No association of factor V Leiden, prothrombin G20210A, and MTHFR C677T gene polymorphisms with kidney allograft survival: A multicenter study

Transplantation

Volumn 83, Issue 8, 2007, Pages 1055-1058

  Meyer, Marko ^a   Laux, Gunter ^a   Scherer, Sabine ^a   Tran, Thuong Hien ^a   Opelz, Gerhard ^a   Mytilineos, Joannis ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Factor V Leiden; MTHFR; PCR SSP; Prothrombin; Single nucleotide polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 5 LEIDEN; PROTHROMBIN;

ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; HUMAN CELL; KIDNEY ALLOGRAFT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; CYSTEINE; FACTOR V; FEMALE; GENOTYPE; GLYCINE; GRAFT SURVIVAL; HUMANS; INFANT; INFANT, NEWBORN; KIDNEY TRANSPLANTATION; MALE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+); MIDDLE AGED; POLYMORPHISM, GENETIC; PROTHROMBIN; SURVIVAL RATE; TIME FACTORS; TISSUE DONORS;

EID: 34247533212     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000259556.99281.47     Document Type: Article

References (24)

1. Wu O, Robertson L, Twaddle S, et al. Screening for thrombophilia in high-risk situations: Systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Health Technol Assess 2006; 10: 1.
2. Heidenreich S, Junker R, Wolters H, et al. Outcome of kidney transplantation in patients with inherited thrombophilia: Data of a prospective study. J Am Soc Nephrol 2003; 14: 234.
3. Wuthrich RP, Cicvara-Muzar S, Booy C, Maly FE. Heterozygosity for the factor V Leiden (G1691A) mutation predisposes renal transplant recipients to thrombotic complications and graft loss. Transplantation 2001; 72: 549.
4. Bertina RM, Koeleman BP, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64.
5. Wuthrich RP. Factor V Leiden mutation: Potential thrombogenic role in renal vein, dialysis graft and transplant vascular thrombosis. Curr Opin Nephrol Hypertens 2001; 10: 409.
6. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698.
7. Fischereder M, Schneeberger H, Lohse P, Kramer BK, Schlondorff D, Land W. Increased rate of renal transplant failure in patients with the G20210A mutation of the prothrombin gene. Am J Kidney Dis 2001; 38: 1061.
8. Quere I, Gris JC, Dauzat M. Homocysteine and venous thrombosis. Semin Vasc Med. 2005; 5:183.
9. Collaborative Transplant Study. Homepage. Available at: www.ctstransplant.org. Accessed on February 14, 2007.
10. Meyer M, Czachurski D, Tran TH, Opelz G, Mytilineos J. A new PCR-SSP typing method for six single-nucleotide polymorphisms impairing the blood-clotting cascade as well as T-cell stimulation. Tissue Antigens 2005; 66: 650.
11. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.
12. Forssmann U, Mytilineos J, Scherer S, Opelz G. A method for HLADQA typing by the PCR-SSP technique. Transpl Int 1994; 7: 515.
13. Merdes M, Laux, G. Towards mobile computing in transplantation medicine. In: Mobile computing in medicine, Hans-Bernd Bludau, Andreas Koop. GI-Edition-Lecture Notes in Informatics (LNI), Bonner Köllen Verlag, 2nd Workshop "Mobile Computing in Medicine" (MCM), 2002: 131.
14. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. Am Stat Assoc 1958; 53: 457.
15. Parmar MKL, Machin D. Survival Analysis - A Practical Approach. New York: John Wiley & Sons; 1995:29-34.
16. Andrassy J, Zeier M, Andrassy K. Do we need screening for thrombophilia prior to kidney transplantation? Nephrol Dial Transplant 2004;19 Suppl 4, 64.
17. Hessner MJ, Luhm RA, Pearson SL, Endean DJ, Friedmann KD, Montgomery RR. Prevalence of prothrombin G20210A, factor V G1691A (Leiden), and methylenetetrahydrofolate reductase (MTHFR) C677T in seven different populations determined by multiplex allele-specific PCR. Thromb Haemost 1999; 81: 733.
18. Hessner MJ, Budish MA, Friedmann KD. Genotyping of factor V G1691A (Leiden) without the use of PCR by invasive cleavage of oligonucleotide probes. Clin Chem 2000; 46: 1051.
19. Bowen DJ, Bowley S, John M, Collins PW. Factor V Leiden (G1691A), the prothrombin 3′-untranslated region variant (G20210A) and thermolabile methylenetetrahydrofolate reductase (C677T): A single genetic test genotypes all three loci - determination of frequencies in the S. Wales population of the UK. Thromb Haemost 1998; 79: 949.
20. Hessner MJ, Dinauer DM, Kwiatkowski R, Neri B, Raife TJ. Age-dependent prevalence of vascular disease-associated polymorphisms among 2689 volunteer blood donors. Clin Chem 2001; 47: 1879.
21. Ioannidis JP. Molecular bias. Eur J Epidemiol. 2005; 20:739.
22. Pherwani AD, Winter PC, McNamee PT, et al. Is screening for factor V Leiden and prothrombin G20210A mutations in renal transplantation worthwhile? Results of a large single-center U.K. study. Transplantation 2003; 76: 603.
23. Viklicky O, Hubacek JA, Kvasnicka J, et al. ssociation of methylenetetrahydrofolate reductase T677 allele with early development of chronic allograft nephropathy. Clin Biochem 2004; 37: 919.
24. Hagen W, Fodinger M, Heinz G, Buchmayer H, Horl WH, Sunder-Plassmann G. Effect of MTHFR genotypes and hyperhomocysteinemia on patient and graft survival in kidney transplant recipients. Kidney Int Suppl 2001; 78: 253.