Xenoendocrine pollutants may reduce size of sexual organs in East Greenland polar bears (Ursus maritimus)

Environmental Science and Technology

Volumn 40, Issue 18, 2006, Pages 5668-5674

  Sonne, Christian ^a   Leifsson, Pall S ^b   Dietz, Rune ^a   Born, Erik W ^c   Letcher, Robert J ^d   Hyldstrup, Lars ^e   Riget, Frank F ^a   Kirkegaard, Maja ^a   Muir, Derek C G ^f  

^a NATIONAL ENVIRONMENTAL RESEARCH INSTITUTE   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c GREENLAND INSTITUTE OF NATURAL RESOURCES   (Greenland)

^d CARLETON UNIVERSITY   (Canada)

^e HVIDOVRE HOSPITAL   (Denmark)

^f ENVIRONMENT CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BEARS; MULTIPLE REGRESSIONS; ORGANOHALOGEN POLLUTANTS; XENOENDOCRINE POLLUTANTS;

BIODIVERSITY; BONE; DENSITY (SPECIFIC GRAVITY); POLLUTION; POLYCHLORINATED BIPHENYLS; TOXIC MATERIALS;

ENVIRONMENTAL ENGINEERING;

CHLORDANE; CHLORPHENOTANE; CYCLOHEXANE DERIVATIVE; DIELDRIN; HEXACHLOROBENZENE; HEXACYCLOHEXANE; ORGANOHALOGEN DERIVATIVE; POLAR BEAR; POLYBROMINATED DIPHENYL ETHER; POLYCHLORINATED BIPHENYL; UNCLASSIFIED DRUG;

BIODIVERSITY; BONE; DENSITY (SPECIFIC GRAVITY); ENVIRONMENTAL ENGINEERING; POLLUTION; POLYCHLORINATED BIPHENYLS; TOXIC MATERIALS;

BEAR; ENDOCRINE DISRUPTOR; HEALTH RISK; HEXACHLOROBENZENE; MULTIPLE REGRESSION; ORGANIC POLLUTANT; ORGANOHALOGEN; PBDE; REPRODUCTIVE BIOLOGY;

ANIMAL TISSUE; ARTICLE; BEAR; BONE DENSITY; BONE MINERAL; EGG; ENVIRONMENTAL EXPOSURE; FEMALE; HISTOPATHOLOGY; LEIOMYOMA; LONG TERM EXPOSURE; MALE; NONHUMAN; ORGAN SIZE; OVARY; PENIS; REPRODUCTIVE TOXICITY; SPERM; TESTIS WEIGHT; UTERUS; WATER CONTAMINATION; WATER POLLUTANT; WILDLIFE;

AGE FACTORS; ANIMALS; BONE DENSITY; ENDOCRINE DISRUPTORS; ENVIRONMENTAL POLLUTANTS; FEMALE; GENITALIA, FEMALE; GENITALIA, MALE; GREENLAND; HYDROCARBONS, CHLORINATED; MALE; ORGAN SIZE; OVARY; PENIS; TESTIS; URSIDAE; UTERUS;

ARCTIC; EAST GREENLAND; GREENLAND;

BACULUM; URSUS MARITIMUS;

EID: 33748875878     PISSN: 0013936X     EISSN: None     Source Type: Journal    
DOI: 10.1021/es060836n     Document Type: Article

References (65)

1. Bunnell, F. L.; Tait, D. E. N. Population dynamics of bears-Implications. In Dynamics of Large Mammal Populations; Fowler, W.E., Smith, T.D., Eds.; lohn Wiley and Sons: New York, 1981.
2. Ramsay, M. A.; Stirling, I. Reproductive biology and ecology of female polar bears (Ursus maritimus). J. Zool. 1988, 214, 601-634.
3. Taylor, M. K.; DeMaster, D. P.; Bunnell, F. L.; Schweinsburg, R. E. Modeling the sustainable harvest of female polar bears. J. Wildl. Manage. 1987, 51, 811-820.
4. Derocher, A. E.; Stirling, I. Age-specific reproductive-performance of female polar bears (Ursus maritimus). Can. J. Zool. 1994, 234 (part 4), 527-536.
5. Lønø, O. The polar bear (Ursus maritimus Phipps) in the Svalbard area. Nor. Polarinst., Skr. 1970, 149, 103.
6. Larsen, T. Population biology of the polar bear (Ursus maritimus) in the Svalbard area. Nor. Polarinst., Skr. 1986, 184, 1-55.
7. Lentfer, J. W. Polar bear (Ursus maritimus). In Wild Mammals of North America: Biology, Management, and Economics; Chapman, J. A., Feldhammer, G. A., Eds.; John Hopkins University Press; Baltimore, MD, 1982.
8. Rosing-Asvid, A.; Born, E. W.; Kingsley, M. S. C. Age at sexual maturity of males and timing of the mating season of polar bears (Ursus maritimus) in Greenland. Polar Biol. 2002, 25, 878-883.
9. Arctic Monitoring and Assessment Programme. Persistent Organic Pollutants in the Arctic: Arctic Pollution 2002; Arctic Monitoring and Assessment Programme: Oslo, Norway, 2004.
10. Derocher, A. E.; Lund, N. J.; Stirling, I. Polar bears in a warming climate. Integr. Comp. Biol. 2004, 44, 163-176.
11. Førland, E. J.; Hanssen-Bauer, I.; Jonsson, T.; Kern-Hansen, C.; Nordli, P. Ø.; Tveito, O. E.; Laursen, E. V. Twentieth-century variations in temperature and precipitation in the Nordic Arctic. Polar Rec. 2002, 38 (206), 203-210.
12. Colborn, T.; Vom Saal, F. S.; Soto, A. M. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ. Health Perspect. 1993, 101, 378-384.
13. Global Assessment of the State-of-the-Science of Endocrine Disruptors; Damstra, T., Barlow, S., Bergman, A., Kavlock, R., Kraak, G. V. D., Eds.; World Health Organization: Geneva, Switzerland, 2002.
14. Bergman, A.; Olsson, M. Pathology of baltic grey seal and ringed seal females with special reference to adrenocortical hyperplasia: Is environmental pollution the cause of a widely distributed disease syndrome? Finn. Game Res. 1985, 44, 47-62.
15. Bergman, A. Health conditon of the Baltic grey seal (Halichoerus grypus) during two decates. APMIS 1999, 107, 270-282.
16. Campagna, C.; Marc-André, S.; Ayotte, P.; Bailey, J. L. Impaired maturation; fertilization; and embryonic development of porcine oocytes following exposure to an environmentally relevant organochlorine mixture. Biol. Reprod. 2001, 65, 554-560.
17. Campagna, C.; Guillemette, C.; Paradis, R.; Sirard, M. A.; Ayotte, P.; Bailey, J. L. An environmentally relevant organochlorine mixture impairs sperm function and embryo development in the porcine model. Biol. Reprod. 2002, 67, 80-87.
18. Braathen, M.; Derocher, A. E.; Wiig, Ø.; Sørmo, E. G.; Lie, E.; Skaare, J. U; Jenssen, B. M. Relationships between PCBs and thyroid hormones and retinol in female and male polar bears. Environ. Health Perspect. 2004, 112, 826-833.
19. Haave, M.; Ropstad, E.; Derocher, A. E.; Lie, E.; Dahl, E.; Wiig, Ø.; Skaare, J. U.; Jenssen, B. M. Polychlorinated biphenyls and reproductive hormones in female polar bears at Svalbard. Environ. Health Perspect. 2003, 111, 431-436.
20. Oskam, I. C.; Ropstad, E.; Dahl, E.; Lie, E.; Derocher, A. E.; Wiig, Ø.; Larsen, S.; Wiger, R.; Skaare, J. U. Organochlorines affect the major androgenic hormone, testosterone, in male polar bears (Ursus maritimus) at Svalbard. J. Toxicol. Environ. Health, Part A 2003, 66, 2119-2139.
21. Oskam, I. C.; Ropstad, E.; Dahl, E.; Lie, E.; Derocher, A. E.; Wiig, Ø.; Dahl, E.; Larsen, S.; Skaare, J. U. Organochlorines affect the steroid hormone cortisol in polar bears (Ursus maritimus) at Svalbard, Norway. J. Toxicol. Environ. Health, Part A 2004, 67, 959-977.
22. Skaare, J. U.; Bernhoft, A.; Wiig, Ø.; Norum, K. R., Haug, E., Eide, D. M.; Derocher, A. M. Relationship between plasma levels of organochlorines, retinol and thyroid hormones from polar bears (Ursus maritimus) at Svalbard. J. Toxicol. Environ. Health, Part A 2001, 62, 227-241.
23. Bernhoft, A.; Skaare, J. U.; Wiig, Ø.; Derocher, A. E.; Larsen, H. J. S. Possible immunotoxic effects of organochlorines in polar bears (Ursus maritimus) at Svalbard. J. Toxicol. Environ. Health, Part A 2000, 57, 561-574.
24. Lie, E.; Larsen, H. J. S.; Larsen, S.; Johansen, G. M.; Derocher, A. E.; Lunn, N. J.; Norstrom, R. J.; Wiig, Ø.; Skaare, J. U. Does high organochlorine (OC) exposure impair the resistance to infection in polar bears (Ursus maritimus)? Part I: Effect of OCs on the humoral immunity. J. Toxicol. Environ. Health, Part A 2004, 67, 555-582.
25. Lie, E.; Larsen, H. J. S.; Larsen, S.; Johansen, G. M.; Derocher, A. E.; Lunn, N. J.; Norstrom, R. J.; Wiig, Ø.; Skaare, J. U. Does high organochlorine (OC) exposure impair the resistance to infection in polar bears (Ursus maritimus)? Part II: Possible effects of OCs on mitogen- and antigen-induced lymphocyte proliferation. J. Toxicol. Environ. Health, Part A 2005, 68, 457-484.
26. Kirkegaard, M.; Sonne, C.; Leifsson, P. S.; Dietz, R.; Born, E. W.; Muir, D. C. G.; Letcher, R. J. Histology of selected immunological organs in polar bear (Ursus maritimus) from East Greenland in relation to levels of organohalogens. Sci. Total Environ. 2005, 341 (1-3), 119-132.
27. Sonne, C.; Dietz, R.; Leifsson, P. S.; Born, E. W.; Kirkegaard, M.; Riget, F. F.; Letcher, R. J.; Muir, D. C. G.; Hyldstrup, L. Do organohalogen contaminants contribute to liver histopathology in East Greenland polar bears (Ursus maritimus)? Environ. Health Perspect. 2005, 113 (11), 1569-1574.
28. Sonne, C.; Dietz, R.; Leifsson, P. S.; Born, E. W.; Kirkegaard, M.; Letcher, R. J.; Muir, D. C. G.; Riget, F. F.; Hyldstrup, L. Are organohalogen contaminants a co-factor in the development of renal lesions in East Greenland polar bears (Ursus maritimus)? Environ. Toxicol. Chem. 2006, 25 (6), 1551-1557.
29. Sonne, C.; Dietz, R.; Born, E. W.; Riget, F. F.; Kirkegaard, M.; Hyldstrup, L.; Letcher, R. J.; Muir, D. C. G. Is bone mineral composition disrupted by organochlorines in East Greenland polar bears (Ursus maritimus)? Environ. Health Perspect. 2004, 112 (17), 1711-1716.
30. Sonne, C.; Dietz, R.; Larsen, H. J. S.; Loft, K. E.; Kirkegaard, M.; Letcher, R. J.; Shahmiri, S.; Møller, P. Impairment of cellular immunity in West Greenland sledge dogs (Canis familiaris) dietary exposed to polluted minke whale (Balaenoptera acutorostrata) blubber. Environ. Sci. Technol. 2006, 40, 2056-2062.
31. Sonne, C.; Dietz, R.; Born, E. W.; Leifsson, P. S.; Andersen, S. Severe perineal and penile hypospadias in East Greenland sledge dogs (Canis familiaris) exposed to organochlorines in utero. Environ. Pollut., submitted for publication.
32. Derocher, A. E.; Wolkers, H.; Colborn, T.; Schlabach, M.; Larsen, T. S.; Wiig, Ø. Contaminants in Svalbard polar bear samples archived since 1967 and possible population level effects. Sci. Total Environ. 2003 301, 163-174.
33. Skaare, J. U.; Larsen H. J. S; Lie, E.; Bernhoft, A.; Derocher A. E.; Norstrom, R.; Ropstad E.; Wiig, Ø. Ecological risk assessment of persistent organic pollutants in the arctic. Toxicology 2002, 181-182, 193-197.
34. Carmichael, L. E.; Krizan, P.; Blum, S. P.; Strobeck, C. Genotyping of pseudohermaphrodite polar bears in Nunavut and advances in DNA sexing techniques. J. Mammal. 2005, 86 (1), 160-169.
35. Sonne, C.; Leifsson, P. S.; Dietz, R.; Born, E. W.; Letcher, R. J.; Kirkegaard, M.; Muir, D. C. G.; Andersen, L. W.; Riget, F. F.; Hyldstrup, L. Enlarged clitoris in wild polar bears (Ursus maritimus) can be misdiagnosed as pseudohermaphroditism. Sci. Total Environ. 2005, 337, 45-58.
36. Wiig, Ø.; Derocher, A. E.; Cronin, M. M.; Skaare, J. U. Female pseudohermaphrodite polar bears at Svalbard. J. Wild. Dis. 1998, 34 (4), 792-796.
37. Dietz, R.; Heide-Jørgensen, M. P.; Härkönen, T.; Teilmann, J.; Valentin, N. Age determination of european harbour seal (Phoca vitulina L.). Sarsia 1991, 76, 17-21.
38. Theory and Strategy in Histochemistry; Lyon, H., Andersen, A. P., Hasselager, E., Høyer, P. E., Møller, M., Prentø, P., Van Deurs. B., Eds.; Springer-Verlag: Berlin, 1991.
39. Dietz, R.; Riget, F. F.; Sonne, C.; Letcher, R. J.; Born, E. W.; Muir, D. C. G. Seasonal and temporal trends in polychlorinated biphenyls and organochlorine pesticides in East Greenland polar bears (Ursus maritimus), 1990-2001. Sci. Total Environ. 2004, 331, 107-124.
40. Muir, D. C. G.; Backus, S.; Derocher, A. E.; Dietz, R.; Evans, T. J.; Gabrielsen, G. W.; Nagy, J.; Norstrom, R. J.; Sonne, C.; Stirling, I.; Taylor, M. K.; Letcher, R. J. Brominated flame retardants in polar bears (Ursus maritimus) from Alaska, the Canadian Arctic, East Greenland, and Svalbard. Environ. Sci. Technol. 2006, 40 (2), 449-455.
41. Ahmad, S. U.; Tariq, S.; Jalali, S.; Ahmad, M. M. Environmental pollutant Aroclor 1242 (PCB) disrupts reproduction in adult male rhesus monkeys (Macaca mulatto). Environ. Res. 2003, 93, 272-278.
42. Hany, J.; Lilienthal, H.; Sarasin, A.; Roth-Härer, A.; Fastabend, A.; Dunemann, L.; Lichtensteiger, W.; Winneke, G. Developmental exposure of rats to a reconstituted PCB mixture or Aroclor 1254: Effects on organ weights; aromatase activity; sex hormone levels and sweet preference behavior. Toxicol. Appl. Pharmacol. 1999, 158, 231-243.
43. Kuriyama, S. N.; Chahould, I. In utero exposure to low-dose 2,3′,4,4′,5-pentachlorobiphenyl (PCB 118) impairs male fertility and alters neurobehavior in rat offspring. Toxicology 2004, 202, 185-197.
44. Boon, J. P.; Everaarts, J. M.; Hillebrand, M. T. J.; Eggens, M. L.; Pijnenburg, J.; Goksoyr, A. Changes in levels of hepatic biotransformation enzymes and hemoglobin levels in female plaice (Pleuronectes platessa) after oral-administration of technical polychlorinated biphenyl mixture (Clophen A40). Sci. Total Environ. 1992, 114, 113-133.
45. Lin, P. P.; Hu, S. W.; Chang, T. H. Correlation between gene expression of aryl hydrocarbon receptor (AhR), hydrocarbon receptor nuclear translocator (Amt), cytochromes P4501A1 (CYP1A1) and 1B1 (CYP1B1), and inducibility of CYP1A1 and CYP1B1 in human lymphocytes. Toxicol. Sci. 2003, 71 (1), 20-26.
46. van Duursen, M. B. M.; Sanderson, J. T.; van der Bruggen, M.; van der Linden, J.; van den Berg, M. Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines. Toxicol. Appl. Pharmacol. 2003, 190 (3), 241-250.
47. Fielden, M. R.; Halgren, R. G.; Tashiro, C. H. M.; Yeo, B. R.; Chittim, B.; Chou, K.; Zacharewski, T. R. Effects of gestational and lactational exposure to aroclor 1242 on sperm quality and in vitro fertility in early adult and middle-aged mice. Reprod. Toxicol. 2001, 15, 281-292.
48. Gray, L. E. Xenoendocrine disruptors: Laboratory studies on male reproductive effects. Toxicol. Lett. 1998, 103, 331-335.
49. Pfleiger-Bruss, S.; Hanf, V.; Behnisch, P.; Hagenmaier, H.; Rune, G. M. Effects of single polychlorinated biphenyls on the morphlogy of cultured rat tubuli seminiferi. Andrologia 1999, 31 (2), 77-82.
50. Rune, G. M.; DeSouza, P.; Krowke, R.; Merker, H. J.; Neubert, D. Morphological and histochemical pattern of response in rat testes after adminstration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Histol. Histopathol. 1991, 6, 459-467.
51. Rune, G. M.; DeSouza, P.; Krowke, R.; Merker, H. J.; Neubert, D. Morphological and histochemical effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on marmoset (Callithrix jacchus) testes. Arch. Androl. 1991, 26, 143-154.
52. Facemire, C. F.; Gross, T. S.; Guillette, L. J. Reproductive impairment in the florida panther-Nature or nurture. Environ. Health Perspect. 1995, 103 (Suppl. 4), 79-86.
53. Guillette, L. J.; Gross, T. S.; Masson, G. R.; Matter, J. M.; Percival, H. F.; Woodward, A. R. Developmental abnormalities of the gonad and abnormal sex-hormone concentations in juvenile alligators from contaminated and control lakes in Florida. Environ. Health Perspect. 1994, 102 (8), 680-688.
54. Manolagas, S. C.; Bellido, T.; Jilka, R. L. New insights into the cellular, biochemical and molecular basis of postmenopausal and senile osteoporosis: Roles of IL-6 and gp130. Int. J. Immunopharmacol 1995, 17 (2), 109-116.
55. Manolagas, S. C.; Jilka, R. L. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N. Engl. J. Med. 1995, 332 (5), 305-311.
56. Alveblom, A. K.; Rylander, L.; Johnell, O.; Hagmar, L. Incidence of hospitalized osteoporotic fractures in cohorts with high dietary intake of persistent organic compounds. Int. Arch. Occup. Environ. Health 2003, 76, 246-248.
57. Harding, L. E.; Harris, M. L.; Stephen, C. R.; Elliott, J, E. Reproductive and morphological condition of wild mink (Mustela vison) and river otters (Lutra canadensis) in relation to chlorinated hydrocarbon contamination. Environ. Health Perspect. 1999, 107 (2), 141-147.
58. Bäcklin, B. M.; Eriksson, L.; Olovsson, M. Histology of uterine leiomyoma and occurrence in relation to reproductive activity in the Baltic ray seal (Halichoerus grypus). Vet. Pathol. 2003, 40 (2), 175-180.
59. Blomkvist, G.; Roos, A.; Jensen, S.; Bignert, A.; Olsson, M. Concentrations of sDDT and PCB in seals from Swedish and Scottish waters. Ambio 1992, 21 (8), 539-545.
60. Rier, S. E.; Turner, W. E.; Maryin, D. C.; Morris, R.; Lucier, G. W.; Clark, G. C. Serum Levels of TCDD and dioxin-like chemicals in rhesus monkeys chronically exposed to dioxin: Correlation of increased serum PCB levels with endometriosis. Toxicol. Sci. 2001, 59, 147-159.
61. Sagar, D. B.; Girard, D. M. Long-term effects on reproductive parameters in female rats after translactational exposure to PCBs. Environ. Res. 1994, 66 (1), 52-76.
62. Diel, P.; Schulz, T.; Smolnikar, K.; Strunck, E.; Vollmer, G.; Michna, H. Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: Estrogenecity profiles and uterotropic activity. J. Steroid Biochem. 2000, 73 (1-2), 1-10.
63. Ferguson, S. H.; Larivière, S. Are long penis bones an adaption to high latitude snowy environments? Oikos 2004, 105, 255-267
64. Wiig, Ø. Are polar bears threatened? Science 2005, 309, 1814-1815.
65. Jenssen, B. M. Endocrine-disrupting chemicals and climate change: a worst-case combination for Arctic marine mammals and seabirds? Environ. Health Persp. 2006, 114 (suppl. 1), 76-80.