Regulation of cholangiocyte proliferation

Liver

Volumn 21, Issue 2, 2001, Pages 73-80

  Lesage, Gene ^a   Glaser, Shannon ^a   Alpini, Gianfranco ^a,b,c  

^a TEXAS A AND M UNIVERSITY SYSTEM   (United States)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Bile ducts; Bile salts; cAMP gastrin; Gastrointestinal hormones; Hyperplasia; Nerves

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; BILE ACID; CYCLIC AMP; ESTROGEN; GASTROINTESTINAL HORMONE; GROWTH FACTOR; PROTEIN KINASE C;

ANIMAL MODEL; ANIMAL TISSUE; BILE DUCT DISEASE; BILE DUCT LIGATION; CELL FUNCTION; CELL GROWTH; CELL HYPERPLASIA; CELL PROLIFERATION; CHOLESTASIS; CONTROLLED STUDY; EPITHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; INTRAHEPATIC BILE DUCT; ISOLATION PROCEDURE; LIVER DISEASE; LIVER RESECTION; NERVE; NONHUMAN; PARENCHYMA; PURIFICATION; RAT; REGULATORY MECHANISM; REVIEW; TARGET CELL; VASCULARIZATION;

ANIMALS; BILE DUCTS, INTRAHEPATIC; CELL DIVISION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; RATS;

EID: 0035035110     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0676.2001.021002073.x     Document Type: Review

References (51)

1. Biliary physiology in rats with bile ductural cell hyperplasia. Evidence for a secretory function of proliferated bile ductules
2. Bile secretory function of intrahepatic biliary epithelium in the rat
3. The biology of the biliary epithelia
4. Morphological, molecular and functional heterogeneity of cholangiocytes from normal rat liver
5. Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation
6. Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes
7. Bile acid feeding induces cholangiocyte proliferation and secretion: Evidence for bile acid-regulated ductal secretion
8. Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver
9. Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from bile duct ligated rat liver
10. Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal bile secretion
11. Cholinergic system modulates growth, apoptosis and secretion of cholangiocytes from bile duct ligated rats
12. Somatostatin analogue (octreotide) inhibits bile duct epithelial cell proliferation and fibrosis after extrahepatic biliary obstruction
13. Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat
14. Primary sclerosing cholangitis
15. Ductular reaction in the liver
16. Isolation, culture, and transplantation of intrahepatic biliary epithelial cells and oval cells
17. 2+-, and PKCα-dependent mechanisms
18. Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation
19. Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation
20. Partial hepatectomy induces proliferative and secretory events in small cholangiocytes
21. cAMP stimulates secretory and proliferative capacity of the rat intrahepatic biliary epithelium through the PKA system
22. Ablation of the D2 dopaminergic innervation by intraportal injection of 6-hydroxidopamine (6-OHDA) reduces cholangiocyte proliferative and secretory activity in bile duct ligated (BDL) rats
23. 6-hydroxydopamine lesion of rat nigrostriatal dopaminergic neurons differentially affects nicotinic acetylcholine receptor subunit mRNA expression
24. Ursodeoxycholic acid feeding inhibits secretin-induced cholangiocyte secretory processes in bile duct ligated rats
25. The inhibitory effect of ursodeoxycholate (UDCA) on cholangiocyte growth and secretion in bile duct ligated (BDL) rats is not affected by its conjugation with taurine
26. Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat
27. Isolation and morphological characterization of bile duct epithelial cells from normal rat liver
28. Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism
29. Large but not small intrahepatic bile duct units are involved in secretin-regulated ductal bile secretion in normal rat liver
30. Large but not small intrahepatic bile ducts (IBDU) from bile duct ligated (BDL) rats proliferate and are involved in secretion-induced ductal bile secretion
31. Isolation of small polarized bile duct units
32. Bile acid depletion and repletion regulate bile duct proliferation and secretion in bile duct ligated (BDL) rats through a phosphatidylinositol 3-kinase (P13K)-dependent pathway
33. Estrogens stimulate proliferation of the intrahepatic biliary epithelium in rats
34. Hepatic microcirculation and peribiliary plexus in experimental biliary cirrhosis: A morphological study
35. Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis
36. Prostaglandin E2 and rat liver regeneration
37. +-dependent bile acid transporter in large but not small rat cholangiocytes
38. Differential response of estrogen receptor alpha and beta to partial estrogen agonists/antagonists
39. Estrogen receptor modulators each induce distinct conformational changes in ER alpha and beta
40. The pathobiology of biliary epithelia
41. G proteins in rat liver proliferation during cholestasis
42. Lipopolysaccharide induces cholangiocyte proliferation via an interleukin-6-mediated activation of p44/p42 mitogen-activated protein kinase
43. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
44. Sequential increases in the intrahepatic expression of epidermal growth factor, basic fibroblast growth factor, and transforming growth factor beta in a bile duct ligated rat model of cirrhosis
45. Cell proliferation and oncogene expression after bile duct ligation in the rat: Evidence of a specific growth effect on bile duct cells
46. Interleukin-6, hepatocyte growth factor, and their receptors in biliary epithelial cells during a type I ductular reaction in mice: Interactions between the periductal inflammatory and stromal cells and the biliary epithelium
47. Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease
48. In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type 2 receptor: A potential therapy for hepatic fibrosis
49. Transforming growth factor-beta 1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat
50. Expression of alpha-fetoprotein and stem cell factor/c-kit system in bile duct ligated young rats
51. Coexpression of flt-3 ligand/flt-3 and SCF/c-kit signal transduction system in bile-duct-ligated SI and W mice