Essential fatty acids and human brain

Acta Neurologica Taiwanica

Volumn 18, Issue 4, 2009, Pages 231-241

  Chang, Chia Yu ^a,b   Ke, Der Shin ^a   Chen, Jen Yin ^a  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Essential fatty acids; Human brain; Omega 3 fatty acids

Indexed keywords

ARACHIDONIC ACID; ARACHIS OIL; CORN OIL; DOCOSAHEXAENOIC ACID; ESSENTIAL FATTY ACID; FISH OIL; ICOSAPENTAENOIC ACID; ICOSAPENTAENOIC ACID ETHYL ESTER; LIPID; NEUROTRANSMITTER; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PHOSPHOLIPID; SAFFLOWER OIL; SESAME SEED OIL; SUNFLOWER OIL; VEGETABLE OIL;

BIPOLAR DISORDER; BORDERLINE STATE; BRAIN; BRAIN DEVELOPMENT; BRAIN FUNCTION; BRAIN GROWTH; CLINICAL OBSERVATION; CLINICAL TRIAL; DEMENTIA; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG DOSE COMPARISON; HUMAN; HUNTINGTON CHOREA; IMMUNE SYSTEM; LEAFY VEGETABLE; LINSEED; MAJOR DEPRESSION; MENTAL DEVELOPMENT; MENTAL DISEASE; MENTAL PERFORMANCE; MILD COGNITIVE IMPAIRMENT; MOOD DISORDER; NERVE CELL LESION; NERVE CELL MEMBRANE; NERVE CELL STIMULATION; NEUROPROTECTION; NEUROPSYCHIATRY; PERINATAL PERIOD; PUERPERAL DEPRESSION; RAPESEED; RESERVOIR; RETINA; REVIEW; SALMON; SARDINE; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SEA FOOD; SIGNAL TRANSDUCTION; VISUAL ACUITY; VISUAL CORTEX; WALNUT; WELLBEING;

BIPOLAR DISORDER; BRAIN; COGNITION; COGNITION DISORDERS; DEMENTIA; DEPRESSION; DIETARY SUPPLEMENTS; FATTY ACIDS, ESSENTIAL; HUMANS; HUNTINGTON DISEASE; SCHIZOPHRENIA;

EID: 72049102114     PISSN: 10196099     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (61)

1. Singh M. Essential fatty acids, DHA and human brain. Indian J Pediatr 2005;72:239-242 (Pubitemid 40529527)
2. Das UN. Essential Fatty acids- a review. Curr Pharm Biotechnol 2006;7:467-482
3. Fernstrom JD. Effects of dietary polyunsaturated fatty acids on neuronal function. Lipids 1999;34:161-169 (Pubitemid 29138313)
4. Simopoulos AP. Evolutionary aspects of diet, the omega- 6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomed Pharmacother 2006;60: 502-507
5. Yehuda S, Rabinovitz S, Mostofsky DI. Essential fatty acids and the brain: from infancy to aging. Neurobiol Aging 2005;26:98-102. (Pubitemid 41739436)
6. Salvati S, Attorri L, Avellino C, et al. Diet, lipids and brain development. Dev Neurosci 2000;22:481-487
7. Stockard JE, Saste MD, Benford VJ, et al. Effect of docosahexaenoic acid content of maternal diet on auditory brainstem conduction times in rat pups. Dev Neurosci 2000;22: 494-499
8. Das UN. Essential fatty acids: biochemistry, physiology and pathology. Biotechnol J 2006;1:420-439
9. Plourde M, Cunnane SC. Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Appl Physiol Nutr Metab 2007;32:619-634
10. Nightingale S, Woo E, Smith AD, et al. Red blood cell and adipose tissue fatty acids in mind inactive multiple sclerosis. Acta Neurol Scand 1990;82:43-50. (Pubitemid 20249251)
11. Adams PB, Lawson S, Sanigorski A, et al. Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 1996; 31:S157-61. (Pubitemid 126673804)
12. Stevens LJ, Zentall SS, Abate ML, et al. Omega-3 fatty acids in boys with behavior, learning, and health problems. Physiol Behav 1996;59:915-920
13. Clandinin MT, Jumpsen J, Suh M. Relationship between fatty acid accretion, membrane composition, and biologic functions. J Pediatr 1994;125:S25-32. (Pubitemid 24347799)
14. Uauy R, Dangour AD. Nutrition in brain development and aging: role of essential fatty acids. Nutr Rev 2006;64(5 Pt 2):S24-33. (Pubitemid 44606855)
15. Makrides M, Neumann MA, Byard RW, et al. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. Am J Clin Nutr 1994;60:189-194 (Pubitemid 24233184)
16. Innis SM. Dietary (n-3) fatty acids and brain development. J Nutr 2007;137:855-859 (Pubitemid 46596878)
17. Hadders-Algra M. Prenatal long-chain polyunsaturated fatty acid status: the importance of a balanced intake of docosahexaenoic acid and arachidonic acid. J Perinat Med 2008;36:101-109
18. Agostoni C. Role of long-chain polyunsaturated fatty acids in the first year of life. J Pediatr Gastroenterol Nutr 2008; 47:S41-4.
19. Brenna JT, Salem N Jr, Sinclair AJ, et al. Alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins Leukot Essent Fatty Acids 2009;80:85-91.
20. Yehuda S, Rabinovitz S, Mostofsky DI. Essential fatty acids and the brain: from infancy to aging. Neurobiol Aging 2005;26:98-102. (Pubitemid 41739436)
21. Yehuda S, Rabinovitz S, Carasso RL, et al. Fatty acids and brain peptides. Peptides 1998;9:407-419
22. Yao JK, van Kammen DP. Membrane phospholipids and cytokine interaction in schizophrenia. Int Rev Neurobiol 2004;59:297-326. (Pubitemid 39753905)
23. Bazan NG. Lipid signaling in neural plasticity, brain repair, and neuroprotection. Mol Neurobiol 2005;32:89-103. (Pubitemid 41113211)
24. Privett OS, Phillips F, Fukazawa T, et al. Studies on the relationship of the synthesis of prostaglandins to the biological activity of essential fatty acid. Biochim Biophys Acta 1972;280:348-355
25. Hibbeln JR, Davis JM, Steer C, et al. Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet 2007;369:578-585 (Pubitemid 46241443)
26. Lucas A, Morley R, Cole TJ, et al. Breast milk and subsequent intelligence quotient in children born preterm. Lancet 1992;339:261-264
27. Fontani G, Corradeschi F, Felici A, et al. Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects. Eur J Clin Invest 2005;35:691-699 (Pubitemid 41640905)
28. Kalmijn S, van Boxtel MP, Ocke M, et al. Dietary intake of fatty acids and fish in relation to cognitive performance at middle age. Neurology 2004;62:275-280 (Pubitemid 38167138)
29. Lukiw WJ, Bazan NG. Docosahexaenoic acid and the aging brain. J Nutr 2008;138:2510-2514
30. Kalmijn S, Launer LJ, Ott A, et al. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol 1997;42:776-782 (Pubitemid 27481550)
31. Morris MC, Evans DA, Bienias JL, et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 2003;60:940-946
32. Schaefer EJ, Bongard V, Beiser AS, et al. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch Neurol 2006;63:1545-1550 (Pubitemid 44748796)
33. Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, et al. Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Arch Neurol 2006;63:1402-1408 (Pubitemid 44547551)
34. Conquer JA, Tierney MC, Zecevic J, et al. Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. Lipids 2000;35:1305-1312 (Pubitemid 32064179)
35. Issa AM, Mojica WA, Morton SC, et al. The efficacy of omega-3 fatty acids on cognitive function in aging and dementia: a systematic review. Dement Geriatr Cogn Disord 2006;21:88-96.
36. Martin JB, Gusella JF. Huntington's disease. Pathogenesis and management. N Engl J Med 1986;315:1267-1276
37. Puri BK, Bydder GM, Counsell SJ, et al. MRI and neuropsychological improvement in Huntington disease following ethyl-EPA treatment. Neuroreport 2002;13:123-126
38. Puri BK, Leavitt BR, Hayden MR, et al. Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo- controlled trial. Neurology 2005;65:286-292 (Pubitemid 41022376)
39. Murck H, Manku M. Ethyl-EPA in Huntington disease: potentially relevant mechanism of action. Brain Res Bull 2007;72:159-164 (Pubitemid 46367461)
40. Hibbeln JR. Fish consumption and major depression. Lancet 1998;351:1213.
41. Tanskanen A, Hibbeln JR, Hintikka J, et al. Fish consumption, depression, and suicidality in a general population. Arch Gen Psychiatry 2001;58:512-513 (Pubitemid 32411335)
42. Freeman MP. Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research. Prostaglandins Leukot Essent Fatty Acids 2006;75:291-297
43. Su KP, Huang SY, Chiu CC, et al. Omega-3 fatty acids in major depressive disorder.A preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol 2003;13:267-271
44. Lin PY, Su KP. A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids. J Clin Psychiatry. 2007;68:1056-1061
45. Noaghiul S, Hibbeln JR. Cross-national comparisons of seafood consumption and rates of bipolar disorders. Am J Psychiatry 2003;160:2222-2227 (Pubitemid 39619617)
46. Stoll AL, Severus WE, Freeman MP, et al. Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry 1999;56:407-412
47. Frangou S, Lewis M, McCrone P. Efficacy of ethyl-eicos3 apentaenoic acid in bipolar depression: randomised double- blind placebo-controlled study. Br J Psychiatry 2006;188: 46-50. (Pubitemid 43021926)
48. Keck PE Jr, Mintz J, McElroy SL. Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder. Biol Psychiatry 2006;60:1020-1022 (Pubitemid 44739928)
49. Marangell LB, Suppes T, Ketter TA. Omega-3 fatty acids in bipolar disorder: clinical and research considerations. Prostaglandins Leukot Essent Fatty Acids 2006;75:315-321 (Pubitemid 44442915)
50. Montgomery P, Richardson AJ. Omega-3 fatty acids for bipolar disorder. Cochrane Database Syst Rev 2008;(2): CD005169. (Pubitemid 351807388)
51. American Psychiatric Association: Diagnostic and statistical manual of mental disorders. Fourth edit. Washington, DC: American Psychiatric Association, 1994.
52. Fenton WS, Hibbeln J, Knable M. Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia. Biol Psychiatry 2000;47:8-21. (Pubitemid 30016075)
53. Peet M, Brind J, Ramchand CN, et al. Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. Schizophr Res 2001;49: 243-251 (Pubitemid 32453225)
54. Peet M, Horrobin DF, E-E Multicentre Study Group. A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms. J Psychiatr Res 2002;36:7-18. (Pubitemid 34037843)
55. Emsley R, Myburgh C, Oosthuizen P, et al. Randomized, placebo-controlled study of ethyl-eicosapentaenoic acid as supplemental treatment in schizophrenia. Am J Psychiatry 2002;159:1596-1598 (Pubitemid 35006744)
56. Fenton WS, Dickerson F, Boronow J, et al. A placebo-controlled trial of omega-3 fatty acid (ethyl eicosapentaenoic acid) supplementation for residual symptoms and cognitive impairment in schizophrenia. Am J Psychiatry 2001;158: 2071-2074 (Pubitemid 33104119)
57. Emsley R, Niehaus DJ, Koen L, et al. The effects of eicosapentaenoic acid in tardive dyskinesia: a randomized, placebo-controlled trial. Schizophr Res 2006;84:112-120 (Pubitemid 44255716)
58. Joy CB, Mumby-Croft R, Joy LA. Polyunsaturated fatty acid supplementation for schizophrenia. Cochrane Database Syst Rev 2006;3:CD001257.
59. Zanarini MC, Frankenburg FR. Omega-3 fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study. Am J Psychiatry 2003;160:167-169
60. Richardson AJ. Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. Int Rev Psychiatry 2006; 18:155-172 (Pubitemid 43791677)
61. Francois CA, Connor SL, Bolewicz LC, et al. Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk. Am J Clin Nutr 2003;77:226-233