메뉴 건너뛰기




Volumn 7, Issue 3, 2009, Pages 158-163

Interview: Dr. Muin J. Khoury discusses the future of public health genomics and why it matters for personalized medicine and global health

Author keywords

Global public health; International development and policy; Personalized medicine; Preventive medicine; Public health genomics

Indexed keywords

ABACAVIR; EPIDERMAL GROWTH FACTOR RECEPTOR 2;

EID: 72449208051     PISSN: 18756921     EISSN: 18756913     Source Type: Journal    
DOI: 10.2174/1875692110907030158     Document Type: Note
Times cited : (19)

References (52)
  • 1
    • 0021796202 scopus 로고
    • Familial aggregation in chronic obstructive pulmonary disease: Use of the loglinear model to analyze intermediate genetic and environmental factors
    • Khoury MJ, Beaty TH, Tockman MS, et al. Familial aggregation in chronic obstructive pulmonary disease: use of the loglinear model to analyze intermediate genetic and environmental factors. Genet Epidemiol 1985; 2: 155-166
    • (1985) Genet Epidemiol , vol.2 , pp. 155-166
    • Khoury, M.J.1    Beaty, T.H.2    Tockman, M.S.3
  • 2
    • 72449161846 scopus 로고
    • Genetic-environmental interaction in chronic obstructive pulmonary disease
    • Khoury MJ, Beaty TH, Newill GA, et al. Genetic-environmental interaction in chronic obstructive pulmonary disease. Int J Epidemiol 1986; 15: 64-71.
    • (1986) Int J Epidemiol , vol.15 , pp. 64-71
    • Khoury, M.J.1    Beaty, T.H.2    Newill, G.A.3
  • 3
    • 0016421342 scopus 로고
    • N-oxidation of sparteine in man and its interindividual differences
    • Eichelbaum M, Spannbrucker N, Dengler HJ. N-oxidation of sparteine in man and its interindividual differences. Arch Pharmacol 1975; 287: R94.
    • (1975) Arch Pharmacol , vol.287
    • Eichelbaum, M.1    Spannbrucker, N.2    Dengler, H.J.3
  • 4
    • 0032700605 scopus 로고    scopus 로고
    • The science of pharmacological variability: An essay
    • Kalow W, Ozdemir V, Tang BK, et al. The science of pharmacological variability: an essay. Clin Pharmacol Ther 1999; 66(5): 445-447
    • (1999) Clin Pharmacol Ther , vol.66 , Issue.5 , pp. 445-447
    • Kalow, W.1    Ozdemir, V.2    Tang, B.K.3
  • 5
    • 15944428571 scopus 로고    scopus 로고
    • Pharmacogenomics in admixed populations
    • Suarez-Kurtz G. Pharmacogenomics in admixed populations. Trends Pharmacol Sci 2005; 26(4): 196-201.
    • (2005) Trends Pharmacol Sci , vol.26 , Issue.4 , pp. 196-201
    • Suarez-Kurtz, G.1
  • 6
    • 84911119235 scopus 로고    scopus 로고
    • Survival of the gene? 21st century visions from genomics, proteomics and the new biology
    • Glasner P, Atkinson P, Greenslade H, Eds. London: Routledge
    • McNally R, Glasner P. Survival of the gene? 21st century visions from genomics, proteomics and the new biology. In: Glasner P, Atkinson P, Greenslade H, Eds. New Genetics, New Social Formations. London: Routledge 2007; pp. 253-278
    • (2007) New Genetics, New Social Formations , pp. 253-278
    • McNally, R.1    Glasner, P.2
  • 7
    • 36148982246 scopus 로고    scopus 로고
    • Pharmacology, vaccinomics, and the second golden age of vaccinology
    • Poland GA. Pharmacology, vaccinomics, and the second golden age of vaccinology. Clin Pharmacol Ther 2007; 82(6): 623-626
    • (2007) Clin Pharmacol Ther , vol.82 , Issue.6 , pp. 623-626
    • Poland, G.A.1
  • 9
    • 72449164203 scopus 로고    scopus 로고
    • PhD Dissertation. Vrije Universiteit: Amsterdam, NL Available at: [Accessed: August 5, 2009]
    • Lunshof J. The new genomics: challenges for ethics. PhD Dissertation. Vrije Universiteit: Amsterdam, NL (2008). Available at: http://hdl.handle.net/ 1871/13070 [Accessed: August 5, 2009].
    • (2008) The New Genomics: Challenges for Ethics
    • Lunshof, J.1
  • 10
    • 55549125228 scopus 로고    scopus 로고
    • Personal genomes: Misdirected precaution
    • Prainsack B, Reardon J, Hindmarsh R, et al. Personal genomes: misdirected precaution. Nature 2008; 456(7218): 34-35
    • (2008) Nature , vol.456 , Issue.7218 , pp. 34-35
    • Prainsack, B.1    Reardon, J.2    Hindmarsh, R.3
  • 11
    • 56149105091 scopus 로고    scopus 로고
    • The pathway less traveled: Moving from candidate genes to candidate pathways in the analysis of genome-wide data from large scale pharmacogenetic association studies
    • Wilke RA, Mareedu RK, Moore JH. The pathway less traveled: moving from candidate genes to candidate pathways in the analysis of genome-wide data from large scale pharmacogenetic association studies. Curr Pharmacogenomics Person Med 2008; 6(3): 150-159
    • (2008) Curr Pharmacogenomics Person Med , vol.6 , Issue.3 , pp. 150-159
    • Wilke, R.A.1    Mareedu, R.K.2    Moore, J.H.3
  • 12
    • 64949127696 scopus 로고    scopus 로고
    • Risk assessment and communication tools for genotype associations with multifactorial phenotypes: The concept of "edge effect" and cultivating an ethical bridge between omics innovations and society
    • Ozdemir V, Suarez-Kurtz G, Stenne R, et al. Risk assessment and communication tools for genotype associations with multifactorial phenotypes: the concept of "edge effect" and cultivating an ethical bridge between omics innovations and society. OMICS 2009; 13(1): 43-61.
    • (2009) OMICS , vol.13 , Issue.1 , pp. 43-61
    • Ozdemir, V.1    Suarez-Kurtz, G.2    Stenne, R.3
  • 13
    • 72449204705 scopus 로고    scopus 로고
    • Nutrigenomics and personalized diet: What are the anticipated impacts for research on chronic diseases and public health?
    • Robitaille J. Nutrigenomics and personalized diet: what are the anticipated impacts for research on chronic diseases and public health? Curr Pharmacogenomics Person Med 2009; 7(2): 106-114
    • (2009) Curr Pharmacogenomics Person Med , vol.7 , Issue.2 , pp. 106-114
    • Robitaille, J.1
  • 14
    • 64049097931 scopus 로고    scopus 로고
    • Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate reductase 677TT genotype
    • Caudill MA, Dellschaft N, Solis C, et al. Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate reductase 677TT genotype. J Nutr 2009; 139(4): 727-733
    • (2009) J Nutr , vol.139 , Issue.4 , pp. 727-733
    • Caudill, M.A.1    Dellschaft, N.2    Solis, C.3
  • 15
    • 40449117970 scopus 로고    scopus 로고
    • The 20-year African biotech plan
    • Singh JA, Daar AS. The 20-year African biotech plan. Nat Biotechnol 2008; 26(3): 272-274
    • (2008) Nat Biotechnol , vol.26 , Issue.3 , pp. 272-274
    • Singh, J.A.1    Daar, A.S.2
  • 16
    • 52149091650 scopus 로고    scopus 로고
    • Genomics, public health and developing countries: The case of the Mexican National Institute of Genomic Medicine (INMEGEN)
    • Séguin B, Hardy BJ, Singer PA, et al. Genomics, public health and developing countries: the case of the Mexican National Institute of Genomic Medicine (INMEGEN). Nat Rev Genet 2008; 9(Suppl. 1): S5-9.
    • (2008) Nat Rev Genet , vol.9 , Issue.SUPPL. 1
    • Séguin, B.1    Hardy, B.J.2    Singer, P.A.3
  • 17
    • 52149090094 scopus 로고    scopus 로고
    • The next steps for genomic medicine: Challenges and opportunities for the developing world
    • Hardy BJ, Séguin B, Goodsaid F, et al. The next steps for genomic medicine: challenges and opportunities for the developing world. Nat Rev Genet 2008; 9(Suppl. 1): S23-7.
    • (2008) Nat Rev Genet , vol.9 , Issue.SUPPL. 1
    • Hardy, B.J.1    Séguin, B.2    Goodsaid, F.3
  • 18
    • 72449189641 scopus 로고    scopus 로고
    • Pharmacogenomics and Personalized Medicine for the Developing World - Too Soon or Just-in-Time? A Personal View from the World Health Organization
    • Pang T. Pharmacogenomics and Personalized Medicine for the Developing World - Too Soon or Just-in-Time? A Personal View from the World Health Organization. Curr Pharmacogenomics Person Med 2009; 7(3): 149-157
    • (2009) Curr Pharmacogenomics Person Med , vol.7 , Issue.3 , pp. 149-157
    • Pang, T.1
  • 19
    • 68149132313 scopus 로고    scopus 로고
    • A decade of public health genomics in the United States: Centers for Disease Control and Prevention 1997-2007
    • Sep 3 [Epub ahead of print]
    • Khoury MJ, Bowen S, Bradley LA, et al. A decade of public health genomics in the United States: Centers for Disease Control and Prevention 1997-2007. Public Health Genomics 2008 Sep 3 [Epub ahead of print].
    • (2008) Public Health Genomics
    • Khoury, M.J.1    Bowen, S.2    Bradley, L.A.3
  • 20
    • 33747874300 scopus 로고    scopus 로고
    • The Path from Genome-Based Research to Population Health: Development of an International Public Health Genomics Network
    • Bellagio working group
    • Burke W, Khoury MJ, Stewart A, Zimmern R. Bellagio working group. The Path from Genome-Based Research to Population Health: Development of an International Public Health Genomics Network. Genet Med 2006; 8: 451-458
    • (2006) Genet Med , vol.8 , pp. 451-458
    • Burke, W.1    Khoury, M.J.2    Stewart, A.3    Zimmern, R.4
  • 21
    • 0030461680 scopus 로고    scopus 로고
    • From genes to public health: A commentary for the application of genetics in disease prevention
    • the Genetics Working Group
    • Khoury MJ, the Genetics Working Group. From genes to public health: a commentary for the application of genetics in disease prevention. Am J Publ Health 1996; 86: 1717-1722
    • (1996) Am J Publ Health , vol.86 , pp. 1717-1722
    • Khoury, M.J.1
  • 22
    • 0034894653 scopus 로고    scopus 로고
    • The integration of genomics into public health research, policy and practice in the United States
    • DOI 10.1159/000051150
    • Beskow L, Khoury MJ, Baker T, et al. The integration of genetics into public health research, policy and practice: a blueprint for action. Community Genet 2001; 4: 2-11. (Pubitemid 32722264)
    • (2001) Community Genetics , vol.4 , Issue.1 , pp. 2-11
    • Beskow, L.M.1    Khoury, M.J.2    Baker, T.G.3    Thrasher, J.F.4
  • 23
    • 34548640543 scopus 로고    scopus 로고
    • Will genomics widen or heal the schism between medicine and public health?
    • Khoury MJ, Gwinn M, Burke W, et al. Will genomics widen or heal the schism between medicine and public health? Am J Prev Med 2007; 33: 310-317
    • (2007) Am J Prev Med , vol.33 , pp. 310-317
    • Khoury, M.J.1    Gwinn, M.2    Burke, W.3
  • 24
    • 57349178475 scopus 로고    scopus 로고
    • Closing the evidence gap in the use of emerging testing technologies in clinical practice
    • Phillips KA. Closing the evidence gap in the use of emerging testing technologies in clinical practice. JAMA 2008; 300: 2542-2544
    • (2008) JAMA , vol.300 , pp. 2542-2544
    • Phillips, K.A.1
  • 25
    • 58149250142 scopus 로고    scopus 로고
    • Abacavir hypersensitivity: A model system for pharmacogenomic test adoption
    • Lai Goldman M, Faruki H. Abacavir hypersensitivity: a model system for pharmacogenomic test adoption. Genet Med 2008; 10(12): 874-878
    • (2008) Genet Med , vol.10 , Issue.12 , pp. 874-878
    • Lai Goldman, M.1    Faruki, H.2
  • 26
    • 40449124033 scopus 로고    scopus 로고
    • Pharmacogenomics-ready for prime time?
    • Shurin SC, Nabel EG. Pharmacogenomics-ready for prime time? N Engl J Med 2008; 358(10): 1061-1063
    • (2008) N Engl J Med , vol.358 , Issue.10 , pp. 1061-1063
    • Shurin, S.C.1    Nabel, E.G.2
  • 27
    • 70350729454 scopus 로고    scopus 로고
    • Comparative effectiveness research and genomic medicine: An evolving relationship for 21st century medicine
    • in press
    • Khoury MJ, Rich EC, Randhawa G, et al. Comparative effectiveness research and genomic medicine: an evolving relationship for 21st century medicine. Genet Med 2009 (in press)
    • (2009) Genet Med
    • Khoury, M.J.1    Rich, E.C.2    Randhawa, G.3
  • 28
    • 59849108152 scopus 로고    scopus 로고
    • The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) initiative: Methods of the EGAPP working group
    • Teutsch SM, Bradley LA, Palomaki G, et al. The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) initiative: methods of the EGAPP working group. Genet Med 2009; 11: 3-14.
    • (2009) Genet Med , vol.11 , pp. 3-14
    • Teutsch, S.M.1    Bradley, L.A.2    Palomaki, G.3
  • 29
    • 70350735679 scopus 로고    scopus 로고
    • EGAPP working group-recommendation statements
    • EGAPP working group-recommendation statements. Genet Med 2009; 11: 15-73.
    • (2009) Genet Med , vol.11 , pp. 15-73
  • 30
    • 37349116252 scopus 로고    scopus 로고
    • The continuum of translation research in genomic medicine: How can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention?
    • Khoury MJ, Gwinn M, Yoon PW, et al. The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genet Med 2007; 9(10): 665-674
    • (2007) Genet Med , vol.9 , Issue.10 , pp. 665-674
    • Khoury, M.J.1    Gwinn, M.2    Yoon, P.W.3
  • 31
    • 0042431931 scopus 로고    scopus 로고
    • Shattuck lecture: Clinical research to clinical practice - Lost in translation?
    • DOI 10.1056/NEJMsa035507
    • Lenfant C. Shattuck lecture: clinical research to clinical practice: lost in translation. N Engl J Med 2003; 349: 868-874 (Pubitemid 37025407)
    • (2003) New England Journal of Medicine , vol.349 , Issue.9 , pp. 868-874
    • Lenfant, C.1
  • 32
    • 38049096095 scopus 로고    scopus 로고
    • The meaning of translational research and why it matters
    • Woolfe SH. The meaning of translational research and why it matters. JAMA 2008; 299(2): 211-213
    • (2008) JAMA , vol.299 , Issue.2 , pp. 211-213
    • Woolfe, S.H.1
  • 33
    • 38049130261 scopus 로고    scopus 로고
    • Letting the genome is out of the bottle - Will we get our wish
    • Hunter DJ, Khoury MJ, Drazen JM. Letting the genome is out of the bottle - will we get our wish. N Engl J Med 2008; 358(2): 105-107
    • (2008) N Engl J Med , vol.358 , Issue.2 , pp. 105-107
    • Hunter, D.J.1    Khoury, M.J.2    Drazen, J.M.3
  • 34
    • 56649100478 scopus 로고    scopus 로고
    • The evidence dilemma in genomic medicine
    • Millwood
    • Khoury MJ, Berg A, Coates RC, et al. The evidence dilemma in genomic medicine. Health Aff (Millwood) 2008; 2e7: 1600-1611
    • (2008) Health Aff , vol.2 E7 , pp. 1600-1611
    • Khoury, M.J.1    Berg, A.2    Coates, R.C.3
  • 35
    • 64549139802 scopus 로고    scopus 로고
    • The disruptive nature of personalized medicine technologies: Implications for the healthcare system
    • Carlson RJ. The disruptive nature of personalized medicine technologies: implications for the healthcare system. Public Health Genomics 2009; 12: 180-184
    • (2009) Public Health Genomics , vol.12 , pp. 180-184
    • Carlson, R.J.1
  • 36
    • 85036779143 scopus 로고    scopus 로고
    • Secretary's Advisory Committee on Genetics, Health and Society (SACGHS). [Accessed August 5, 2009]. Available from
    • Secretary's Advisory Committee on Genetics, Health and Society (SACGHS). [Accessed August 5, 2009]. Available from: http://oba.od.nih.gov/sacghs/sacghs- home.html
  • 37
    • 69549104496 scopus 로고    scopus 로고
    • The scientific foundation for personal genomics: Recommendations from an NIH-CDC multidisciplinary workshop
    • in press
    • Khoury MJ, McBride CA, Schully S, et al. The scientific foundation for personal genomics: recommendations from an NIH-CDC multidisciplinary workshop. Genet Med 2009 (in press).
    • (2009) Genet Med
    • Khoury, M.J.1    McBride, C.A.2    Schully, S.3
  • 38
    • 77952999813 scopus 로고    scopus 로고
    • Secretary's Advisory Committee on Genetics, Health and Society (SACGHS). [Accessed: August 5, 2009]. Available from
    • Secretary's Advisory Committee on Genetics, Health and Society (SACGHS). US system of oversight of genetic testing 2008. [Accessed: August 5, 2009]. Available from: http://oba.od.nih.gov/ oba/SACGHS/reports/SACGHS-oversight- report.pdf
    • (2008) US System of Oversight of Genetic Testing
  • 39
    • 72449124425 scopus 로고    scopus 로고
    • Developin a blueprint for a genetic test registry
    • Published online June 29 DOI: 10.1159/000226593
    • Javitt G, Katsanis S, Scott J, et al. Developin a blueprint for a genetic test registry. Public Health Genomics 2009; Published online June 29 DOI: 10.1159/000226593.
    • (2009) Public Health Genomics
    • Javitt, G.1    Katsanis, S.2    Scott, J.3
  • 40
    • 68749112850 scopus 로고    scopus 로고
    • The Genomic Applications in Practice and Prevention Network
    • May 22. PMID: 19471162
    • Khoury MJ, Feero WG, Reyes M, et al. The Genomic Applications in Practice and Prevention Network. Genet Med 2009; May 22. PMID: 19471162.
    • (2009) Genet Med
    • Khoury, M.J.1    Feero, W.G.2    Reyes, M.3
  • 41
    • 61449255938 scopus 로고    scopus 로고
    • Strengthening the Reporting of Genetic Association Studies (STREGA): An extension of the STROBE statement
    • Little J, Higgins JP, Ioannidis JP, et al. Strengthening the Reporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. PLoS Med 2009; 6(2): e22.
    • (2009) PLoS Med , vol.6 , Issue.2
    • Little, J.1    Higgins, J.P.2    Ioannidis, J.P.3
  • 42
    • 85036778521 scopus 로고    scopus 로고
    • The Human Genome Epidemiology Network (HuGENet). [Accessed: August 5, 2009] Available from
    • The Human Genome Epidemiology Network (HuGENet). [Accessed: August 5, 2009] Available from: http://www.cdc.gov/ genomics/hugenet/default.htm
  • 44
    • 20444374342 scopus 로고    scopus 로고
    • A model process for evaluating data on emerging genetic tests
    • Khoury MJ, Little J, Burke W, Eds. New York: Oxford University Press
    • Haddow JE, Palomaki GE. A model process for evaluating data on emerging genetic tests. In: Khoury MJ, Little J, Burke W, Eds. Human genome epidemiology: scope and strategies. New York: Oxford University Press 2004; pp. 217-233.
    • (2004) Human Genome Epidemiology: Scope and Strategies , pp. 217-233
    • Haddow, J.E.1    Palomaki, G.E.2
  • 45
    • 4944263635 scopus 로고    scopus 로고
    • Implementing the Institute of Medicine's recommended curriculum content in schools of public health: A baseline assessment
    • Shortell SM, Weist EM, Mah-Sere KW, et al. Implementing the Institute of Medicine's recommended curriculum content in schools of public health: a baseline assessment. Am J Publ Health 2004; 94(10): 1671-1674
    • (2004) Am J Publ Health , vol.94 , Issue.10 , pp. 1671-1674
    • Shortell, S.M.1    Weist, E.M.2    Mah-Sere, K.W.3
  • 46
    • 33750216884 scopus 로고    scopus 로고
    • Genomics, epidemiology, and common complex diseases: Let's not throw out the baby with the bathwater! [6]
    • DOI 10.1093/ije/dyl214
    • Khoury MJ, Gwinn M. Genomics, epidemiology and common complex diseases: let's not throw out the baby with the bathwater. Int J Epidemiol 2006; 35: 1363-1364 (Pubitemid 44605571)
    • (2006) International Journal of Epidemiology , vol.35 , Issue.5 , pp. 1363-1364
    • Khoury, M.J.1    Gwinn, M.2
  • 47
    • 17744373679 scopus 로고    scopus 로고
    • Do we need genomic research for the prevention of common diseases with environmental causes?
    • Khoury MJ, Davis RL, Gwinn M, et al. Do we need genomic research for the prevention of common diseases with environmental causes? Am J Epidemiol 2005; 161: 799-805.
    • (2005) Am J Epidemiol , vol.161 , pp. 799-805
    • Khoury, M.J.1    Davis, R.L.2    Gwinn, M.3
  • 48
    • 85036783007 scopus 로고    scopus 로고
    • Natural History Museum. [Accessed: August 5, 2009] Available from
    • Natural History Museum. Darwin200. [Accessed: August 5, 2009] Available from: http://www.darwin200.org/index.html
  • 50
    • 46449097443 scopus 로고    scopus 로고
    • The Science of Team Science. Overview of the Field and Introduction to the Supplement
    • DOI 10.1016/j.amepre.2008.05.002, PII S074937970800408X
    • Stokols D, Hall KL, Taylor BK, et al. The science of team science. Overview of the field and introduction to the supplement. Am J Prev Med 2008; 35(Suppl. 2): S77-S89. (Pubitemid 351932066)
    • (2008) American Journal of Preventive Medicine , vol.35 , Issue.2 SUPPL.
    • Stokols, D.1    Hall, K.L.2    Taylor, B.K.3    Moser, R.P.4
  • 52
    • 0036653105 scopus 로고    scopus 로고
    • Can family history be used as a tool for public health and preventive medicine?
    • Yoon PW, Scheuner MT, Peterson-Oehlke KL, et al. Can family history be used as a tool for public health and preventive medicine? Genet Med 2002; 4: 304-310
    • (2002) Genet Med , vol.4 , pp. 304-310
    • Yoon, P.W.1    Scheuner, M.T.2    Peterson-Oehlke, K.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.