Technical and economical evaluation of downstream processing options for monoclonal antibody (MAb) production

BioPharm International

Volumn 19, Issue SUPPL., 2006, Pages 10-19

  Jagschies, Günter ^a   Grönberg, Anna ^a   Björkman, Tomas ^a   Lacki, Karol ^a   Johansson, Hans J ^a  

^a GE Healthcare Bio Sciences AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; PROTEIN A; RESIN;

ANTIBODY PRODUCTION; BATCH CAPACITY; BATCH PROCESS; COST CONTROL; DOWNSTREAM PROCESSING; ECONOMIC EVALUATION; EVALUATION; PROCESS DESIGN; PROCESS TECHNOLOGY; PROCESS YIELD; PRODUCT RECOVERY; PRODUCTIVITY; REVIEW; SCALE UP;

EID: 33744966875     PISSN: 1542166X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (11)

1. Slaff G. Application of Technology Platforms to the Purification of Monoclonal Antibodies; presentation at BioProcess International European Conference, 2005 April 11-14, Berlin, Germany.
2. Grönberg A, Monié E, Murby M, Rodrigo G, Wallby E, Johansson HJ. A strategy for development of a mAb purification platform; poster presentation at BioProcess International European Conference, 2006 February 20-23, Prague, Czech Republic.
3. Wurm F. Production of recombinant protein therapeutics in cultivated mammalian cells. Nature Biotechnol. 2004; 22(11): 1393-1398.
4. Johansson, HJ. Advances in the Purification of Monoclonal Antibody-Based Therapeutics, presented at IBC Life Sciences Conference "Antibody Development & Production," 2006 March 1-3, Carlsbad, CA.
5. Werner R. presentation at 4th Annual Biological Production Forum, 2005 April, Edinburgh, UK.
6. Bezy P. Efficient Pilot Plant Utilization, presented at BioProcess International European Conference, 2005 April 11-14, Berlin, Germany.
7. Ambrosius D. Assessment of Purification Technologies, presented at BioProcess International European Conference, 2005 April 11-14, Berlin, Germany.
8. Ghose S, Hubbard B, Cramer SM. Biotechnol. Prog. 2005; 21: 498-508.
9. Zhou JX, Tressel T. Basic Concepts in Q Membrane Chromatography for Large-Scale Antibody Production, Biotechnol. Prog. 2006; 22: 341-349.
10. Johansson HJ, Lacki K, Brekkan E, Antti M, Björkman T, Grönberg A. Multi-modal chromatography for purification of monoclonal antibodies, poster presentation at Recovery of Biological Products XII, 2006 April 2-7, Phoenix, AZ.
11. Ghose S, Allen M, Hubbard B, Brooks C, Cramer. SM. Antibody variable region interactions with Protein A: Implications for the Development of Generic Purification Processes. Biotechnol and Bioeng. 2005; 92(6): 665-673.