Structure-activity relationship (SAR) studies of 3-(2-amino-ethyl)-5-(4-ethoxy-benzylidene)-thiazolidine-2,4-dione: Development of potential substrate-specific ERK1/2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 6042-6046

  Li, Qianbin ^a   Al Ayoubi, Adnan ^b   Guo, Tailiang ^a   Zheng, Hui ^b   Sarkar, Aurijit ^a   Nguyen, Tri ^a   Eblen, Scott T ^b   Grant, Steven ^a   Kellogg, Glen E ^a   Zhang, Shijun ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

ERK1 2; Molecular modeling; Rational design; SAR; Substrate specific inhibitor; Synthesis; Thiazolidine 2,4 dione

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 (2 AMINO ETHYL) 5 (4 ETHOXYBENZYLIDENE) THIAZOLIDINE 2,4 DIONE; BENZENE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIAZOLIDINEDIONES;

EID: 71749119790     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.057     Document Type: Article

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