Recombinant human interleukin-24 suppresses gastric carcinoma cell growth in vitro and in vivo

Cancer Investigation

Volumn 28, Issue 1, 2010, Pages 85-93

  Yan, Su ^a   Zhang, Haifeng ^a   Xie, Yufeng ^a   Sheng, Weihua ^a   Xiang, Jim ^b   Ye, Zhenmin ^b   Chen, Weichang ^a   Yang, Jicheng ^a  

^a SOOCHOW UNIVERSITY   (China)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Antitumor effect; Gastric carcinoma; Human interleukin 24; Prokaryotic expression

Indexed keywords

CD34 ANTIGEN; CISPLATIN; GAMMA INTERFERON; INTERLEUKIN 24; INTERLEUKIN 6; PROTEIN BAX; PROTEIN BCL 2; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 24; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTIANGIOGENIC THERAPY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CAPILLARY; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ESCHERICHIA COLI; EXPRESSION VECTOR; FETUS MEMBRANE; GENE EXPRESSION SYSTEM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; STOMACH CARCINOMA; TRANSGENE; TUMOR VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTIGENS, CD34; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA; CELL LINE, TUMOR; CELL PROLIFERATION; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; CLONING, MOLECULAR; CYTOKINES; HUMANS; INTERLEUKINS; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; STOMACH NEOPLASMS; TIME FACTORS; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 72449156055     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.3109/07357900903095672     Document Type: Article

References (37)

1. Jemal, A.; Tiwari, R.C.; Murray, T.; Ghafoor, A.; Samuels, A.;Ward, E.; Feuer, E.J.; Thun, M.J. Cancer statistics, 2004. CA Cancer J Clin 2004, 54, 8-29.
2. Jiang, H.; Lin, J.J.; Su, Z.Z.; Goldstein, N.I.; Fisher, P.B. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 1995, 11, 2477-2486.
3. Sauane, M.; Gopalkrishnan, R.V.; Sarkar, D.; Su, Z.Z.; Lebedeva, I.V.; Dent, P.; Pestka, S.; Fisher, P.B. Mda-7/il-24: novel cancer growth suppressing and apoptosis inducing cytokine. Cytokine Growth Factor Rev 2003, 14, 35-51.
4. Chada, S.; Sutton, R.B.; Ekmekcioglu, S.; Ellerhorst, J.; Mumm, J.B.; Leitner, W.W.; Yang, H.Y.; Sahin, A.A.; Hunt, K.K.; Fuson, K.L.; Poindexter, N.; Roth, J.A.; Ramesh, R.; Grimm, E.A.; Mhashilkar, A.M. Mda-7/il-24 is a unique cytokine-tumor suppressor in the il-10 family. Int Immunopharmacol 2004, 4, 649-667.
5. Lebedeva, I.V.; Su, Z.Z.; Chang, Y.; Kitada, S.; Reed, J.C.; Fisher, P.B. The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells. Oncogene 2002, 21, 708-718.
6. Su, Z.Z.; Lebedeva, I.V.; Sarkar, D.; Gopalkrishnan, R.V.; Sauane, M.; Sigmon, C.; Yacoub, A.; Valerie, K.; Dent, P.; Fisher, P.B. Melanoma differentiation associated gene-7, mda-7/il-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.Oncogene 2003, 22, 1164-1180.
7. Saeki, T.; Mhashilkar, A.; Swanson, X.; Zou-Yang, X.H.; Sieger, K.; Kawabe, S.; Branch, C.D.; Zumstein, L.; Meyn, R.E.; Roth, J.A.; Chada, S.; Ramesh, R. Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo. Oncogene 2002, 21, 4558-4566. (Pubitemid 34785732)
8. Saito, Y.; Miyahara, R.; Gopalan, B.; Litvak, A.; Inoue, S.; Shanker, M.; Branch, C.D.; Mhashilkar, A.M.; Roth, J.A.; Chada, S.; Ramesh, R. Selective induction of cell cycle arrest and apoptosis in human prostate cancer cells through adenoviral transfer of the melanoma differentiation-associated-7 (mda-7)/interleukin-24 (il-24) gene. Cancer Gene Ther 2005, 12, 238-247.
9. Su, Z.Z.; Madireddi, M.T.; Lin, J.J.; Young, C.S.; Kitada, S.; Reed, J.C.; Goldstein, N.I.; Fisher, P.B. The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. Proc Natl Acad Sci USA 1998, 95, 14400-14405.
10. Wei, L.; Wang, Z.; Cui, T.; Yi, F.; Bu, Y.; Ding, S.; Ma, Y.; Song, F. Proteomic analysis of cervical cancer cells treated with adenovirus-mediated mda-7. Cancer Biol Ther 2008, 7, 510-516. (Pubitemid 351847024)
11. Zhao, L.; Gu, J.; Dong, A.; Zhang, Y.; Zhong, L.; He, L.; Wang, Y.; Zhang, J.; Zhang, Z.; Huiwang, J.; Qian, Q.; Qian, C.; Liu, X. Potent antitumor activity of oncolytic adenovirus expressing mda-7/il-24 for colorectal cancer. Hum Gene Ther 2005, 16, 845-858.
12. Caudell, E.G.; Mumm, J.B.; Poindexter, N.; Ekmekcioglu, S.; Mhashilkar, A.M.; Yang, X.H.; Retter, M.W.; Hill, P.; Chada, S.; Grimm, E.A. The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated il-24. J Immunol 2002, 168, 6041-6046.
13. Ferrantini, M.; Belardelli, F. Gene therapy of cancer with interferon: lessons from tumor models and perspectives for clinical applications. Semin Cancer Biol 2000, 10, 145-157.
14. Tasaki, K.; Yoshida, Y.; Maeda, T.; Miyauchi, M.; Kawamura, K.; Takenaga, K.; Yamamoto, H.; Kouzu, T.; Asano, T.; Ochiai, T.; Sakiyama, S.; Tagawa, M. Protective immunity is induced in murine colon carcinoma cells by the expression of interleukin-12 or interleukin-18, which activate type 1 helper t cells. Cancer Gene Ther 2000, 7, 247-254.
15. Halin, C.; Rondini, S.; Nilsson, F.; Berndt, A.; Kosmehl, H.; Zardi, L.; Neri, D. Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature. Nat Biotechnol 2002, 20, 264-269.
16. Sarkar, D.; Su, Z.Z.; Lebedeva, I.V.; Sauane, M.; Gopalkrishnan, R.V.; Dent, P.; Fisher, P.B. Mda-7 (il-24): signaling and functional roles. Biotechniques 2002. (Suppl.), 30-39.
17. Ye, Z.; Wang, X.; Hao, S.; Zhong, J.; Xiang, J.; Yang, J. Oncolytic adenovirus-mediated e1a gene therapy induces tumor-cell apoptosis and reduces tumor angiogenesis leading to inhibition of hepatocellular carcinoma growth in animal model. Cancer Biother Radiopharm 2006, 21, 225-234.
18. Wang, D.; Lippard, S.J. Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 2005, 4, 307-320.
19. Huang, T.; Zhang, Y.; Wang, J.; Huang, J.; Liu, D.; Mong, S. Pingyangmycin as a 99mtc carrier in tumor localization. Nucl Med Biol 1995, 22, 537-542.
20. Weidner, N. Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 1995, 36, 169-180.
21. Chen, Z.; Moyana, T.; Saxena, A.;Warrington, R.; Jia, Z.; Xiang, J. Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells. Int J Cancer 2001, 93, 539-548.22.
22. Cao, X.X.; Mohuiddin, I.; Chada, S.; Mhashilkar, A.M.; Ozvaran, M.K.; McConkey, D.J.; Miller, S.D.; Daniel, J.C.; Smythe,W.R. Adenoviral transfer of mda-7 leads to bax up-regulation and apoptosis in mesothelioma cells, and is abrogated by over-expression of bclxl. Mol Med 2002, 8, 869-876.
23. Pataer, A.; Vorburger, S.A.; Barber, G.N.; Chada, S.; Mhashilkar, A.M.; Zou-Yang, H.; Stewart, A.L.; Balachandran, S.; Roth, J.A.; Hunt, K.K.; Swisher, S.G. Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded rnadependent protein kinase (pkr). Cancer Res 2002, 62, 2239-2243.
24. Sarkar, D.; Su, Z.Z.; Lebedeva, I.V.; Sauane, M.; Gopalkrishnan, R.V.; Valerie, K.; Dent, P.; Fisher, P.B. Mda-7 (il-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the gadd family of genes by means of p38 mapk. Proc Natl Acad Sci USA 2002, 99, 10054-10059.
25. Gopalan, B.; Litvak, A.; Sharma, S.; Mhashilkar, A.M.; Chada, S.; Ramesh, R. Activation of the fas-fasl signaling pathway by mda- 7/il-24 kills human ovarian cancer cells. Cancer Res 2005, 65, 3017-3024.
26. Sieger, K.A.; Mhashilkar, A.M.; Stewart, A.; Sutton, R.B.; Strube, R.W.; Chen, S.Y.; Pataer, A.; Swisher, S.G.; Grimm, E.A.; Ramesh, R.; Chada, S. The tumor suppressor activity of mda-7/il-24 is mediated by intracellular protein expression in nsclc cells. Mol Ther 2004, 9, 355-367.
27. Mhashilkar, A.M.; Stewart, A.L.; Sieger, K.; Yang, H.Y.; Khimani, A.H.; Ito, I.; Saito, Y.; Hunt, K.K.; Grimm, E.A.; Roth, J.A.; Meyn, R.E.; Ramesh, R.; Chada, S. Mda-7 negatively regulates the betacatenin and pi3k signaling pathways in breast and lung tumor cells. Mol Ther 2003, 8, 207-219.
28. Wang, M.; Tan, Z.; Zhang, R.; Kotenko, S.V.; Liang, P. Interleukin 24 (mda-7/mob-5) signals through two heterodimeric receptors, il-22r1/il-20r2 and il-20r1/il-20r2. J Biol Chem 2002, 277, 7341-7347.
29. Wolk, K.; Kunz, S.; Witte, E.; Friedrich, M.; Asadullah, K.; Sabat, R. Il-22 increases the innate immunity of tissues. Immunity 2004, 21, 241-254.
30. Nagalakshmi, M.L.; Murphy, E.; McClanahan, T.; de Waal Malefyt, R. Expression patterns of il-10 ligand and receptor gene families provide leads for biological characterization. Int Immunopharmacol 2004, 4, 577-592.
31. Ishikawa, M.; Kitayama, J.; Kazama, S.; Nagawa, H. Expression of vascular endothelial growth factor c and d (vegf-c and -d) is an important risk factor for lymphatic metastasis in undifferentiated early gastric carcinoma. Jpn J Clin Oncol 2003, 33, 21-27.
32. Ramesh, R.; Mhashilkar, A.M.; Tanaka, F.; Saito, Y.; Branch, C.D.; Sieger, K.; Mumm, J.B.; Stewart, A.L.; Boquoi, A.; Dumoutier, L.; Grimm, E.A.; Renauld, J.C.; Kotenko, S.; Chada, S. Melanoma differentiation-associated gene 7/interleukin (il)-24 is a novel ligand that regulates angiogenesis via the il-22 receptor. Cancer Res 2003, 63, 5105-5113.
33. Tedjarati, S.; Baker, C.H.; Apte, S.; Huang, S.; Wolf, J.K.; Killion, J.J.; Fidler, I.J. Synergistic therapy of human ovarian carcinoma implanted orthotopically in nude mice by optimal biological dose of pegylated interferon alpha combined with paclitaxel. Clin Cancer Res 2002, 8, 2413-2422.
34. Inoue, K.; Chikazawa, M.; Fukata, S.; Yoshikawa, C.; Shuin, T. Frequent administration of angiogenesis inhibitor tnp-470 (agm-1470) at an optimal biological dose inhibits tumor growth and metastasis of metastatic human transitional cell carcinoma in the urinary bladder. Clin Cancer Res 2002, 8, 2389-2398.
35. Hirata, A.; Ogawa, S.; Kometani, T.; Kuwano, T.; Naito, S.; Kuwano, M.; Ono, M. Zd1839 (iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Res 2002, 62, 2554-2560.
36. Emdad, L.; Lebedeva, I.V.; Su, Z.Z.; Gupta, P.; Sarkar, D.; Settleman, J.; Fisher, P.B. Combinatorial treatment of non-small-cell lung cancers with gefitinib and ad.Mda-7 enhances apoptosis-induction and reverses resistance to a single therapy. J Cell Physiol 2007, 210, 549-559.
37. Dvorak, H.F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002, 20, 4368-4380.