Reproductive performance in East Greenland polar bears (Ursus maritimus) may be affected by organohalogen contaminants as shown by physiologically-based pharmacokinetic (PBPK) modelling

Chemosphere

Volumn 77, Issue 11, 2009, Pages 1558-1568

  Sonne, Christian ^a   Gustavson, Kim ^b   Rigét, Frank F ^a   Dietz, Rune ^a   Birkved, Morten ^b,c   Letcher, Robert J ^d   Bossi, Rossana ^a   Vorkamp, Katrin ^a   Born, Erik W ^e   Petersen, Gitte ^b  

^a NATIONAL ENVIRONMENTAL RESEARCH INSTITUTE   (Denmark)

^b DHI   (Denmark)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d ENVIRONMENT CANADA   (Canada)

^e GREENLAND INSTITUTE OF NATURAL RESOURCES   (Greenland)

Author keywords

Dieldrin; PBPK modelling; PCBs; PFCs; Polar bear; Reproductive toxicity

Indexed keywords

CELL PROLIFERATION; HEALTH; INSECTICIDES; ORGANIC POLLUTANTS; PHARMACOKINETICS; PHYSIOLOGY; POLYCHLORINATED BIPHENYLS; RATS; TISSUE;

DIELDRIN; ORGANOHALOGEN CONTAMINANTS; PFCS; PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS; POLAR BEARS; REPRODUCTIVE PERFORMANCE; REPRODUCTIVE TOXICITIES; SUBCUTANEOUS ADIPOSE TISSUES;

PHYSIOLOGICAL MODELS;

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; DIELDRIN; HEXACHLOROBENZENE; LINDANE; ORGANOHALOGEN DERIVATIVE; OXYCHLORDANE; PERFLUOROOCTANESULFONIC ACID; POLYBROMINATED DIPHENYL ETHER; POLYCHLORINATED BIPHENYL;

BEAR; BIOLOGICAL UPTAKE; CONCENTRATION (COMPOSITION); DDT; ECOLOGICAL IMPACT; ECOTOXICOLOGY; FOOD WEB; HCH; ORGANOHALOGEN; PCB; PHYSIOLOGICAL RESPONSE; POLLUTION EXPOSURE; REPRODUCTIVE SUCCESS; TOXICITY TEST;

ADIPOSE TISSUE; AGE DETERMINATION; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; EMBRYOTOXICITY; ENVIRONMENTAL EXPOSURE; FEMALE; MALE; NONHUMAN; POLAR BEAR; QUANTITATIVE ANALYSIS; REPRODUCTIVE TOXICITY; RISK ASSESSMENT; TERATOGENICITY;

ARCTIC; EAST GREENLAND; GREENLAND;

PHOCA HISPIDA; RATTUS NORVEGICUS; RATTUS RATTUS; URSUS MARITIMUS;

EID: 72049099608     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2009.09.044     Document Type: Article

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