Thrombophilic factors do not predict outcomes in renal transplant recipients under prophylactic acetylsalicylic acid

American Journal of Transplantation

Volumn 10, Issue 1, 2010, Pages 99-105

  Ghisdal, L ^a   Broeders, N ^a   Wissing, K M ^a   Saidi, A ^a   Bensalem, T ^a   Mbaba Mena, J ^a   Lemy, A ^a   Wijns, W ^b   Pradier, O ^b   Hoang, A D ^b   Mikhalski, D ^b   Donckier, V ^b   Cochaux, P ^c   El Housni, H ^c   Abramowicz, M ^c   Vereerstraeten, P ^a   Abramowicz, D ^a  

^a Renal Transplantation Clinic

^b Department of Clinical Pathology ^*

^c ERASME HOSPITAL   (Belgium)

Author keywords

Acute allograft rejection; Factor V Leiden; Kidney transplantation; Prothrombin gene mutation; Thrombophilia; Thrombosis

Indexed keywords

ACENOCOUMAROL; ACETYLSALICYLIC ACID; ANTITHROMBIN; APC; AZATHIOPRINE; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 5 LEIDEN; BLOOD CLOTTING FACTOR 8 CONCENTRATE; BLOOD CLOTTING FACTOR 9; CREATININE; CYCLOSPORIN A; GLYCOPROTEIN IIIA; INTERLEUKIN 2; LOW MOLECULAR WEIGHT HEPARIN; LUPUS ANTICOAGULANT; METHYLPREDNISOLONE; MYCOPHENOLIC ACID; PHOSPHOLIPID ANTIBODY; PROTEIN C; PROTEIN S; PROTHROMBIN; TACROLIMUS;

ADULT; ARTICLE; BIOASSAY; BLOOD SAMPLING; CARDIOVASCULAR RISK; COHORT ANALYSIS; CREATININE BLOOD LEVEL; DEMOGRAPHY; FEMALE; GENE MUTATION; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; INFORMED CONSENT; KIDNEY GRAFT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PREVALENCE; PRIORITY JOURNAL; PROPHYLAXIS; PROSPECTIVE STUDY; RISK FACTOR; THROMBOEMBOLISM; TREATMENT OUTCOME;

ACUTE DISEASE; ADULT; ASPIRIN; CARDIOVASCULAR DISEASES; COHORT STUDIES; CREATININE; FEMALE; FIBRINOLYTIC AGENTS; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SURVIVAL RATE; THROMBOEMBOLISM; THROMBOPHILIA; TIME FACTORS; TREATMENT OUTCOME;

EID: 72549100949     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02855.x     Document Type: Article

References (33)

1. Penny MJ, Nankivell BJ, Disney AP, Byth K, Chapman JR. Renal graft thrombosis. A survey of 134 consecutive cases. Transplantation 1994 58 : 565 569.
2. Bakir N, Sluiter WJ, Ploeg RJ, van Son WJ, Tegzess AM. Primary renal graft thrombosis. Nephrol Dial Transplant 1996 11 : 140 147.
3. Abramowicz D, De Pauw L, Le Moine A et al. Prevention of OKT3 nephrotoxicity after kidney transplantation. Kidney Int Suppl 1996 53 : S39 S43.
4. Robertson AJ, Nargund V, Gray DW, Morris PJ. Low dose aspirin as prophylaxis against renal-vein thrombosis in renal-transplant recipients. Nephrol Dial Transplant 2000 15 : 1865 1868.
5. Friedman GS, Meier-Kriesche HU, Kaplan B et al. Hypercoagulable states in renal transplant candidates: Impact of anticoagulation upon incidence of renal allograft thrombosis. Transplantation 2001 72 : 1073 1078.
6. Alakulppi NS, Kyllonen LE, Partanen J, Salmela KT, Laine JT. Lack of association between thrombosis-associated and cytokine candidate gene polymorphisms and acute rejection or vascular complications after kidney transplantation. Nephrol Dial Transplant 2008 23 : 364 368.
7. Wuthrich RP, Cicvara-Muzar S, Booy C, Maly FE. Heterozygosity for the factor V Leiden (G1691A) mutation predisposes renal transplant recipients to thrombotic complications and graft loss. Transplantation 2001 72 : 549 550.
8. Humar A, Johnson EM, Gillingham KJ et al. Venous thromboembolic complications after kidney and kidney-pancreas transplantation: A multivariate analysis. Transplantation 1998 65 : 229 234.
9. Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med 2001 344 : 1222 1231.
10. Irish AB, Green FR, Gray DW, Morris PJ. The factor V Leiden (R506Q) mutation and risk of thrombosis in renal transplant recipients. Transplantation 1997 64 : 604 607.
11. Heidenreich S, Dercken C, August C, Koch HG, Nowak-Gottl U. High rate of acute rejections in renal allograft recipients with thrombophilic risk factors. J Am Soc Nephrol 1998 9 : 1309 1313.
12. Ducloux D, Pellet E, Fournier V et al. Prevalence and clinical significance of antiphospholipid antibodies in renal transplant recipients. Transplantation 1999 67 : 90 93.
13. Ekberg H, Svensson PJ, Simanaitis M, Dahlback B. Factor V R506Q mutation (activated protein C resistance) is an additional risk factor for early renal graft loss associated with acute vascular rejection. Transplantation 2000 69 : 1577 1581.
14. Salido E, Martin B, Barrios Y et al. The PlA2 polymorphism of the platelet glycoprotein IIIA gene as a risk factor for acute renal allograft rejection. J Am Soc Nephrol 1999 10 : 2599 2605.
15. Massy ZA, Chadefaux-Vekemans B, Chevalier A et al. Hyperhomocysteinaemia: A significant risk factor for cardiovascular disease in renal transplant recipients. Nephrol Dial Transplant 1994 9 : 1103 1108.
16. Fischereder M, Schneeberger H, Lohse P, Kramer BK, Schlondorff D, Land W. Increased rate of renal transplant failure in patients with the G20210A mutation of the prothrombin gene. Am J Kidney Dis 2001 38 : 1061 1064.
17. El Housni H, Heimann P, Parma J, Vassart G. Single-nucleotide polymorphism genotyping by melting analysis of dual-labeled probes: Examples using factor V Leiden and prothrombin 20210A mutations. Clin Chem 2003 49 : 1669 1672.
18. Wissing KM, Fomegne G, Broeders N et al. HLA mismatches remain risk factors for acute kidney allograft rejection in patients receiving quadruple immunosuppression with anti-interleukin-2 receptor antibodies. Transplantation 2008 85 : 411 416.
19. Meyer M, Laux G, Scherer S, Tran TH, Opelz G, Mytilineos J. No association of factor V Leiden, prothrombin G20210A, and MTHFR C677T gene polymorphisms with kidney allograft survival: A multicenter study. Transplantation 2007 83 : 1055 1058.
20. Heidenreich S, Junker R, Wolters H et al. Outcome of kidney transplantation in patients with inherited thrombophilia: Data of a prospective study. J Am Soc Nephrol 2003 14 : 234 239.
21. Ducloux D, Bourrinet E, Motte G, Chalopin JM. Antiphospholipid antibodies as a risk factor for atherosclerotic events in renal transplant recipients. Kidney Int 2003 64 : 1065 1070.
22. Fischereder M, Gohring P, Schneeberger H et al. Early loss of renal transplants in patients with thrombophilia. Transplantation 1998 65 : 936 939.
23. Ekberg H, Tedesco-Silva H, Demirbas A et al. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 2007 357 : 2562 2575.
24. Rosendaal FR. Venous thrombosis: A multicausal disease. Lancet 1999 353 : 1167 1173.
25. Stechman MJ, Charlwood N, Gray DW, Handa A. Administration of 75 mg of aspirin daily for 28 days is sufficient prophylaxis against renal transplant vein thrombosis. Phlebology 2007 22 : 83 85.
26. Nampoory MR, Das KC, Johny KV et al. Hypercoagulability, a serious problem in patients with ESRD on maintenance hemodialysis, and its correction after kidney transplantation. Am J Kidney Dis 2003 42 : 797 805.
27. Garcia-Martin F, De Arriba G, Carrascosa T et al. Anticardiolipin antibodies and lupus anticoagulant in end-stage renal disease. Nephrol Dial Transplant 1991 6 : 543 547.
28. Fernandez-Abreu MC, Diez-Ewald M, Briceno S, Torres-Guerra E, Rodriguez Z, Fernandez N. Frequency and clinical implications of lupus anticoagulant in patients with terminal chronic renal failure in hemodialysis. Invest Clin 2007 48 : 69 79.
29. Skouri H, Gandouz R, Abroug S et al. A prospective study of the prevalence of heparin-induced antibodies and other associated thromboembolic risk factors in pediatric patients undergoing hemodialysis. Am J Hematol 2006 81 : 328 334.
30. Quereda C, Pardo A, Lamas S et al. Lupus-like in vitro anticoagulant activity in end-stage renal disease. Nephron 1988 49 : 39 44.
31. Kastrati A, Koch W, Gawaz M et al. PlA polymorphism of glycoprotein IIIa and risk of adverse events after coronary stent placement. J Am Coll Cardiol 2000 36 : 84 89.
32. Meleady R, Ueland PM, Blom H et al. Thermolabile methylenetetrahydrofolate reductase, homocysteine, and cardiovascular disease risk: The European Concerted Action Project. Am J Clin Nutr 2003 77 : 63 70.
33. Varga E. Inherited thrombophilia: Key points for genetic counseling. J Genet Couns 2007 16 : 261 277.