firing rates at derecruitment than those at recruitment

Journal of Neurophysiology

Volumn 102, Issue 6, 2009, Pages 3698-3710

  Wienecke, J ^a   Zhang, M ^a   Hultborn, H ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AFTERHYPERPOLARIZATION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROMYOGRAM; EXPERIMENTAL CAT; MEMBRANE POTENTIAL; MEMBRANE STEADY POTENTIAL; MOTONEURON; MOTOR UNIT; NONHUMAN; PRIORITY JOURNAL; SPIKE WAVE;

ACTION POTENTIALS; ADJUVANTS, ANESTHESIA; ANIMALS; CATS; DECEREBRATE STATE; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; LAMINECTOMY; MOTOR NEURONS; MUSCLE CONTRACTION; MUSCLE, SKELETAL; PATCH-CLAMP TECHNIQUES; PENTOBARBITAL; RECRUITMENT, NEUROPHYSIOLOGICAL;

EID: 72749090348     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.90995.2008     Document Type: Article

References (56)

1. Adrian ED, Bronk DW. The discharge of impulses in motor nerve fibres: Part II. The frequency of discharge in reflex and voluntary contractions. J Physiol 67: 119-151, 1929.
2. Baldissera F, Gustafsson B, Parmiggiani F. Saturating summation of the afterhyperpolarization conductance in spinal motor neurones: a mechanism for "secondary range" repetitive firing. Brain Res 146: 69-82, 1978.
3. Baldissera F, Gustafsson B. Firing behaviour of a neurone model based on the afterhyperpolarization conductance time course and algebraical summation. Adaptation and steady state firing. Acta Physiol Scand 92: 27-47, 1974.
4. Bennett DJ, Hultborn H, Fedirchuk B, Gorassini M. Synaptic activation of plateaus in hindlimb motor neurons of decerebrate cats. J Neurophysiol 80: 2023-2037, 1998. (Pubitemid 28489130)
5. Bennett DJ, Li Y, Harvey PJ, Gorassini M. Evidence for plateau potentials in tail motor neurons of awake chronic spinal rats with spasticity. J Neurophysiol 86: 1972-1982, 2001a.
6. Bennett DJ, Li Y, Siu M. Plateau potentials in sacrocaudal motor neurons of chronic spinal rats, recorded in vitro. J Neurophysiol 86: 1955-1971, 2001b.
7. Bradley K, Somjen GG. Accommodation in motor neurones of the rat and the cat. J Physiol 156: 75-92, 1961.
8. Brock LG, Coombs JS, Eccles JC. The recording of potentials from motor neurones with an intracellular electrode. J Physiol 117: 431-460, 1952.
9. Button DC, Gardiner K, Marqueste T, Gardiner PF. Frequency-current relationships of rat hindlimb alpha-motor neurones. J Physiol 573: 663-677, 2006. (Pubitemid 43842509)
10. Christova P, Kossev A. Motor unit activity during long-lasting intermittent muscle contractions in humans. Eur J Appl Physiol Occupat Physiol 77: 379-387, 1998. (Pubitemid 28142586)
11. Conway BA, Hultborn H, Kiehn O, Mintz I. Plateau potentials in alphamotor neurones induced by intravenous injection of L-dopa and clonidine in the spinal cat. J Physiol 405: 369-384, 1988. (Pubitemid 18250344)
12. Crone C, Hultborn H, Kiehn O, Mazieres L, Wigstrom H. Maintained changes in motor neuronal excitability by short-lasting synaptic inputs in the decerebrate cat. J Physiol 405: 321-343, 1988. (Pubitemid 18250342)
13. De Luca CJ, LeFever RS, McCue MP, Xenakis AP. Behaviour of human motor units in different muscles during linearly varying contractions. J Physiol 329: 113-128, 1982.
14. DiFrancesco D, Tortora P. Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature 351: 145-147, 1991. (Pubitemid 21896552)
15. Eccles JC, Eccles RM, Lundberg A. The action potentials of the alpha motor neurones supplying fast and slow muscles. J Physiol 142: 275-291, 1958.
16. Gorassini M, Bennett DJ, Kiehn O, Eken T, Hultborn H. Activation patterns of hindlimb motor units in the awake rat and their relation to motor neuron intrinsic properties. J Neurophysiol 82: 709-717, 1999. (Pubitemid 29387845)
17. Gorassini M, Eken T, Bennett DJ, Kiehn O, Hultborn H. Activity of hindlimb motor units during locomotion in the conscious rat. J Neurophysiol 83: 2002-2011, 2000.
18. Gorassini M, Yang JF, Siu M, Bennett DJ. Intrinsic activation of human motor neurons: possible contribution to motor unit excitation. J Neurophysiol 87: 1850-1858, 2002a.
19. Gorassini M, Yang JF, Siu M, Bennett DJ. Intrinsic activation of human motor neurons: reduction of motor unit recruitment thresholds by repeated contractions. J Neurophysiol 87: 1859-1866, 2002b.
20. Granit R, Kernell D, Shortess GK. Quantitative aspects of repetitive firing of mammalian motor neurones, caused by injected currents. J Physiol 168: 911-931, 1963.
21. Guertin PA, Hounsgaard J. Non-volatile general anaesthetics reduce spinal activity by suppressing plateau potentials. Neuroscience 88: 353-358, 1999. (Pubitemid 28479998)
22. Gustafsson B. Afterhyperpolarization and the control of repetitive firing in spinal neurones of the cat. Acta Physiol Scand 416: 1-47, 1974.
23. Gustafsson B, Pinter MJ. Relations among passive electrical properties of lumbar alpha-motor neurones of the cat. J Physiol 356: 401-431, 1984. (Pubitemid 14011556)
24. Gustafsson B, Pinter MJ. Factors determining the variation of the afterhyperpolarization duration in cat lumbar alpha-motor neurones. Brain Res 326: 392-395, 1985. (Pubitemid 15160055)
25. Heckman CJ, Gorassini MA, Bennett DJ. Persistent inward currents in motor neuron dendrites: implications for motor output. Muscle Nerve 31: 135-156, 2005.
26. Hounsgaard J, Hultborn H, Jespersen B, Kiehn O. Bistability of alphamotor neurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J Physiol 405: 345-367, 1988. (Pubitemid 18250343)
27. Hounsgaard J, Mintz I. Calcium conductance and firing properties of spinal motor neurones in the turtle. J Physiol 398: 591-603, 1988. (Pubitemid 18070025)
28. Hultborn H, Brownstone RB, Toth TI, Gossard JP. Key mechanisms for setting the input-output gain across the motor neuron pool. Prog Brain Res 143: 77-95, 2004. (Pubitemid 37442983)
29. Ito M, Oshima T. Temporal summation of after-hyperpolarization following a motor neurone spike. Nature 195: 910-911, 1962.
30. Ito M, Oshima T. Electrical behaviour of the motor neurone membrane during intracellularly applied current steps. J Physiol 180: 607-635, 1965.
31. Kernell D. High-frequency repetitive firing of cat lumbosacral motor neurones stimulated by long-lasting injected currents. Acta Physiol Scand 65: 74-86, 1965a.
32. Kernell D. The limits of firing frequency in cat lumbosacral motor neurones possessing different time course of afterhyperpolarization. Acta Physiol Scand 65: 87-100, 1965b.
33. Kernell D. The Motor Neurone and Its Muscle Fibres. New York: Oxford Univ. Press, 2006.
34. Kernell D, Monster AW. Time course and properties of late adaptation in spinal motor neurones of the cat. Exp Brain Res 46: 191-196, 1982. (Pubitemid 12092916)
35. Krnjevic K, Puil E, Werman R. EGTA and motor neuronal after-potentials. J Physiol 275: 199-223, 1978.
36. Kudina LP. Analysis of firing behaviour of human motor neurones within "subprimary range." J Physiol (Paris) 93: 115-123, 1999.
37. Kuo JJ, Lee RH, Zhang L, Heckman CJ. Essential role of the persistent sodium current in spike initiation during slowly rising inputs in mouse spinal neurones. J Physiol 574: 819-834, 2006. (Pubitemid 44089073)
38. Lee RH, Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in rhythmic firing patterns. J Neurophysiol 80: 572-582, 1998. (Pubitemid 28387642)
39. Li Y, Gorassini MA, Bennett DJ. Role of persistent sodium and calcium currents in motor neuron firing and spasticity in chronic spinal rats. J Neurophysiol 91: 767-783, 2004. (Pubitemid 38168850)
40. Matthews PB. Relationship of firing intervals of human motor units to the trajectory of post-spike after-hyperpolarization and synaptic noise. J Physiol 492: 597-628, 1996.
41. Matthews PB. Properties of human motor neurones and their synaptic noise deduced from motor unit recordings with the aid of computer modelling. J Physiol (Paris) 93: 135-145, 1999.
42. Miles GB, Dai Y, Brownstone RM. Mechanisms underlying the early phase of spike frequency adaptation in mouse spinal motoneurones. J Physiol 566: 519-532, 2005. (Pubitemid 41030557)
43. Powers RK, Binder MD. Relationship between the time course of the afterhyperpolarization and discharge variability in cat spinal motoneurones. J Physiol 528: 131-150, 2000.
44. Powers RK, Binder MD. Input-output functions of mammalian motor neurons. Rev Physiol Biochem Pharmacol 143: 137-263, 2001.
45. Powers RK, Sawczuk A, Musick JR, Binder MD. Multiple mechanisms of spike-frequency adaptation in motoneurones. J Physiol (Paris) 93: 101-114, 1999. (Pubitemid 29305284)
46. Rekling JC, Funk GD, Bayliss DA, Dong XW, Feldman JL. Synaptic control of motor neuronal excitability. Physiol Rev 80: 767-852, 2000. (Pubitemid 30164949)
47. Romaiguere P, Vedel JP, Pagni S. Comparison of fluctuations of motor unit recruitment and derecruitment thresholds in man. Exp Brain Res 95: 517-522, 1993. (Pubitemid 23288363)
48. + current, IAHP, in the rat sympathetic neurone. J Physiol 483: 15-27, 1995.
49. + channels in the soma of rat motor neurones. J Physiol 497: 727-734, 1996.
50. Schwindt P, Crill W. Membrane properties of cat motor neurons. In: Handbook of Spinal Cord, edited by Davidoff RA. New York: Marcel Decker, 1984, p. 199-242.
51. + current. Soc Neurosci Abstr 53.2, 2003.
52. 2+ dependent afterhyperpolarization in lamprey neurons. Soc Neurosci Abstr 546.9, 2002.
53. Wallén P, Robertson B, Cangiano L, Löw P, Bhattacharjee A, Kaczmarek LK, Grillner S. Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons. J Physiol 585: 75-90, 2007. (Pubitemid 350131104)
54. Wienecke J, Zhang M, Hultborn H. Spike trains prolong the post-spike after hyperpolarization in cat spinal motor neurones. Joint Int Meeting Physiol Soc FEPS Abstr C64, 2005a.
55. Wienecke J, Zhang M, Hultborn H. The post-spike afterhyperpolarization (AHP) following single spikes is prolonged by a preceding spike-train in cat spinal motor neurons. Soc Neuroscience Abstr 750.8, 2005b.
56. Zengel JE, Reid SA, Sypert GW, Munson JB. Membrane electrical properties and prediction of motor-unit type of medial gastrocnemius motor neurons in the cat. J Neurophysiol 53: 1323-1344, 1985.