-
1
-
-
33644775686
-
-
Szakács G., Paterson J.K., Ludwig J.A., Booth-Genthe C., and Gottesman M.M. Nat Rev Drug Discov 5 (2006) 219-234
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 219-234
-
-
Szakács, G.1
Paterson, J.K.2
Ludwig, J.A.3
Booth-Genthe, C.4
Gottesman, M.M.5
-
2
-
-
0021797892
-
Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines
-
Riordan J.R., Deuchars K., Kartner N., Alon N., Trent J., and Ling V. Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 316 (1985) 817-819
-
(1985)
Nature
, vol.316
, pp. 817-819
-
-
Riordan, J.R.1
Deuchars, K.2
Kartner, N.3
Alon, N.4
Trent, J.5
Ling, V.6
-
3
-
-
42949171158
-
-
American Cancer Society, Atlanta, GA
-
Garcia M., Jemal A., Ward E.M., et al. Global cancer facts and figures 2007 (2007), American Cancer Society, Atlanta, GA
-
(2007)
Global cancer facts and figures 2007
-
-
Garcia, M.1
Jemal, A.2
Ward, E.M.3
-
4
-
-
13644254794
-
Molecular mechanisms of drug resistance
-
Longley D.B., and Johnston P.G. Molecular mechanisms of drug resistance. J Pathol 205 (2005) 275-292
-
(2005)
J Pathol
, vol.205
, pp. 275-292
-
-
Longley, D.B.1
Johnston, P.G.2
-
5
-
-
2542491777
-
The role of ABC transporters in drug resistance, metabolism and toxicity
-
Glavinas H., Krajcsi P., Cserepes J., and Sarkadi B. The role of ABC transporters in drug resistance, metabolism and toxicity. Curr Drug Deliv 1 (2004) 27-42
-
(2004)
Curr Drug Deliv
, vol.1
, pp. 27-42
-
-
Glavinas, H.1
Krajcsi, P.2
Cserepes, J.3
Sarkadi, B.4
-
6
-
-
33748644877
-
Structure of a bacterial multidrug ABC transporter
-
Dawson R., Kaspar J.P., and Locher P. Structure of a bacterial multidrug ABC transporter. Nature 443 (2006) 180-185
-
(2006)
Nature
, vol.443
, pp. 180-185
-
-
Dawson, R.1
Kaspar, J.P.2
Locher, P.3
-
7
-
-
60149098422
-
An ABC transporter controls export of a Drosophila germ cell attractant
-
Ricardo S., and Lehmann R. An ABC transporter controls export of a Drosophila germ cell attractant. Science 323 (2009) 943-946
-
(2009)
Science
, vol.323
, pp. 943-946
-
-
Ricardo, S.1
Lehmann, R.2
-
8
-
-
60149095846
-
The ABCs of lipophile transport
-
Hla T., and Im D.S. The ABCs of lipophile transport. Science 323 (2009) 883-884
-
(2009)
Science
, vol.323
, pp. 883-884
-
-
Hla, T.1
Im, D.S.2
-
9
-
-
0030797650
-
The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor
-
Christensen P.U., Davey J., and Nielsen O. The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor. Mol Gen Genet 255 (1997) 226-236
-
(1997)
Mol Gen Genet
, vol.255
, pp. 226-236
-
-
Christensen, P.U.1
Davey, J.2
Nielsen, O.3
-
10
-
-
0024375860
-
The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein
-
McGrath J.P., and Varshavsky A. The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein. Nature 340 (1989) 400-404
-
(1989)
Nature
, vol.340
, pp. 400-404
-
-
McGrath, J.P.1
Varshavsky, A.2
-
11
-
-
0026585065
-
Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene
-
Raymond M., Gros P., Whiteway M., and Thomas D.Y. Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene. Science 256 (1992) 232-234
-
(1992)
Science
, vol.256
, pp. 232-234
-
-
Raymond, M.1
Gros, P.2
Whiteway, M.3
Thomas, D.Y.4
-
12
-
-
0032518394
-
A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene
-
van Veen H.W., Callaghan R., Soceneantu L., Sardini A., Konings W.N., and Higgins C.F. A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene. Nature 391 (1998) 291-295
-
(1998)
Nature
, vol.391
, pp. 291-295
-
-
van Veen, H.W.1
Callaghan, R.2
Soceneantu, L.3
Sardini, A.4
Konings, W.N.5
Higgins, C.F.6
-
13
-
-
14344254868
-
Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice
-
Liu M., Bryant M.S., Chen J., et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res 58 (1998) 4947-4956
-
(1998)
Cancer Res
, vol.58
, pp. 4947-4956
-
-
Liu, M.1
Bryant, M.S.2
Chen, J.3
-
14
-
-
0035887454
-
The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein
-
Wang E., Casciano C.N., Clement R.P., and Johnson W.W. The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein. Cancer Res 61 (2001) 7525-7529
-
(2001)
Cancer Res
, vol.61
, pp. 7525-7529
-
-
Wang, E.1
Casciano, C.N.2
Clement, R.P.3
Johnson, W.W.4
-
15
-
-
0345735895
-
The farnesyl protein transferase inhibitor lonafarnib (SCH66336) is an inhibitor of multidrug resistance proteins 1 and 2
-
Wang E.J., and Johnson W.W. The farnesyl protein transferase inhibitor lonafarnib (SCH66336) is an inhibitor of multidrug resistance proteins 1 and 2. Chemotherapy 49 (2003) 303-308
-
(2003)
Chemotherapy
, vol.49
, pp. 303-308
-
-
Wang, E.J.1
Johnson, W.W.2
-
16
-
-
27244450832
-
Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells
-
Morgan M.A., Sebil T., Aydilek E., Peest D., Ganser A., and Reuter C.W. Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Br J Haematol 130 (2005) 912-925
-
(2005)
Br J Haematol
, vol.130
, pp. 912-925
-
-
Morgan, M.A.1
Sebil, T.2
Aydilek, E.3
Peest, D.4
Ganser, A.5
Reuter, C.W.6
-
17
-
-
33744925129
-
The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis
-
Horie N., Murata H., Nishigaki Y., et al. The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis. Cancer Lett 238 (2006) 111-118
-
(2006)
Cancer Lett
, vol.238
, pp. 111-118
-
-
Horie, N.1
Murata, H.2
Nishigaki, Y.3
-
18
-
-
37249013938
-
ABT-737 is a useful component of combinatory chemotherapies for chronic myeloid leukemias with diverse drug-resistance mechanisms
-
Kuroda J., Kimura S., Andreef M., et al. ABT-737 is a useful component of combinatory chemotherapies for chronic myeloid leukemias with diverse drug-resistance mechanisms. Brit J Haematol 140 (2008) 181-190
-
(2008)
Brit J Haematol
, vol.140
, pp. 181-190
-
-
Kuroda, J.1
Kimura, S.2
Andreef, M.3
-
19
-
-
67749130945
-
Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation
-
Zhang Y., Cao R., Yin F., et al. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J Am Chem Soc 131 (2009) 5153-5162
-
(2009)
J Am Chem Soc
, vol.131
, pp. 5153-5162
-
-
Zhang, Y.1
Cao, R.2
Yin, F.3
-
20
-
-
60549097419
-
Endocrine therapy plus zoledronic acid in premenopausal breast cancer
-
Gnant M., Mlineritsch B., Schippinger W., et al. Endocrine therapy plus zoledronic acid in premenopausal breast cancer. N Engl J Med 360 (2009) 679-691
-
(2009)
N Engl J Med
, vol.360
, pp. 679-691
-
-
Gnant, M.1
Mlineritsch, B.2
Schippinger, W.3
-
21
-
-
63449139456
-
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding
-
Aller S.G., Yu J., Ward A., et al. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science 323 (2009) 1718-1722
-
(2009)
Science
, vol.323
, pp. 1718-1722
-
-
Aller, S.G.1
Yu, J.2
Ward, A.3
-
22
-
-
0035879957
-
Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance
-
McFadyen M.C., McLeod H.L., Jackson F.C., Melvin W.T., Doehmer J., and Murray G.I. Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance. Biochem Pharmacol 62 (2001) 207-212
-
(2001)
Biochem Pharmacol
, vol.62
, pp. 207-212
-
-
McFadyen, M.C.1
McLeod, H.L.2
Jackson, F.C.3
Melvin, W.T.4
Doehmer, J.5
Murray, G.I.6
-
23
-
-
0030977145
-
Phosphatidylcholine and phosphatidylethanolamine behave as substrates of the human MDR1 P-glycoprotein
-
Bosch I., Dunussi-Joannopoulos K., Wu R.L., Furlong S.T., and Croop J. Phosphatidylcholine and phosphatidylethanolamine behave as substrates of the human MDR1 P-glycoprotein. Biochemistry 36 (1997) 5685-5694
-
(1997)
Biochemistry
, vol.36
, pp. 5685-5694
-
-
Bosch, I.1
Dunussi-Joannopoulos, K.2
Wu, R.L.3
Furlong, S.T.4
Croop, J.5
-
24
-
-
0141994817
-
Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein
-
Loo T.W., Bartlett M.C., and Clarke D.M. Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein. J Biol Chem 278 (2003) 39706-39710
-
(2003)
J Biol Chem
, vol.278
, pp. 39706-39710
-
-
Loo, T.W.1
Bartlett, M.C.2
Clarke, D.M.3
-
25
-
-
27144451192
-
Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs
-
Lugo M.R., and Sharom F.J. Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs. Biochemistry 44 (2005) 14020-14029
-
(2005)
Biochemistry
, vol.44
, pp. 14020-14029
-
-
Lugo, M.R.1
Sharom, F.J.2
-
26
-
-
0028106016
-
Glutathione-associated enzymes in anticancer drug resistance
-
Tew K.D. Glutathione-associated enzymes in anticancer drug resistance. Cancer Res 54 16 (1994) 4313-4320
-
(1994)
Cancer Res
, vol.54
, Issue.16
, pp. 4313-4320
-
-
Tew, K.D.1
-
27
-
-
30644478973
-
HMG-CoA reductase inhibitors (statins) as anticancer drugs (review)
-
Fritz G. HMG-CoA reductase inhibitors (statins) as anticancer drugs (review). Int J Oncol 27 (2005) 1401-1409
-
(2005)
Int J Oncol
, vol.27
, pp. 1401-1409
-
-
Fritz, G.1
-
28
-
-
28844490054
-
Statins and cancer prevention
-
Demierre M.F., Higgins P.D., Gruber S.B., Hawk E., and Lippman S.M. Statins and cancer prevention. Nat Rev Cancer 5 (2005) 930-942
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 930-942
-
-
Demierre, M.F.1
Higgins, P.D.2
Gruber, S.B.3
Hawk, E.4
Lippman, S.M.5
-
30
-
-
0032766426
-
Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells
-
Agarwal B., Bhendwal S., Halmos B., Moss S.F., Ramey W.G., and Holt P.R. Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. Clin Cancer Res 5 (1999) 2223-2229
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2223-2229
-
-
Agarwal, B.1
Bhendwal, S.2
Halmos, B.3
Moss, S.F.4
Ramey, W.G.5
Holt, P.R.6
-
31
-
-
0035552572
-
Synergistic interaction of lovastatin and paclitaxel in human cancer cells
-
Holstein S.A., and Hohl R.J. Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther 1 (2001) 141-149
-
(2001)
Mol Cancer Ther
, vol.1
, pp. 141-149
-
-
Holstein, S.A.1
Hohl, R.J.2
-
32
-
-
0036643517
-
Lovastatin potentiates antitumor activity of doxorubicin in murine melanoma via an apoptosis-dependent mechanism
-
Feleszko W., Mlynarczuk I., Olszewska D., et al. Lovastatin potentiates antitumor activity of doxorubicin in murine melanoma via an apoptosis-dependent mechanism. Int J Cancer 100 (2002) 111-118
-
(2002)
Int J Cancer
, vol.100
, pp. 111-118
-
-
Feleszko, W.1
Mlynarczuk, I.2
Olszewska, D.3
-
33
-
-
4444282702
-
The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase
-
Schmidmaier R., Baumann P., Simsek M., Dayyani F., Emmerich B., and Meinhardt G. The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase. Blood 104 (2004) 1825-1832
-
(2004)
Blood
, vol.104
, pp. 1825-1832
-
-
Schmidmaier, R.1
Baumann, P.2
Simsek, M.3
Dayyani, F.4
Emmerich, B.5
Meinhardt, G.6
-
34
-
-
34547798983
-
First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma
-
Schmidmaier R., Baumann P., Bumeder I., Meinhardt G., Straka C., and Emmerich B. First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma. Eur J Haematol 79 (2007) 240-243
-
(2007)
Eur J Haematol
, vol.79
, pp. 240-243
-
-
Schmidmaier, R.1
Baumann, P.2
Bumeder, I.3
Meinhardt, G.4
Straka, C.5
Emmerich, B.6
-
35
-
-
38949101479
-
High dose simvastatin does not reverse resistance to vincristine, adriamycin, and dexamethasone (VAD) in myeloma
-
van der Spek E., Bloem A.C., Sinnige H.A., and Lokhorst H.M. High dose simvastatin does not reverse resistance to vincristine, adriamycin, and dexamethasone (VAD) in myeloma. Haematologica 92 (2007) e130-e131
-
(2007)
Haematologica
, vol.92
-
-
van der Spek, E.1
Bloem, A.C.2
Sinnige, H.A.3
Lokhorst, H.M.4
|