Interleukin 17 Is Not Required for Autoimmune-Mediated Pathologic Damage during Chronic Graft-versus-Host Disease

Biology of Blood and Marrow Transplantation

Volumn 16, Issue 1, 2010, Pages 123-128

  Chen, Xiao ^a   Das, Rupali ^a   Komorowski, Richard ^a   van Snick, Jacques ^b   Uyttenhove, Catherine ^b   Drobyski, William R ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

Author keywords

Autoimmunity; Chronic graft versus host disease; Interleukin 17

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 17;

ACUTE GRAFT VERSUS HOST DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CHRONIC GRAFT VERSUS HOST DISEASE; CONTROLLED STUDY; DISEASE COURSE; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; TH1 CELL;

ANIMALS; AUTOIMMUNE DISEASES; BONE MARROW TRANSPLANTATION; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CHIMERA; CHRONIC DISEASE; COLON; CYTOKINES; DISEASE PROGRESSION; FLOW CYTOMETRY; GRAFT VS HOST DISEASE; INTERLEUKIN-17; LYMPHOCYTES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MUCOUS MEMBRANE; ORGAN SPECIFICITY; SIGNAL TRANSDUCTION;

EID: 72649088089     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2009.09.008     Document Type: Article

References (24)

1. Welniak L.A., Blazar B.R., and Murphy W.J. Immunobiology of allogeneic hematopoietic stem cell transplantation. Ann Rev Immunol 25 (2007) 139-170
2. Piguet P.-F., Grau G.E., Allet B., and Vassalli P. Tumor necrosis factor/cachectin is an effector of the skin and gut lesions of the acute phase of graft versus host disease. J Exp Med 166 (1987) 1280-1289
3. Nestel F.P., Price K.S., Seemayer T.A., and Lapp W.S. Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor α during graft versus host disease. J Exp Med 175 (1992) 405-413
4. Chen X., Das R., Komorowski R., et al. Blockade of interleukin 6 signaling augments regulatory T cell reconstitution and attenuates the severity of graft versus host disease. Blood 114 (2009) 891-900
5. H17 cells is responsible for the autoimmune-mediated pathology in chronic graft versus host disease. Blood 110 (2007) 3804-3813
6. H1 differentiation and exacerbated acute graft versus host disease. Blood 112 (2008) 2101-2110
7. Carlson M.J., West M.L., Coghill J.M., Panoskaltsis-Mortari A., Blazar B.R., and Serody J.S. In vitro differentiated TH17 cells mediate lethal acute graft versus host disease with severe cutaneous and pulmonary pathologic manifestations. Blood 113 (2009) 1365-1374
8. Kappel L.W., Goldberg G.L., King C.G., et al. IL-17 contributes to CD4-mediated graft versus host disease. Blood 113 (2009) 945-952
9. Filipovich A.H., Weisdorf D., Pavletic S., et al. National Institutes of health Consensus Development Project on criteria for clinical trails in chronic graft versus host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 11 (2005) 945-955
10. Rouquette-Gally A.M., Boyeldieu D., Gluckman E., Abuaf N., and Combrisson A. Autoimmunity in 28 patients after allogeneic bone marrow transplantation: comparison with Sjogren's syndrome and scleroderma. Br J Haematol 66 (1987) 45-47
11. Rouquette-Gally A.M., Boyeldieu D., Prost A.C., and Gluckman E. Autoimmunity after allogeneic bone marrow transplantation. A study of 53 long-term-surviving patients. Transplantation 46 (1988) 238-240
12. Nakae S., Nambu A., Sudo K., and Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17 deficient mice. J Immunol 171 (2003) 6173-6177
13. Komiyama Y., Nakae S., Matsuki T., et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 177 (2006) 566-573
14. + regulatory T cells ameliorate ongoing chronic graft versus host disease. Blood 112 (2008) 2129-2138
15. Tivol E.A., Komorowski R., and Drobyski W.R. Emergent autoimmunity in graft versus host disease. Blood 105 (2005) 4887-4893
16. Uyttenhove C., and Van Snick J. Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis. Eur J Immunol 36 (2006) 2868-2874
17. Uyttenhove C., Sommereyns C., Theate I., Michiels T., and van Snick J. Anti-IL-17A autovaccination prevents clinical and histological manifestations of experimental autoimmune encephalomyelitis. Ann NY Acad Sci 1110 (2007) 330-336
18. Das R., Chen X., Komorowski R., Hessner M.J., and Drobyski W.R. Interleukin 23 secretion by donor antigen presenting cells is critical for organ-specific pathology in graft versus host disease. Blood 113 (2009) 2352-2362
19. Fossiez F., Djossou O., Chomarat P., et al. T cell interleukin 17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 183 (1996) 2593-2603
20. Schwarzenberger P., La Russa V., Miller A., et al. IL-17 stimulates granulopoiesis in mice: Use of an alternate novel gene therapy-derived method for in vivo evaluation of cytokines. J Immunol 161 (1998) 6383-6389
21. Ferretti S., Bonneau O., Dubois G.R., Jones C.E., and Trifilieff A. IL-17 produced by lymphocytes and neutrophils is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J Immunol 170 (2003) 2106-2112
22. Bettelli E., Carrier Y., Gao W., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
23. Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGF in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
24. + cytotoxic effectors and type 1 interferon-mediated processes in cGVHD of the oral mucosa. Blood 113 (2009) 3620-3630