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Volumn 74, Issue 2, 2010, Pages 237-239

Overcoming multidrug-resistance in cancer: Statins offer a logical candidate

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; GERANYLTRANSFERASE; GLYCOPROTEIN P; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 49; PHEROMONE; PROTEIN STE6; SIMVASTATIN; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

EID: 72649092760     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2009.09.039     Document Type: Article
Times cited : (10)

References (35)
  • 2
    • 0021797892 scopus 로고
    • Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines
    • Riordan J.R., Deuchars K., Kartner N., Alon N., Trent J., and Ling V. Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 316 (1985) 817-819
    • (1985) Nature , vol.316 , pp. 817-819
    • Riordan, J.R.1    Deuchars, K.2    Kartner, N.3    Alon, N.4    Trent, J.5    Ling, V.6
  • 4
    • 13644254794 scopus 로고    scopus 로고
    • Molecular mechanisms of drug resistance
    • Longley D.B., and Johnston P.G. Molecular mechanisms of drug resistance. J Pathol 205 (2005) 275-292
    • (2005) J Pathol , vol.205 , pp. 275-292
    • Longley, D.B.1    Johnston, P.G.2
  • 5
    • 2542491777 scopus 로고    scopus 로고
    • The role of ABC transporters in drug resistance, metabolism and toxicity
    • Glavinas H., Krajcsi P., Cserepes J., and Sarkadi B. The role of ABC transporters in drug resistance, metabolism and toxicity. Curr Drug Deliv 1 (2004) 27-42
    • (2004) Curr Drug Deliv , vol.1 , pp. 27-42
    • Glavinas, H.1    Krajcsi, P.2    Cserepes, J.3    Sarkadi, B.4
  • 6
    • 33748644877 scopus 로고    scopus 로고
    • Structure of a bacterial multidrug ABC transporter
    • Dawson R., Kaspar J.P., and Locher P. Structure of a bacterial multidrug ABC transporter. Nature 443 (2006) 180-185
    • (2006) Nature , vol.443 , pp. 180-185
    • Dawson, R.1    Kaspar, J.P.2    Locher, P.3
  • 7
    • 60149098422 scopus 로고    scopus 로고
    • An ABC transporter controls export of a Drosophila germ cell attractant
    • Ricardo S., and Lehmann R. An ABC transporter controls export of a Drosophila germ cell attractant. Science 323 (2009) 943-946
    • (2009) Science , vol.323 , pp. 943-946
    • Ricardo, S.1    Lehmann, R.2
  • 8
    • 60149095846 scopus 로고    scopus 로고
    • The ABCs of lipophile transport
    • Hla T., and Im D.S. The ABCs of lipophile transport. Science 323 (2009) 883-884
    • (2009) Science , vol.323 , pp. 883-884
    • Hla, T.1    Im, D.S.2
  • 9
    • 0030797650 scopus 로고    scopus 로고
    • The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor
    • Christensen P.U., Davey J., and Nielsen O. The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor. Mol Gen Genet 255 (1997) 226-236
    • (1997) Mol Gen Genet , vol.255 , pp. 226-236
    • Christensen, P.U.1    Davey, J.2    Nielsen, O.3
  • 10
    • 0024375860 scopus 로고
    • The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein
    • McGrath J.P., and Varshavsky A. The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein. Nature 340 (1989) 400-404
    • (1989) Nature , vol.340 , pp. 400-404
    • McGrath, J.P.1    Varshavsky, A.2
  • 11
    • 0026585065 scopus 로고
    • Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene
    • Raymond M., Gros P., Whiteway M., and Thomas D.Y. Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene. Science 256 (1992) 232-234
    • (1992) Science , vol.256 , pp. 232-234
    • Raymond, M.1    Gros, P.2    Whiteway, M.3    Thomas, D.Y.4
  • 12
    • 0032518394 scopus 로고    scopus 로고
    • A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene
    • van Veen H.W., Callaghan R., Soceneantu L., Sardini A., Konings W.N., and Higgins C.F. A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene. Nature 391 (1998) 291-295
    • (1998) Nature , vol.391 , pp. 291-295
    • van Veen, H.W.1    Callaghan, R.2    Soceneantu, L.3    Sardini, A.4    Konings, W.N.5    Higgins, C.F.6
  • 13
    • 14344254868 scopus 로고    scopus 로고
    • Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice
    • Liu M., Bryant M.S., Chen J., et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res 58 (1998) 4947-4956
    • (1998) Cancer Res , vol.58 , pp. 4947-4956
    • Liu, M.1    Bryant, M.S.2    Chen, J.3
  • 14
    • 0035887454 scopus 로고    scopus 로고
    • The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein
    • Wang E., Casciano C.N., Clement R.P., and Johnson W.W. The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein. Cancer Res 61 (2001) 7525-7529
    • (2001) Cancer Res , vol.61 , pp. 7525-7529
    • Wang, E.1    Casciano, C.N.2    Clement, R.P.3    Johnson, W.W.4
  • 15
    • 0345735895 scopus 로고    scopus 로고
    • The farnesyl protein transferase inhibitor lonafarnib (SCH66336) is an inhibitor of multidrug resistance proteins 1 and 2
    • Wang E.J., and Johnson W.W. The farnesyl protein transferase inhibitor lonafarnib (SCH66336) is an inhibitor of multidrug resistance proteins 1 and 2. Chemotherapy 49 (2003) 303-308
    • (2003) Chemotherapy , vol.49 , pp. 303-308
    • Wang, E.J.1    Johnson, W.W.2
  • 16
    • 27244450832 scopus 로고    scopus 로고
    • Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells
    • Morgan M.A., Sebil T., Aydilek E., Peest D., Ganser A., and Reuter C.W. Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Br J Haematol 130 (2005) 912-925
    • (2005) Br J Haematol , vol.130 , pp. 912-925
    • Morgan, M.A.1    Sebil, T.2    Aydilek, E.3    Peest, D.4    Ganser, A.5    Reuter, C.W.6
  • 17
    • 33744925129 scopus 로고    scopus 로고
    • The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis
    • Horie N., Murata H., Nishigaki Y., et al. The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis. Cancer Lett 238 (2006) 111-118
    • (2006) Cancer Lett , vol.238 , pp. 111-118
    • Horie, N.1    Murata, H.2    Nishigaki, Y.3
  • 18
    • 37249013938 scopus 로고    scopus 로고
    • ABT-737 is a useful component of combinatory chemotherapies for chronic myeloid leukemias with diverse drug-resistance mechanisms
    • Kuroda J., Kimura S., Andreef M., et al. ABT-737 is a useful component of combinatory chemotherapies for chronic myeloid leukemias with diverse drug-resistance mechanisms. Brit J Haematol 140 (2008) 181-190
    • (2008) Brit J Haematol , vol.140 , pp. 181-190
    • Kuroda, J.1    Kimura, S.2    Andreef, M.3
  • 19
    • 67749130945 scopus 로고    scopus 로고
    • Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation
    • Zhang Y., Cao R., Yin F., et al. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J Am Chem Soc 131 (2009) 5153-5162
    • (2009) J Am Chem Soc , vol.131 , pp. 5153-5162
    • Zhang, Y.1    Cao, R.2    Yin, F.3
  • 20
    • 60549097419 scopus 로고    scopus 로고
    • Endocrine therapy plus zoledronic acid in premenopausal breast cancer
    • Gnant M., Mlineritsch B., Schippinger W., et al. Endocrine therapy plus zoledronic acid in premenopausal breast cancer. N Engl J Med 360 (2009) 679-691
    • (2009) N Engl J Med , vol.360 , pp. 679-691
    • Gnant, M.1    Mlineritsch, B.2    Schippinger, W.3
  • 21
    • 63449139456 scopus 로고    scopus 로고
    • Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding
    • Aller S.G., Yu J., Ward A., et al. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science 323 (2009) 1718-1722
    • (2009) Science , vol.323 , pp. 1718-1722
    • Aller, S.G.1    Yu, J.2    Ward, A.3
  • 23
    • 0030977145 scopus 로고    scopus 로고
    • Phosphatidylcholine and phosphatidylethanolamine behave as substrates of the human MDR1 P-glycoprotein
    • Bosch I., Dunussi-Joannopoulos K., Wu R.L., Furlong S.T., and Croop J. Phosphatidylcholine and phosphatidylethanolamine behave as substrates of the human MDR1 P-glycoprotein. Biochemistry 36 (1997) 5685-5694
    • (1997) Biochemistry , vol.36 , pp. 5685-5694
    • Bosch, I.1    Dunussi-Joannopoulos, K.2    Wu, R.L.3    Furlong, S.T.4    Croop, J.5
  • 24
    • 0141994817 scopus 로고    scopus 로고
    • Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein
    • Loo T.W., Bartlett M.C., and Clarke D.M. Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein. J Biol Chem 278 (2003) 39706-39710
    • (2003) J Biol Chem , vol.278 , pp. 39706-39710
    • Loo, T.W.1    Bartlett, M.C.2    Clarke, D.M.3
  • 25
    • 27144451192 scopus 로고    scopus 로고
    • Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs
    • Lugo M.R., and Sharom F.J. Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs. Biochemistry 44 (2005) 14020-14029
    • (2005) Biochemistry , vol.44 , pp. 14020-14029
    • Lugo, M.R.1    Sharom, F.J.2
  • 26
    • 0028106016 scopus 로고
    • Glutathione-associated enzymes in anticancer drug resistance
    • Tew K.D. Glutathione-associated enzymes in anticancer drug resistance. Cancer Res 54 16 (1994) 4313-4320
    • (1994) Cancer Res , vol.54 , Issue.16 , pp. 4313-4320
    • Tew, K.D.1
  • 27
    • 30644478973 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors (statins) as anticancer drugs (review)
    • Fritz G. HMG-CoA reductase inhibitors (statins) as anticancer drugs (review). Int J Oncol 27 (2005) 1401-1409
    • (2005) Int J Oncol , vol.27 , pp. 1401-1409
    • Fritz, G.1
  • 30
    • 0032766426 scopus 로고    scopus 로고
    • Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells
    • Agarwal B., Bhendwal S., Halmos B., Moss S.F., Ramey W.G., and Holt P.R. Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. Clin Cancer Res 5 (1999) 2223-2229
    • (1999) Clin Cancer Res , vol.5 , pp. 2223-2229
    • Agarwal, B.1    Bhendwal, S.2    Halmos, B.3    Moss, S.F.4    Ramey, W.G.5    Holt, P.R.6
  • 31
    • 0035552572 scopus 로고    scopus 로고
    • Synergistic interaction of lovastatin and paclitaxel in human cancer cells
    • Holstein S.A., and Hohl R.J. Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther 1 (2001) 141-149
    • (2001) Mol Cancer Ther , vol.1 , pp. 141-149
    • Holstein, S.A.1    Hohl, R.J.2
  • 32
    • 0036643517 scopus 로고    scopus 로고
    • Lovastatin potentiates antitumor activity of doxorubicin in murine melanoma via an apoptosis-dependent mechanism
    • Feleszko W., Mlynarczuk I., Olszewska D., et al. Lovastatin potentiates antitumor activity of doxorubicin in murine melanoma via an apoptosis-dependent mechanism. Int J Cancer 100 (2002) 111-118
    • (2002) Int J Cancer , vol.100 , pp. 111-118
    • Feleszko, W.1    Mlynarczuk, I.2    Olszewska, D.3
  • 33
    • 4444282702 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase
    • Schmidmaier R., Baumann P., Simsek M., Dayyani F., Emmerich B., and Meinhardt G. The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase. Blood 104 (2004) 1825-1832
    • (2004) Blood , vol.104 , pp. 1825-1832
    • Schmidmaier, R.1    Baumann, P.2    Simsek, M.3    Dayyani, F.4    Emmerich, B.5    Meinhardt, G.6
  • 34
    • 34547798983 scopus 로고    scopus 로고
    • First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma
    • Schmidmaier R., Baumann P., Bumeder I., Meinhardt G., Straka C., and Emmerich B. First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma. Eur J Haematol 79 (2007) 240-243
    • (2007) Eur J Haematol , vol.79 , pp. 240-243
    • Schmidmaier, R.1    Baumann, P.2    Bumeder, I.3    Meinhardt, G.4    Straka, C.5    Emmerich, B.6
  • 35
    • 38949101479 scopus 로고    scopus 로고
    • High dose simvastatin does not reverse resistance to vincristine, adriamycin, and dexamethasone (VAD) in myeloma
    • van der Spek E., Bloem A.C., Sinnige H.A., and Lokhorst H.M. High dose simvastatin does not reverse resistance to vincristine, adriamycin, and dexamethasone (VAD) in myeloma. Haematologica 92 (2007) e130-e131
    • (2007) Haematologica , vol.92
    • van der Spek, E.1    Bloem, A.C.2    Sinnige, H.A.3    Lokhorst, H.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.