Purinergic regulation of the epithelial Na+ channel

Clinical and Experimental Pharmacology and Physiology

Volumn 36, Issue 10, 2009, Pages 1016-1022

  O'Mullane, Lauren M ^a   Cook, David I ^a   Dinudom, Anuwat ^a,b  

^a University of Sydney   (Australia)

^b Medical Foundation Building   (Australia)

Author keywords

Amiloride; Bumetanide; Epithelial Na+ channel (ENaC); G ; P2Y2 receptor; Pertussis toxin; Phospholipase C 4; Uridine 5 triphosphate

Indexed keywords

CALCIUM ION; CHLORIDE ION; EPITHELIAL SODIUM CHANNEL; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; HORMONE; HUMORAL ANTIBODY; NUCLEOTIDE; PERTUSSIS TOXIN; PHOSPHOLIPASE C BETA4; POTASSIUM ION; PURINERGIC P2Y2 RECEPTOR; PURINERGIC RECEPTOR; SODIUM ION; URIDINE TRIPHOSPHATE;

APICAL MEMBRANE; BASOLATERAL MEMBRANE; CONFERENCE PAPER; DESCENDING COLON; ENZYME ACTIVATION; EPITHELIUM CELL; EXOCRINE GLAND; HUMAN; NEPHRON; NONHUMAN; REGULATORY MECHANISM; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION; SODIUM TRANSPORT;

ANIMALS; CHLORIDES; EPITHELIAL SODIUM CHANNEL; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HUMANS; MODELS, BIOLOGICAL; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; URIDINE TRIPHOSPHATE;

EID: 72449169462     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2009.05256.x     Document Type: Conference Paper

References (84)

1. Garry H, Palmer LG. Epithelial sodium channels. Function, structure, and regulation. Physiol. Rev. 1997; 77: 359-396 (Pubitemid 27184343)
2. Kellenberger S, Schild L. Epithelial sodium channel/degenerin family of ion channels: A variety of functions for a shared structure. Physiol. Rev. 2002; 82: 735-767 (Pubitemid 34743337)
3. Kapus A, Szaszi K. Coupling between apical, and paracellular transport processes. Biochem. Cell Biol 2006; 84: 870-880 (Pubitemid 46450687)
4. Tarran R, Button B, Picher M. et al. Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections. J. Biol. Chem. 2005; 280: 35 751-759
5. + channel is made of three homologous subunits. Nature 1994; 367: 463-46
6. Firsov D, Schild L, Gautschi I, Merillat AM, Schneeberger E, Rossier BC. Cell surface expression of the epithelial Na+ channel and a mutant causing Liddle syndrome: A quantitative approach. Proc. Natl Acad. Sci. USA 1996;93:15 370-375
7. Fyfe GK, Canessa CM. Subunit composition determines the single channel kinetics of the epithelial sodium channel. J. Gen. Physiol. 1998; 112: 423-432 (Pubitemid 28467599)
8. Hwang TH, Schwiebert EM, Guggino WB. Apical and basolateral ATP stimulates tracheal epithelial chloride secretion via multiple purinergic receptors. Am. J. Physiol. 1.996; 270: C1611-23.
9. Paradiso AM, Ribeiro CM, Boucher RC. Polarized signaling via purinoceptors in normal and cystic fibrosis airway epithelia. J. Gen. Physiol. 2001;117:53-67.
10. + channels by aldosterone. Role of Sgk1. Clin. Exp. Pharmacol. Physiol. 2008; 35: 235-241
11. 2 receptor tone. J. Biol Chem. 2008; 283: 36 599-607.
12. Bhalla V, Daidie D, Li H et al. Serum- and glucocorticoid-regulated kinase 1 regulates ub.iquit.in ligase neural, precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction, with 14-3-3. Mol. Endocrinol. 2005; 19: 3073-3084 (Pubitemid 41697722)
13. Gormley K, Dong Y, Sagnella GA. Regulation of the epithelial sodium channel by accessory proteins. Biochem. J. 2003; 371: 1-14. (Pubitemid 36458074)
14. + conductance by the cystic fibrosis transmembrane conductance regulator. Pflügers Arch. 2000; 440:193-201.
15. Rossier BC, Stuns MJ. Activation of the epithelial sodium channel (ENaC) by serine proteases. Annu. Rev. Physiol. 2009; 71: 361-379
16. Bhalla V, Hallows KR. Mechanisms of ENaC regulation and clinical implications. J. Am. Soc. Nephrol. 2008; 19: 1845-1854
17. + channels by CFTR and purinergic stimulation. Kidney Int. 2001; 60: 455-461
18. Lee IH, Dinudom A, Sanchez-Perez A, Kumar S, Cook DI. Akt mediates the effect of insulin, on epithelial sodium channels by inhibiting Nedd4-2. J. Biol. Chem. 2007; 282:29 866-873
19. Lofflng J, Korbmacher C. Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC). Pflügers Arch. 2009; 458: 111-135.
20. Butterworth MB, Edinger RS, Frizzell RA, Johnson. JP. Regulation, of the epithelial sodium channel by membrane trafficking. Am. J. Physiol. Renal Physiol, 2009; 296: F10-24.
21. + channel trafficking. Endocrinology 2005; 146: 5079-5085
22. Huang P, Gilmore E, Kultgen P, Barnes P, Milgram S, Stutts MJ. Local regulation of cystic fibrosis transmembrane regulator and epithelial sodium channel in airway epithelium. Proc. Am. Thorac. Soc. 2004; 1:33-37
23. Bucheimer RE, Linden J. Purinergic regulation of epithelial transport. J.Physiol. 2004; 555:311-321
24. Leipziger J. Control, of epithelial transport via luminal P2 receptors. Am. J. Physiol. Renal Physiol. 2003; 284: F419-32. (Pubitemid 36227903)
25. Fitz JG. Regulation of cellular ATP release. Trans. Am. Clin. Climatol. Assoc. 2007;118: 199-208.
26. Grygorczyk RHJ. CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli. Am. J. Physiol. 1997; 272: C1058-66.
27. Homolya L, Steinberg TH, Boucher RC. Cell to cell communication in. response to mechanical stress via bilateral release of ATP and UTP in polarized epithelial. Cell Biol. 2000; 150: 1349-1360 (Pubitemid 30728907)
28. Bell PD, Lapointe JY, Sabirov R et al. Macula densa cell signaling involves ATP release through a maxi anion channel. Proc. Natl Acad. Sci. USA 2003; 100:4322-4327 (Pubitemid 36418201)
29. i increase depends on. nucleotide release and subsequent purinergic signaling in the intact nephron. J. Am. Soc. Nephrol. 2007; 18: 2062-2070
30. Schwiebert EM, Wallace DP, Braunstein GM et al. Autocrine extracellular purinergic signaling in epithelial, cells derived from polycystic kidneys. Am. J. Physiol. Renal Physiol. 2002; 282: F763-75.
31. Crane JK, Naeher TM, Choudhari SS, Giroux EM. Two pathways for ATP release from host cells in enteropathogenic Escherichia coli infection. Am. J. Physiol. Gastrointest. Liver Physiol. 2005; 289: G407-17.
32. Crane JK, Olson RA, Jones HM, Duffey ME. Release of ATP during host cell killing by enteropathogenic E. coli and its role as a secretory mediator. Am. J. Physiol. Gastrointest. Liver Physiol. 2002; 283: G74-86.
33. Vallon. V. P2 receptors in the regulation, of renal transport mechanisms. Am. J. Physiol. Renal Physiol. 2008; 294: F.10-27.
34. + and water .reabsorption, FASEB J. 2007; 21: 3717-3726
35. Kishore BK, Krane CM, Miller RL et al. P2Y2 receptor mRNA and protein expression is altered in inner medullas of hydrated and dehydrated rats: Relevance to AVP-independent regulation of IMCD function. Am. J. Physiol. Renal Physiol. 2005; 288: F1164-72.
36. Kolachala VL, Bajaj R, Chalasani M, Sitaraman SV. Purinergic receptors in gastrointestinal, inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 2008; 294: G401-10.
37. 2 receptors. Pflügers Arch. 2007; 454: 977-987
38. Tarran R, Trout L, Donaldson. SH, Boucher RC. Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia. J. Gen. Physiol. 2006; 127: 591-604.
39. 2 receptor agonists as a treatment for patients with cystic fibrosis lung disease. Adv. Drug Deliv. Rev. 2002; 54: 1463-1474
40. Patel AS, Reigada D, Mitchell CH, Bates SR, Margulies SS, Koval M. Paracrine stimulation of surfactant secretion by extracellular ATP in response to mechanical, deformation. Am. J. Physiol. Lung Cell. Mol. Physiol. 2005; 289: L489-96. (Pubitemid 41192725)
41. Okada SF, Nicholas RA, Kreda SM, Lazarowski ER, Boucher RC. Physiological regulation of ATP release at the apical surface of human airway epithelia. J. Biol. Chem. 2006; 281:22 992-3002.
42. Lazarowski ER, Harden TK. Quantitation of extracellular UTP using a sensitive enzymatic assay. Br. J. Pharmacol. 1999; 127: 1272-1278
43. Burnstock G. Physiology and pathophysiology of purinergic neurotransmission. Physiol. Rev. 2007; 87: 659-797.
44. Schwiebert EM, Kishore BK. Extracellular nucleotide signaling along the renal, epithelium. Am. J. Physiol. Renal Physiol. 2001; 280: F945-63.
45. + absorption in distal, bronchi. Pflügers Arch. 1999; 438: 621-627
46. - absorption in wild-type and AF508 CFTR-expressing human bronchial epithelia. Am. J. Physiol. 1.999; 276: C827-37.
47. + absorption by extracellular nucleotides in mouse trachea. Pflügers Arch. 2002; 444: 220-226
48. 2 receptor-mediated inhibition of ion transport in distal lung epithelial cells. Br. J. Pharmacol. 1999; 128: 293-300.
49. - secretion in mouse trachea. Cell. Physiol. Biochem. 2005; 16:99-108.
50. + absorption in guinea pig distal colon. Am. J. Physiol. Gastrointest Liver Physiol. 2002; 283: G300-8.
51. Konig J, Schreiber R, Mall M, Kunzelmann. K. No evidence for inhibition of ENaC through CFTR-mediated release of ATP. Biochim. Biophys. Acta 2002; 1565:17-28. (Pubitemid 35239828)
52. Falin R, Veizis IE, Cotton CU. A. role for ERKI/2 in EGF- and ATP-dependent regulation of amiloride-sensitive sodium absorption. Am. J. Physiol. Cell Physiol. 2005; 288: C1003-11. (Pubitemid 40559376)
53. 2 receptor mediated inhibition of amiloride-sensitive short circuit current in M-1 mouse cortical collecting duct cells. J. Membr. Biol. 2001; 183: 115-124
54. Lee SY, Palmer ML, Maniak PJ, Jang SH, Ryu PD, O'Grady SM. P2Y receptor regulation of sodium transport in human mammary epithelial cells. Am. J. Physiol. Cell Physiol. 2007; 293: C1472-80.
55. + absorption requires activation of PKC in endometrial epithelial cells. J. Gen. Physiol. 2002; 120: 897-906.
56. Erb L1 Liao Z, Seye CI, Weisman GA. P2 receptors: Intracellular signaling. Pflügers Arch. 2006; 452: 552-562
57. Lee IH, Campbell CR, Song SH et al. The activity of the epithelial sodium channels is regulated by caveolin-1. via a nedd4-2-dependent mechanism.. J Biol. Chem. 2009; 284: 12 663-669
58. Inglis SK, Olver RE, Wilson SM. Differential effects of UTP and ATP on ion transport in porcine tracheal epithelium. Br. J. Pharmacol. 2000; 130: 367-374
59. + absorption in isolated perfused mouse CCD. J. Am. Soc. Nephrol. 2002; 13: 10-18.
60. 2+ in human, erythroleukemia cells. J. Biol. Chem, 1997; 272: 10 151-159
61. Murthy KS, Makhlouf GM. Coexpression of ligand-gated P2X and G protein-coupled P2Y receptors in smooth muscle. Preferential activation of P2Y receptors coupled to PLC-β1 via Gαq/11 and to PLC-β3 via Gβ7gamma;i3 J. Biol. Chem. 1998; 273: 4695-4704
62. 2 receptor, PLC-βl, and IP3R-I and -II in Merkel, cells in rat sinus hair follicles. Histochem. Cell Biol. 2003; 120: 13-21.
63. 3 muscarinic acetylcholine receptors activate different phospholipase C-β isoforms that are uniquely susceptible to protein kinase C-dependent phosphorylation and inactivation. J. Biol. Chem. 2000; 275: 39 767-772
64. Bumstock G, Knight GE. Cellular distribution and functions of P2 receptor subtypes in different systems. Int. Rev. Cytol. 2004; 240: 31-104
65. Huang CL, Feng S, Hilgemann DW. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβy. Nature 1998; 391: 803-806 (Pubitemid 28099680)
66. Cummins MM, O'MuUane LM, Barden JA, Cook DI, Poronnik P. Purinergic responses in HT-29 colonic epithelial cells are mediated by G protein α-subunits. Cell Calcium 2000; 27:247-255 (Pubitemid 30459928)
67. Hou C, Kirchner T, Singer M, Matheis M, Argentieri D, Cavender D. In vivo activity of a phospholipase C inhibitor, 1-(6-((17b-3-methoxyestra-1,3,5(10)- trien-17-yl)amino)hexyl)-1 H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions. J. Pharmacol. Exp. Ther. 2004; 309: 697-704. (Pubitemid 38542625)
68. Lockhart LK, McNicol A. The phospholipase C inhibitor U731.22 inhibits phorbol ester-induced platelet activation. J. Pharmacol. Exp. Ther. 1999;289:721-728
69. Jan CR, Ho CM, Wu SN, Tseng CJ. The phospholipase C inhibitor U73122 increases cytosolic calcium in MDCK cells by activating calcium, influx and releasing stored calcium. Life Sci. 1998; 63: 895-908.
70. Rhee SG. Regulation of phosphoinositide-specinc phospholipase C. Annu. Rev. Biochem. 2001; 70: 281-312.
71. Kunzelmann K, Mall M, Electrolyte transport in the mammalian colon: Mechanisms and implications for disease. Physiol. Rev. 2002; 82:245-289 (Pubitemid 34654220)
72. Russell JM. Sodium-potassium-chloride cotransport. Physiol. Rev. 2000;80:211-276
73. Poulsen AN, Klausen TL, Pedersen PS, Willumsen NJ, Frederiksen O. Regulation of ion transport via apical purinergic receptors in intact rabbit airway epithelium. Pflügers Arch. 2005; 450: 227-235 (Pubitemid 40966576)
74. 2+- dependent stimulation, of Ml collecting duct cells. Pflügers Arch. 2005; 449:470-478
75. - concentration in the intralobular duct cells of mouse mandibular glands. J. Membr. Biol. 1993; 135: 289-295
76. + current in mouse salivary ducts by intracellular anions is mediated by a G protein. J. Physiol. 1995; 487: 549-555
77. + conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways. J.. Clin. Invest 1998; 102: 15-21.
78. + conductance in human colon is defective in cystic fibrosis. Am. J. Physiol. Gastrointest Liver Physiol. 1999;277:G709-16.
79. König J, Schreiber R, Voelcker T, Mall M, Kunzelmann K. The cystic fibrosis transmembrane conductance regulator (CFTR) inhibits ENaC through an increase in the intracellular Cl- concentration. EMBO Rep. 2001;2:1047-1051 (Pubitemid 33130614)
80. Schreiber R, Boucherot A, Murle B, Sun J, Kunzelmann K. Control of epithelial ion transport by CI and PDZ proteins. J. Membr. Biol. 2004; 199: 85-98. (Pubitemid 38858455)
81. - in an MDCK clone with high ENaC expression. Am. J. Physiol. Renal Physiol. 2004; 287: F722-31.
82. 2. FASEB J. 2005; 19:142-143
83. + channel (ENaC) by phosphatidylinositides. Am. J. Physiol. Renal Physiol. 2006; 290: F949-57.
84. Ma HP, Chou CF, Wei SP, Eaton DC. Regulation of the epithelial sodium channel by phosphatidylinositides. Experiments, implications, and speculations. Pflügers Arch. 2007; 455: 169-180