Patients with B cell chronic lymphocytic leukaemia have an expanded population of CD4+ perforin expressing T cells enriched for human cytomegalovirus specificity and an effector-memory phenotype

British Journal of Haematology

Volumn 148, Issue 2, 2010, Pages 274-284

  Walton, James A ^a   Lydyard, Peter M ^a   Nathwani, Amit ^b   Emery, Vincent ^b   Akbar, Arne ^b   Glennie, Martin J ^c   Porakishvili, Nino ^a  

^a UNIVERSITY OF WESTMINSTER   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Chronic lymphocytic leukaemia; Cytomegalovirus; Cytotoxic CD4 cells; Cytotoxicity

Indexed keywords

ALEMTUZUMAB; CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; CHLORAMBUCIL; FLUDARABINE; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PERFORIN; RITUXIMAB;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CANCER PATIENT; CD4+ T LYMPHOCYTE; CELL EXPANSION; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROL GROUP; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CYTOMEGALOVIRUS; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MEMORY T LYMPHOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; TELOMERE;

AGED; AGED, 80 AND OVER; CD4-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTERFERON-GAMMA; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; PERFORIN; PHENOTYPE;

EID: 72649087324     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07964.x     Document Type: Article

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