Sigma-1 ligands: Tic-hydantoin as a key pharmacophore

European Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2010, Pages 256-263

  Toussaint, Marion ^a   Mousset, Deborah ^a   Foulon, Catherine ^b   Jacquemard, Ulrich ^a   Vaccher, Claude ^b   Melnyk, Patricia ^a  

^a CNRS   (France)

^b UNIV LILLE   (France)

Author keywords

Hydantoin; Sigma receptor; Tetrahydroisoquinoline

Indexed keywords

2 [3 [BENZYL(METHYL)AMINO]PROPYL] 10,10A DIHYDRO 5H IMIDAZO[1,5 B]ISOQUINOLINE 1,3 DIONE; 2 [3 [BENZYL(METHYL)AMINO]PROPYL] 3 THIOXO 2,3,10,10A TETRAHYDRO 5H IMIDAZO[1,5 B]ISOQUINOLINE 1 ONE; 2 [3 [BENZYL(METHYL)AMINO]PROPYL] 3A,4,9,9A TETRAHYDROBENZO[F]ISOINDOLE 1,3 DIONE; 2 [3 [BENZYL(METHYL)AMINO]PROPYL]PYRROLO[3,4 C]PYRIDINE 1,3 DIONE; 3 [3 [BENZYL(METHYL)AMINO]PROPYL] 1H QUINAZOLINE 2,4 DIONE; 3 [3 [BENZYL(METHYL)AMINO]PROPYL] 6 CHLORO 1H QUINAZOLINE 2,4 DIONE; 3 [3 [BENZYL(METHYL)AMINO]PROPYL] 6 IODO 1H QUINAZOLINE 2,4 DIONE; 5 BENZYL 3 [3 [BENZYL(METHYL)AMINO]PROPYL] 1 METHYLIMIDAZOLIDINE 2,4 DIONE; 6 [3 [BENZYL(METHYL)AMINO]PROPYL]PYRROLO[3,4 B]PYRIDINE 5,7 DIONE; HYDANTOIN DERIVATIVE; ISOQUINOLINE; MALEIMIDE; PYRIDINE; QUINAZOLINE DERIVATIVE; SIGMA 1 OPIATE RECEPTOR; TETRAHYDROISOQUINOLINE HYDANTOIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; PHARMACOPHORE; RECEPTOR AFFINITY; RING OPENING; STEREOCHEMISTRY;

EID: 72449160578     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.10.004     Document Type: Article

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