Identification and cloning of a type III polyketide synthase required for diffusible pigment biosynthesis in Saccharopolyspora erythraea

Molecular Microbiology

Volumn 44, Issue 5, 2002, Pages 1213-1224

  Cortés, Jesús ^a   Velasco, Javier ^a   Foster, Graham ^b   Blackaby, Andrew P ^b   Rudd, Brian A M ^a   Wilkinson, Barrie ^a,c  

^a Strategic Technologies   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c BIOTICA TECHNOLOGY LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2,3,6,8 TETRAHYDROXYNAPHTHALENE; ERYTHROMYCIN; FLAVIOLIN; FUNGAL DNA; MALONYL COENZYME A; NAPHTHALENE DERIVATIVE; PIGMENT; POLYKETIDE SYNTHASE; PRIMER DNA; UNCLASSIFIED DRUG; 1,3,6,8 TETRAHYDROXYNAPHTHALENE; 1,3,6,8-TETRAHYDROXYNAPHTHALENE; BACTERIAL PROTEIN; MULTIENZYME COMPLEX; NAPHTHOL DERIVATIVE; NAPHTHOQUINONE; RPPA PROTEIN, SYNECHOCYSTIS;

ALBINISM; ARTICLE; BACTERIAL GENE; BIOSYNTHESIS; CHROMOSOME; CONTROLLED STUDY; DNA VECTOR; FUNGUS MUTANT; GENE DISRUPTION; GENE INSERTION; GENE ISOLATION; GENE LOCUS; GENE SEQUENCE; GENETIC CODE; GENETIC VARIABILITY; MOLECULAR CLONING; MOLECULAR MECHANICS; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PLANT; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; SACCHAROMYCES; SACCHAROMYCES ERYTHRAEA; SEQUENCE HOMOLOGY; STREPTOMYCES GRISEUS; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; OPERON; PHYLOGENY; SACCHAROPOLYSPORA;

BACTERIAL PROTEINS; CLONING, MOLECULAR; DNA PRIMERS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; MUTATION; NAPHTHOLS; NAPHTHOQUINONES; OPERON; PHENOTYPE; PHYLOGENY; PIGMENTS; SACCHAROPOLYSPORA; PIGMENTS, BIOLOGICAL;

BACTERIA (MICROORGANISMS); FUNGI; INSERTION SEQUENCES; SACCHAROMYCES; SACCHAROPOLYSPORA; SACCHAROPOLYSPORA ERYTHRAEA; STREPTOMYCES; STREPTOMYCES GRISEUS;

EID: 0036015638     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02975.x     Document Type: Article

References (42)

1. Basic local alignment search tool
2. Identification and characterization of a gene cluster for synthesis of the polyketide antibiotic 2,4-diacetylphloroglucinol from Pseudomonas fluorescens Q2-87
3. Ketosynthase domain probes identify two subclasses of fungal polyketide synthase genes
4. The biosynthesis of vancomycin-type glycopeptide antibiotics - New insights into the cyclisation steps
5. The biosynthesis of vancomycin-type glycopeptide antibiotics - The order of the cyclisation steps
6. Biosynthesis of the polyene antifungal nystatin in Streptomyces noursei ATCC 11455: Analysis of the gene cluster and deduction of the biosynthetic pathway
7. Brown pigments produced by Yarrowia lipolytica result from extra-cellular accumulation of homogentisic acid
8. Spore colour in Streptomyces coelicolor A3(2) involves the developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics
9. A Streptomyces avermitilis gene encoding a 4-hydroxyphenylpyruvic dioxygenase-like protein that directs the production of homogentisic acid and an ochronotic pigment in Escherichia coli
10. A second branched-chain α-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: Its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins
11. Interspecies complementation in Saccharopolyspora erythraea: Elucidation of the function of oleP1, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives
12. Enzymatic synthesis of 1,3,6,8-tetrahydroxynapthalene solely from malonyl coenzyme A by a fungal iterative type I polyketide synthase
13. A new pathway for polyketide synthesis in microorganisms
14. Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea
15. Isolation of isoflavanones from soy-based fermentations of the erythromycin-producing bacterium Saccharopolyspora erythraea
16. Cloning and sequence analysis of the highly expressed melanin-synthesising gene operon from Streptomyces castaneoglobisporus
17. Recent developments in the area of macrolide antibiotics
18. Manipulation of modular polyketide synthases
19. Cloning and expression of the tyrosinase gene from Streptomyces antibioticus in Streptomyces lividans
20. Biosynthesis of the vancomycin group of antibiotics: Characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine
21. Cloning of the genes encoding thymidine diphosphoglucose 4,6-dehydratase and thymidine diphosphate-4-keto-6-deoxyglucose 3,5-epimerase from the erythromycin-producing Saccharopolyspora erythraea
22. An efficient approach for screening minimal PKS genes from Streptomyces
23. Discovery of a new bacterial polyketide biosynthetic pathway
24. Design and utility of oligonucleotide probes for fungal polyketide synthases
25. Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
26. Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908
27. A polyketide synthase in glycopeptide biosynthesis
28. Multifunctional peptide synthetases required for nonribosomal biosynthesis of peptide antibiotics
29. Construction of new vectors for high-level expression in Actinomycetes
30. The chalcone/stilbene synthase-type family of condensing enzymes
31. Towards engineered polyketides
32. Use of T7 RNA polymerase to direct expression of cloned genes
33. New advances in biosynthesis of glycopeptide antibiotics of the vancomycin type from Amycolatopsis mediterranei
34. Overexpression of a gene cluster encoding a chalcone synthase-like protein confers redbrown pigment production in Streptomyces griseus
35. Sequencing and analysis of genes in the biosynthesis of a vancomycin group antibiotic
36. Recent advances in the molecular genetics of the erythromycin-producing organism Saccharopolyspora erythraea
37. Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase
38. Highlights of semi-synthetic developments from erythromycin A
39. Transformation of Streptomyces erythraeus