Studies of structure-transport relationships in biodegradable polymer microspheres for drug delivery using NMR cryodiffusometry

Chemical Engineering Science

Volumn 65, Issue 2, 2010, Pages 611-625

  Perkins, Emily L ^a,b   Lowe, John P ^b   Edler, Karen J ^b   Rigby, Sean P ^a  

^a University of Bath   (United Kingdom)

^b University of Bath Claverton Down   (United Kingdom)

Author keywords

Biomedical engineering; Controlled release; NMR cryoporometry; PFG NMR; Polymer; Porous media; Transport processes; Voidage

Indexed keywords

CONTROLLED RELEASE; CRYOPOROMETRY; PFG-NMR; POROUS MEDIA; TRANSPORT PROCESS; VOIDAGE;

BIODEGRADABLE POLYMERS; BIOMEDICAL ENGINEERING; FREEZING; FUNCTIONAL POLYMERS; MACHINE DESIGN; MICROSPHERES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POROUS MATERIALS; TRANSPORT PROPERTIES;

CONTROLLED DRUG DELIVERY;

EID: 71849117250     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2009.06.036     Document Type: Article

References (27)

1. Allison S.D. Effect of structural relaxation on the preparation and drug release behaviour of poly(lactic-co-glycolic) acid microparticle drug delivery systems. Journal of Pharmaceutical Sciences 97 (2008) 2022-2035
2. Beurroies I., Denoyel R., Llewellyn P., and Rouquerol J. A comparison between melting-solidification and capillary condensation hysteresis in mesoporous materials: application to the interpretation of thermoporometry data. Thermochimica Acta 421 (2004) 11-18
3. Brownstein K.R., and Tarr C.E. Spin-lattice relaxation in a system governed by diffusion. Journal of Magnetic Resonance 26 (1977) 17-24
4. Brun M., Lallemand A., Quinson J.F., and Eyraud C. A new method for the simultaneous determination of the size and the shape of pores. Thermochimica Acta 21 (1977) 59-88
5. Collins J.H.P., Gladden L.F., Hardy I.J., and Mantle M.D. Characterizing the evolution of porosity during controlled drug release. Applied Magnetic Resonance 32 (2007) 185-204
6. Djemai A., Gladden L.F., Booth J., Kittlety R.S., and Gellert P.R. MRI investigation of hydration and heterogeneous degradation of aliphatic polyesters derived from lactic and glycolic acids: a controlled drug delivery device. Magnetic Resonance Imaging 19 (2001) 521-523
7. Filippov A.V., and Skirda V.D. An investigation of the structure of a porous substance by NMR cryodiffusometry. Colloid Journal 62 (2000) 759-764
8. Freiburg S., and Zhu X. Polymer microspheres for controlled drug release. International Journal of Pharmaceutics 282 (2004) 1-18
9. Gao P., and Fagerness P.E. Diffusion in HPMC gels. 1. Determination of drug and water diffusivity by pulsed-field gradient spin-echo NMR. Pharmaceutical Research 12 (1995) 955-964
10. Gjerdåker L., Humborstad Sørland G., and Aksnes D. Application of the short diffusion time model to diffusion measurements by NMR in microporous crystallites. Microporous and Mesoporous Materials 32 (1999) 305-310
11. Harding S., Baumann H., Gren T., and Sao A. NMR microscopy of the uptake, distribution and mobility of dissolution media in small, sub-millimetre drug-delivery systems. Journal of Controlled Release 66 (2000) 81-99
12. Kang J., and Schwendeman S.P. Determination of diffusion coefficient of a small hydrophobic probe in poly(lactide-co-glycolide) microparticles by laser scanning confocal microscopy. Macromolecules 36 (2003) 1324-1330
13. Kang J., and Schwendeman S.P. Pore closing and opening in biodegradable polymers and their effect on the controlled release of proteins. Molecular Pharmaceutics 4 (2007) 104-118
14. Khokhlov A., Valiullin R., Kärger J., Steinbach F., and Feldhoff A. Freezing and melting transitions of liquids in mesopores with ink-bottle geometry. New Journal of Physics 9 (2007) 272
15. Kim J.S., and Yethiraj A. A diffusion anomaly of water in aqueous sodium chloride solutions at low temperatures. Journal of Physical Chemistry B 112 (2008) 1729-1735
16. Lee T.H., Wang J.J., and Wang C.H. Double-walled microspheres for the sustained release of a highly water soluble drug: characterization and irradiation studies. Journal of Controlled Release 83 (2002) 437-452
17. Lipsicas M., Banavar J.R., and Willemsen J. Surface relaxation and pore sizes in rocks-a nuclear magnetic resonance analysis. Applied Physics Letters 48 (1986) 1544-1546
18. Messaritaki A., Black S.J., van der Walle C.F., and Rigby S.P. NMR and confocal microscopy studies of the mechanisms of burst drug release from PLGA microspheres. Journal of Controlled Release 108 (2005) 271-281
19. Mitra P.P., Sen P.N., and Schwartz L.M. Short time behaviour of the diffusion coefficient as a geometrical probe of porous media. Physical Review B 47 (1993) 8565-8574
20. Morishige K., Yasunaga H., Denoyel R., and Wernert V. Pore-blocking-controlled freezing of water in cagelike pores of KIT-5. Journal of Physical Chemistry C 111 (2007) 9488-9495
21. Noorsal K., Mantle M.D., Gladden L.F., and Cameron R.E. Degradation and drug-release studies of a poly(glycolide-co-trimethylene carbonate) copolymer (Maxon). Journal of Applied Polymer Science 95 (2005) 475-486
22. Perkins E.L., Lowe J.P., Edler K.J., Tanko N., and Rigby S.P. Determination of the percolation properties and pore connectivity for mesoporous solids using NMR cryodiffusometry. Chemical Engineering Science 63 (2008) 1929-1940
23. Petrov O., and Furó I. Curvature-dependent metastability of the solid phase and the freezing-melting hysteresis in pores. Physical Review E 73 (2006) 011-608
24. Petrov O., Furo I., Schuleit M., Domanig R., Plunkett M., and Daicic J. Pore size distributions of biodegradable polymer microparticles in aqueous environments measured by NMR cryoporometry. International Journal of Pharmaceutics 309 (2006) 157-162
25. Sant S., Nadeau W., and Hildgen P. Effect of porosity on the release kinetics of propafenone-loaded PEG-g-PLA nanoparticles. Journal of Controlled Release 107 (2005) 203-214
26. Strange J.H., Rahman M., and Smith E.G. Characterization of porous solids by NMR. Physical Review Letters 71 (1993) 3589-3591
27. Wu D., Chen A., and Johnson Jr. C.S. An improved diffusion-ordered spectroscopy experiment incorporating bipolar-gradient pulses. Journal of Magnetic Resonance (A) 115 (1995) 260-264