Pharmacological analysis of dopamine stimulation of [35S]-GTPγS binding via human D(2short) and D(2long) dopamine receptors expressed in recombinant cells

British Journal of Pharmacology

Volumn 118, Issue 6, 1996, Pages 1544-1550

  Gardner, B ^a   Hall, D A ^a   Strange, P G ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

Author keywords

D2; D3; Dopamine antagonists; Dopamine receptors; G protein; 35S GTP S binding

Indexed keywords

ADENYLATE CYCLASE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); RADIOLIGAND; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; DOSE RESPONSE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING;

EID: 0029976759     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15572.x     Document Type: Article

References (34)

1. ASANO, T. & ROSS, E.M. (1984). Catecholamine-stimulated guanosine 5′-O-(3-thiotriphosphate) binding to stimulatory GTP-binding protein of adenylyl cyclase: kinetic analysis in reconstituted phospholipid vesicles. Biochemistry, 23, 5467-5471.
2. BLACK, J.W. & LEFF, P. (1983). Operational models of pharmacological agonism. Proc. R. Soc. B., 220, 141-162.
3. BLACK, J.W. & SHANKLEY, N.P. (1990). Interpretation of agonist affinity estimations: The question of distributed receptor states. Proc. R. Soc. B, 240, 503-518.
4. 2 dopamine receptor. J. Neurochem., 60, 372-375.
5. 3 dopamine receptors to G-proteins. FEBS Lett., 315, 223-226.
6. 4 dopamine receptor-mediated signalling events determined in transfected Chinese hamster ovary cells. J. Biol. Chem., 269, 11813-11819.
7. CHIO, C.L., LAJINESS, M.E. & HUFF, R.M. (1994b). Activation of heterologously expressed D3 dopamine receptors: Comparison with D2 dopamine receptors. Mol. Pharmacol., 45, 51-60.
8. CIVELLI, O., BUNZOW, J.R. & GRANDY, D.K. (1993). Molecular diversity of the dopamine-receptors. Annu. Rev. Pharmacol. Toxicol, 33, 281-307.
9. CONKLIN, B.R. & BOURNE, H.R. (1993). Structural elements of Gα subunits that interact with Gβ, receptors, and effectors. Cell, 73, 631-641.
10. COSTA, T., OGINO, Y., MUNSON, P.J., ONARAN, H.O. & RODBARD, D. (1992). Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: Thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand. Mol. Pharmacol., 41, 549-560.
11. DE LEAN, A., STADEL, J.M. & LEFKOWITZ, R.J. (1980). A ternary complex model explains the agonist-specific binding properties of the adenylyl cyclase-coupled β-adrenergic receptor. J. Biol. Chem., 255, 7108-7117.
12. 2 dopamine receptor from bovine striatum. EMBO J., 8, 2353-2357.
13. i2 in GH4C1 pituitary cells. J. Biol. Chem., 269, 13880-13886.
14. FREISSMUTH, M., CASEY, P.J. & GILMAN, A.G. (1989). G proteins control diverse pathways of transmembrane signalling. FASEB J., 3, 2125-2131.
15. 3 dopamine receptor is negatively coupled to adenylyl cyclase. Br. J. Pharmacol. 114, 344.
16. 2B subtypes in a heterologous cell line. Mol. Endocrinol., 6, 920-926.
17. HILF, G., GIERSCHIK, P. & JAKOBS, K.H. (1992). Muscarinic acetylcholine receptors-stimulated binding of guanosine 5′-O-(3-thiotriphosphate) to guanine-nucleotide-binding proteins in cardiac membranes. Eur. J. Biochem., 186, 725-731.
18. KENAKIN, T.P. (1993). Pharmacologic Analysis of Drug-receptor Interactions, pp. 39-68. New York: Raven Press.
19. LAZARENO, S. & BIRDSALL, N.J.M. (1993a). Estimation of competitive antagonist affinity from functional inhibition curves using Gaddum, Schild and Cheng-Prusoff equations. Br. J. Pharmacol., 109, 1110-1119.
20. 35S]-GTPγS binding mediated by human muscarinic m1-m4 receptors: antagonist studies. Br. J. Pharmacol., 109, 1120-1127.
21. LAZARENO, S., FARRIES, T. & BIRDSALL, N.J.M. (1993). Pharmacological characterisation of guanine nucleotide exchange reactions in membranes from CHO cells stably transfected with human muscarinic receptors m1-m4. Life Sci., 52, 449-456.
22. LIMBIRD, L.E. (1988). Receptors linked to inhibition of adenylyl cyclase: Additional signalling mechanisms. FASEB J., 2, 2686-2695.
23. 3 receptors. Mol. Pharmacol., 43, 749-754.
24. 2 receptors. Proc. Natl. Acad. Sci. U.S.A., 88, 3135-3139.
25. 2 receptors and G-proteins. Mol. Endocrinol., 7, 161-170.
26. ROSS, E.M. (1989). Signal sorting and amplification through G protein-coupled receptors. Neuron, 3, 141-152.
27. SALOMON, Y., LONDOS, C. & RODBELL, M. (1974). A highly sensitive adenylate cyclase assay. Anal. Biochem., 58, 541-548.
28. iα proteins. J. Biol. Chem., 269, 23120-23127.
29. 2 dopamine receptor in a reconstituted system. J. Biol. Chem., 265, 4507-4514.
30. SIBLEY, D.R. & MONSMA, F.J. (1992). Molecular-biology of dopamine-receptors. Trends Pharmacol. Sci., 13, 61-69.
31. 1D receptor subtypes. J. Recep. Res., 15, 199-211.
32. 2-adrenergic receptor activation of G proteins: Evidence for a precoupled receptor/G protein state. Mol. Pharmacol., 45, 524-531.
33. 2 receptor. Trends Pharmacol. Sci., 10, 74-77.
34. 2-dopamine receptor of the anterior pituitary gland. Mol. Pharmacol., 26, 214-227.