Neuropharmacological profile of a selective sigma ligand, igmesine: A potential antidepressant

Neuropharmacology

Volumn 41, Issue 1, 2001, Pages 138-149

  Akunne, H C ^a   Zoski, K T ^a   Whetzel, S Z ^a   Cordon, J J ^a   Brandon, R M ^a   Roman, F ^b   Pugsley, T A ^a  

^a PFIZER INC   (United States)

^b Institut de Recherche Jouveinal   (France)

Author keywords

cGMP; Dissociation constant; Monoamine oxidase; N Methyl D aspartate; Neuronal uptake; Nitric oxide synthase; Receptor density; Sigma binding site; Synaptosome; Tyrosine hydroxylase

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; AMINE OXIDASE (FLAVIN CONTAINING); BETA ADRENERGIC RECEPTOR; CYCLIC GMP; DESIPRAMINE; FLUOXETINE; IGMESINE; N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE; NORADRENALIN; SEROTONIN; SEROTONIN 1A RECEPTOR; SIGMA 1 OPIATE RECEPTOR; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; IC 50; MALE; MONOAMINERGIC SYSTEM; NEUROCHEMISTRY; NEUROPHARMACOLOGY; NEUROTRANSMITTER UPTAKE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SYNTHESIS;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ANTIDEPRESSIVE AGENTS; BIOGENIC MONOAMINES; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CINNAMATES; CYCLIC AMP; CYCLOPROPANES; IDAZOXAN; MALE; MONOAMINE OXIDASE; NEURONS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, GABA-B; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECEPTORS, SIGMA; SYNAPTOSOMES; TYROSINE 3-MONOOXYGENASE;

EID: 0034964739     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00049-1     Document Type: Article

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