NMR and confocal microscopy studies of the mechanisms of burst drug release from PLGA microspheres

Journal of Controlled Release

Volumn 108, Issue 2-3, 2005, Pages 271-281

  Messaritaki, Antigoni ^a,b   Black, Steven J ^b   Van Der Walle, Christopher F ^c   Rigby, Sean P ^a  

^a University of Bath   (United Kingdom)

^b University of Bath   (United Kingdom)

^c UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Microspheres; Percolation theory; PFG NMR; Release kinetics

Indexed keywords

DRYING; EMULSIONS; MECHANICAL PERMEABILITY; NUCLEAR MAGNETIC RESONANCE; PERCOLATION (FLUIDS); PORE SIZE;

MICROSPHERES; PERCOLATION THEORY; PFG NMR; RELEASE KINETICS;

DRUG DOSAGE;

4 TRIFLUOROMETHYLUMBELLIFERONE; FLUOROURACIL; MICROSPHERE; POLYGLACTIN; POLYMER; UMBELLIFERONE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

AQUEOUS SOLUTION; ARTICLE; CONFOCAL MICROSCOPY; DRUG PENETRATION; DRUG RELEASE; IMMERSION; NUCLEAR MAGNETIC RESONANCE; POROSITY; PRIORITY JOURNAL;

ALGORITHMS; DATA INTERPRETATION, STATISTICAL; EMULSIONS; EXCIPIENTS; FREEZE DRYING; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MOLECULAR WEIGHT; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; POLYGLYCOLIC ACID; POLYMERS;

EID: 27744447094     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.08.010     Document Type: Article

References (24)

1. M.J. Alonso, S. Cohen, T.G. Park, R.K. Gupta, G.R. Siber, and R. Langer Determinants of release rate of tetanus vaccine from polyester microspheres Pharm. Res. 10 1993 945 953
2. M. van de Weert, R. van 't Hof, J. van der Weerd, R.M. Heeren, G. Posthuma, W.E. Hennink, and D.J. Crommelin Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques J. Control. Release 68 2000 31 40
3. R.P. Batycky, J. Hanes, R. Langer, and D.A. Edwards A theoretical model of erosion and macromolecular drug release from biodegrading microspheres J. Pharm. Sci. 86 1997 1464 1477
4. P.T. Callaghan Principles of Nuclear Magnetic Resonance Microscopy 1991 Oxford University Press Oxford
5. R. Ek, T. Gren, U. Henriksson, H. Nyqvist, C. Nystöm, and L. Ödberg Prediction of drug release by the characterisation of tortuosity in porous cellulose beads using a spin-echo NMR technique Int. J. Pharm. 124 1995 9 18
6. S. Harding, H. Baumann, T. Gren, and A. Seo NMR microscopy of the uptake, distribution and mobility of dissolution media in small, sub-millimetre drug delivery systems J. Control. Release 66 2000 81 99
7. M.P. Hollewand, and L.F. Gladden Transport heterogeneity in porous pellets: I. PGSE NMR studies Chem. Eng. Sci. 50 1995 309 326
8. P.T. Callaghan, and K.W. Jolley Diffusion of fat and water in cheese as studied by pulsed field gradient nuclear magnetic resonance J. Colloid Interface Sci. 93 1983 521 529
9. J. Crank The Mathematics of Diffusion 1975 Clarendon Press Oxford
10. S. Sircar, and J.R. Hufton Why does the linear driving force model for adsorption kinetics work? Adsorption 6 2000 137 147
11. S.P. Rigby, K. Beanlands, I.O. Evbuomwan, M.J. Watt-Smith, K.J. Edler, and R.S. Fletcher Nanocasting of novel, designer-structured catalyst supports Chem. Eng. Sci. 59 2004 5113 5120
12. H. Sah A new strategy to determine the actual protein content of poly(lactide-co-glycolide) microspheres J. Pharm. Sci. 86 1997 1315 1318
13. T.H. Kim, and T.G. Park Critical effect of freezing/freeze-drying on sustained release of FITC-dextran encapsulated within PLGA microspheres Int. J. Pharm. 271 2004 207 214
14. Y.Y. Yang, T.S. Chung, and N.P. Ng Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method Biomaterials 22 2001 231 241
15. M. Hussain, G. Beale, M. Hughes, and S. Akhtar Co-delivery of an antisense oligonucleotide 5-fluorouracil using sustained release poly(lactide-co-glycolide) microsphere formulations for potential combination therapy in cancer Int. J. Pharm. 234 2002 129 138
16. T. Chandy, G.S. Das, and G.H.R. Rao 5-Fluorouracil-loaded chitosan coated polylactic acid microspheres as biodegradable drug carriers for cerebral tumours Microencapsulation 17 2000 625 638
17. M. Boisdron-Celle, Ph. Menei, and J.P. Benoit Preparation and characterization of 5-fluorouracil-loaded microparticles as biodegradable anticancer drug carriers J. Pharm. Pharmacol. 47 1995 108 114
18. Y.Y. Yang, T.S. Chung, X.L. Bai, and W.K. Chan Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion method Chem. Eng. Sci. 55 2000 2223 2236
19. F. Qualia, G. De Rosa, E. Granata, F. Ungaro, E. Fattal, and M. Immacolata La Rotonda Feeding liquid, non-ionic surfactant and cyclodextrin affect the properties of insulin-loaded poly(lactide-co-glycolide) microspheres prepared by spray drying J. Control. Release 86 2003 267 278
20. C. Bouissou, U. Potter, H. Altroff, H. Mardon, and C. van der Walle Controlled release of the fibronectin central binding domain from polymeric microspheres J. Control. Release 95 2004 557 566
21. T. Ehtezazi, and C. Washington Controlled release of macromolecules from PLA microspheres: using porous structure topology J. Control. Release 68 2000 361 372
22. Y.-Y. Yang, H.-H. Chia, and T.-S. Chung Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method J. Control. Release 69 2000 81 96
23. M. Sandor, D. Enscore, P. Weston, and E. Mathiowitz Effect of protein molecular weight on release from micron-sized PLGA microspheres J. Control. Release 76 2001 297 311
24. V. Lemaire, J. Belair, and P. Hildgen Structural modeling of drug release from biodegradable porous matrices based on a combined diffusion/erosion process Int. J. Pharm. 258 2003 95 107