메뉴 건너뛰기




Volumn 23, Issue 8, 2009, Pages 1132-1139

Deployment-related severe fatigue with depressive symptoms is associated with increased glucocorticoid binding to peripheral blood mononuclear cells

Author keywords

Cortisol; Depression; Glucocorticoid receptor; Stress; Vulnerability

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE;

EID: 72649083772     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2009.07.004     Document Type: Article
Times cited : (23)

References (50)
  • 1
    • 43449136182 scopus 로고    scopus 로고
    • Understanding fatigue in major depressive disorder and other medical disorders
    • Arnold L.M. Understanding fatigue in major depressive disorder and other medical disorders. Psychosomatics 49 (2008) 185-190
    • (2008) Psychosomatics , vol.49 , pp. 185-190
    • Arnold, L.M.1
  • 3
    • 67649440703 scopus 로고    scopus 로고
    • Bet, P.M., Penninx, B.W.J.H., Bochdanovits, Z., Uitterlinden, A.G., Beekman, A.T.F., van Schoor, N.M., Deeg, D.J.H., Hoogendijk, W.J.G., 2009. Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: new evidence for a gene-environment interaction. Am. J. Med. Genet. B: Neuropsychiatr. Genet. Available from: (Epub ahead of print, retrieved March 26, 2009).
    • Bet, P.M., Penninx, B.W.J.H., Bochdanovits, Z., Uitterlinden, A.G., Beekman, A.T.F., van Schoor, N.M., Deeg, D.J.H., Hoogendijk, W.J.G., 2009. Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: new evidence for a gene-environment interaction. Am. J. Med. Genet. B: Neuropsychiatr. Genet. Available from: (Epub ahead of print, retrieved March 26, 2009).
  • 4
    • 34247554289 scopus 로고    scopus 로고
    • Psychometric properties of the early trauma inventory-self report
    • Bremner J.D., Bolus R., and Mayer E.A. Psychometric properties of the early trauma inventory-self report. J. Nerv. Ment. Dis. 195 (2007) 211-218
    • (2007) J. Nerv. Ment. Dis. , vol.195 , pp. 211-218
    • Bremner, J.D.1    Bolus, R.2    Mayer, E.A.3
  • 6
    • 0035076263 scopus 로고    scopus 로고
    • Temporal and spatial dynamics of corticosteroid receptor down-regulation in rat brain following social defeat
    • Buwalda B., Felszeghy K., Horváth K.M., Nyakas C., de Boer S.F., Bohus B., and Koolhaas J.M. Temporal and spatial dynamics of corticosteroid receptor down-regulation in rat brain following social defeat. Physiol. Behav. 72 (2001) 349-354
    • (2001) Physiol. Behav. , vol.72 , pp. 349-354
    • Buwalda, B.1    Felszeghy, K.2    Horváth, K.M.3    Nyakas, C.4    de Boer, S.F.5    Bohus, B.6    Koolhaas, J.M.7
  • 9
    • 14544277869 scopus 로고    scopus 로고
    • Signaling pathways in brain involved in predisposition and pathogenesis of stress-related disease: genetic and kinetic factors affecting the MR/GR balance
    • de Kloet E.R., and deRijk R.H. Signaling pathways in brain involved in predisposition and pathogenesis of stress-related disease: genetic and kinetic factors affecting the MR/GR balance. Ann. NY Acad. Sci. 1032 (2004) 14-34
    • (2004) Ann. NY Acad. Sci. , vol.1032 , pp. 14-34
    • de Kloet, E.R.1    deRijk, R.H.2
  • 10
    • 0032467785 scopus 로고    scopus 로고
    • Brain corticosteroid receptor balance in health and disease
    • de Kloet E.R., Vreugdenhil E., Oitzl M.S., and Joels M. Brain corticosteroid receptor balance in health and disease. Endocr. Rev. 19 (1998) 269-301
    • (1998) Endocr. Rev. , vol.19 , pp. 269-301
    • de Kloet, E.R.1    Vreugdenhil, E.2    Oitzl, M.S.3    Joels, M.4
  • 12
    • 0041880361 scopus 로고    scopus 로고
    • Relationship between multiple forms of childhood maltreatment and adult mental health in community respondents: results from the adverse childhood experiences study
    • Edwards V.J., Holden G.W., Felitti V.J., and Anda R.F. Relationship between multiple forms of childhood maltreatment and adult mental health in community respondents: results from the adverse childhood experiences study. Am. J. Psychiatry 160 (2003) 1453-1460
    • (2003) Am. J. Psychiatry , vol.160 , pp. 1453-1460
    • Edwards, V.J.1    Holden, G.W.2    Felitti, V.J.3    Anda, R.F.4
  • 13
    • 0037322334 scopus 로고    scopus 로고
    • Flow cytometric determination of glucocorticoid receptor (GCR) expression in lymphocyte subpopulations: lower quantity of GCR in patients with post-traumatic stress disorder (PTSD)
    • Gotovac K., Sabioncello A., Rabatíac S., Berki T., and Dekaris D. Flow cytometric determination of glucocorticoid receptor (GCR) expression in lymphocyte subpopulations: lower quantity of GCR in patients with post-traumatic stress disorder (PTSD). Clin. Exp. Immunol. 131 (2003) 335-339
    • (2003) Clin. Exp. Immunol. , vol.131 , pp. 335-339
    • Gotovac, K.1    Sabioncello, A.2    Rabatíac, S.3    Berki, T.4    Dekaris, D.5
  • 14
    • 0033992534 scopus 로고    scopus 로고
    • The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders
    • Heim C., Ehlert U., and Hellhammer D.H. The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 25 (2000) 1-35
    • (2000) Psychoneuroendocrinology , vol.25 , pp. 1-35
    • Heim, C.1    Ehlert, U.2    Hellhammer, D.H.3
  • 15
    • 58149520651 scopus 로고    scopus 로고
    • Childhood trauma and risk for chronic fatigue syndrome: association with neuroendocrine dysfunction
    • Heim C., Nater U.M., Maloney E., Boneva R., Jones J.F., and Reeves W.C. Childhood trauma and risk for chronic fatigue syndrome: association with neuroendocrine dysfunction. Arch. Gen. Psychiatry 66 (2009) 72-80
    • (2009) Arch. Gen. Psychiatry , vol.66 , pp. 72-80
    • Heim, C.1    Nater, U.M.2    Maloney, E.3    Boneva, R.4    Jones, J.F.5    Reeves, W.C.6
  • 16
    • 13244268391 scopus 로고    scopus 로고
    • Increased levels of glucocorticoid receptors and enhanced glucocorticoid receptor auto-regulation after hydrocortisone challenge in B-lymphoblastoids from patients with affective disorders
    • Henning U., Krieger K., Loeffler S., Rivas F., Orozco G., de Castro M.G., Rietschel M., Noethen M.M., and Klimke A. Increased levels of glucocorticoid receptors and enhanced glucocorticoid receptor auto-regulation after hydrocortisone challenge in B-lymphoblastoids from patients with affective disorders. Psychoneuroendocrinology 30 (2005) 325-332
    • (2005) Psychoneuroendocrinology , vol.30 , pp. 325-332
    • Henning, U.1    Krieger, K.2    Loeffler, S.3    Rivas, F.4    Orozco, G.5    de Castro, M.G.6    Rietschel, M.7    Noethen, M.M.8    Klimke, A.9
  • 18
    • 0033797445 scopus 로고    scopus 로고
    • The corticosteroid receptor hypothesis of depression
    • Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23 (2000) 477-501
    • (2000) Neuropsychopharmacology , vol.23 , pp. 477-501
    • Holsboer, F.1
  • 20
    • 7044262921 scopus 로고    scopus 로고
    • The munich vulnerability study on affective disorders: premorbid neuroendocrine profile of affected high-risk probands
    • Ising M., Lauer C.J., Holsboer F., and Modell S. The munich vulnerability study on affective disorders: premorbid neuroendocrine profile of affected high-risk probands. J. Psychiatr. Res. 39 (2005) 21-28
    • (2005) J. Psychiatr. Res. , vol.39 , pp. 21-28
    • Ising, M.1    Lauer, C.J.2    Holsboer, F.3    Modell, S.4
  • 21
    • 0037438677 scopus 로고    scopus 로고
    • Post-traumatic stress disorder and chronic fatigue syndrome-like illness among gulf war veterans: a population-based survey of 30,000 veterans
    • Kang H.K., Natelson B.H., Mahan C.M., Lee K.Y., and Murphy F.M. Post-traumatic stress disorder and chronic fatigue syndrome-like illness among gulf war veterans: a population-based survey of 30,000 veterans. Am. J. Epidemiol. 157 (2003) 141-148
    • (2003) Am. J. Epidemiol. , vol.157 , pp. 141-148
    • Kang, H.K.1    Natelson, B.H.2    Mahan, C.M.3    Lee, K.Y.4    Murphy, F.M.5
  • 22
    • 0033977778 scopus 로고    scopus 로고
    • Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice
    • Linthorst A.C.E., Flachskamm C., Barden N., Holsboer F., and Reul J.M.H.M. Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice. Eur. J. Neurosci. 12 (2000) 283-291
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 283-291
    • Linthorst, A.C.E.1    Flachskamm, C.2    Barden, N.3    Holsboer, F.4    Reul, J.M.H.M.5
  • 23
    • 0032521829 scopus 로고    scopus 로고
    • Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression
    • López J.F., Chalmers D.T., Little K.Y., and Watson S.J. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. Biol. Psychiatry 43 (1998) 547-573
    • (1998) Biol. Psychiatry , vol.43 , pp. 547-573
    • López, J.F.1    Chalmers, D.T.2    Little, K.Y.3    Watson, S.J.4
  • 24
    • 0024347258 scopus 로고
    • Quantification of type I and II adrenal steroid receptors in neuronal, lymphoid and pituitary tissues
    • Lowy M.T. Quantification of type I and II adrenal steroid receptors in neuronal, lymphoid and pituitary tissues. Brain Res. 503 (1989) 191-197
    • (1989) Brain Res. , vol.503 , pp. 191-197
    • Lowy, M.T.1
  • 25
    • 0025738871 scopus 로고
    • Corticosterone regulation of brain and lymphoid corticosteroid receptors
    • Lowy M.T. Corticosterone regulation of brain and lymphoid corticosteroid receptors. J. Steroid Biochem. Mol. Biol. 39 (1991) 147-154
    • (1991) J. Steroid Biochem. Mol. Biol. , vol.39 , pp. 147-154
    • Lowy, M.T.1
  • 26
    • 34247482472 scopus 로고    scopus 로고
    • Increased waking salivary cortisol levels in young people at familial risk of depression
    • Mannie Z.N., Harmer C.J., and Cowen P.J. Increased waking salivary cortisol levels in young people at familial risk of depression. Am. J. Psychiatry 164 (2007) 617-621
    • (2007) Am. J. Psychiatry , vol.164 , pp. 617-621
    • Mannie, Z.N.1    Harmer, C.J.2    Cowen, P.J.3
  • 28
    • 33644866384 scopus 로고    scopus 로고
    • Depression, attribution style and self-esteem in chronic fatigue syndrome and fibromyalgia patients: is there a link?
    • Michielsen H.J., Van Houdenhove B., Leirs L., Vandenbroeck A., and Onghena P. Depression, attribution style and self-esteem in chronic fatigue syndrome and fibromyalgia patients: is there a link?. Clin. Rheumatol. 25 (2006) 183-188
    • (2006) Clin. Rheumatol. , vol.25 , pp. 183-188
    • Michielsen, H.J.1    Van Houdenhove, B.2    Leirs, L.3    Vandenbroeck, A.4    Onghena, P.5
  • 29
    • 0035280252 scopus 로고    scopus 로고
    • Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    • Pariante C.M., and Miller A.H. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry 49 (2001) 391-404
    • (2001) Biol. Psychiatry , vol.49 , pp. 391-404
    • Pariante, C.M.1    Miller, A.H.2
  • 30
    • 47049110150 scopus 로고    scopus 로고
    • Self-reported early trauma as a predictor of adult personality: a study in a military sample
    • Rademaker A.R., Vermetten E., Geuze E., Muilwijk A., and Kleber R.J. Self-reported early trauma as a predictor of adult personality: a study in a military sample. J. Clin. Psychol. 64 (2008) 863-875
    • (2008) J. Clin. Psychol. , vol.64 , pp. 863-875
    • Rademaker, A.R.1    Vermetten, E.2    Geuze, E.3    Muilwijk, A.4    Kleber, R.J.5
  • 31
    • 0442272538 scopus 로고    scopus 로고
    • When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
    • Raison C.L., and Miller A.H. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am. J. Psychiatry 160 (2003) 1554-1565
    • (2003) Am. J. Psychiatry , vol.160 , pp. 1554-1565
    • Raison, C.L.1    Miller, A.H.2
  • 33
    • 1642320206 scopus 로고    scopus 로고
    • Hypocortisolism and increased glucocorticoid sensitivity of pro-inflammatory cytokine production in bosnian war refugees with posttraumatic stress disorder
    • Rohleder N., Joksimovic L., Wolf J.M., and Kirschbaum C. Hypocortisolism and increased glucocorticoid sensitivity of pro-inflammatory cytokine production in bosnian war refugees with posttraumatic stress disorder. Biol. Psychiatry 55 (2004) 745-751
    • (2004) Biol. Psychiatry , vol.55 , pp. 745-751
    • Rohleder, N.1    Joksimovic, L.2    Wolf, J.M.3    Kirschbaum, C.4
  • 34
    • 0141957380 scopus 로고    scopus 로고
    • Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone
    • Schuld A., Schmid D.A., Haack M., Holsboer F., Friess E., and Pollmächer T. Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone. J. Psychiatr. Res. 37 (2003) 463-470
    • (2003) J. Psychiatr. Res. , vol.37 , pp. 463-470
    • Schuld, A.1    Schmid, D.A.2    Haack, M.3    Holsboer, F.4    Friess, E.5    Pollmächer, T.6
  • 35
    • 0033850433 scopus 로고    scopus 로고
    • Clarifying the relationship between unexplained chronic fatigue and psychiatric morbidity: results from a community survey in Great Britain
    • Skapinakis P., Lewis G., and Meltzer H. Clarifying the relationship between unexplained chronic fatigue and psychiatric morbidity: results from a community survey in Great Britain. Am. J. Psychiatry 157 (2000) 1492-1498
    • (2000) Am. J. Psychiatry , vol.157 , pp. 1492-1498
    • Skapinakis, P.1    Lewis, G.2    Meltzer, H.3
  • 36
    • 38749132961 scopus 로고    scopus 로고
    • Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: implications for stress-related disorders
    • Sterlemann V., Ganea K., Liebl C., Harbich D., Alam S., Holsboer F., Müller M., and Schmidt M.V. Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: implications for stress-related disorders. Horm. Behav. 53 (2008) 386-394
    • (2008) Horm. Behav. , vol.53 , pp. 386-394
    • Sterlemann, V.1    Ganea, K.2    Liebl, C.3    Harbich, D.4    Alam, S.5    Holsboer, F.6    Müller, M.7    Schmidt, M.V.8
  • 37
    • 29744443778 scopus 로고    scopus 로고
    • Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: reversal by escitalopram
    • Uys J.D.K., Muller C.J.F., Marais L., Harvey B.H., Stein D.J., and Daniels W.M.U. Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: reversal by escitalopram. Neuroscience 137 (2006) 619-625
    • (2006) Neuroscience , vol.137 , pp. 619-625
    • Uys, J.D.K.1    Muller, C.J.F.2    Marais, L.3    Harvey, B.H.4    Stein, D.J.5    Daniels, W.M.U.6
  • 42
    • 0035116020 scopus 로고    scopus 로고
    • Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors
    • Visser J., Lentjes E., Haspels I., Graffelman W., Blauw B., de Kloet R., and Nagelkerken L. Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors. J. Investig. Med. 49 (2001) 195-204
    • (2001) J. Investig. Med. , vol.49 , pp. 195-204
    • Visser, J.1    Lentjes, E.2    Haspels, I.3    Graffelman, W.4    Blauw, B.5    de Kloet, R.6    Nagelkerken, L.7
  • 43
    • 63149124165 scopus 로고    scopus 로고
    • Epigenetic effects of glucocorticoids
    • Weaver I.C.G. Epigenetic effects of glucocorticoids. Semin. Fetal Neonatal Med. 14 (2009) 143-150
    • (2009) Semin. Fetal Neonatal Med. , vol.14 , pp. 143-150
    • Weaver, I.C.G.1
  • 45
    • 0029043632 scopus 로고
    • Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder
    • Yehuda R., Boisoneau D., Lowy M.T., and Giller E.L. Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder. Arch. Gen. Psychiatry 52 (1995) 583-593
    • (1995) Arch. Gen. Psychiatry , vol.52 , pp. 583-593
    • Yehuda, R.1    Boisoneau, D.2    Lowy, M.T.3    Giller, E.L.4
  • 46
    • 0027203816 scopus 로고
    • Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders
    • Yehuda R., Boisoneau D., Mason J.W., and Giller E.L. Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders. Biol. Psychiatry 34 (1993) 18-25
    • (1993) Biol. Psychiatry , vol.34 , pp. 18-25
    • Yehuda, R.1    Boisoneau, D.2    Mason, J.W.3    Giller, E.L.4
  • 47
    • 0026081904 scopus 로고
    • Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder
    • Yehuda R., Lowy M., Southwick S., Shaffer D., and Giller Jr. E. Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder. Am. J. Psychiatry 148 (1991) 499-504
    • (1991) Am. J. Psychiatry , vol.148 , pp. 499-504
    • Yehuda, R.1    Lowy, M.2    Southwick, S.3    Shaffer, D.4    Giller Jr., E.5
  • 48
    • 2542423960 scopus 로고    scopus 로고
    • Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder
    • Yehuda R., Golier J.A., Yang R., and Tischler L. Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder. Biol. Psychiatry 55 (2004) 1110-1116
    • (2004) Biol. Psychiatry , vol.55 , pp. 1110-1116
    • Yehuda, R.1    Golier, J.A.2    Yang, R.3    Tischler, L.4
  • 49
    • 0141957377 scopus 로고    scopus 로고
    • Relationship between dexamethasone-inhibited lysozyme activity in peripheral mononuclear leukocytes and the cortisol and glucocorticoid receptor response to dexamethasone
    • Yehuda R., Yang R., Ling Guo S., Makotkine I., and Singh B. Relationship between dexamethasone-inhibited lysozyme activity in peripheral mononuclear leukocytes and the cortisol and glucocorticoid receptor response to dexamethasone. J. Psychiatr. Res. 37 (2003) 471-477
    • (2003) J. Psychiatr. Res. , vol.37 , pp. 471-477
    • Yehuda, R.1    Yang, R.2    Ling Guo, S.3    Makotkine, I.4    Singh, B.5
  • 50
    • 50949086142 scopus 로고    scopus 로고
    • Expressions of hippocampal mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the single-prolonged stress-rats
    • Zhe D., Fang H., and Yuxiu S. Expressions of hippocampal mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the single-prolonged stress-rats. Acta Histochem. Cytochem. 41 (2008) 89-95
    • (2008) Acta Histochem. Cytochem. , vol.41 , pp. 89-95
    • Zhe, D.1    Fang, H.2    Yuxiu, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.