pH-Sensitive imaging by low-frequency EPR: A model study for biological applications

Physics in Medicine and Biology

Volumn 43, Issue 7, 1998, Pages 1921-1930

  Sotgiu, Antonello ^a   Mäder, Karsten ^b   Placidi, Giuseppe ^a   Colacicchi, Silvia ^a   Ursini, Cinzia Lucia ^a   Alecci, Marcello ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NITROXIDE;

ARTICLE; DIAGNOSTIC IMAGING; ELECTRON SPIN RESONANCE; IMAGE QUALITY; NUCLEAR MAGNETIC RESONANCE; PH; PHANTOM; PRIORITY JOURNAL; PROTON TRANSPORT; RADIOFREQUENCY;

EID: 2642651896     PISSN: 00319155     EISSN: None     Source Type: Journal    
DOI: 10.1088/0031-9155/43/7/013     Document Type: Article

References (39)

1. Alecci M, Colacicchi S, Indovina P L, Momo F, Pavone P and Sotgiu A 1990 Three-dimensional in vivo ESR imaging in rats Magn. Reson. Imaging 8 59-63
2. Alecci M, Delia Penna S, Sotgiu A, Testa L and Vannucci I 1992 Electron paramagnetic resonance spectrometer for three dimensional in vivo imaging at very low frequency Rev. Sci. Instrum. 63 4263-70
3. Alecci M, Ferrari M, Quaresima V, Sotgiu A and Ursini C L 1994 Simultaneous 280 MHz EPR imaging of the rat organs during nitroxide free radical clearance Biophys. J. 67 1274-9
4. Breit G and Rabi I I 1932 Measurement of nuclear spin Phys. Rev. 38 2082-3
5. Cafiso D S and Hubbell W L 1978 Estimation of transmembrane pH gradients from phase equilibria of spin-labeled amines Biochemistry 17 3871-7
6. Colacicchi S, Alecci M, Gualtieri G, Quaresima V, Ursini C L, Ferrari M and Sotgiu A 1993 New experimental procedures for in vivo L-band and radio frequency EPR spectroscopy/imaging J. Chem. Soc. Perkin Trans. 2 11 2077-82
7. Colacicchi S, Indovina P L, Momo F and Sotgiu A 1988 Low-frequency three-dimensional ESR imaging of large samples J. Phys. E: Sci. Instrum. 21 910-13
8. Eaton G R and Eaton S S 1995 Introduction to EPR imaging using magnetic-field gradients Concepts Magn. Reson. 7 49-6
9. Eaton G R, Eaton S S and Ohno K 1991 EPR Imaging and in vivo EPR (Boca Raton, FL: CRC)
10. Ernst R R 1996 Sensitivity enhancement in magnetic resonance Adv. Magn. Reson. 2 1-135
11. Gallez B, Mäder K and Swartz H M 1996 Non-invasive measurement of the pH inside the gut using pH-sensitive nitroxides: an in vivo EPR study Mag. Reson. Med. 36 694-7
12. Galster H 1991 pH Measurements: Fundamentals, Methods, Applications, Instrumentation (Weinhein: VCH)
13. Gerweck L E and Seetharaman K 1996 Cellular pH gradient in tumour versus normal tissue - potential exploitation for the treatment of cancer Cancer Res. 56 1194-8
14. Halpern H, Peric M, Yu C, Barth E D, Chandramouli G V R, Maniken M W and Rosen G M 1996 In vivo spin-label murine pharmacodynamics using low-frequency electron paramagnetic resonance imaging Biophys. J. 71 403-9
15. Harguindey S, Pedraz J L, Canero R G, Dediego J P and Cragoe E J 1995 Hydrogen ion dependent oncogenesis and parallel new avenues to cancer prevention and treatment using a H+ mediated unifying approach - pH-related and pH-unrelated mechanisms Crit. Rev. Oncogen. 6 1-33
16. Hunt H 1994 Hp and pH - the relevance of gastric acid to the treatment of Heliobacter pylori infections J. Gastroenterol. 29 (suppl 7) 128-33
17. Jacobsen L and Cohen J S 1982 Non-invasive Probes of Tissue Metabolism ed J S Cohen (New York: Wiley)
18. N with pH J. Am. Chem. Soc. 104 827-30
19. Khramtsov V V, Marsh D, Weiner L M and Reznikov V A 1992 The application of pH-sensitive spin labels to studies of surface potential and polarity of phospholipid membranes and proteins Biochim. Biophys. Acta 1104 317-24
20. Khramtsov V V and Weiner L M 1988 Proton exchange in stable nitroxyl radicals: pH-sensitive spin probes Imidazoline Nitroxides vol II ed L B Volodarsky (Boca Raton, FL: CRC) pp 37-80
21. Khramtsov V V, Weiner L M, Grigoriev I A and Volodarsky L B 1982 Proton exchange in stable nitroxyl radicals. EPR study of the pH of aqueous solutions Chem. Phys. Lett. 91 69-72
22. Kuppusamy P, Chzhan M, Samouilov A, Wang P and Zweier J L 1995 Mapping the spin-density and lineshape distribution of free radicals using 4D spectral-spatial EPR imaging J. Magn. Reson. B 107 116-25
23. Lauterbur P C, Levin D N and Marr R B 1984 Theory and simulation of NMR spectroscopic imaging and field plotting by projection reconstruction involving an intrinsic frequency dimension J. Magn. Reson. 59 536-41
24. Mader K, Bacic G, Domb A, Elmalak O, Langer R and Swartz H M 1997 Noninvasive in vivo monitoring of drug release and polymer erosion from biodegradable polymers by EPR spectroscopy and NMR imaging J. Pharm. Sci. 86 126-34
25. Mäder K, Domb A and Swartz H M 1996a Gamma sterilization induced radicals in biodegradable drug delivery systems Appl. Radiat. Isot. 47 1669-74
26. Mäder K, Gallez B, Liu K J and Swartz H M 1996b Non-invasive in vivo characterization of release processes in biodegradable polymers by low frequency electron paramagnetic resonance spectroscopy Biomaterials 17 459-63
27. Mäder K, Swartz H M, Stösser R and Borchert H H 1994 The application of EPR spectroscopy in the field of pharmacy Pharmazie 49 97-101
28. Malhotra D and Shapiro J I 1993 Nuclear magnetic resonance measurements of intracellular pH: biomedical implications Conc. Mag. Reson. 5 123-50
29. Maltempo M M, Eaton S S and Eaton G R 1987 Spectral-spatial two-dimensional EPR imaging J. Magn. Reson. 72 449-55
30. _1988 Reconstruction of spectral-spatial two-dimensional EPR images from incomplete sets of projections without prior knowledge of the components spectra J. Magn. Reson. 77 75-83
31. McCallum S J, Alecci M and Lurie D J 1996 Modification of a whole body NMR imager into a radio frequency EPR spectrometer suitable for in vivo measurements Meas. Sci. Technol. 7 1012-18
32. Mignano A G and Baldini F 1996 Biomedical sensors using optical fibres Rep. Prog. Phys. 59 1-28
33. Placidi G 1996 Tecniche di ricostruzione e filtrazione di immagini tomografiche, con applicazione alle risonanze magnetiche elettronica e nucleare PhD Thesis Universita' dell'Aquila, Italy
34. Placidi G, Alecci M and Sotgiu A 1994 Spline-based deconvolution technique in electron paramagnetic resonance imaging Rev. Sci. Instrum. 65 58-62
35. Quintanilha A T and Mehlhorn R J 1978 pH gradients across thylakoid membranes measured with a spin-labeled amine FEBS Lett. 91 104-8
36. Sotgiu A, Alecci M, Brivati J, Placidi G and Testa L 1995 Bioradicals Detected by ESR Spectroscopy ed H Ohya-Nishiguchi and L Packer (Basel: Birkhauser) pp 69-92
37. Sotgiu A, Mäder K, Alecci M, Ursini C L and Placidi G 1996 EPR spectroscopy/imaging at RF (280 MHz) with pH-sensitive paramagnetic probes: a model study for in vivo applications Proc. ISMRM 3 1375
38. Swallow C J, Grinstein S and Rotstein O D 1992 Lipopolysaccharide impairs macrophage cytoplasmic pH regulation under conditions simulating the inflammatory microenvironment J. Leukocyte Biol. 52 395-9
39. Wu M P, Tamada J A, Brem H and Langer R 1994 In vivo versus in vitro degradation of controlled release polymers for intracranial surgery J. Biomed. Mater. Res. 28 387-95