The Role of Striatal Nmda Receptors in Drug Addiction

International Review of Neurobiology

Volumn 89, Issue C, 2009, Pages 131-146

  Ma, Yao Ying ^a   Cepeda, Carlos ^b   Cui, Cai Lian ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Drug addiction; NMDA receptors; Nucleus accumbens; Opioids; Psychostimulants; Striatum

Indexed keywords

DOPAMINE; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

CORPUS STRIATUM; DRUG DEPENDENCE; HUMAN; INNERVATION; NERVE CELL PLASTICITY; NEUROPATHOLOGY; NEUROPHARMACOLOGY; NONHUMAN; NUCLEUS ACCUMBENS; OPIATE ADDICTION; PLACE PREFERENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RECEPTOR UPREGULATION; REVIEW; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TISSUE DISTRIBUTION; WITHDRAWAL SYNDROME;

ANIMALS; GLUTAMIC ACID; HUMANS; NEOSTRIATUM; PHOSPHORYLATION; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SUBSTANCE-RELATED DISORDERS; SYNAPSES;

EID: 71749119381     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7742(09)89006-5     Document Type: Review

References (81)

1. Afifi A.K. Basal ganglia: Functional anatomy and physiology. Part 2. J. Child Neurol. 9 (1994) 352-361
2. Aguilar M.A., Manzanedo C., Do Couto B.R., Rodriguez-Arias M., and Minarro J. Memantine blocks sensitization to the rewarding effects of morphine. Brain Res. 1288 (2009) 95-104
3. Bevins R.A., Besheer J., Palmatier M.I., Jensen H.C., Pickett K.S., and Eurek S. Novel-object place conditioning: Behavioral and dopaminergic processes in expression of novelty reward. Behav. Brain Res. 129 (2002) 41-50
4. Bibb J.A., Snyder G.L., Nishi A., Yan Z., Meijer L., Fienberg A.A., Tsai L.H., Kwon Y.T., Girault J.A., Czernik A.J., Huganir R.L., Hemmings Jr. H.C., et al. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature 402 (1999) 669-671
5. Bonuccelli U., and Del Dotto P. New pharmacologic horizons in the treatment of Parkinson disease. Neurology 67 (2006) S30-S38
6. Cepeda C., Buchwald N.A., and Levine M.S. Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated. Proc. Natl. Acad. Sci. USA 90 (1993) 9576-9580
7. Cepeda C., and Levine M.S. Dopamine and N-methyl-D-aspartate receptor interactions in the neostriatum. Dev. Neurosci. 20 (1998) 1-18
8. Cepeda C., Colwell C.S., Itri J.N., Chandler S.H., and Levine M.S. Dopaminergic modulation of NMDA-induced whole cell currents in neostriatal neurons in slices: Contribution of calcium conductances. J. Neurophysiol. 79 (1998) 82-94
9. Cervo L., and Samanin R. Effects of dopaminergic and glutamatergic receptor antagonists on the establishment and expression of conditioned locomotion to cocaine in rats. Brain Res. 731 (1996) 31-38
10. Chao J., and Nestler E.J. Molecular neurobiology of drug addiction. Annu. Rev. Med. 55 (2004) 113-132
11. Chapman D.E., Keefe K.A., and Wilcox K.S. Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. J. Neurophysiol. 89 (2003) 69-80
12. Chergui K., and Lacey M.G. Modulation by dopamine D1-like receptors of synaptic transmission and NMDA receptors in rat nucleus accumbens is attenuated by the protein kinase C inhibitor Ro 32-0432. Neuropharmacology 38 (1999) 223-231
13. Comer S.D., and Sullivan M.A. Memantine produces modest reductions in heroin-induced subjective responses in human research volunteers. Psychopharmacology (Berl) 193 (2007) 235-245
14. Cowan C.M., Fan M.M., Fan J., Shehadeh J., Zhang L.Y., Graham R.K., Hayden M.R., and Raymond L.A. Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: Impact on NMDA receptor function and toxicity. J. Neurosci. 28 (2008) 12725-12735
15. Crespo J.A., Oliva J.M., Ghasemzadeh M.B., Kalivas P.W., and Ambrosio E. Neuroadaptive changes in NMDAR1 gene expression after extinction of cocaine self-administration. Ann. N. Y. Acad. Sci. 965 (2002) 78-91
16. Darlison M.G. Invertebrate GABA and glutamate receptors: Molecular biology reveals predictable structures but some unusual pharmacologies. Trends Neurosci. 15 (1992) 469-474
17. De Kock M.F., and Lavand'homme P.M. The clinical role of NMDA receptor antagonists for the treatment of postoperative pain. Best Pract. Res. Clin. Anaesthesiol. 21 (2007) 85-98
18. Dingledine R., Borges K., Bowie D., and Traynelis S.F. The glutamate receptor ion channels. Pharmacol. Rev. 51 (1999) 7-61
19. Dudman J.T., Eaton M.E., Rajadhyaksha A., Macias W., Taher M., Barczak A., Kameyama K., Huganir R., and Konradi C. Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1. J. Neurochem. 87 (2003) 922-934
20. Dunah A.W., and Standaert D.G. Subcellular segregation of distinct heteromeric NMDA glutamate receptors in the striatum. J. Neurochem. 85 (2003) 935-943
21. Dunah A.W., Sirianni A.C., Fienberg A.A., Bastia E., Schwarzschild M.A., and Standaert D.G. Dopamine D1-dependent trafficking of striatal N-methyl-D-aspartate glutamate receptors requires Fyn protein tyrosine kinase but not DARPP-32. Mol. Pharmacol. 65 (2004) 121-129
22. Estrada-Sanchez A.M., Montiel T., Segovia J., and Massieu L. Glutamate toxicity in the striatum of the R6/2 Huntington's disease transgenic mice is age-dependent and correlates with decreased levels of glutamate transporters. Neurobiol. Dis. 34 (2009) 78-86
23. Fan M.M., Fernandes H.B., Zhang L.Y., Hayden M.R., and Raymond L.A. Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease. J. Neurosci. 27 (2007) 3768-3779
24. Gerfen C.R. The neostriatal mosaic: Compartmentalization of corticostriatal input and striatonigral output systems. Nature 311 (1984) 461-464
25. Gerfen C.R. Molecular effects of dopamine on striatal-projection pathways. Trends Neurosci. 23 (2000) S64-S70
26. Ghasemzadeh M.B., Mueller C., and Vasudevan P. Behavioral sensitization to cocaine is associated with increased glutamate receptor trafficking to the postsynaptic density after extended withdrawal period. Neuroscience 159 (2009) 414-426
27. Hall R.A., and Soderling T.R. Differential surface expression and phosphorylation of the N-methyl-D-aspartate receptor subunits NR1 and NR2 in cultured hippocampal neurons. J. Biol. Chem. 272 (1997) 4135-4140
28. Hallett P.J., Spoelgen R., Hyman B.T., Standaert D.G., and Dunah A.W. Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking. J. Neurosci. 26 (2006) 4690-4700
29. Hammerman C., and Kaplan M. Ischemia and reperfusion injury. The ultimate pathophysiologic paradox. Clin. Perinatol. 25 (1998) 757-777
30. Harvey J., and Lacey M.G. A postsynaptic interaction between dopamine D1 and NMDA receptors promotes presynaptic inhibition in the rat nucleus accumbens via adenosine release. J. Neurosci. 17 (1997) 5271-5280
31. Huang Y.H., Lin Y., Mu P., Lee B.R., Brown T.E., Wayman G., Marie H., Liu W., Yan Z., Sorg B.A., Schluter O.M., Zukin R.S., et al. In vivo cocaine experience generates silent synapses. Neuron 63 (2009) 40-47
32. Hyman S.E., Malenka R.C., and Nestler E.J. Neural mechanisms of addiction: The role of reward-related learning and memory. Annu. Rev. Neurosci. 29 (2006) 565-598
33. Kato H., Narita M., Suzuki M., Yoshimoto K., Yasuhara M., and Suzuki T. Role of tyrosine kinase-dependent phosphorylation of NR2B subunit-containing NMDA receptor in morphine reward. Nihon Arukoru Yakubutsu Igakkai Zasshi 42 (2007) 13-20
34. Kerdsan W., Thanoi S., and Nudmamud-Thanoi S. Changes in glutamate/NMDA receptor subunit 1 expression in rat brain after acute and subacute exposure to methamphetamine. J. Biomed. Biotechnol. 2009 (2009) 329631
35. Kim J.A., Pollak K.A., Hjelmstad G.O., and Fields H.L. A single cocaine exposure enhances both opioid reward and aversion through a ventral tegmental area-dependent mechanism. Proc. Natl. Acad. Sci. USA 101 (2004) 5664-5669
36. Kreitzer A.C., and Malenka R.C. Striatal plasticity and basal ganglia circuit function. Neuron 60 (2008) 543-554
37. Kuppenbender K.D., Standaert D.G., Feuerstein T.J., Penney Jr. J.B., Young A.B., and Landwehrmeyer G.B. Expression of NMDA receptor subunit mRNAs in neurochemically identified projection and interneurons in the human striatum. J. Comp. Neurol. 419 (2000) 407-421
38. Kutsuwada T., Kashiwabuchi N., Mori H., Sakimura K., Kushiya E., Araki K., Meguro H., Masaki H., Kumanishi T., Arakawa M., et al. Molecular diversity of the NMDA receptor channel. Nature 358 (1992) 36-41
39. Lee D.K., Bian S., Rahman M.A., Shim Y.B., Shim I., and Choe E.S. Repeated cocaine administration increases N-methyl-d-aspartate NR1 subunit, extracellular signal-regulated kinase and cyclic AMP response element-binding protein phosphorylation and glutamate release in the rat dorsal striatum. Eur. J. Pharmacol. 590 (2008) 157-162
40. Liu X.Y., Chu X.P., Mao L.M., Wang M., Lan H.X., Li M.H., Zhang G.C., Parelkar N.K., Fibuch E.E., Haines M., Neve K.A., Liu F., et al. Modulation of D2R-NR2B interactions in response to cocaine. Neuron 52 (2006) 897-909
41. Liu Z., Mao L., Parelkar N.K., Tang Q., Samdani S., and Wang J.Q. Distinct expression of phosphorylated N-methyl-D-aspartate receptor NR1 subunits by projection neurons and interneurons in the striatum of normal and amphetamine-treated rats. J. Comp. Neurol. 474 (2004) 393-406
42. Loftis J.M., and Janowsky A. Cocaine treatment- and withdrawal-induced alterations in the expression and serine phosphorylation of the NR1 NMDA receptor subunit. Psychopharmacology (Berl) 164 (2002) 349-359
43. Lu W., Monteggia L.M., and Wolf M.E. Withdrawal from repeated amphetamine administration reduces NMDAR1 expression in the rat substantia nigra, nucleus accumbens and medial prefrontal cortex. Eur. J. NeuroSci. 11 (1999) 3167-3177
44. Ma Y.Y., Chu N.N., Guo C.Y., Han J.S., and Cui C.L. NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement. Exp. Neurol. 203 (2007) 309-319
45. Ma Y.Y., Guo C.Y., Yu P., Lee D.Y., Han J.S., and Cui C.L. The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats. Exp. Neurol. 200 (2006) 343-355
46. Marino M.J., and Conn P.J. Direct and indirect modulation of the N-methyl D-aspartate receptor. Curr. Drug Targets CNS Neurol. Disord. 1 (2002) 1-16
47. Meredith G.E., Baldo B.A., Andrezjewski M.E., and Kelley A.E. The structural basis for mapping behavior onto the ventral striatum and its subdivisions. Brain Struct. Funct. 213 (2008) 17-27
48. Michaelis E.K. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog. Neurobiol. 54 (1998) 369-415
49. Monyer H., Burnashev N., Laurie D.J., Sakmann B., and Seeburg P.H. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12 (1994) 529-540
50. Mori H., and Mishina M. Structure and function of the NMDA receptor channel. Neuropharmacology 34 (1995) 1219-1237
51. Nakazawa T., Komai S., Tezuka T., Hisatsune C., Umemori H., Semba K., Mishina M., Manabe T., and Yamamoto T. Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. J. Biol. Chem. 276 (2001) 693-699
52. Narita M., Aoki T., and Suzuki T. Molecular evidence for the involvement of NR2B subunit containing N-methyl-D-aspartate receptors in the development of morphine-induced place preference. Neuroscience 101 (2000) 601-606
53. Nelson C.L., Milovanovic M., Wetter J.B., Ford K.A., and Wolf M.E. Behavioral sensitization to amphetamine is not accompanied by changes in glutamate receptor surface expression in the rat nucleus accumbens. J. Neurochem. 109 (2009) 35-51
54. Nestler E.J. Historical review: Molecular and cellular mechanisms of opiate and cocaine addiction. Trends Pharmacol. Sci. 25 (2004) 210-218
55. Nestler E.J. Molecular mechanisms of drug addiction. Neuropharmacology 47 Suppl. 1 (2004) 24-32
56. Ozaki S., Narita M., Ozaki M., Khotib J., and Suzuki T. Role of extracellular signal-regulated kinase in the ventral tegmental area in the suppression of the morphine-induced rewarding effect in mice with sciatic nerve ligation. J. Neurochem. 88 (2004) 1389-1397
57. Reynolds J.N., and Wickens J.R. Dopamine-dependent plasticity of corticostriatal synapses. Neural Netw. 15 (2002) 507-521
58. Sanchez-Blazquez P., Rodriguez-Munoz M., de la Torre-Madrid E., and Garzon J. Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell. Signal. 21 (2009) 1444-1454
59. Scheggi S., Mangiavacchi S., Masi F., Gambarana C., Tagliamonte A., and De Montis M.G. Dizocilpine infusion has a different effect in the development of morphine and cocaine sensitization: Behavioral and neurochemical aspects. Neuroscience 109 (2002) 267-274
60. Scheggi S., Rauggi R., Gambarana C., Tagliamonte A., and De Montis M.G. Dopamine and cyclic AMP-regulated phosphoprotein-32 phosphorylation pattern in cocaine and morphine-sensitized rats. J. Neurochem. 90 (2004) 792-799
61. Schoepfer R., Monyer H., Sommer B., Wisden W., Sprengel R., Kuner T., Lomeli H., Herb A., Kohler M., Burnashev N., et al. Molecular biology of glutamate receptors. Prog. Neurobiol. 42 (1994) 353-357
62. Schumann J., and Yaka R. Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens. J. Neurosci. 29 (2009) 6955-6963
63. Sesack S.R., and Grace A.A. Cortico-basal ganglia reward network: Microcircuitry. Neuropsychopharmacology (2009)
64. Shaham Y., Shalev U., Lu L., De Wit H., and Stewart J. The reinstatement model of drug relapse: History, methodology and major findings. Psychopharmacology (Berl) 168 (2003) 3-20
65. Simoes P.F., Silva A.P., Pereira F.C., Marques E., Grade S., Milhazes N., Borges F., Ribeiro C.F., and Macedo T.R. Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory. Neuroscience 150 (2007) 433-441
66. Smith Y., and Villalba R. Striatal and extrastriatal dopamine in the basal ganglia: An overview of its anatomical organization in normal and Parkinsonian brains. Mov. Disord. 23 Suppl. 3 (2008) S534-S547
67. Standaert D.G., Landwehrmeyer G.B., Kerner J.A., Penney Jr. J.B., and Young A.B. Expression of NMDAR2D glutamate receptor subunit mRNA in neurochemically identified interneurons in the rat neostriatum, neocortex and hippocampus. Brain Res. Mol. Brain Res. 42 (1996) 89-102
68. Stipanovich A., Valjent E., Matamales M., Nishi A., Ahn J.H., Maroteaux M., Bertran-Gonzalez J., Brami-Cherrier K., Enslen H., Corbille A.G., Filhol O., Nairn A.C., et al. A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature 453 (2008) 879-884
69. Sun X., Milovanovic M., Zhao Y., and Wolf M.E. Acute and chronic dopamine receptor stimulation modulates AMPA receptor trafficking in nucleus accumbens neurons cocultured with prefrontal cortex neurons. J. Neurosci. 28 (2008) 4216-4230
70. Suzuki T., and Okumura-Noji K. NMDA receptor subunits epsilon 1 (NR2A) and epsilon 2 (NR2B) are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain. Biochem. Biophys. Res. Commun. 216 (1995) 582-588
71. Svenningsson P., Nishi A., Fisone G., Girault J.A., Nairn A.C., and Greengard P. DARPP-32: An integrator of neurotransmission. Annu. Rev. Pharmacol. Toxicol. 44 (2004) 269-296
72. Thomas G.M., and Huganir R.L. MAPK cascade signalling and synaptic plasticity. Nat. Rev. Neurosci. 5 (2004) 173-183
73. Tzschentke T.M. Glutamatergic mechanisms in different disease states: Overview and therapeutical implications-An introduction. Amino Acids 23 (2002) 147-152
74. Valjent E., Corbille A.G., Bertran-Gonzalez J., Herve D., and Girault J.A. Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference. Proc. Natl. Acad. Sci. USA 103 (2006) 2932-2937
75. Valjent E., Corvol J.C., Pages C., Besson M.J., Maldonado R., and Caboche J. Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. J. Neurosci. 20 (2000) 8701-8709
76. Valjent E., Pascoli V., Svenningsson P., Paul S., Enslen H., Corvol J.C., Stipanovich A., Caboche J., Lombroso P.J., Nairn A.C., Greengard P., Herve D., et al. Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proc. Natl. Acad. Sci. USA 102 (2005) 491-496
77. Voorn P., Vanderschuren L.J., Groenewegen H.J., Robbins T.W., and Pennartz C.M. Putting a spin on the dorsal-ventral divide of the striatum. Trends Neurosci. 27 (2004) 468-474
78. Wang J.Q., Liu X., Zhang G., Parelkar N.K., Arora A., Haines M., Fibuch E.E., and Mao L. Phosphorylation of glutamate receptors: A potential mechanism for the regulation of receptor function and psychostimulant action. J. Neurosci. Res. 84 (2006) 1621-1629
79. Watanabe M., Inoue Y., Sakimura K., and Mishina M. Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain. J. Comp. Neurol. 338 (1993) 377-390
80. Watanabe M., Mishina M., and Inoue Y. Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum. J. Comp. Neurol. 343 (1994) 513-519
81. Zheng F., Gingrich M.B., Traynelis S.F., and Conn P.J. Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Nat. Neurosci. 1 (1998) 185-191