Frequent allelic loss of Dkk-1 locus (10q11.2) is related with low distant metastasis and better prognosis in head and neck squamous cell carcinomas

Cancer Investigation

Volumn 28, Issue 1, 2010, Pages 103-110

  Katase, Naoki ^a   Gunduz, Mehmet ^a,b   Beder, Levent Bekir ^b   Gunduz, Esra ^a   Sheikh Ali, Mahmoud Al ^a   Tamamura, Ryo ^a   Yaykasli, Kursat Oguz ^a   Yamanaka, Noboru ^b   Shimizu, Kenji ^a   Nagatsuka, Hitoshi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Biomarker; Dickkopf (Dkk) 1; Head and neck squamous cell carcinoma; Loss of heterozygosity; Metastasis

Indexed keywords

DICKKOPF 1 PROTEIN;

ADULT; ARTICLE; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DISTANT METASTASIS; FEMALE; GENE FREQUENCY; GENE LOCUS; HEAD AND NECK CARCINOMA; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; HYPOPHARYNX CARCINOMA; LARYNX CARCINOMA; MALE; MAXILLA CANCER; MOUTH CARCINOMA; OROPHARYNX CARCINOMA; PRIORITY JOURNAL; PROGNOSIS; SQUAMOUS CELL CARCINOMA; SURVIVAL TIME;

AGED; CARCINOMA, SQUAMOUS CELL; CHROMOSOMES, HUMAN, PAIR 10; DISEASE-FREE SURVIVAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE FREQUENCY; HEAD AND NECK NEOPLASMS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KAPLAN-MEIERS ESTIMATE; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; TIME FACTORS; TREATMENT OUTCOME;

EID: 72449125627     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.3109/07357900903095680     Document Type: Article

References (32)

1. Platz, H.; Fries, R.; Hudec, M. Retrospective DOSAK study on carcinomas of the oral cavity: results and consequences. J Maxillofac Surg 1985, 13, 147-153.
2. Kearsley, J.H.; Thomas, S. Prognostic markers in cancers of the head and neck region. Anticancer Drug 1993, 4, 419-429.
3. Roland, N.J.; Caslin, A.W.; Nash, J.; Stell, P.M. Value of grading squamous cell carcinoma of the head and neck. Head Neck 1992, 14, 224-229.
4. B́aez, A. Genetic and environmental factors in head and neck cancer genesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2008, 26, 174-200.
5. Brennan, J.A.; Boyle, J.O.; Koch, W.M.; Goodman, S.N.; Hruban, R.H.; Eby, Y.J.; Couch, M.J.; Forastiere, A.A.; Sidransky, D. Association between cigarette smoking and mutation of the p53 gene in squamous cell carcinoma of the head and neck. N Engl J Med 1995, 332, 712-717.
6. Shimizu, S.; Seki, N.; Sugimoto, T.; Horiguchi, S.; Tanzawa, H.; Hanazawa, T.; Okamoto, Y. Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling. Oncol Rep 2007, 18, 1489-1497.
7. Willmore-Payne,C.; Holden, J.A.; Layfield, L.J. Detection of EGFRand HER2- activating mutation in squamous cell carcinoma involving the head and neck. Mod Pathol 2006, 19, 634-640.
8. Reed, A.L.; Califano, J.; Cairns, P.; Westra, W.H.; Jones, R.M.; Koch, W.; Ahrendt, S.; Eby, Y.; Sewell, D.; Nawroz, H.; Bartek, J.; Sidransky, D. High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res 1996, 56, 3630-3633.
9. Gunduz, M.; Ouchida, M.; Fukushima, K.; Hanafusa, H.; Etani, T.; Nishioka, S.; Nishizaki, K.; Shimizu, K. Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. Cancer Res 2000, 60, 3143-3146.
10. Gunduz, M.; Ouchida, M.; Fukushima, K.; Ito, S.; Jitsumori, Y.; Nakashima, T.; Nagai, N.; Nishizaki, K.; Shimizu K. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. Oncogene 2002, 21, 4462-4470.
11. Gunduz, M.; Nagatsuka, H.; Demircan, K.; Gunduz, E.; Cengiz, B.; Ouchida, M.; Tsujigiwa, H.; Yamachika, E.; Fukushima, K.; Beder, L.B.; Hirohata, S.; Ninomiya, Y.; Nishizaki, K.; Shimizu, K.; Nagai, N. Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas. Gene 2005, 356, 109-117.
12. Beder, L.B.; Gunduz, M.; Ouchida, M.; Fukushima, K.; Gunduz, E.; Ito, S.; Sakai, A.; Nagai, N.; Nishizaki, K.; Shimizu, K. Genomewide analyses on loss of heterozygosity in head and neck squamous cell carcinomas. Lab Invest 2003, 83, 99-105.
13. Sato, H.; Suzuki, H.; Toyota, M.; Nojima, M.; Maruyama, R.; Sasaki, S.; Takagi, H.; Sogabe, Y.; Sasaki, Y.; Idogawa, M.; Sonoda, T.; Mori, M.; Imai, K.; Tokino, T.; Shinomura, Y. Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. Carcinogenesis 2007, 28, 2459-2466.
14. Moon, R.T.; Kohn, A.D.; De Ferrari, G.V.; Kaykas, A. WNT and beta-catenin signaling: diseases and therapies. Nat Rev Genet 2004, 5, 691-701.
15. Veeman, M.T.; Axelrod, J.D.;Moon, R.T. A second canon: functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell 2003, 5, 367-377.
16. Kawano, Y.; Kypta, R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003, 116, 2627-2634.
17. Licchesi, J.D.; Westra, W.H.; Hooker, C.M.; Machida, E.O.; Baylin, S.B.; Herman, J.G. Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis 2008, 29, 895-904.
18. Urakami, S.; Shiina, H.; Enokida, H.; Hirata, H.; Kawamoto, K.; Kawakami, T.; Kikuno, N.; Tanaka, Y.; Majid, S.; Nakagawa, M.; Igawa, M., Dahiya, R. Wnt antagonist family genes as biomarkers for diagnosis, staging, and prognosis of renal cell carcinoma using tumor and serum DNA. Clin Cancer Res 2006, 12, 6989-6997.
19. Urakami, S.; Shiina, H.; Enokida, H.; Kawakami, T.; Kawamoto, K.; Hirata, H.; Tanaka, Y.; Kikuno, N.; Nakagawa, M.; Igawa, M.; Dahiya, R. Combination analysis of hypermethylated Wntantagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. Clin Cancer Res 2006, 12, 2109-2116.
20. Kuphal, S.; Lodermeyer, S.; Bataille, F.; Schuierer, M., Hoang, B.H.; Bosserhoff, A.K. Expression of Dickkopf genes is strongly reduced in malignant melanoma. Oncogene 2006, 25, 5027-5036. (Pubitemid 44246361)
21. Lodygin, D.; Epanchintsev, A.; Menssen, A.; Diebold, J.; Hermeking, H. Functional epigenomics identifies genes frequently silenced in prostate cancer. Cancer Res 2005, 65, 4218-4227.
22. Ha, P.K.; Califano, J.A. Promoter methylation and inactivation of tumor-suppressor genes in oral squamous cell carcinoma. Lancet Oncol 2006, 7, 77-82.
23. Niehrs, C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 2006, 25, 7469-7481.
24. Niida, A.; Hiroko, T.; Kasai, M.; Furukawa, Y.; Nakamura, Y.; Suzuki, Y.; Sugano S.; Akiyama, T. DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway. Oncogene 2004, 23, 8520-8526.
25. Gonźalez-Sancho, J.M.; Aguilera, O.; Garćia, J.M.; Pend́as- Franco, N.; Pe~na, C.; Cal, S.; Garćia de Herreros, A.; Bonilla, F.; Mu ~noz, A. The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. Oncogene 2005, 24, 1098-1103.
26. Mao, B.; Niehrs, C. Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. Gene 2003, 302, 179-183.
27. Katase, N.; Gunduz, M.; Beder, L.B.; Gunduz, E.; Lefeuvre, M.; Hatipoglu, O.F.; Borkosky, S.S.; Tamamura, R.; Tominaga, S.; Yamanaka, N.; Shimizu, K.; Nagai, N.; Nagatsuka, H. Deletion at Dickkopf (Dkk)-3 Locus (11p15.2) is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomas. Oncology Res 2008, 17, 273-282.
28. Pend́as-Franco, N.; Garćia, J.M.; Pẽna, C.; Valle, N.; Ṕalmer, H.G. Hein̈aniemi, M.; Carlberg, C.; Jiḿenez, B.; Bonilla, F.; Mũnoz, A.; Gonźalez-Sancho, J.M. DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1 alpha, 25-dihydroxyvitamin D3. Oncogene 2008, 27, 4467-4477.
29. Aguilera, O.; Fraga, M.F.; Ballestar, E.; Paz, M.F.; Herranz, M.; Espada, J.; Garćia, J.M.; Mũnoz, A.; Esteller, M.; Gonźalez-Sancho, J.M. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene 2006, 25, 4116-4121.
30. Lee, J.; Yoon, Y.S.; Chung, J.H. Epigenetic silencing of the WNT antagonist DICKKOPF-1 in cervical cancer cell lines. Gynecol Oncol 2008, 109, 270-274.
31. Qin, X.; Zhang, H.; Zhou, X.; Wang, C.; Zhang, H.; Zhang, X.; Ye, L. Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells. Transl Res 2007, 150, 281-294.
32. Mikheev, A.M.; Mikheeva, S.A.; Rostomily, R.; Zarbl, H. Dickkopf- 1 activates cell death in MDA-MB435 melanoma cells. Biochem Biophys Res Commun 2007, 352, 675-680.