A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells

Journal of Steroid Biochemistry and Molecular Biology

Volumn 118, Issue 1-2, 2010, Pages 70-76

  Takemura, Hitomi ^a,b   Uchiyama, Harue ^a   Ohura, Takeshi ^a   Sakakibara, Hiroyuki ^a   Kuruto, Ryoko ^c   Amagai, Takashi ^a   Shimoi, Kayoko ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b MATSUMOTO UNIVERSITY   (Japan)

^c HAMAMATSU UNIVERSITY   (Japan)

Author keywords

4 Hydroxyestradiol; Chemoprevention; Chrysoeriol; CYP1B1; Estrogen

Indexed keywords

4 HYDROXYESTRADIOL; 4 METHOXYESTRADIOL; CATECHOL ESTROGEN; CATECHOL METHYLTRANSFERASE; CHRYSOERIOL; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; ETHOXYRESORUFIN DEETHYLASE; FLAVONOID; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CARCINOGENIC ACTIVITY; CELL STRAIN MCF 7; CHEMOPROPHYLAXIS; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETOXIFICATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME MECHANISM; ESTROGEN METABOLISM; GENE EXPRESSION; HUMAN; HUMAN CELL; HYDROXYLATION; IN VITRO STUDY; PROTEIN METHYLATION;

BIOCATALYSIS; BREAST NEOPLASMS; CARCINOGENS; CATECHOL O-METHYLTRANSFERASE; CELL LINE, TUMOR; CHEMOPREVENTION; CULTURE MEDIA, CONDITIONED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; CYTOSOL; ENZYME INHIBITORS; ESTRADIOL; FEMALE; FLAVONOIDS; GENE EXPRESSION; GLUCURONIDASE; HUMANS; HYDROXYLATION; KINETICS; METHYLATION; OXAZINES; RECOMBINANT PROTEINS; SULFATASES;

EID: 72449145262     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2009.10.002     Document Type: Article

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