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Volumn 4, Issue 1, 2004, Pages 151-161

Targeted cancer therapy with gonadotropin-releasing hormone chimeric proteins

Author keywords

Apoptosis; Associated antigens; Cancer treatment; Chimeric proteins; Gonadotropin releasing hormone; Gonadotropin releasing hormone receptor; Tumor

Indexed keywords

BACTERIAL PROTEIN; CASPASE 3; CASPASE 9; CASPASE ACTIVATED DEOXYRIBONUCLEASE; CHIMERIC PROTEIN; CYTOTOXIC AGENT; DEOXYRIBONUCLEASE; DNA FRAGMENT; DOXORUBICIN; FAS LIGAND; GONADORELIN; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; GONADORELIN ANTIBODY; GONADORELIN DERIVATIVE; GONADORELIN RECEPTOR; GONADORELIN[6 DEXTRO LYSINE] DOXORUBICIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN PE66; RITUXIMAB; TRASTUZUMAB; TUMOR ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; TUMOR VACCINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 1142299483     PISSN: 14737140     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737140.4.1.151     Document Type: Review
Times cited : (28)

References (56)
  • 1
    • 0036631492 scopus 로고    scopus 로고
    • Identification of tumour-associated T-cell epitopes for vaccine development
    • Stevanovic S. Identification of tumour-associated T-cell epitopes for vaccine development. Nature Rev. Cancer 2, 514-520 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 514-520
    • Stevanovic, S.1
  • 2
    • 0037320594 scopus 로고    scopus 로고
    • Cancer/testis tumour-associated antigens: Immunohistochemical detection with monoclonal antibodies
    • Juretic A, Spagnoli GC, Schultz-Thater E, Sarcevic B. Cancer/testis tumour-associated antigens: immunohistochemical detection with monoclonal antibodies. Lancet Oncol. 4, 104-109 (2003).
    • (2003) Lancet Oncol. , vol.4 , pp. 104-109
    • Juretic, A.1    Spagnoli, G.C.2    Schultz-Thater, E.3    Sarcevic, B.4
  • 4
    • 0033943365 scopus 로고    scopus 로고
    • Direct identification of human tumor-associated peptide antigens and a preclinical model to evaluate their use
    • Engelhard VH, Bullock TN, Colella TA, Mullins DW. Direct identification of human tumor-associated peptide antigens and a preclinical model to evaluate their use. Cancer 6(Suppl. 3), S272-S280 (2000).
    • (2000) Cancer , vol.6 , Issue.SUPPL. 3
    • Engelhard, V.H.1    Bullock, T.N.2    Colella, T.A.3    Mullins, D.W.4
  • 5
    • 0035451392 scopus 로고    scopus 로고
    • From cancer genomics to cancer immunotherapy: Toward second-generation tumor antigens
    • Schultze JL, Vonderheide RH. From cancer genomics to cancer immunotherapy: toward second-generation tumor antigens. Trends Immunol. 22, 516-523 (2001).
    • (2001) Trends Immunol. , vol.22 , pp. 516-523
    • Schultze, J.L.1    Vonderheide, R.H.2
  • 6
    • 0036781811 scopus 로고    scopus 로고
    • Ligand-targeted therapeutics in anticancer therapy
    • Allen TM. Ligand-targeted therapeutics in anticancer therapy. Nature Rev. Cancer 2, 750-763 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 750-763
    • Allen, T.M.1
  • 7
    • 0037395628 scopus 로고    scopus 로고
    • Renal cell carcinoma: Tumor markers, T-cell epitopes and potential for new therapies
    • Michael A, Pandha HS. Renal cell carcinoma: tumor markers, T-cell epitopes and potential for new therapies. Lancet Oncol. 4, 215-223 (2003).
    • (2003) Lancet Oncol. , vol.4 , pp. 215-223
    • Michael, A.1    Pandha, H.S.2
  • 10
    • 0035030604 scopus 로고    scopus 로고
    • Antibody engineering for targeted therapy of cancer: Recombinant Fv-immunotoxins
    • Niv R, Cohen CJ, Denkberg G, Segal D, Reiter Y. Antibody engineering for targeted therapy of cancer: recombinant Fv-immunotoxins. Curr. Pharm. Biotechnol. 2, 19-46 (2001).
    • (2001) Curr. Pharm. Biotechnol. , vol.2 , pp. 19-46
    • Niv, R.1    Cohen, C.J.2    Denkberg, G.3    Segal, D.4    Reiter, Y.5
  • 11
    • 0034978758 scopus 로고    scopus 로고
    • Recombinant immunotoxins in targeted cancer cell therapy
    • Reiter Y. Recombinant immunotoxins in targeted cancer cell therapy. Adv. Cancer Res. 81, 93-124 (2001).
    • (2001) Adv. Cancer Res. , vol.81 , pp. 93-124
    • Reiter, Y.1
  • 12
    • 0011745743 scopus 로고    scopus 로고
    • Bacterial and plant toxins-general mode of action
    • Lorberboum-Galski H, Lazarovici P (Eds), Harwood Academic Publishers, NY, USA
    • Frankel AH. Bacterial and plant toxins-general mode of action. In: Chimeric Toxins: Mechanisms of action and Therapeutic Applications. Lorberboum-Galski H, Lazarovici P (Eds), Harwood Academic Publishers, NY, USA, 1-14 (2002).
    • (2002) Chimeric Toxins: Mechanisms of Action and Therapeutic Applications , pp. 1-14
    • Frankel, A.H.1
  • 13
    • 0034821591 scopus 로고    scopus 로고
    • Chimeric fusion proteins-Pseudomonas exotoxin-based
    • Kreitman RJ. Chimeric fusion proteins-Pseudomonas exotoxin-based. Curr. Opin. Investig. Drugs 2, 1282-1293 (2001).
    • (2001) Curr. Opin. Investig. Drugs , vol.2 , pp. 1282-1293
    • Kreitman, R.J.1
  • 14
    • 1142305712 scopus 로고    scopus 로고
    • Chimeric proteins: A novel approach for eliminating specific cell populations for targeted human therapy
    • Lorberboum-Gaiski H, Lazarovici P (Eds), Harwood Academic Publishers, NY, USA
    • Ben-Yehudah A, Belostotsky R, Aqeilan R et al. Chimeric proteins: a novel approach for eliminating specific cell populations for targeted human therapy. In: Chimeric Proteins. Lorberboum-Gaiski H, Lazarovici P (Eds), Harwood Academic Publishers, NY, USA, 148-167 (2002).
    • (2002) Chimeric Proteins , pp. 148-167
    • Ben-Yehudah, A.1    Belostotsky, R.2    Aqeilan, R.3
  • 15
    • 0036760042 scopus 로고    scopus 로고
    • Chimeric proteins as candidates for cancer treatment
    • Ben-Yehudah A, Belostotsky R. Lichtenstein M et al. Chimeric proteins as candidates for cancer treatment. Drugs Future 27, 851-861 (2002).
    • (2002) Drugs Future , vol.27 , pp. 851-861
    • Ben-Yehudah, A.1    Belostotsky, R.2    Lichtenstein, M.3
  • 16
    • 0035944837 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone receptor antagonists
    • Huirne JA, Lambalk CB. Gonadotropin-releasing hormone receptor antagonists. Lancet 358, 1793-1803 (2001).
    • (2001) Lancet , vol.358 , pp. 1793-1803
    • Huirne, J.A.1    Lambalk, C.B.2
  • 17
    • 0029063001 scopus 로고
    • Evolutionary aspects of gonadotropin-releasing hormone and its receptor
    • King JA, Millar RP. Evolutionary aspects of gonadotropin-releasing hormone and its receptor. Cell Mol. Neurobiol. 15, 5-23 (1995).
    • (1995) Cell Mol. Neurobiol. , vol.15 , pp. 5-23
    • King, J.A.1    Millar, R.P.2
  • 18
    • 85047684264 scopus 로고    scopus 로고
    • GnRH and GnRH receptor genes in the human genome
    • Neill JD. GnRH and GnRH receptor genes in the human genome. Endocrinology 143, 737-743 (2002).
    • (2002) Endocrinology , vol.143 , pp. 737-743
    • Neill, J.D.1
  • 20
    • 0029196026 scopus 로고
    • Signaling mechanisms during the response of pituitary gonadotropes to GnRH
    • Hille B, Tse A, Tse FW, Bosma MM. Signaling mechanisms during the response of pituitary gonadotropes to GnRH. Recent Prog. Horm. Res. 50, 75-95 (1995).
    • (1995) Recent Prog. Horm. Res. , vol.50 , pp. 75-95
    • Hille, B.1    Tse, A.2    Tse, F.W.3    Bosma, M.M.4
  • 21
    • 0037012226 scopus 로고    scopus 로고
    • Evolutionary development of three gonadotropin-releasing hormone (GnRH) systems in vertebrates
    • Dubois EA, Zandbergen MA, Peute J, Goos HJ. Evolutionary development of three gonadotropin-releasing hormone (GnRH) systems in vertebrates. Brain Res. Bull. 57, 413-418 (2002).
    • (2002) Brain Res. Bull. , vol.57 , pp. 413-418
    • Dubois, E.A.1    Zandbergen, M.A.2    Peute, J.3    Goos, H.J.4
  • 22
    • 0032739426 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone analogs: Their impact on the control of tumorigenesis
    • Schally AV. Luteinizing hormone-releasing hormone analogs: their impact on the control of tumorigenesis. Peptides 20, 1247-1262 (1999).
    • (1999) Peptides , vol.20 , pp. 1247-1262
    • Schally, A.V.1
  • 24
    • 0037432496 scopus 로고    scopus 로고
    • New approaches to treatment of various cancers based on cytotoxic analogs of LHRH, somatostatin and bombesin
    • Schally AV, Nagy A. New approaches to treatment of various cancers based on cytotoxic analogs of LHRH, somatostatin and bombesin. Life Sci. 72, 2305-2320 (2003).
    • (2003) Life Sci. , vol.72 , pp. 2305-2320
    • Schally, A.V.1    Nagy, A.2
  • 25
    • 0030937284 scopus 로고    scopus 로고
    • Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor
    • Sealfon SC, Weinstein H, Millar RP. Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor. Endocr. Rev. 18, 180-205 (1997).
    • (1997) Endocr. Rev. , vol.18 , pp. 180-205
    • Sealfon, S.C.1    Weinstein, H.2    Millar, R.P.3
  • 26
    • 0032455349 scopus 로고    scopus 로고
    • Nucleotide sequence analyses predict that human pituitary and human placental gonadotropin-releasing hormone receptors have identical primary structures
    • Boyle TA, Belt-Davis DI, Duello TM. Nucleotide sequence analyses predict that human pituitary and human placental gonadotropin-releasing hormone receptors have identical primary structures. Endocrine 9, 281-287 (1998).
    • (1998) Endocrine , vol.9 , pp. 281-287
    • Boyle, T.A.1    Belt-Davis, D.I.2    Duello, T.M.3
  • 27
    • 0028586112 scopus 로고
    • The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary
    • Kakar SS, Grizzle WE, Neill JD. The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary. Mol. Cell. Endocrinol. 106, 145-149 (1994).
    • (1994) Mol. Cell. Endocrinol. , vol.106 , pp. 145-149
    • Kakar, S.S.1    Grizzle, W.E.2    Neill, J.D.3
  • 28
    • 0031446639 scopus 로고    scopus 로고
    • Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor
    • Grosse R, Schoneberg T, Schultz G, Gudermann T. Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor. Mol. Endocrinol. 11, 1305-1318 (1997).
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1305-1318
    • Grosse, R.1    Schoneberg, T.2    Schultz, G.3    Gudermann, T.4
  • 29
    • 0032974235 scopus 로고    scopus 로고
    • Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene
    • Kottler ML, Bergametti F, Carre MC et al. Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene. Eur. J. Endocrinol. 140, 561-569 (1999).
    • (1999) Eur. J. Endocrinol. , vol.140 , pp. 561-569
    • Kottler, M.L.1    Bergametti, F.2    Carre, M.C.3
  • 30
    • 0035859957 scopus 로고    scopus 로고
    • A novel mammalian receptor for the evolutionarily conserved Type II GnRH
    • Millar R, Lowe S, Conklin D et al. A novel mammalian receptor for the evolutionarily conserved Type II GnRH. Proc. Natl Acad. Sci. USA 98, 9636-9641 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9636-9641
    • Millar, R.1    Lowe, S.2    Conklin, D.3
  • 31
    • 0038069320 scopus 로고    scopus 로고
    • GnRH II and Type II GnRH receptors
    • Millar RP. GnRH II and Type II GnRH receptors. Trends Endocrinol. Metab. 14(1), 35-43 (2003).
    • (2003) Trends Endocrinol. Metab. , vol.14 , Issue.1 , pp. 35-43
    • Millar, R.P.1
  • 33
    • 0011745748 scopus 로고    scopus 로고
    • Are GnRH-based chimeric proteins the future targeting therapy for adenocarcinomas?
    • Ben-Yehudah A, Lorberboum-Galski H. Are GnRH-based chimeric proteins the future targeting therapy for adenocarcinomas? Res. Trends 4, 49-59 (2001).
    • (2001) Res. Trends , vol.4 , pp. 49-59
    • Ben-Yehudah, A.1    Lorberboum-Galski, H.2
  • 34
    • 0036241442 scopus 로고    scopus 로고
    • Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors
    • McArdle CA, Franklin J, Green L, Hislop JN. Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors. J. Endocrinol. 173, 1-11 (2002).
    • (2002) J. Endocrinol. , vol.173 , pp. 1-11
    • McArdle, C.A.1    Franklin, J.2    Green, L.3    Hislop, J.N.4
  • 35
    • 0036000180 scopus 로고    scopus 로고
    • The gonadotropin-releasing hormone receptor: Signalling, cycling and desensitisation
    • McArdle CA, Franklin J, Green L, Hislop JN. The gonadotropin-releasing hormone receptor: signalling, cycling and desensitisation. Arch. Physiol. Biochem. 110, 113-122 (2002).
    • (2002) Arch. Physiol. Biochem. , vol.110 , pp. 113-122
    • McArdle, C.A.1    Franklin, J.2    Green, L.3    Hislop, J.N.4
  • 36
    • 0034660891 scopus 로고    scopus 로고
    • Vaccination against gonadotropin-releasing hormone (GnRH) using toxin receptor-binding domain-conjugated GnRH repeats
    • Hsu CT, Ting CY, Ting CJ et al. Vaccination against gonadotropin-releasing hormone (GnRH) using toxin receptor-binding domain-conjugated GnRH repeats. Cancer Res. 60, 3701-3705 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 3701-3705
    • Hsu, C.T.1    Ting, C.Y.2    Ting, C.J.3
  • 37
    • 0030897815 scopus 로고    scopus 로고
    • Adenocarcinoma cells are targeted by the new GnRH-PE66 chimeric toxin through specific gonadotropin-releasing hormone binding sites
    • Nechushtan A, Yarkoni S, Marianovsky I, Lorberboum-Galski H. Adenocarcinoma cells are targeted by the new GnRH-PE66 chimeric toxin through specific gonadotropin-releasing hormone binding sites. J. Biol. Chem. 272, 11597-11603 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 11597-11603
    • Nechushtan, A.1    Yarkoni, S.2    Marianovsky, I.3    Lorberboum-Galski, H.4
  • 39
    • 0034725097 scopus 로고    scopus 로고
    • Cytotoxic activity of a recombinant GnRH-PAP fusion toxin on human tumor cell lines
    • Schlick J, Dulieu P, Desvoyes B et al. Cytotoxic activity of a recombinant GnRH-PAP fusion toxin on human tumor cell lines. FEBS Lett. 472, 241-246 (2000).
    • (2000) FEBS Lett. , vol.472 , pp. 241-246
    • Schlick, J.1    Dulieu, P.2    Desvoyes, B.3
  • 40
    • 0037390439 scopus 로고    scopus 로고
    • Cytotoxic activity of gonadotropin-releasing hormone (GnRH)-pokeweed antiviral protein conjugates in cell lines expressing GnRH receptors
    • Yang WH, Wieczorck M, Allen MC, Nett TM. Cytotoxic activity of gonadotropin-releasing hormone (GnRH)-pokeweed antiviral protein conjugates in cell lines expressing GnRH receptors. Endocrinology 144, 1456-1463 (2003).
    • (2003) Endocrinology , vol.144 , pp. 1456-1463
    • Yang, W.H.1    Wieczorck, M.2    Allen, M.C.3    Nett, T.M.4
  • 41
    • 0032879545 scopus 로고    scopus 로고
    • Immunotoxins in cancer therapy
    • Kreitman RJ. Immunotoxins in cancer therapy. Curr. Opin. Immunol. 11, 570-578 (1999).
    • (1999) Curr. Opin. Immunol. , vol.11 , pp. 570-578
    • Kreitman, R.J.1
  • 43
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature 407, 770-776 (2000).
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 45
    • 0036308059 scopus 로고    scopus 로고
    • Mitochondria, the killer organelles and their weapons
    • Ravagnan I, Roumier T, Kroemer G. Mitochondria, the killer organelles and their weapons. J. Cell. Physiol. 192, 131-137 (2002).
    • (2002) J. Cell. Physiol. , vol.192 , pp. 131-137
    • Ravagnan, I.1    Roumier, T.2    Kroemer, G.3
  • 46
    • 0032779831 scopus 로고    scopus 로고
    • Interleukin-2-Bax: A novel prototype of human chimeric proteins for targeted therapy
    • Aqeilan R. Yarkoni S, Lorberboum-Galski H. Interleukin-2-Bax: a novel prototype of human chimeric proteins for targeted therapy. FEBS Lett. 457, 271-276 (1999).
    • (1999) FEBS Lett. , vol.457 , pp. 271-276
    • Aqeilan, R.1    Yarkoni, S.2    Lorberboum-Galski, H.3
  • 47
    • 0035146929 scopus 로고    scopus 로고
    • Life-or-death decisions by the Bcl-2 protein family
    • Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem. Sci. 26, 61-66 (2001).
    • (2001) Trends Biochem. Sci. , vol.26 , pp. 61-66
    • Adams, J.M.1    Cory, S.2
  • 48
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl2 family: Regulators of the cellular life-or-death switch
    • Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nature Rev. Cancer 2, 647-656 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 49
    • 0034474902 scopus 로고    scopus 로고
    • GnRH-Bik/Bax/Bak chimeric proteins target and kill adenocarcinoma cells; the general use of proapoptotic proteins of the Bcl-2 family as novel killing components of targeting chimeric proteins
    • Azar Y, Lorberboum-Galski H. GnRH-Bik/Bax/Bak chimeric proteins target and kill adenocarcinoma cells; the general use of proapoptotic proteins of the Bcl-2 family as novel killing components of targeting chimeric proteins. Apoptosis 5, 531-542 (2000).
    • (2000) Apoptosis , vol.5 , pp. 531-542
    • Azar, Y.1    Lorberboum-Galski, H.2
  • 50
    • 0034630317 scopus 로고    scopus 로고
    • Apoptotic DNA fragmentation
    • Nagata S. Apoptotic DNA fragmentation. Exp. Cell Res. 256, 12-18 (2000).
    • (2000) Exp. Cell Res. , vol.256 , pp. 12-18
    • Nagata, S.1
  • 51
    • 0034584574 scopus 로고    scopus 로고
    • The DFF40/CAD endonuclease and its role in apoptosis
    • Widlak P. The DFF40/CAD endonuclease and its role in apoptosis. Acta Biochem. Pol. 47, 1037-1044 (2000).
    • (2000) Acta Biochem. Pol. , vol.47 , pp. 1037-1044
    • Widlak, P.1
  • 52
    • 0037341303 scopus 로고    scopus 로고
    • Using apoptosis for targeted cancer therapy by a new gonadotropin releasing hormone-DNA fragmentation factor 40 chimeric protein
    • Ben-Yehudah A, Aqeilan R, Robashkevich D, Lorberboum-Galski H. Using apoptosis for targeted cancer therapy by a new gonadotropin releasing hormone-DNA fragmentation factor 40 chimeric protein. Clin. Cancer Res. 9, 1179-1190 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1179-1190
    • Ben-Yehudah, A.1    Aqeilan, R.2    Robashkevich, D.3    Lorberboum-Galski, H.4
  • 54
    • 0026565027 scopus 로고
    • Gonadotropin-releasing hormone specific binding sites in normal and malignant renal tissue
    • Sion-Vardi N, Kaneti J, Segal-Abramson T et al. Gonadotropin-releasing hormone specific binding sites in normal and malignant renal tissue. J. Urol. 148, 1568-1570 (1992).
    • (1992) J. Urol. , vol.148 , pp. 1568-1570
    • Sion-Vardi, N.1    Kaneti, J.2    Segal-Abramson, T.3
  • 55
    • 0037320294 scopus 로고    scopus 로고
    • A Transcriptionally active human Type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12
    • Morgan K, Conklin D, Pawson AJ et al. A Transcriptionally active human Type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12. Endocrinology 144, 423-436 (2003).
    • (2003) Endocrinology , vol.144 , pp. 423-436
    • Morgan, K.1    Conklin, D.2    Pawson, A.J.3


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