Mapping the aspartic acid binding site of Escherichia coli asparagine synthetase B using substrate analogs

Journal of Medicinal Chemistry

Volumn 39, Issue 12, 1996, Pages 2367-2378

  Parr, Ian B ^a   Boehlein, Susan K ^b   Dribben, Anthony B ^a   Schuster, Sheldon M ^b,c   Richards, Nigel G J ^a  

^a University of Florida ^*  (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMMONIA LIGASE; ASPARTIC ACID; ASPARTIC ACID DERIVATIVE;

ARTICLE; BINDING KINETICS; BINDING SITE; ENZYME BINDING; ESCHERICHIA COLI; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALKYLATION; ANTINEOPLASTIC AGENTS; ASPARAGINE; ASPARTATE-AMMONIA LIGASE; ASPARTIC ACID; BACTERIAL PROTEINS; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; GLUTAMINE; HUMANS; ISOENZYMES; KINETICS; LEUKEMIA, LYMPHOCYTIC, ACUTE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NEOPLASM PROTEINS; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0030014161     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9601009     Document Type: Article

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