Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice

Carcinogenesis

Volumn 29, Issue 5, 2008, Pages 1057-1063

  Miyamoto, Shingo ^a   Yasui, Yumiko ^a   Tanaka, Takuji ^a   Ohigashi, Hajime ^b   Murakami, Akira ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

^b FUKUI PREFECTURAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; AZOXYMETHANE; BIOFLAVONOID; DEXTRAN SULFATE; DOCUSATE SODIUM; DRINKING WATER; INTERLEUKIN 6; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE; NOBILETIN; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CARBOHYDRATE METABOLISM; CELL PROLIFERATION; CHEMOPROPHYLAXIS; COLITIS; COLON CARCINOGENESIS; CONTROLLED STUDY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HYPERLEPTINEMIA; IN VITRO STUDY; IN VIVO STUDY; INSTITUTE FOR CANCER RESEARCH MOUSE; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION;

ANIMALS; ANTIOXIDANTS; AZOXYMETHANE; CARCINOGENS; CELL DIVISION; CELL LINE, TUMOR; COLITIS; COLONIC NEOPLASMS; FLAVONES; HUMANS; LEPTIN; MALE; MICE; MICE, INBRED ICR;

EID: 47249110701     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgn080     Document Type: Article

References (63)

1. Parkin,D. et al. (2005) Global cancer statistics, 2002. CA Cancer J. Clin., 55, 74-108.
2. Flood,D. et al. (2000) Colorectal cancer incidence in Asian migrants to the United States and their descendants. Cancer Causes Control, 11, 403-411.
3. Johnson,I. et al. (2007) Review article: Nutrition, obesity and colorectal cancer. Aliment. Pharmacol. Ther., 26, 161-181.
4. National Institutes of Health. (1998) Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults - the evidence report. Obes. Res., 6 (suppl. 2), 51S-209S.
5. Heiat,A. et al. (2001) An evidence-based assessment of federal guidelines for overweight and obesity as they apply to elderly persons. Arch. Intern. Med., 161, 1194-1203.
6. Garofalo,C. et al. (2006) Leptin and cancer. J. Cell. Physiol. 207, 12-22.
7. Kuriyama,S. et al. (2005) Obesity and risk of cancer in Japan. Int. J. Cancer, 113, 148-157.
8. MacInnis,R. et al. (2006) Body size and composition and colon cancer risk in women. Int. J. Cancer, 118, 1496-1500.
9. Russo,A. et al. (1998) Body size and colorectal-cancer risk. Int. J. Cancer, 78, 161-165.
10. Le Marchand,L. et al. (1997) Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer. Cancer Res., 57, 4787-4794.
11. McMillan,D. et al. (2006) ABC of obesity. Obesity and cancer. Br. Med. J., 333, 1109-1111.
12. Yakar,S. et al. (2006) Increased tumor growth in mice with diet-induced obesity: Impact of ovarian hormones. Endocrinology, 147, 5826-5834.
13. Hursting,S. et al. (2003) Calorie restriction, aging, and cancer prevention: Mechanisms of action and applicability to humans. Annu. Rev. Med., 54, 131-152.
14. Zhang,Y. et al. (1994) Positional cloming of the mouse obese gene and its human homologue. Nature, 372, 425-432.
15. Berggren,J. et al. (2005) Fat as an endocrine organ: Influence of exercise. J. Appl. Physiol., 99, 757-764.
16. Kopelman,P, (2000) Obesity as a medical problem. Nature, 404 635-643.
17. Tanaka,T. et al. (2003) A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci., 94, 965-973.
18. Kohno,H. et al. (2001) Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in rats. Life Sci., 69, 901-913.
19. Suzuki,R. et al. (2004) Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats. Biofactors 22, 111-114.
20. Ward,J. (1974) Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats. Lab. Invest., 30, 505-513.
21. Ogunwobi,O. et al. (2007) The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/ Akt. Int. J. Colorectal Dis. 22, 401-409.
22. Maeda,H. et al. (2006) Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int. J. Mol. Med., 18, 147-152.
23. Niho,N. et al. (2003) Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Cancer Res., 63, 6090-6095.
24. Hardwick,J. et al. (2001) Leptin is a growth factor for colonic epithelial cells. Gastroenterology, 121, 79-90.
25. Rouet-Benzineb,P. et al. (2004) Leptin counteracts sodium butyrate-induced apoptosis in human colon cancer HT-29 cells via NF-kappaB signaling. J. Biol. Chem., 279, 16495-16502.
26. Kim,J. et al. (2004) Regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes, 53, 2748-2756.
27. Szkudelski,T. (2007) Intracellular mediators in regulation of leptin secretion from adipocytes. Physiol. Res, 56, 503-512.
28. Hsu,C. et al. (2007) Effects of flavonoids and phenolic acids on the inhibition of adipogenesis in 3T3-L1 adipocytes. J. Agric. Food Chem., 55, 8404-8410.
29. Calle,E. et al. (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 4, 579-591.
30. Funikawa,S. et al. (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest., 114, 1752-1761.
31. Kaaks,R. et al. (2001) Energy balance and cancer: The role of insulin and insulin-like growth factor-I. Proc. Nutr. Soc., 60 91-106.
32. McKeown-Eyssen,G. (1994) Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol. Biomarkers Prev., 3, 687-695.
33. Järvinen,R. et al. (2001) Dietary fat, cholesterol and colorectal cancer in a prospective study. Br. J. Cancer, 85, 357-361.
34. Niho,N. et al. (2007) Improvement of hyperlipidemia by indomethacin in Min mice. Int. J. Cancer, 121, 1665-1669.
35. Wellen,K. et al. (2003) Obesity-induced inflammatory changes in adipose tissue. J. Clin. Invest., 112, 1785-1788.
36. Bråkenhielm,E. et al. (2004) Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc. Natl Acad. Sci. USA, 101, 2476-2481.
37. Wei,E. et al. (2005) Low plasma adiponectin levels and risk of colorectal cancer in men: A prospective study. J. Natl Cancer Inst. 97, 1688-1694.
38. Guzik,T. et al. (2006) Adipocytokines - novel link between inflammation and vascular function? J. Physiol. Pharmacol., 57 505-528.
39. Borst,S. (2004) The role of TNF-alpha in insulin resistance. Endocrine, 23, 177-182.
40. Yoshimura,A. (2006) Signal transduction of inflammatory cytokines and tumor development. Cancer Sci., 97, 439-447.
41. Hamilton,B. et al. (1995) Increased obese mRNA expression in omental fat cells from massively obese humans. Nat. Med., 1, 953-956.
42. Kolaczynski,J. et al. (1996) Response of leptin to short-term and prolonged overfeeding in humans. J. Clin. Endocrinol. Metab., 81, 4162-4165.
43. Sinha,M. et al. (1996) Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J. Clin. Invest., 97, 1344-1347.
44. Lee,G. et al. (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature, 379, 632-635.
45. Frühbeck,G. et al. (2001) Rationale for the existence of additional adipostatic hormones. FASEB J., 15, 1996-2006.
46. Barbier,M. et al. (2003) Overexpression of leptin mRNA in mesenteric adipose tissue in inflammatory bowel diseases. Gastroenterol. Clin. Biol., 27, 987-991.
47. Paul,G. et al. (2006) Profiling adipocytokine secretion from creeping fat in Crohn's disease. Inflamm. Bowel Dis., 12, 471-477.
48. Okayasu,I. et al. (1990) A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology, 98, 694-702.
49. Liu,Z. et al. (2001) High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin. Int. J. Oncol., 19, 1009-1014.
50. Hirose,Y. et al. (2004) Enhancement of development of azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice. Carcinogenesis, 25, 821-825.
51. Chen,J. et al. (1997) Two new polymethoxylated flavones, a class of compounds with potential anticancer activity, isolated from cold pressed dancy tangerine peel oil solids. J. Agric. Food Chem., 45, 364-368.
52. Kandaswami,C. et al. (1992) Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids. Anticancer Drugs, 3, 525-530.
53. Murakami,A. et al. (2000) Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice. Cancer Res., 60, 5059-5066.
54. Saito,T. et al. (2007) Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes. Biochem, Biophys. Res. Commun., 357, 371-376.
55. Tartaglia,L. (1997) The leptin receptor. J. Biol. Chem., 272 6093-46096.
56. Frühbeck,G. (2006) Intracellular signalling pathways activated by leptin. Biochem J., 393, 7-20.
57. Eguchi,A. et al. (2006) Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells. FEBS Lett., 580, 3321-3328.
58. Lynch,C. et al. (2002) Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue. Am. J. Physiol. Endocrinol. Metab., 283, E503-E513.
59. Fox,H. et al. (1998) Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters. Ant. J. Physiol., 274, C206-C213.
60. Roh,C. et al. (2003) Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes. Am. J. Physiol. Endocrinol. Metab., 284, E322-E330.
61. Kawabata,K. et al. (2006) Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism. FEBS Lett., 580, 5288-5294.
62. Gardner,A. et al. (1994) MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase: Analysis of phosphopeptides and regulation of activity. Mol. Biol. Cell, 5, 193-201.
63. Miyata,Y. et al. (2004) Activation of protein kinase C betaII/ epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin. Mol. Cancer Ther., 3, 839-847.