메뉴 건너뛰기




Volumn 297, Issue 5, 2009, Pages

Protease activation during in vivo pancreatitis is dependent on calcineurin activation

Author keywords

Acinar cell; Calcium signaling; Protein phosphatase 2B; Tacrolimus; Zymogen activation

Indexed keywords

AMYLASE; CALCINEURIN; CALCIUM ION; CERULETIDE; HEAT SHOCK PROTEIN 70; INTERLEUKIN 6; LUNG ENZYME; MYELOPEROXIDASE; TACROLIMUS; TRYPSIN;

EID: 72249090044     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00181.2009     Document Type: Article
Times cited : (60)

References (58)
  • 1
    • 0021763125 scopus 로고
    • The structure of the B subunit of calcineurin
    • Aitken A, Klee CB, Cohen P. The structure of the B subunit of calcineurin. Eur J Biochem 139: 663-671, 1984.
    • (1984) Eur J Biochem , vol.139 , pp. 663-671
    • Aitken, A.1    Klee, C.B.2    Cohen, P.3
  • 4
    • 0033918085 scopus 로고    scopus 로고
    • Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation
    • Bhagat L, Singh VP, Hietaranta AJ, Agrawal S, Steer ML, Saluja AK. Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation. J Clin Invest 106: 81-89, 2000. (Pubitemid 30437243)
    • (2000) Journal of Clinical Investigation , vol.106 , Issue.1 , pp. 81-89
    • Bhagat, L.1    Singh, V.P.2    Hietaranta, A.J.3    Agrawal, S.4    Steer, M.L.5    Saluja, A.K.6
  • 5
    • 12344302086 scopus 로고    scopus 로고
    • Effects of increased intracellular cAMP on carbachol-stimulated zymogen activation, secretion, and injury in the pancreatic acinar cell
    • DOI 10.1152/ajpgi.00334.2004
    • Chaudhuri A, Kolodecik TR, Gorelick FS. Effects of increased intracellular cAMP on carbachol-stimulated zymogen activation, secretion, and injury in the pancreatic acinar cell. Am J Physiol Gastrointest Liver Physiol 288: G235-G243, 2005. (Pubitemid 40129574)
    • (2005) American Journal of Physiology - Gastrointestinal and Liver Physiology , vol.288 , Issue.2
    • Chaudhuri, A.1    Kolodecik, T.R.2    Gorelick, F.S.3
  • 6
    • 49649083092 scopus 로고    scopus 로고
    • An improved method for extracting myeloperoxidase and determining its activity in the pancreas and lungs during pancreatitis
    • Dawra R, Ku YS, Sharif R, Dhaulakhandi D, Phillips P, Dudeja V, Saluja AK. An improved method for extracting myeloperoxidase and determining its activity in the pancreas and lungs during pancreatitis. Pancreas 37: 62-68, 2008.
    • (2008) Pancreas , vol.37 , pp. 62-68
    • Dawra, R.1    Ku, Y.S.2    Sharif, R.3    Dhaulakhandi, D.4    Phillips, P.5    Dudeja, V.6    Saluja, A.K.7
  • 7
    • 0027417455 scopus 로고
    • Structural and functional changes of exocrine pancreas induced by FK506 in rats
    • Doi R, Inoue K, Chowdhury P, Kaji H, Rayford PL. Structural and functional changes of exocrine pancreas induced by FK506 in rats. Gastroenterology 104: 1153-1164, 1993. (Pubitemid 23090771)
    • (1993) Gastroenterology , vol.104 , Issue.4 , pp. 1153-1164
    • Doi, R.1    Inoue, K.2    Chowdhury, P.3    Kaji, H.4    Rayford, P.L.5
  • 8
    • 0034078320 scopus 로고    scopus 로고
    • FK506, an immunosuppressant targeting calcineurin function
    • Dumont FFJ. FK506, an immunosuppressant targeting calcineurin function. Curr Med Chem 7: 731-748, 2000.
    • (2000) Curr Med Chem , vol.7 , pp. 731-748
    • Dumont, F.F.J.1
  • 12
    • 0028175820 scopus 로고
    • 2+/calmodulin-dependent protein phosphatase and secretion in pancreatic acinar cells
    • 2+/calmodulin-dependent protein phosphatase and secretion in pancreatic acinar cells. J Biol Chem 269: 15111-15117, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 15111-15117
    • Groblewski, G.E.1    Wagner, A.C.2    Williams, J.A.3
  • 13
    • 0032575666 scopus 로고    scopus 로고
    • Purification and characterization of a novel physiological substrate for calcineurin in mammalian cells
    • DOI 10.1074/jbc.273.35.22738
    • Groblewski GE, Yoshida M, Bragado MJ, Ernst SA, Leykam J, Williams JA. Purification and characterization of a novel physiological substrate for calcineurin in mammalian cells. J Biol Chem 273: 22738-22744, 1998. (Pubitemid 28399846)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.35 , pp. 22738-22744
    • Groblewski, G.E.1    Yoshida, M.2    Bragado, M.J.3    Erns, S.A.4    Leykam, J.5    Williams, J.A.6
  • 16
    • 38749118955 scopus 로고    scopus 로고
    • Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo
    • DOI 10.1091/mbc.E07-05-0430
    • Gurda GT, Guo L, Lee SH, Molkentin JD, Williams JA. Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo. Mol Biol Cell 19: 198-206, 2008. (Pubitemid 351186145)
    • (2008) Molecular Biology of the Cell , vol.19 , Issue.1 , pp. 198-206
    • Gurda, G.T.1    Guo, L.2    Lee, S.-H.3    Molkentin, J.D.4    Williams, J.A.5
  • 17
    • 33646051224 scopus 로고    scopus 로고
    • Ciclosporin aggravates tissue damage in ischemia reperfusion-induced acute pancreatitis
    • Hackert T, Pfeil D, Hartwig W, Fritz S, Gebhard MM, Klar E, Werner J. Ciclosporin aggravates tissue damage in ischemia reperfusion-induced acute pancreatitis. Pancreas 32: 145-151, 2006.
    • (2006) Pancreas , vol.32 , pp. 145-151
    • Hackert, T.1    Pfeil, D.2    Hartwig, W.3    Fritz, S.4    Gebhard, M.M.5    Klar, E.6    Werner, J.7
  • 19
    • 33748323383 scopus 로고    scopus 로고
    • Regulation of cardiac hypertrophy by intracellular signalling pathways
    • DOI 10.1038/nrm1983, PII NRM1983
    • Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 7: 589-600, 2006. (Pubitemid 44325350)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.8 , pp. 589-600
    • Heineke, J.1    Molkentin, J.D.2
  • 21
    • 0028202753 scopus 로고
    • Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia
    • Hotchkiss RS, Karl IE. Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. Proc Natl Acad Sci USA 91: 3039-3043, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3039-3043
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 24
    • 0028289492 scopus 로고
    • Protective effects of gabexate mesilate on acute pancreatitis induced by tacrolimus (FK-506) in rats in which the pancreas was stimulated by caerulein
    • DOI 10.1007/BF02358370
    • Ito T, Kimura T, Furukawa M, Yamaguchi H, Goto M, Nakano I, Nawata H. Protective effects of gabexate mesilate on acute pancreatitis induced by tacrolimus (FK-506) in rats in which the pancreas was stimulated by caerulein. J Gastroenterol 29: 305-313, 1994. (Pubitemid 24188657)
    • (1994) Journal of Gastroenterology , vol.29 , Issue.3 , pp. 305-313
    • Ito, T.1    Kimura, T.2    Furukawa, M.3    Yamaguchi, H.4    Goto, M.5    Nakano, I.6    Nawata, H.7
  • 25
    • 0033621324 scopus 로고    scopus 로고
    • 2+/calmodulin-independent activation of calcineurin from Dictyostelium by unsaturated long chain fatty acids
    • 2+/calmodulin- independent activation of calcineurin from Dictyostelium by unsaturated long chain fatty acids. J Biol Chem 274: 37821-37826, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 37821-37826
    • Kessen, U.1    Schaloske, R.2    Aichem, A.3    Mutzel, R.4
  • 26
    • 0042970735 scopus 로고    scopus 로고
    • FK506 and its analogs - Therapeutic potential for neurological disorders
    • Klettner A, Herdegen T. FK506 and its analogs - therapeutic potential for neurological disorders. Curr Drug Targets 2: 153-162, 2003.
    • (2003) Curr Drug Targets , vol.2 , pp. 153-162
    • Klettner, A.1    Herdegen, T.2
  • 27
    • 0017324230 scopus 로고
    • Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue
    • Lampel M, Kern HF. Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch A Pathol Anat Histol 373: 97-117, 1977. (Pubitemid 8054175)
    • (1977) Virchows Archiv - Abteilung a Pathologische Anatomie , vol.373 , Issue.2 , pp. 97-117
    • Lampel, M.1    Kern, H.F.2
  • 30
    • 0026318383 scopus 로고
    • FK 506 rescue therapy in liver transplantation: Outcome and complications
    • McDiarmid SV, Klintmalm G, Busuttil RW. FK 506 rescue therapy in liver transplantation: outcome and complications. Transplant Proc 23: 2996-2999, 1991.
    • (1991) Transplant Proc , vol.23 , pp. 2996-2999
    • McDiarmid, S.V.1    Klintmalm, G.2    Busuttil, R.W.3
  • 32
    • 67651087198 scopus 로고    scopus 로고
    • Acute pancreatitis: Hypertonic saline increases heat shock proteins 70 and 90 and reduces neutrophil infiltration in lung injury
    • Moretti AI, Rios EC, Soriano FG, de Souza HP, Abatepaulo F, Barbeiro DF, Velasco IT. Acute pancreatitis: hypertonic saline increases heat shock proteins 70 and 90 and reduces neutrophil infiltration in lung injury. Pancreas 38: 507-514, 2009.
    • (2009) Pancreas , vol.38 , pp. 507-514
    • Moretti, A.I.1    Rios, E.C.2    Soriano, F.G.3    De Souza, H.P.4    Abatepaulo, F.5    Barbeiro, D.F.6    Velasco, I.T.7
  • 33
    • 67651087198 scopus 로고    scopus 로고
    • Acute pancreatitis: Hypertonic saline increases heat shock proteins 70 and 90 and reduces neutrophil infiltration in lung injury
    • Moretti AI, Rios EC, Soriano FG, de Souza HP, Abatepaulo F, Barbeiro DF, Velasco IT. Acute pancreatitis: hypertonic saline increases heat shock proteins 70 and 90 and reduces neutrophil infiltration in lung injury. Pancreas 38: 507-514, 2009.
    • (2009) Pancreas , vol.38 , pp. 507-514
    • Moretti, A.I.1    Rios, E.C.2    Soriano, F.G.3    De Souza, H.P.4    Abatepaulo, F.5    Barbeiro, D.F.6    Velasco, I.T.7
  • 35
    • 0021907247 scopus 로고
    • Caerulein-induced acute necrotizing pancreatitis in mice: Protective effects of proglumide, benzotript, and secretin
    • Niederau C, Ferrell LD, Grendell JH. Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Gastroenterology 88: 1192-1204, 1985. (Pubitemid 15087622)
    • (1985) Gastroenterology , vol.88 , Issue.5 I , pp. 1192-1204
    • Niederau, C.1    Ferrell, L.D.2    Grendell, J.H.3
  • 36
    • 0033949793 scopus 로고    scopus 로고
    • Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation
    • Nieto Y, Russ P, Everson G, Bearman SI, Cagnoni PJ, Jones RB, Shpall EJ. Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation. Bone Marrow Transplant 26: 109-111, 2000. (Pubitemid 30456118)
    • (2000) Bone Marrow Transplantation , vol.26 , Issue.1 , pp. 109-111
    • Nieto, Y.1    Russ, P.2    Everson, G.3    Bearman, S.I.4    Cagnoni, P.J.5    Jones, R.B.6    Shpall, E.J.7
  • 38
  • 40
    • 0026495863 scopus 로고
    • Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes
    • Peattie DA, Harding MW, Fleming MA, DeCenzo MT, Lippke JA, Livingston DJ, Benasutti M. Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. Proc Natl Acad Sci USA 89: 10974-10978, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10974-10978
    • Peattie, D.A.1    Harding, M.W.2    Fleming, M.A.3    DeCenzo, M.T.4    Lippke, J.A.5    Livingston, D.J.6    Benasutti, M.7
  • 42
    • 0033779701 scopus 로고    scopus 로고
    • Calcineurin: Form and function
    • Rusnak F, Mertz P. Calcineurin: form and function. Physiol Rev 80: 1483-1521, 2000.
    • (2000) Physiol Rev , vol.80 , pp. 1483-1521
    • Rusnak, F.1    Mertz, P.2
  • 43
    • 40749120949 scopus 로고    scopus 로고
    • Heat shock proteins in pancreatic diseases
    • Saluja A, Dudeja V. Heat shock proteins in pancreatic diseases. J Gastroenterol Hepatol 23, Suppl 1: S42-S45, 2008.
    • (2008) J Gastroenterol Hepatol , vol.23 , Issue.SUPPL. 1
    • Saluja, A.1    Dudeja, V.2
  • 45
    • 2442647038 scopus 로고    scopus 로고
    • Calcineurin is required for translational control of protein synthesis in rat pancreatic acini
    • Sans MD, Williams JA. Calcineurin is required for translational control of protein synthesis in rat pancreatic acini. Am J Physiol Cell Physiol 287: C310-C319, 2004.
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Sans, M.D.1    Williams, J.A.2
  • 46
    • 1942506088 scopus 로고    scopus 로고
    • Acute pancreatitis due to tacrolimus in a case of allogeneic bone marrow transplantation [1]
    • DOI 10.1038/sj.bmt.1704429
    • Sastry J, Young S, Shaw PJ. Acute pancreatitis due to tacrolimus in a case of allogeneic bone marrow transplantation. Bone Marrow Transplant 33: 867-868, 2004. (Pubitemid 38519251)
    • (2004) Bone Marrow Transplantation , vol.33 , Issue.8 , pp. 867-868
    • Sastry, J.1    Young, S.2    Shaw, P.J.3
  • 48
    • 0002170116 scopus 로고
    • Experimental acute pancreatitis: Studies of the early events that lead to cell injury
    • edited by Go VL, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, and Scheele GA. New York: Raven
    • Steer ML, Saluja AK. Experimental acute pancreatitis: studies of the early events that lead to cell injury. In: The Pancreas: Biology, Pathobiology, and Disease, edited by Go VL, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, and Scheele GA. New York: Raven, 1993, p. 489-500.
    • (1993) The Pancreas: Biology, Pathobiology, and Disease , pp. 489-500
    • Steer, M.L.1    Saluja, A.K.2
  • 50
    • 18744403789 scopus 로고    scopus 로고
    • Acute pancreatitis
    • edited by Yamada T, Alpers DH, Kaplowitz N, Laine L, Owyang C, and Powell DW. Philadelphia, PA: Lippincott Williams & Wilkins
    • Topazian M, Gorelick FS. Acute pancreatitis. In: Textbook of Gastroenterology, edited by Yamada T, Alpers DH, Kaplowitz N, Laine L, Owyang C, and Powell DW. Philadelphia, PA: Lippincott Williams & Wilkins, 2003, p. 2026-2060.
    • (2003) Textbook of Gastroenterology , pp. 2026-2060
    • Topazian, M.1    Gorelick, F.S.2
  • 52
    • 0029759409 scopus 로고    scopus 로고
    • Superoxide dismutase protects calcineurin from inactivation
    • DOI 10.1038/383434a0
    • Wang X, Culotta VC, Klee CB. Superoxide dismutase protects calcineurin from inactivation. Nature 383: 434-437, 1996. (Pubitemid 26330831)
    • (1996) Nature , vol.383 , Issue.6599 , pp. 434-437
    • Wang, X.1    Culotta, V.C.2    Klee, C.B.3
  • 53
    • 0027340184 scopus 로고
    • Effects of the immunosuppressants cyclosporin a and FK 506 on exocytosis in the rat exocrine pancreas in vitro
    • Waschulewski IH, Hall DV, Kern HF, Edwardson JM. Effects of the immunosuppressants cyclosporin A and FK 506 on exocytosis in the rat exocrine pancreas in vitro. Br J Pharmacol 108: 892-900, 1993.
    • (1993) Br J Pharmacol , vol.108 , pp. 892-900
    • Waschulewski, I.H.1    Hall, D.V.2    Kern, H.F.3    Edwardson, J.M.4
  • 54
    • 0001563463 scopus 로고
    • Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: Early morphological changes during development of experimental pancreatitis
    • Watanabe O, Baccino FM, Steer ML, Meldolesi J. Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol 246: G457-G467, 1984. (Pubitemid 14143678)
    • (1984) American Journal of Physiology - Gastrointestinal and Liver Physiology , vol.9 , Issue.4
    • Watanabe, O.1    Baccino, F.M.2    Steer, M.L.3    Meldolesi, J.4
  • 56
    • 34247482269 scopus 로고    scopus 로고
    • Suppression of transforming growth factor β signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations
    • DOI 10.1136/gut.2006.105833
    • Wildi S, Kleeff J, Mayerle J, Zimmermann A, Bottinger EP, Wakefield L, Buchler MW, Friess H, Korc M. Suppression of transforming growth factor β signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations. Gut 56: 685-692, 2007. (Pubitemid 46662936)
    • (2007) Gut , vol.56 , Issue.5 , pp. 685-692
    • Wildi, S.1    Kleeff, J.2    Mayerle, J.3    Zimmermann, A.4    Bottinger, E.P.5    Wakefield, L.6    Buchler, M.W.7    Friess, H.8    Korc, M.9
  • 58
    • 0035893023 scopus 로고    scopus 로고
    • Pharmacological preconditioning with low-dose cyclosporine or FK506 reduces subsequent ischemia/reperfusion injury in rat kidney
    • Yang CW, Ahn HJ, Han HJ, Kim WY, Li C, Shin MJ, Kim SK, Park JH, Kim YS, Moon IS, Bang BK. Pharmacological preconditioning with low-dose cyclosporine or FK506 reduces subsequent ischemia/reperfusion injury in rat kidney. Transplantation 72: 1753-1759, 2001. (Pubitemid 33144228)
    • (2001) Transplantation , vol.72 , Issue.11 , pp. 1753-1759
    • Yang, C.W.1    Ahn, H.J.2    Han, H.J.3    Kim, W.Y.4    Li, C.5    Shin, M.J.6    Kim, S.K.7    Park, J.H.8    Kim, Y.S.9    Moon, I.S.10    Bang, B.K.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.