Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene

Cancer Chemotherapy and Pharmacology

Volumn 50, Issue 5, 2002, Pages 360-366

  Noy, Roy ^a   Ben Zvi, Zvi ^a   Elezra, Miri ^a   Candotti, Fabio ^b   Ford Jr , Harry ^c   Morris, John C ^d   Marquez, Victor E ^c   Johns, David G ^c   Agbaria, Riad ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

(N) MCT; Cancer; Gene therapy; HSV tk; N Methanocarbathymidine

Indexed keywords

N METHANOCARBATHYMIDINE; THYMIDINE DERIVATIVE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; COLON CARCINOMA; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOLECULAR BIOLOGY; MOUSE; MOUSE STRAIN; NONHUMAN; ORGAN DISTRIBUTION; PRIORITY JOURNAL; SUBCUTANEOUS TISSUE TUMOR; WILD TYPE;

ADENOCARCINOMA; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLONIC NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GENE THERAPY; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, INBRED C57BL; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; PRODRUGS; SIMPLEXVIRUS; THYMIDINE; THYMIDINE KINASE; TISSUE DISTRIBUTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036452180     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-002-0505-8     Document Type: Article

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