Adenoviral transfer of mda-7 leads to BAX up-regulation and apoptosis in mesothelioma cells, and is abrogated by over-expression of BCL-XL

Molecular Medicine

Volumn 8, Issue 12, 2002, Pages 869-876

  Cao, Xiaobo X ^a   Mohuiddin, Imran ^a   Chada, Sunil ^c   Mhashilkar, Abner M ^c   Ozvaran, Mustafa K ^a   McConkey, David J ^b   Miller, Steven D ^a   Daniel, Jonathon C ^a   Smythe, W Roy ^a,b  

^a Dept of Thorac/Cardiovasc Surgery   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Introgen Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; PROTEIN BAX; PROTEIN BCL XL;

ADENOVIRUS; ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL GROWTH; CELL LINE; CELL VIABILITY; COLORIMETRY; CONTROLLED STUDY; ENZYME ASSAY; MESOTHELIOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPPRESSOR GENE; UPREGULATION; WESTERN BLOTTING;

EID: 0037002589     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03402093     Document Type: Article

References (32)

1. Ong ST, Vogelzang NJ. (1996) Chemotherapy in malignant pleural mesothelioma. A review. J. Clin. Oncol. 14(3): 1007-1017.
2. Sahmoud T, Postmus PE, van Pottelsberghe C, et al. (1997) Etoposide in malignant pleural mesothelioma: two phase II trails of the EORTC Lung Cancer cooperative Group. Eur. J. Cancer. 33(13): 2211-2215.
3. Antman KH. (1989) Natural history and staging of malignant mesothelioma. Chest. 96(1 Suppl): 93S-95S.
4. Frizelle SP, Rubins JB, Zhou JX, et al. (2000) Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirus. Cancer Gene Ther. 7(11): 1421-1425.
5. Smythe WR, Hwang HC, Amin KM, et al. (1994) Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system. Cancer Res. 54(8): 2055-2059.
6. Smythe WR, Hwang HC, Elshami AA, et al. (1995) Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene. Ann. Surg. 222(1): 78-86.
7. Pass HI, Robinson BW, Testa JR, Carbone M. (1999) Emerging translational therapies for mesothelioma. Chest. 116(6 Suppl): 455S-460S.
8. Sterman DH, Treat J, Litzky LA, et al. (1998) Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma. Hum. Gene Ther. 9(7): 1083-1092.
9. Taguchi T, Jhanwar SC, Siegfried JM, et al. (1993) Recurrent deletions of specific chromosomal sites in 1p, 3p, 6q, and 9p in human malignant mesothelioma. Cancer Res. 53(18): 4349-4355.
10. Mor O, Yaron P, Huszar M, et al. (1997) Absence of p53 mutations in malignant mesotheliomas. Am. J. Respir. Cell Mol. Biol. 16(1): 9-13.
11. Nishiyama Y, Suwa H, Okamoto K, (1995) Low incidence of point mutations in H-, K- and N-ras oncogenes and p53 tumor suppressor gene in renal cell carcinoma and peritoneal mesothelioma of Wistar rats induced by ferric nitrilotriacetate. Jpn. J. Cancer Res. 86(12): 1150-1158.
12. Soini Y, Kinnula V, Kaarteenaho-Wiik R, et al. (1999) Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-X, and bax in malignant mesothelioma. Clin. Cancer Res. 5(11): 3508-3515.
13. Narasimhan SR, Yang L, Gerwin BI, Broaddus VC. (1998) Resistance of pleural mesothelioma cell lines to apoptosis: relation to expression of Bcl-2 and Bax. Am. J. Physiol. 275(1 Pt 1): L165-L171.
14. Jiang H, Lin J, Su Z-Z, et al. (1995) Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene. 11: 2477-2486.
15. Madireddi MT, Dent P, Fisher PB. (2000) Regulation of mda-7 gene expression during human melanoma differentiation. Oncogene. 19(10): 1362-1368.
16. Ekmekcioglu S, Ellerhorst J, Mhashilkar AM, et al. (2001) Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas. Intl. J. Cancer. 94(1): 54-59.
17. Jiang H, Su Z-Z, Lin JJ, et al. (1996) The Melanoma Differentiation Associated Gene MDA-7 Suppresses Cancer Cell Growth. Proc. Natl. Acad. Sci. USA. 93: 9160-9165.
18. Su ZZ, Madireddi MT, Lin JJ, et al. (1998) The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. Proc. Natl. Acad. Sci. USA. 95(24): 14400-14405.
19. Saeki T, Mhashilkar A, Chada S, et al. (2000) Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer in vitro. Gene Ther. 7: 2051-2057.
20. Madireddi MT, Su ZZ, Young CS, et al. (2000) Mda-7, a novel melanoma differentiation associated gene with promise for cancer gene therapy. Adv. Exp. Med. Biol. 465: 239-261.
21. Mhashilkar AM, Schrock RD, Hindi M, et al. (2001) Melanoma differentiation associated gene (mda-7): a novel anti-tumor gene for cancer gene therapy. Mol. Med. 7(4): 271-282.
22. Cao XX, Mohiuddin I, Ece F, et al. (2001) Histone deacetylase inhibitor down-regulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma. Am. J. Respir. Cell Mol. Biol. 25(5): 562-568.
23. Korsmeyer SJ. (1999) BCL-2 gene family and the regulation of programmed cell death. Cancer Res. 59(7 Suppl): 1693s-1700s.
24. Nasreen N, Mohammed KA, Dowling PA, et al. (2000) Talc induces apoptosis in human malignant mesothelioma cells in vitro. Am. J. Respir. Crit. Care Med. 161(2 Pt 1): 595-600.
25. Rubins JB, Greatens T, Kratzke RA, et al. (1998) Lovastatin induces apoptosis in malignant mesothelioma cells. Am. J. Respir. Crit. Care Med. 157(5 Pt 1): 1616-1622.
26. Broaddus VC, Yang L, Scavo LM, et al. (1996) Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J. Clin. Invest. 98(9): 2050-2059.
27. Marklund L, Henriksson R, Grankvist K. (2000) Amphotericin B-induced apoptosis and cytotoxicity is prevented by the Na+, K+, 2Cl(-)-cotransport blocker bumetanide. Life Sci. 66(23): L319-L324.
28. Su Z, Madireddi M, Lin J, et al. (1998) The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. Proc. Natl. Acad. Sci. USA. 95: 14400-14405.
29. Mohiuddin I, Cao X, Fang B, et al. (2001) Significant augmentation of pro-apoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesothelioma. Cancer Gene Ther. 8: 547-554.
30. Shimizu S, Shinohara Y, Tsujimoto Y. (2000) Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator. Oncogene. 19(38): 4309-4318.
31. Kim CN, Wang X, Huang Y, et al. (1997) Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res. 57(15): 3115-3120.
32. Gottlieb E, Vander Heiden MG, Thompson CB. (2000) Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis. Mol. Cell Biol. 20(15): 5680-5689.