메뉴 건너뛰기




Volumn 6, Issue 6, 2009, Pages 1868-1875

Real time, noninvasive imaging and quantitation of the accumulation of ligand-targeted drugs into receptor-expressing solid tumors

Author keywords

Folic acid; Real time imaging; Targeted cancer therapy; Tumor uptake

Indexed keywords

FOLATE RECEPTOR; FOLIC ACID; HOE 33342; RHODAMINE B;

EID: 71949089489     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900158d     Document Type: Article
Times cited : (22)

References (48)
  • 2
    • 33750610030 scopus 로고    scopus 로고
    • Protein kinases as drug targets in cancer
    • DOI 10.2174/156800906778742479
    • Arslan, M. A.; Kutuk, O.; Basaga, H. Protein kinases as drug targets in cancer. Curr. Cancer Drug Targets 2006, 6, 623-634 (Pubitemid 44691004)
    • (2006) Current Cancer Drug Targets , vol.6 , Issue.7 , pp. 623-634
    • Arslan, M.A.1    Kutuk, O.2    Basaga, H.3
  • 3
    • 0035344667 scopus 로고    scopus 로고
    • STI571: A gene product-targeted therapy for leukemia
    • Mauro, M. J.; Druker, B. J. STI571: a gene product-targeted therapy for leukemia. Curr. Oncol. Rep. 2001, 3, 223-227
    • (2001) Curr. Oncol. Rep. , vol.3 , pp. 223-227
    • Mauro, M.J.1    Druker, B.J.2
  • 4
    • 33644842102 scopus 로고    scopus 로고
    • Gefitinib (ZD1839, Iressatrade mark) as palliative treatment in recurrent or metastatic head and neck cancer
    • Kirby, A. M.; A'Hern, R. P.; D'Ambrosio, C.; et al. Gefitinib (ZD1839, Iressatrade mark) as palliative treatment in recurrent or metastatic head and neck cancer. Br. J. Cancer 2006.
    • (2006) Br. J. Cancer
    • Kirby, A.M.1    A'Hern, R.P.2    D'Ambrosio, C.3
  • 5
    • 21744432350 scopus 로고    scopus 로고
    • Erlotinib in non-small cell lung cancer: A review
    • DOI 10.1517/14656566.6.6.995
    • Blackhall, F. H.; Rehman, S.; Thatcher, N. Erlotinib in non-small cell lung cancer: a review. Expert Opin. Pharmacother. 2005, 6, 995-1002. (Pubitemid 40946160)
    • (2005) Expert Opinion on Pharmacotherapy , vol.6 , Issue.6 , pp. 995-1002
    • Blackhall, F.H.1    Rehman, S.2    Thatcher, N.3
  • 6
    • 31444451572 scopus 로고    scopus 로고
    • Trastuzumab-based treatment of HER2-positive breast cancer: An antibody-dependent cellular cytotoxicity mechanism
    • Arnould, L.; Gelly, M.; Penault-Llorca, F.; et al. Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism. Br. J. Cancer 2006, 94, 259-267
    • (2006) Br. J. Cancer , vol.94 , pp. 259-267
    • Arnould, L.1    Gelly, M.2    Penault-Llorca, F.3
  • 8
    • 31144458716 scopus 로고    scopus 로고
    • How avastin potentiates chemotherapeutic drugs: Action and reaction in antiangiogenic therapy
    • Blagosklonny, M. V. How avastin potentiates chemotherapeutic drugs: action and reaction in antiangiogenic therapy. Cancer Biol. Ther. 2005, 4, 1307-1310
    • (2005) Cancer Biol. Ther. , vol.4 , pp. 1307-1310
    • Blagosklonny, M.V.1
  • 9
    • 28444476260 scopus 로고    scopus 로고
    • Angiogenic inhibitors: A new therapeutic strategy in oncology
    • DOI 10.1038/ncponc0342, PII N0342
    • Gasparini, G.; Longo, R.; Toi, M.; Ferrara, N. Angiogenic inhibitors: a new therapeutic strategy in oncology. Nat. Clin. Pract. Oncol. 2005, 2, 562-577 (Pubitemid 41721816)
    • (2005) Nature Clinical Practice Oncology , vol.2 , Issue.11 , pp. 562-577
    • Gasparini, G.1    Longo, R.2    Toi, M.3    Ferrara, N.4
  • 10
    • 0034753903 scopus 로고    scopus 로고
    • Mylotarg: Antibody-targeted chemotherapy comes of age
    • Sievers, E. L.; Linenberger, M. Mylotarg: antibody-targeted chemotherapy comes of age. Curr. Opin. Oncol. 2001, 13, 522-527
    • (2001) Curr. Opin. Oncol. , vol.13 , pp. 522-527
    • Sievers, E.L.1    Linenberger, M.2
  • 11
    • 33750686584 scopus 로고    scopus 로고
    • Targeted anticancer immunotoxins and cytotoxic agents with direct killing moieties
    • Kawakami, K.; Nakajima, O.; Morishita, R.; Nagai, R. Targeted anticancer immunotoxins and cytotoxic agents with direct killing moieties. TheScientificWorld 2006, 6, 781-790
    • (2006) TheScientificWorld , vol.6 , pp. 781-790
    • Kawakami, K.1    Nakajima, O.2    Morishita, R.3    Nagai, R.4
  • 12
    • 0029383661 scopus 로고
    • Targeting Pseudomonas exotoxin to hematologic malignancies
    • Kreitman, R. J.; Pastan, I. Targeting Pseudomonas exotoxin to hematologic malignancies. Semin. Cancer Biol. 1995, 6, 297-306.
    • (1995) Semin. Cancer Biol. , vol.6 , pp. 297-306
    • Kreitman, R.J.1    Pastan, I.2
  • 14
    • 0028301330 scopus 로고
    • Selective targeting of malignant cells with cytotoxin-folate conjugates
    • Leamon, C. P.; Low, P. S. Selective targeting of malignant cells with cytotoxin-folate conjugates. J. Drug Targeting 1994, 2, 101-112 (Pubitemid 24194288)
    • (1994) Journal of Drug Targeting , vol.2 , Issue.2 , pp. 101-112
    • Leamon, C.P.1    Low, P.S.2
  • 15
    • 0028301752 scopus 로고
    • Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines: Physiologic and clinical implications
    • Ross, J. F.; Chaudhuri, P. K.; Ratnam, M. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications. Cancer 1994, 73, 2432-2443 (Pubitemid 24129130)
    • (1994) Cancer , vol.73 , Issue.9 , pp. 2432-2443
    • Ross, J.F.1    Chaudhuri, P.K.2    Ratnam, M.3
  • 17
    • 1942503277 scopus 로고    scopus 로고
    • Folate receptor-targeted immunotherapy of cancer: Mechanism and therapeutic potential
    • DOI 10.1016/j.addr.2004.01.009, PII S0169409X04000195
    • Lu, Y.; Sega, E.; Leamon, C. P.; Low, P. S. Folate receptor-targeted immunotherapy of cancer: mechanism and therapeutic potential. Adv. Drug Delivery Rev. 2004, 56, 1161-1176 (Pubitemid 38496513)
    • (2004) Advanced Drug Delivery Reviews , vol.56 , Issue.8 , pp. 1161-1176
    • Lu, Y.1    Sega, E.2    Leamon, C.P.3    Low, P.S.4
  • 18
    • 27944455140 scopus 로고    scopus 로고
    • Folate receptor-mediated drug targeting: From therapeutics to diagnostics
    • DOI 10.1002/jps.20457
    • Hilgenbrink, A. R.; Low, P. S. Folate receptor-mediated drug targeting: from therapeutics to diagnostics. J. Pharm. Sci. 2005, 94, 2135-2146 (Pubitemid 41665275)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.10 , pp. 2135-2146
    • Hilgenbrink, A.R.1    Low, P.S.2
  • 20
    • 10844268815 scopus 로고    scopus 로고
    • Synthesis and characterization of a cobalamin-colchicine conjugate as a novel tumor-targeted cytotoxin
    • DOI 10.1021/jo049953w
    • Bagnato, J. D.; Eilers, A. L.; Horton, R. A.; Grissom, C. B. Synthesis and characterization of a cobalamin-colchicine conjugate as a novel tumor-targeted cytotoxin. J. Org. Chem. 2004, 69, 8987-8996 (Pubitemid 40004017)
    • (2004) Journal of Organic Chemistry , vol.69 , Issue.26 , pp. 8987-8996
    • Bagnato, J.D.1    Eilers, A.L.2    Horton, R.A.3    Grissom, C.B.4
  • 21
    • 27944479629 scopus 로고    scopus 로고
    • Targeted chemotherapy with cytotoxic bombesin analogue AN-215 inhibits growth of experimental human prostate cancers
    • Stangelberger, A.; Schally, A. V.; Letsch, M.; et al. Targeted chemotherapy with cytotoxic bombesin analogue AN-215 inhibits growth of experimental human prostate cancers. Int. J. Cancer 2006, 118, 222-229
    • (2006) Int. J. Cancer , vol.118 , pp. 222-229
    • Stangelberger, A.1    Schally, A.V.2    Letsch, M.3
  • 22
    • 25844439526 scopus 로고    scopus 로고
    • Inhibition of growth of experimental human and hamster pancreatic cancers in vivo by a targeted cytotoxic bombesin analog
    • DOI 10.1097/01.mpa.0000175892.97036.a7
    • Szepeshazi, K.; Schally, A. V.; Nagy, A.; Halmos, G. Inhibition of growth of experimental human and hamster pancreatic cancers in vivo by a targeted cytotoxic bombesin analog. Pancreas 2005, 31, 275-282 (Pubitemid 41400486)
    • (2005) Pancreas , vol.31 , Issue.3 , pp. 275-282
    • Szepeshazi, K.1    Schally, A.V.2    Nagy, A.3    Halmos, G.4
  • 23
    • 15544371477 scopus 로고    scopus 로고
    • Targeting cytotoxic conjugates of somatostatin, luteinizing hormone-releasing hormone and bombesin to cancers expressing their receptors: A "smarter" chemotherapy
    • Nagy, A.; Schally, A. V. Targeting cytotoxic conjugates of somatostatin, luteinizing hormone-releasing hormone and bombesin to cancers expressing their receptors: a "smarter" chemotherapy. Curr. Pharm. Des. 2005, 11, 1167-1180
    • (2005) Curr. Pharm. Des. , vol.11 , pp. 1167-1180
    • Nagy, A.1    Schally, A.V.2
  • 24
    • 24644496584 scopus 로고    scopus 로고
    • Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide
    • Dharap, S. S.; Wang, Y.; Chandna, P.; et al. Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 12962-12967
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 12962-12967
    • Dharap, S.S.1    Wang, Y.2    Chandna, P.3
  • 25
    • 10944259100 scopus 로고    scopus 로고
    • Surface antigens/receptors for targeted cancer treatment: The GnRH receptor/binding site for targeted adenocarcinoma therapy
    • DOI 10.2174/1568009043332745
    • Eaveri, R.; Ben-Yehudah, A.; Lorberboum-Galski, H. Surface antigens/receptors for targeted cancer treatment: the GnRH receptor/binding site for targeted adenocarcinoma therapy. Curr. Cancer Drug Targets 2004, 4, 673-687 (Pubitemid 40013573)
    • (2004) Current Cancer Drug Targets , vol.4 , Issue.8 , pp. 673-687
    • Eaveri, R.1    Ben-Yehudah, A.2    Lorberboum-Galski, H.3
  • 26
    • 1142299483 scopus 로고    scopus 로고
    • Targeted cancer therapy with gonadotropin-releasing hormone chimeric proteins
    • DOI 10.1586/14787210.4.1.151
    • Ben-Yehudah, A.; Lorberboum-Galski, H. Targeted cancer therapy with gonadotropin-releasing hormone chimeric proteins. Expert Rev. Anticancer Ther. 2004, 4, 151-161 (Pubitemid 38208494)
    • (2004) Expert Review of Anticancer Therapy , vol.4 , Issue.1 , pp. 151-161
    • Ben-Yehudah, A.1    Lorberboum-Galski, H.2
  • 27
    • 0029820712 scopus 로고    scopus 로고
    • Influence of route of administration on [3H]-camptothecin distribution and tumor uptake in CASE-bearing nude mice: Whole-body autoradiographic studies
    • Ahmed, A. E.; Jacob, S.; Giovanella, B. C.; Kozielski, A. J.; Stehlin, J. S., Jr.; Liehr, J. G. Influence of route of administration on [3H]-camptothecin distribution and tumor uptake in CASE-bearing nude mice: whole-body autoradiographic studies. Cancer Chemother. Pharmacol. 1996, 39, 122-130
    • (1996) Cancer Chemother. Pharmacol. , vol.39 , pp. 122-130
    • Ahmed, A.E.1    Jacob, S.2    Giovanella, B.C.3    Kozielski, A.J.4    Stehlin Jr., J.S.5    Liehr, J.G.6
  • 28
    • 0036452180 scopus 로고    scopus 로고
    • Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene
    • Noy, R.; Ben-Zvi, Z.; Elezra, M.; et al. Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene. Cancer Chemother. Pharmacol. 2002, 50, 360-366
    • (2002) Cancer Chemother. Pharmacol. , vol.50 , pp. 360-366
    • Noy, R.1    Ben-Zvi, Z.2    Elezra, M.3
  • 29
    • 21744460519 scopus 로고    scopus 로고
    • Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice
    • Harivardhan Reddy, L.; Sharma, R. K.; Chuttani, K.; Mishra, A. K.; Murthy, R. S. Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice. J. Controlled Release 2005, 105, 185-198
    • (2005) J. Controlled Release , vol.105 , pp. 185-198
    • Harivardhan Reddy, L.1    Sharma, R.K.2    Chuttani, K.3    Mishra, A.K.4    Murthy, R.S.5
  • 31
    • 0025376171 scopus 로고
    • A modeling analysis of monoclonal antibody percolation through tumors: A binding-site barrier
    • Fujimori, K.; Covell, D. G.; Fletcher, J. E.; Weinstein, J. N. A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier. J. Nucl. Med. 1990, 31, 1191-1198
    • (1990) J. Nucl. Med. , vol.31 , pp. 1191-1198
    • Fujimori, K.1    Covell, D.G.2    Fletcher, J.E.3    Weinstein, J.N.4
  • 32
    • 0026739369 scopus 로고
    • Micropharmacology of monoclonal antibodies in solid tumors: Direct experimental evidence for a binding site barrier
    • Juweid, M.; Neumann, R.; Paik, C.; et al. Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res. 1992, 52, 5144-5153
    • (1992) Cancer Res. , vol.52 , pp. 5144-5153
    • Juweid, M.1    Neumann, R.2    Paik, C.3
  • 33
    • 0026747885 scopus 로고
    • Early intervention in cancer using monoclonal antibodies and other biological ligands: Micropharmacology and the "binding site barrier"
    • Weinstein, J. N.; van Osdol, W. Early intervention in cancer using monoclonal antibodies and other biological ligands: micropharmacology and the "binding site barrier". Cancer Res. 1992, 52, 2747s-51s.
    • (1992) Cancer Res. , vol.52
    • Weinstein, J.N.1    Van Osdol, W.2
  • 34
    • 0029114671 scopus 로고
    • Targeting cancer micrometastases with monoclonal antibodies: A binding-site barrier
    • Saga, T.; Neumann, R. D.; Heya, T.; et al. Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 8999-9003.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 8999-9003
    • Saga, T.1    Neumann, R.D.2    Heya, T.3
  • 35
  • 36
    • 0026752798 scopus 로고
    • Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues
    • Weitman, S. D.; Lark, R. H.; Coney, L. R.; et al. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res. 1992, 52, 3396-3401
    • (1992) Cancer Res. , vol.52 , pp. 3396-3401
    • Weitman, S.D.1    Lark, R.H.2    Coney, L.R.3
  • 37
    • 0032883172 scopus 로고    scopus 로고
    • Expression of folate receptor type alpha in relation to cell type, malignancy, and differentiation in ovary, uterus, and cervix
    • Wu, M.; Gunning, W.; Ratnam, M. Expression of folate receptor type alpha in relation to cell type, malignancy, and differentiation in ovary, uterus, and cervix. Cancer Epidemiol. Biomarkers Prev. 1999, 8, 775-782 (Pubitemid 29445014)
    • (1999) Cancer Epidemiology Biomarkers and Prevention , vol.8 , Issue.9 , pp. 775-782
    • Wu, M.1    Gunning, W.2    Ratnam, M.3
  • 38
    • 14644392093 scopus 로고    scopus 로고
    • Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
    • Parker, N.; Turk, M. J.; Westrick, E.; Lewis, J. D.; Low, P. S.; Leamon, C. P. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal. Biochem. 2005, 338, 284-293
    • (2005) Anal. Biochem. , vol.338 , pp. 284-293
    • Parker, N.1    Turk, M.J.2    Westrick, E.3    Lewis, J.D.4    Low, P.S.5    Leamon, C.P.6
  • 39
    • 0030662090 scopus 로고    scopus 로고
    • Efficient syntheses of pyrofolic acid and pteroyl azide, reagents for the production of carboxyl-differentiated derivatives of folic acid
    • Luo, J. S. M.; Lantrip, D. A.; Wang, S.; Fuchs, P. L. Efficient syntheses of pyrofolic acid and pteroyl azide, reagents for the production of carboxyl-differentiated derivatives of folic acid. J. Am. Chem. Soc. 1997, 119, 10004-10013
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 10004-10013
    • Luo, J.S.M.1    Lantrip, D.A.2    Wang, S.3    Fuchs, P.L.4
  • 41
    • 0030163022 scopus 로고    scopus 로고
    • Tumor-selective radiopharmaceutical targeting via receptor-mediated endocytosis of gallium-67-deferoxamine-folate
    • Mathias, C. J.; Wang, S.; Lee, R. J.; Waters, D. J.; Low, P. S.; Green, M. A. Tumor-selective radiopharmaceutical targeting via receptor-mediated endocytosis of gallium-67-deferoxamine-folate. J. Nucl. Med. 1996, 37, 1003-1008
    • (1996) J. Nucl. Med. , vol.37 , pp. 1003-1008
    • Mathias, C.J.1    Wang, S.2    Lee, R.J.3    Waters, D.J.4    Low, P.S.5    Green, M.A.6
  • 42
    • 0026425576 scopus 로고
    • An analysis of monoclonal antibody distribution in microscopic tumor nodules: Consequences of a "binding site barrier"
    • van Osdol, W.; Fujimori, K.; Weinstein, J. N. An analysis of monoclonal antibody distribution in microscopic tumor nodules: consequences of a "binding site barrier". Cancer Res. 1991, 51, 4776-4784
    • (1991) Cancer Res. , vol.51 , pp. 4776-4784
    • Van Osdol, W.1    Fujimori, K.2    Weinstein, J.N.3
  • 43
    • 0037444270 scopus 로고    scopus 로고
    • Theoretical analysis of antibody targeting of tumor spheroids: Importance of dosage for penetration, and affinity for retention
    • Graff, C. P.; Wittrup, K. D. Theoretical analysis of antibody targeting of tumor spheroids: importance of dosage for penetration, and affinity for retention. Cancer Res. 2003, 63, 1288-1296
    • (2003) Cancer Res. , vol.63 , pp. 1288-1296
    • Graff, C.P.1    Wittrup, K.D.2
  • 44
    • 0026549005 scopus 로고
    • Effects of target antigen competition on distribution of monoclonal antibody to solid tumors
    • Kennel, S. J. Effects of target antigen competition on distribution of monoclonal antibody to solid tumors. Cancer Res. 1992, 52, 1284-1290
    • (1992) Cancer Res. , vol.52 , pp. 1284-1290
    • Kennel, S.J.1
  • 45
    • 27744592174 scopus 로고    scopus 로고
    • Fast cancer uptake of 99mTc-labelled bombesin (99mTc BN1)
    • Scopinaro, F.; Di Santo, G. P.; Tofani, A.; et al. Fast cancer uptake of 99mTc-labelled bombesin (99mTc BN1). In vivo 2005, 19, 1071-1076
    • (2005) In Vivo , vol.19 , pp. 1071-1076
    • Scopinaro, F.1    Di Santo, G.P.2    Tofani, A.3
  • 47
    • 33747349484 scopus 로고    scopus 로고
    • Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide
    • Vlahov, I. R.; Santhapuram, H. K.; Kleindl, P. J.; Howard, S. J.; Stanford, K. M.; Leamon, C. P. Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide. Bioorg. Med. Chem. Lett. 2006, 16, 5093-5096
    • (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 5093-5096
    • Vlahov, I.R.1    Santhapuram, H.K.2    Kleindl, P.J.3    Howard, S.J.4    Stanford, K.M.5    Leamon, C.P.6
  • 48
    • 0038578294 scopus 로고    scopus 로고
    • Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation
    • Brown, E.; McKee, T.; diTomaso, E.; et al. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat. Med. 2003, 9, 796-800.
    • (2003) Nat. Med. , vol.9 , pp. 796-800
    • Brown, E.1    McKee, T.2    DiTomaso, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.