Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: Insights into antioxidant compensatory mechanisms

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 6, 2009, Pages

  Lim, Chee Chew ^a,b   Bryan, Nathan S ^b,e   Jain, Mohit ^c   Garcia Saura, Maria F ^b   Fernandez, Bernadette O ^b,d   Sawyer, Douglas B ^a,b   Handy, Diane E ^c   Loscalzo, Joseph ^c   Feelisch, Martin ^b,d   Liao, Ronglih ^b,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF WARWICK   (United Kingdom)

^e UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Antioxidants; Ascorbate; Free radicals; Gender; Ischemia; Nitric oxide; Nitrite; Reperfusion

Indexed keywords

BIOLOGICAL MARKER; CREATINE KINASE; GLUTATHIONE PEROXIDASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; ENZYME DEFICIENCY; FEMALE; GENE DELETION; GLUTATHIONE PEROXIDASE DEFICIENCY; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HOMEOSTASIS; HOMOZYGOSITY; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PREDICTION; PRIORITY JOURNAL; REPERFUSION INJURY;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CREATINE KINASE; DISEASE MODELS, ANIMAL; FEMALE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALE; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NITRATES; NITRIC OXIDE; NITRITES; OXIDATION-REDUCTION; OXIDATIVE STRESS; RECOVERY OF FUNCTION; SEX FACTORS; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 72249121863     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00673.2009     Document Type: Article

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