Variable Field Proton-Electron Double-Resonance Imaging: Application to pH mapping of aqueous samples

Journal of Magnetic Resonance

Volumn 202, Issue 2, 2010, Pages 267-273

  Khramtsov, Valery V ^a   Caia, George L ^a   Shet, Keerthi ^a   Kesselring, Eric ^a   Petryakov, Sergey ^a   Zweier, Jay L ^a   Samouilov, Alexandre ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

DNP; dynamic nuclear polarization; Functional imaging; Nitroxide; PEDRI; pH; Proton Electron Double Resonance Imaging; spin pH probe

Indexed keywords

DYNAMIC NUCLEAR POLARIZATION; FUNCTIONAL IMAGING; NITROXIDE; NITROXIDES; PEDRI; PH PROBE;

ELECTRON RESONANCE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTRONS; EXTRACTION; IMAGE RESOLUTION; MAPPING; OPTICAL DEVICES; OXYGEN; PARAMAGNETIC RESONANCE; PH EFFECTS; PROTONS; QUANTUM THEORY; SPIN DYNAMICS; SPIN POLARIZATION;

PROBES;

NITROGEN OXIDE; OXYGEN; PROTON; REACTIVE NITROGEN SPECIES; WATER;

ARTICLE; CHEMISTRY; ELECTRON; ELECTRON SPIN RESONANCE; IMAGE QUALITY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATION REDUCTION REACTION; PH;

ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTRONS; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE IMAGING; NITROGEN OXIDES; OXIDATION-REDUCTION; OXYGEN; PHANTOMS, IMAGING; PROTONS; REACTIVE NITROGEN SPECIES; WATER;

EID: 72449172996     PISSN: 10907807     EISSN: 10960856     Source Type: Journal    
DOI: 10.1016/j.jmr.2009.11.017     Document Type: Article

References (49)

1. In: Eaton G.R., Eaton S.E., and Ohno K. (Eds). EPR Imaging and In vivo EPR (1991), CRC Press, Boca Raton
2. Kuppusamy P., and Zweier J.L. Cardiac applications of EPR imaging. NMR Biomed. 17 (2004) 226-239
3. Subramanian S., and Krishna M.C. Dancing with the electrons: time-domain and CW in vivo EPR imaging. Magn. Reson. Insights 2 (2008) 43-74
4. Matsumoto K., Subramanian S., Murugesan R., Mitchell J.B., and Krishna M.C. Spatially resolved biologic information from in vivo EPRI, OMRI, and MRI. Antioxidants Redox Signal. 9 (2007) 1125-1141
5. Hyodo F., Matsumoto S., Devasahayam N., Dharmaraj C., Subramanian S., Mitchell J.B., and Krishna M.C. Pulsed EPR imaging of nitroxides in mice. J. Magn. Reson. 197 (2009) 181-185
6. Berliner J.L., and Fujii H. Magnetic resonance imaging of biological specimens by electron paramagnetic resonance of nitroxide spin labels. Science 227 (1985) 517-519
7. He G., Deng Y., Li H., Kuppusamy P., and Zweier J.L. EPR/NMR co-imaging for anatomic registration of free-radical images. Magn. Reson. Med. 47 (2002) 571-578
8. Samouilov A., Caia G.L., Kesselring E., Petryakov S., Wasowicz T., and Zweier J.L. Development of a hybrid EPR/NMR coimaging system. Magn. Reson. Med. 58 (2007) 156-166
9. He G., Samouilov A., Kuppusamy P., and Zweier J.L. In vivo imaging of free radicals: applications from mouse to man. Mol. Cell. Biochem. 234-235 (2002) 359-367
10. Eaton S.S., Maltempo M.M., Stemp E.D.A., and Eaton G.R. 3-Dimensional electron-paramagnetic-res imaging with one spectral and 2 spatial dimensions. Chem. Phys. Lett. 142 (1987) 567-569
11. Halpern H.J., Yu C., Peric M., Barth E., Grdina D.J., and Teicher B.A. Oxymetry deep in tissues with low-frequency electron paramagnetic resonance. Proc. Natl. Acad. Sci. USA 91 (1994) 13047-13051
12. Krishna M.C., Kuppusamy P., Afeworki M., Zweier J.L., Cook J.A., Subramanian S., and Mitchell J.B. Development of functional electron paramagnetic resonance imaging. Breast Dis. 10 (1998) 209-220
13. Khramtsov V.V. Biological imaging and spectroscopy of pH. Curr. Org. Chem. 9 (2005) 909-923
14. He G., Samouilov A., Kuppusamy P., and Zweier J.L. In vivo EPR imaging of the distribution and metabolism of nitroxide radicals in human skin. J. Magn. Reson. 148 (2001) 155-164
15. Lurie D.J., Bussell D.M., Bell L.H., and Mallard J.R. Proton electron double magnetic resonance imaging of free radical solutions. J. Magn. Reson. 76 (1988) 366-370
16. Golman K., Leunbach I., Ardenkjaer-Larsen J.H., Ehnholm G.J., Wistrand L.G., Petersson J.S., Jarvi A., and Vahasalo S. Overhauser-enhanced MR imaging (OMRI). Acta Radiol. 39 (1998) 10-17
17. Lurie D.J., Hutchison J.M.S., Bell L.H., Nicholson I., Bussell D.M., and Mallard J.R. Field-cycled proton-electron double resonance imaging of free radicals in large aqueous samples. J. Magn. Reson. 84 (1989) 431-437
18. Overhauser A.W. Polarization of nuclei in metals. Phys. Rev. 92 (1953) 411-415
19. Ardenkjaer-Larsen J.H., Laursen I., Leunbach I., Ehnholm G., Wistrand L.G., Petersson J.S., and Golman K. EPR and DNP properties of certain novel single electron contrast agents intended for oximetric imaging. J. Magn. Reson. 133 (1998) 1-12
20. Krishna M.C., English S., Yamada K., Yoo J., Murugesan R., Devasahayam N., Cook J.A., Golman K., Ardenkjaer-Larsen J.H., Subramanian S., and Mitchell J.B. Overhauser enhanced magnetic resonance imaging for tumor oximetry: coregistration of tumor anatomy and tissue oxygen concentration. Proc. Natl. Acad. Sci. USA 99 (2002) 2216-2221
21. Li H., Deng Y., He G., Kuppusamy P., Lurie D.J., and Zweier J.L. Proton electron double resonance imaging of the in vivo distribution and clearance of a triaryl methyl radical in mice. Magn. Reson. Med. 48 (2002) 530-534
22. Li H., He G., Deng Y., Kuppusamy P., and Zweier J.L. In vivo proton electron double resonance imaging of the distribution and clearance of nitroxide radicals in mice. Magn. Reson. Med. 55 (2006) 669-675
23. Lurie D.J., Davies G.R., Foster M.A., and Hutchison J.M. Field-cycled PEDRI imaging of free radicals with detection at 450 mT. Magn. Reson. Imaging 23 (2005) 175-181
24. Foster M.A., Seimenis I., and Lurie D.J. The application of PEDRI to the study of free radicals in vivo. Phys. Med. Biol. 43 (1998) 1893-1897
25. Utsumi H. Molecular imaging of in-vivo ROS generation in oxidative diseases using ESRI and OMRI. Nippon Ronen Igakkai Zasshi 44 (2007) 11-16
26. Grucker D., and Chambron J. Oxygen imaging in perfused hearts by dynamic nuclear polarization. Magn. Reson. Imaging 11 (1993) 691-696
27. Golman K., Petersson J.S., Ardenkjaer-Larsen J.H., Leunbach I., Wistrand L.G., Ehnholm G., and Liu K.J. Dynamic in vivo oxymetry using overhauser enhanced MR imaging. J. Magn. Reson. Imaging 12 (2000) 929-938
28. Utsumi H., Yamada K., Ichikawa K., Sakai K., Kinoshita Y., Matsumoto S., and Nagai M. Simultaneous molecular imaging of redox reactions monitored by overhauser-enhanced MRI with 14N- and 15N-labeled nitroxyl radicals. Proc. Natl. Acad. Sci. USA 103 (2006) 1463-1468
29. Potapenko D.I., Foster M.A., Lurie D.J., Kirilyuk I.A., Hutchison J.M., Grigor'ev I.A., Bagryanskaya E.G., and Khramtsov V.V. Real-time monitoring of drug-induced changes in the stomach acidity of living rats using improved pH-sensitive nitroxides and low-field EPR techniques. J. Magn. Reson. 182 (2006) 1-11
30. Volodarsky L.B., and Grigor'ev I.A. Synthesis of heterocyclic nitroxides. In: Volodarsky L.B. (Ed). Imidazoline Nitroxides (1988), CRC Press, Boca Raton 5-28
31. Petryakov S., Samouilov A., Roytenberg M., Li H., and Zweier J.L. Modified Alderman-Grant resonator with high-power stability for proton electron double resonance imaging. Magn. Reson. Med. 56 (2006) 654-659
32. Khramtsov V.V., Grigor'ev I.A., Foster M.A., Lurie D.J., and Nicholson I. Biological applications of spin pH probes. Cell. Mol. Biol. 46 (2000) 1361-1374
33. Breit G., and Rabi I.I. Measurement of nuclear spin. Phys. Rev. 38 (1931) 2082-2083
34. Lora-Michiels M., Yu D., Sanders L., Poulson J.M., Azuma C., Case B., Vujaskovic Z., Thrall D.E., Charles H.C., and Dewhirst M.W. Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy. Clin. Cancer Res. 12 (2006) 5733-5740
35. Gillies R.J., Raghunand N., Garcia-Martin M.L., and Gatenby R.A. pH imaging. A review of pH measurement methods and applications in cancers. IEEE Eng. Med. Biol. Mag. 23 (2004) 57-64
36. Pietri S., Martel S., Culcasi M., Delmas-Beauvieux M.C., Canioni P., and Gallis J.L. Use of diethyl(2-methylpyrrolidin-2-yl)phosphonate as a highly sensitive extra- and intracellular 31P NMR pH indicator in isolated organs. Direct NMR evidence of acidic compartments in the ischemic and reperfused rat liver. J. Biol. Chem. 276 (2001) 1750-1758
37. Gillies R.J., Alger J.R., den Hollander J.A., and Shulman R.G. Intracellular pH measured by NMR: methods and results. In: Nuccitelli R., and Deamer D.W. (Eds). Intracellular pH: its measurement, regulation and utilization in cellular functions (1982), Alan R. Liss, New York 79-104
38. Khramtsov V.V., and Volodarsky L.B. Use of imidazoline nitroxides in studies of chemical reactions. ESR measurements of the concentration and reactivity of protons, thiols and nitric oxide. In: Berliner L.J. (Ed). Spin labeling. The next Millennium (1998), Plenum Press, New York 109-180
39. Mader K., Gallez B., Liu K.J., and Swartz H.M. Non-invasive in vivo characterization of release processes in biodegradable polymers by low-frequency electron paramagnetic resonance spectroscopy. Biomaterials 17 (1996) 457-461
40. Foster M.A., Grigor'ev I.A., Lurie D.J., Khramtsov V.V., McCallum S., Panagiotelis I., Hutchison J.M., Koptioug A., and Nicholson I. In vivo detection of a pH-sensitive nitroxide in the rat stomach by low-field ESR-based techniques. Magn. Reson. Med. 49 (2003) 558-567
41. Sotgiu A., Mader K., Placidi G., Colacicchi S., Ursini C.L., and Alecci M. pH-sensitive imaging by low-frequency EPR: a model study for biological applications. Phys. Med. Biol. 43 (1998) 1921-1930
42. Khramtsov V.V., Grigor'ev I.A., Foster M.A., Lurie D.J., Zweier J.L., and Kuppusamy P. Spin pH and SH probes: enhancing functionality of EPR-based techniques. Spectroscopy 18 (2004) 213-225
43. Zweier J.L., Wang P., Samouilov A., and Kuppusamy P. Enzyme-independent formation of nitric oxide in biological tissues. Nat. Med. 1 (1995) 804-809
44. Kirilyuk I.A., Bobko A.A., Grigor'ev I.A., and Khramtsov V.V. Synthesis of the tetraethyl substituted pH-sensitive nitroxides of imidazole series with enhanced stability towards reduction. Org. Biomol. Chem. 2 (2004) 1025-1030
45. Woldman Y.Y., Semenov S.V., Bobko A.A., Kirilyuk I.A., Polienko J.F., Voinov M.A., Bagryanskaya E.G., and Khramtsov V.V. Design of liposome-based pH sensitive nanoSPIN probes: nano-sized particles with incorporated nitroxides. Analyst 134 (2009) 904-910
46. Bobko A.A., Dhimitruka I., Zweier J.L., and Khramtsov V.V. Trityl radicals as persistent dual function pH and oxygen probes for in vivo electron paramagnetic resonance spectroscopy and imaging: concept and experiment. J. Am. Chem. Soc. 129 (2007) 7240-7241
47. Dhimitruka I., Bobko A.A., Hadad C.M., Zweier J.L., and Khramtsov V.V. Synthesis and characterization of amino derivatives of persistent trityl radicals as dual function pH and oxygen paramagnetic probes. J. Am. Chem. Soc. 130 (2008) 10780-10787
48. Bobko A.A., Dhimitruka I., Eubank T.D., Marsh C.B., Zweier J.L., and Khramtsov V.V. Synthesis and characterization of trityl-based EPR probe with enhanced sensitivity to oxygen. Free Rad. Biol. Med. 47 (2009) 654-658
49. Roshchupkina G.I., Bobko A.A., Bratasz A., Reznikov V.A., Kuppusamy P., and Khramtsov V.V. In vivo EPR measurement of glutathione in tumor-bearing mice using improved disulfide biradical probe. Free Rad. Biol. Med. 45 (2008) 312-320