Exposure of intestinal epithelial cells to UV-killed lactobacillus GG but not bifidobacterium breve enhances the effector immune response in vitro

International Archives of Allergy and Immunology

Volumn 152, Issue 2, 2010, Pages 159-168

  Van Hoffen, Els ^a   Korthagen, Nicoline M ^b   De Kivit, Sander ^b   Schouten, Bastiaan ^b   Bardoel, Bart ^a   Duivelshof, Arjan ^c   Knol, Jan ^c   Garssen, Johan ^b,c   Willemsen, Linette E M ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c DANONE RESEARCH   (Netherlands)

Author keywords

Bifidobacterium breve; Co culture; HT 29; Immune modulation; Intestinal epithelial cells; Lactobacillus GG; Nucleotide binding oligomerization domain; Probiotics; Toll like receptor

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; LIGAND; PROBIOTIC AGENT; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BIFIDOBACTERIUM BREVE; CELL STIMULATION; CELL STRAIN HT29; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG ACTIVITY; DRUG EXPOSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; INTESTINE EPITHELIUM; LACTOBACILLUS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; ULTRAVIOLET RADIATION;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADJUVANTS, IMMUNOLOGIC; ANTIBODIES; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BIFIDOBACTERIUM; CELL PROLIFERATION; COCULTURE TECHNIQUES; EPITHELIAL CELLS; HT29 CELLS; HUMANS; INTERFERON-GAMMA; INTERLEUKINS; INTESTINAL MUCOSA; LACTOBACILLUS; LEUKOCYTES, MONONUCLEAR; LIPOPEPTIDES; NOD2 SIGNALING ADAPTOR PROTEIN; PROBIOTICS; T-LYMPHOCYTE SUBSETS; TOLL-LIKE RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA; ULTRAVIOLET RAYS;

EID: 72049129725     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000265537     Document Type: Article

References (40)

1. Bischoff S, Crowe SE: Gastrointestinal food allergy: new insights into pathophysiology and clinical perspectives. Gastroenterology 2005;128:1089-1113.
2. Laiho K, Hoppu U, Ouwehand AC, Salminen S, Isolauri E: Probiotics: on-going research on atopicindividuals. Br J Nutr 2002;88(suppl 1): S19-S27.
3. Isolauri E, Majamaa H, Arvola T, Rantala I, Virtanen E, Arvilommi H: Lactobacillus casei strain GG reverses increased intestinal permeability induced by cow milk in suckling rats. Gastroenterology 1993;105:1643-1650. (Pubitemid 24002779)
4. Savilahti E, Kuitunen M, Vaarala O: Preand probiotics in the prevention and treatment of food allergy. Curr Opin Allergy Clin Immunol 2008;8:243-248.
5. Abrahamsson TR, Jakobsson T, Bottcher MF, Fredrikson M, Jenmalm MC, Bjorksten B, Oldaeus G: Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 2007;119:1174-1180.
6. Prescott SL, Bjorksten B: Probiotics for the prevention or treatment of allergic diseases. J Allergy Clin Immunol 2007;120:255-262.
7. Mowat AM: Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 2003;3:331-341.
8. Kagnoff MF, Eckmann L: Epithelial cells as sensors for microbial infection. J Clin Invest 1997;100:6-10.
9. Haller D, Bode C, Hammes WP, Pfeifer AM, Schiffrin EJ, Blum S: Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures. Gut 2000;47:79-87.
10. Hormannsperger G, Clavel T, Hoffmann M, Reiff C, Kelly D, Loh G, Blaut M, Holzlwimmer G, Laschinger M, Haller D: Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: impact on chronic inflammation. PLoS One 2009;4: e4365.
11. Iliev ID, Spadoni I, Mileti E, Matteoli G, Sonzogni A, Sampietro GM, Foschi D, Caprioli F, Viale G, Rescigno M: Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut 2009, E-pub ahead of print.
12. Vinderola G, Matar C, Perdigon G: Role of intestinal epithelial cells in immune effects mediated by gram-positive probiotic bacteria: involvement of toll-like receptors. Clin Diagn Lab Immunol 2005;12:1075-1084.
13. Zoumpopoulou G, Tsakalidou E, Dewulf J, Pot B, Grangette C: Differential crosstalk between epithelial cells, dendritic cells and bacteria in a co-culture model. Int J Food Microbiol 2009;131:40-51.
14. Strober W, Murray PJ, Kitani A, Watanabe T: Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol 2006;6:9-20.
15. Forchielli ML, Walker WA: The role of gutassociated lymphoid tissues and mucosal defence. Br J Nutr 2005;93(suppl 1): S41-S48.
16. Flinterman AE, Knol EF, van Ieperen-van Dijk AG, Timmerman HM, Knulst AC, Bruijnzeel-Koomen CA, Pasmans SG, van Hoffen E: Probiotics have a different immunomodulatory potential in vitro versus ex vivo upon oral administration in children with food allergy. Int Arch Allergy Immunol 2007;143:237-244.
17. Mohamadzadeh M, Olson S, Kalina WV, Ruthel G, Demmin GL, Warfield KL, Bavari S, Klaenhammer TR: Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization. Proc Natl Acad Sci USA 2005;102:2880-2885.
18. Niers LE, Timmerman HM, Rijkers GT, van Bleek GM, van Uden NO, Knol EF, Kapsenberg ML, Kimpen JL, Hoekstra MO: Identification of strong interleukin-10 inducing lactic acid bacteria which down-regulate T helper type 2 cytokines. Clin Exp Allergy 2005;35:1481-1489.
19. Iwabuchi N, Takahashi N, Xiao JZ, Miyaji K, Iwatsuki K: In vitro Th1 cytokine-independent Th2 suppressive effects of bifidobacteria. Microbiol Immunol 2007;51:649-660.
20. Medina M, Izquierdo E, Ennahar S, Sanz Y: Differential immunomodulatory properties of Bifidobacterium logum strains: relevance to probiotic selection and clinical applications. Clin Exp Immunol 2007;150:531-538.
21. Kopp MV, Goldstein M, Dietschek A, Sofke J, Heinzmann A, Urbanek R: Lactobacillus GG has in vitro effects on enhanced interleukin-10 and interferon-gamma release of mononuclear cells but no in vivo effects in supplemented mothers and their neonates. Clin Exp Allergy 2008;38:602-610.
22. low monocytes inhibit lymphocyte-dependent activation of intestinal epithelial cells by commensal bacteria. Microbiol Immunol 2002;46:195-205.
23. Christ AD, Colgan SP, Balk SP, Blumberg RS: Human intestinal epithelial cell lines produce factor (s) that inhibit CD3-mediated T-lymphocyte proliferation. Immunol Lett 1997;58:159-165.
24. Zeuthen LH, Fink LN, Frokiaer H: Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor-beta. Immunology 2008;123:197-208.
25. Baba N, Samson S, Bourdet-Sicard R, Rubio M, Sarfati M: Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells. J Leukoc Biol 2008;84:468-476.
26. Rimoldi M, Chieppa M, Salucci V, Avogadri F, Sonzogni A, Sampietro GM, Nespoli A, Viale G, Allavena P, Rescigno M: Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol 2005;6:507-514.
27. Berin MC, Dwinell MB, Eckmann L, Kagnoff MF: Production of MDC/CCL22 by human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2001;280: G1217-G1226.
28. O'Hara AM, O'Regan P, Fanning A, O'Mahony C, Macsharry J, Lyons A, Bienenstock J, O'Ma hony L, Shana han F: Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius. Immunology 2006;118:202-215.
29. Furrie E, Macfarlane S, Thomson G, Macfarlane GT: Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria. Immunology 2005;115:565-574.
30. Melmed G, Thomas LS, Lee N, Tesfay SY, Lukasek K, Michelsen KS, Zhou Y, Hu B, Arditi M, Abreu MT: Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut. J Immunol 2003;170:1406-1415.
31. Hanby AM, Chinery R, Poulsom R, Playford RJ, Pignatelli M: Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract. Am J Pathol 1996;148:723-729.
32. Maassen CB, van Holten-Neelen C, Balk F, den Bak-Glashouwer MJ, Leer RJ, Laman JD, Boersma WJ, Claassen E: Strain-dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains. Vaccine 2000;18:2613-2623.
33. Viljanen M, Kuitunen M, Haahtela T, Juntunen-Backman K, Korpela R, Savilahti E: Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants. Pediatr Allergy Immunol 2005;16:65-71.
34. Viljanen M, Pohjavuori E, Haahtela T, Korpela R, Kuitunen M, Sarnesto A, Vaarala O, Savilahti E: Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema-dermatitis syndrome. J Allergy Clin Immunol 2005;115:1254-1259.
35. Marschan E, Kuitunen M, Kukkonen K, Poussa T, Sarnesto A, Haahtela T, Kor pela R, Savilahti E, Vaarala O: Probiotics in infancy induce protective immune profiles that are characteristic for chronic low-grade inflammation. Clin Exp Allergy 2008;38:611-618.
36. Pohjavuori E, Viljanen M, Korpela R, Kuitunen M, Tiittanen M, Vaarala O, Savilahti E: Lactobacillus GG effect in increasing IFN-gamma production in infants with cow's milk allergy. J Allergy Clin Immunol 2004;114:131-136.
37. Begue B, Dumant C, Bambou JC, Beaulieu JF, Chamaillard M, Hugot JP, Goulet O, Schmitz J, Philpott DJ, et al: Microbial induction of CARD15 expression in intestinal epithelial cells via toll-like receptor 5 triggers an antibacterial response loop. J Cell Physiol 2006;209:241-252.
38. Charrier L, Merlin D: The oligopeptide transporter hPepT1:gateway to the innate immune response. Lab Invest 2006;86:538-546.
39. Girardin SE, Travassos LH, Herve M, Blanot D, Boneca IG, Philpott DJ, Sansonetti PJ, Mengin-Lecreulx D: Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem 2003;278:41702-41708.
40. Ismair MG, Vavricka SR, Kullak-Ublick GA, Fried M, Mengin-Lecreulx D, Girardin SE: hPepT1 selectively transports muramyl dipeptide but not Nod1-activating muramyl peptides. Can J Physiol Pharmacol 2006;84:1313-1319.