Evaluation of [11C]-DAA1106 for imaging and quantification of neuroinflammation in a rat model of herpes encephalitis

Nuclear Medicine and Biology

Volumn 37, Issue 1, 2010, Pages 9-15

  Doorduin, Janine ^a   Klein, Hans C ^a   de Jong, Johan R ^a   Dierckx, Rudi A ^a   de Vries, Erik F J ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

11C DAA1106; 11C PK11195; Herpes viruses; Microglia; Neuroinflammation; Positron emission tomography; TSPO

Indexed keywords

DAA 1106; N (2,5 DIMETHOXYBENZYL) N (4 FLUORO 2 PHENOXYPHENYL)ACETAMIDE C 11; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; RADIOPHARMACEUTICAL AGENT; TRACER; UNCLASSIFIED DRUG; ACETAMIDE DERIVATIVE; DIAGNOSTIC AGENT; DIPHENYL ETHER DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; BRAIN REGION; CELL ACTIVATION; CLINICAL FEATURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG TISSUE LEVEL; DRUG UPTAKE; ENCEPHALITIS; EX VIVO STUDY; HERPES SIMPLEX ENCEPHALITIS; HERPES SIMPLEX VIRUS 1; MALE; MICROGLIA; NEUROIMAGING; NEUROPATHOLOGY; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ANALYSIS; RADIOISOTOPE DISTRIBUTION; RAT; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; ANIMAL; DISEASE MODEL; INFLAMMATION; PATHOLOGY; PHYSIOLOGY; SCINTISCANNING; WISTAR RAT;

ACETAMIDES; ANIMALS; DISEASE MODELS, ANIMAL; ENCEPHALITIS, HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; INFLAMMATION; MALE; PHENYL ETHERS; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 72449166307     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2009.09.002     Document Type: Article

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