Homocysteine activates cAMP-response element binding protein in HepG2 through cAMP/PKA signaling pathway

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 26, Issue 5, 2006, Pages 1043-1050

  Woo, Connie W H ^a   Siow, Yaw L ^a   Karmin, O ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b ST BONIFACE GENERAL HOSPITAL   (Canada)

Author keywords

cAMP; CREB; HMG CoA reductase; Homocysteine; PKA

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HOMOCYSTEINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CARDIOVASCULAR RISK; CELL STRAIN HEPG2; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; ENZYME INHIBITION; FATTY LIVER; GLUCOSE METABOLISM; HYPERCHOLESTEROLEMIA; HYPERHOMOCYSTEINEMIA; LIPID METABOLISM; MALE; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; RAT; RISK FACTOR; VASCULAR ENDOTHELIUM; ANIMAL; CELL CULTURE; HUMAN; LIVER CELL; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HEPATOCYTES; HOMOCYSTEINE; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYPERHOMOCYSTEINEMIA; MALE; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RESEARCH SUPPORT, NON-U.S. GOV'T; SIGNAL TRANSDUCTION;

EID: 33646677716     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000214981.58499.32     Document Type: Article

References (39)

1. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med. 1991;324:1149-1155.
2. Refsum H, Ueland PM, Nygård O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med. 1998;49:31-62.
3. Lentz SR, Sobey CG, Piegors DJ, Bhopatkar MY, Faraci FM, Malinow MR, Heistad DD. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest. 1996;98:24-29.
4. Bellamy MF, McDowell IF, Ramsey MW, Brownlee M, Bones C, Newcombe RG, Lewis MJ. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation. 1998;98:1848-1852.
5. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002;346:476-483.
6. McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med. 2004;350:2042-2049.
7. Werstuck GH, Lentz SR, Dayal S, Hossain GS, Sood SK, Shi YY, Zhou J, Maeda N, Krisans SK, Malinow MR, Austin RC. Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J Clin Invest. 2001;107:1263-1273.
8. McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969;56:111-128.
9. Robert K, Nehme J, Bourdon E, Pivert G, Friguet B, Delcayre C, Delabar JM, Janel N. Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver. Gastroenterology. 2005;128:1405-1415.
10. Wang G, Woo CW, Sung FL, Siow YL, O K. Increased monocyte adhesion to aortic endothelium in rats with hyperhomocysteinemia: Role of chemokine and adhesion molecules. Arterioscler Thromb Vasc Biol. 2002;22:1777-1783.
11. Au-Yeung KKW, Woo CW, Sung FL, Yip JCW, Siow YL, O K. Hyperhomocysteinemia activates nuclear factor-κB in endothelial cells via oxidative stress. Circ Res. 2004;94:28-36.
12. Woo CW, Siow YL, Pierce GN, Choy PC, Minuk GY, Mymin D, O K. Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors. Am J Physiol Endocrinol Metab. 2005;288:E1002-E1010.
13. O K, Lynn EG, Chung YH, Siow YL, Man RY, Choy PC. Homocysteine stimulates the production and secretion of cholesterol in hepatic cells. Biochim Biophys Acta. 1998;1393:317-324.
14. Montminy M, Koo SH, Zhang X. The CREB family: key regulators of hepatic metabolism. Ann Endocrinol (Paris). 2004;65:73-75.
15. Rosenberg D, Groussin L, Jullian E, Perlemoine K, Bertagna X, Bertherat J. Role of the PKA-regulated transcription factor CREB in development and tumorigenesis of endocrine tissues. Ann N Y Acad Sci. 2002;968:65-74.
16. Gonzalez GA, Montminy MR. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell. 1989;59:675-680.
17. Dalle S, Longuet C, Costes S, Broca C, Faruque O, Fontes G, Haniel H, Bataille D. Glucagon promotes cAMP-response element-binding protein phosphorylation via activation of ERK1/2 in MIN6 cell line and isolated islets of Langerhans. J Biol Chem. 2004;279:20345-20355.
18. Klemm DJ, Roesler WJ, Boras T, Colton LA, Felder K, Reusch JE. Insulin stimulates cAMP-response element binding protein activity in HepG2 and 3T3-L1 cell lines. J Biol Chem. 1998;273:917-923.
19. Dooley KA, Bennett MK, Osborne TF. A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter. J Biol Chem. 1999;274:5285-5291.
20. Ngo TT, Bennett MK, Bourgeois AL, Toth JI, Osborne TF. A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of the promoter for 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Biol Chem. 2002;277: 33901-33905.
21. Shaywitz AJ, Greenberg ME. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem. 1999;68:821-861.
22. Pilkis SJ, Exton JH, Johnson RA, Park CR. Effects of glucagon on cyclic AMP and carbohydrate metabolism in livers from diabetic rats. Biochim Biophys Acta. 1974;343:250-267.
23. Sherline P, Lynch A, Glinsmann WH. Cyclic AMP and adrenergic receptor control of rat liver glycogen metabolism. Endocrinology. 1972;91:680-690.
24. Sung FL, Siow YL, Wang G, Lynn EG, O K. Homocysteine stimulates the expression of monocyte chemoattractant protein-1 in endothelial cells leading to enhanced monocyte chemotaxis. Mol Cell Biochem. 2001;216:121-128.
25. Brown JC, Rosenquist TH, Monaghan DT. ERK2 activation by homocysteine in vascular smooth muscle cells. Biochem Biophys Res Commun. 1998;251:669-676.
26. Javitt NB. Hep G2 cells as a resource for metabolic studies: lipoprotein, cholesterol, and bile acids. FASEB J. 1990;4:161-168.
27. Gibbons GF. A comparison of in-vitro models to study hepatic lipid and lipoprotein metabolism. Curr Opin Lipidol. 1994;5:191-199.
28. Roesler WJ, Graham JG, Kolen R, Klemm DJ, McFie PJ. The cAMP response element binding protein synergizes with other transcription factors to mediate cAMP responsiveness. J Biol Chem. 1995;270:8225-8232.
29. Sitrin RG, Pan PM, Srikanth S, and Todd RF. 3rd Fibrinogen activates NF-kappa B transcription factors in mononuclear phagocytes. J Immunol. 1998;161:1462-1470.
30. Siow YL, Chilcote TJ, Benfenati F, Greengard P, Thiel G. Synapsin IIa: expression in insect cells, purification, and characterization. Biochemistry. 1992;31:4268-4275.
31. Walsh DA, Perkins JP, Krebs EG. An adenosine 3′,5′- monophosphate-dependant protein kinase from rabbit skeletal muscle. J Biol Chem. 1968;243:3763-3765.
32. Sutherland EW, Rall TW, Menton T. Adenyl cylase. I. Distribution, preparation, and properties. J Biol Chem. 1962;237:1220-1227.
33. Herzig S, Hedrick S, Morantte I, Koo SH, Galimi F, Montminy M. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature. 2003;426:190-193.
34. Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol. 2001;2:599-609.
35. Johannessen M, Delghandi MP, Moens U. What turns CREB on? Cell Signal 2004;16:1211-1227.
36. Francis SH, Kono T. Hormone-sensitive cAMP phosphodiesterase in liver and fat cells. Mol Cell Biochem. 1982;42:109-116.
37. Lentz SR, Sadler JE. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest. 1991;88:1906-1914.
38. Lentz SR, Sadler JE. Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum. Blood. 1993;81:683-689.
39. Jefferson LS, Exton JH, Butcher RW, Sutherland EW, Park CR. Role of adenosine 3′,5′-monophosphate in the effects of insulin and anti-insulin serum on liver metabolism. J Biol Chem. 1968;243:1031-1038.