Design and synthesis of novel P2 substituents in diol-based HIV protease inhibitors

European Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2010, Pages 160-170

  Adrian Meredith, Jenny ^a   Wallberg, Hans ^b   Vrang, Lotta ^b   Oscarson, Stefan ^a,c   Parkes, Kevin ^b   Hallberg, Anders ^d   Samuelsson, Bertil ^a,b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b MEDIVIR AB   (Sweden)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

Aspartic protease; HIV; HIV PI; PI

Indexed keywords

2,5 BIS(BENZYLOXY) 3,4 DIHYDROXY N1 2 HYDROXY 2,3 DIHYDRO 1H INDEN 1 YL) N6 4 METHOXY 3 METHYL 1 (METHYLAMINO) 1 OXOBUTAN 2 YL)HEXANEDIAMIDE; 2,5 BIS(BENZYLOXY) N1 1 (2 FLUOROETHYAMINO) 3 METHYL 1 OXOBUTAN 2 YL) 3,4 DIHYDROXY N6 2 HYDROXY 2,3 DIHYDRO 1H INDEN 1 YL)HEXANEDIAMIDE; ASPARTIC ACID; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION;

ALCOHOLS; ANIMALS; CELL LINE; DRUG DESIGN; DRUG RESISTANCE, VIRAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; MODELS, MOLECULAR; PERMEABILITY; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72049109927     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.09.038     Document Type: Article

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